PMC:7441788 / 664-1091 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7441788","sourcedb":"PMC","sourceid":"7441788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7441788","text":". These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist. Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progressio","tracks":[{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T10","span":{"begin":79,"end":87},"obj":"Disease"},{"id":"T11","span":{"begin":192,"end":200},"obj":"Disease"},{"id":"T12","span":{"begin":363,"end":371},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T3","span":{"begin":55,"end":56},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":89,"end":90},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":312,"end":313},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10","span":{"begin":149,"end":151},"obj":"Chemical"},{"id":"T11","span":{"begin":276,"end":278},"obj":"Chemical"},{"id":"T12","span":{"begin":314,"end":323},"obj":"Chemical"}],"attributes":[{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_25106"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T7","span":{"begin":149,"end":151},"obj":"Chemical"},{"id":"T8","span":{"begin":276,"end":278},"obj":"Chemical"},{"id":"T9","span":{"begin":314,"end":323},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_25106"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T8","span":{"begin":79,"end":87},"obj":"Species"},{"id":"T9","span":{"begin":192,"end":202},"obj":"Species"},{"id":"T10","span":{"begin":363,"end":371},"obj":"Species"}],"attributes":[{"id":"A8","pred":"ncbi_taxonomy_id","subj":"T8","obj":"NCBItxid:2697049"},{"id":"A9","pred":"ncbi_taxonomy_id","subj":"T9","obj":"NCBItxid:2697049"},{"id":"A10","pred":"ncbi_taxonomy_id","subj":"T10","obj":"NCBItxid:2697049"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T11","span":{"begin":2,"end":88},"obj":"Sentence"},{"id":"T12","span":{"begin":89,"end":238},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T11","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"40","span":{"begin":276,"end":282},"obj":"Gene"},{"id":"44","span":{"begin":167,"end":180},"obj":"Species"},{"id":"45","span":{"begin":192,"end":202},"obj":"Species"},{"id":"52","span":{"begin":149,"end":151},"obj":"Chemical"},{"id":"53","span":{"begin":152,"end":155},"obj":"Chemical"},{"id":"54","span":{"begin":314,"end":323},"obj":"Chemical"},{"id":"67","span":{"begin":79,"end":87},"obj":"Disease"},{"id":"68","span":{"begin":363,"end":371},"obj":"Disease"},{"id":"69","span":{"begin":403,"end":416},"obj":"Disease"}],"attributes":[{"id":"A44","pred":"pubann:denotes","subj":"44","obj":"Tax:11118"},{"id":"A67","pred":"pubann:denotes","subj":"67","obj":"MESH:C000657245"},{"id":"A52","pred":"pubann:denotes","subj":"52","obj":"MESH:D002738"},{"id":"A54","pred":"pubann:denotes","subj":"54","obj":"MESH:D018942"},{"id":"A53","pred":"pubann:denotes","subj":"53","obj":"MESH:D006886"},{"id":"A69","pred":"pubann:denotes","subj":"69","obj":"MESH:D003141"},{"id":"A68","pred":"pubann:denotes","subj":"68","obj":"MESH:C000657245"},{"id":"A45","pred":"pubann:denotes","subj":"45","obj":"Tax:2697049"},{"subj":"40","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"44","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"45","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"52","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"53","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"54","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"67","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"68","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"69","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T3","span":{"begin":351,"end":359},"obj":"http://purl.obolibrary.org/obo/OGMS_0000020"},{"id":"T4","span":{"begin":409,"end":416},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T4","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T8","span":{"begin":79,"end":87},"obj":"Disease"},{"id":"T9","span":{"begin":192,"end":202},"obj":"Disease"},{"id":"T10","span":{"begin":363,"end":371},"obj":"Disease"}],"attributes":[{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"40","span":{"begin":276,"end":282},"obj":"Gene"},{"id":"44","span":{"begin":167,"end":180},"obj":"Species"},{"id":"45","span":{"begin":192,"end":202},"obj":"Species"},{"id":"52","span":{"begin":149,"end":151},"obj":"Chemical"},{"id":"53","span":{"begin":152,"end":155},"obj":"Chemical"},{"id":"54","span":{"begin":314,"end":323},"obj":"Chemical"},{"id":"67","span":{"begin":79,"end":87},"obj":"Disease"},{"id":"68","span":{"begin":363,"end":371},"obj":"Disease"},{"id":"69","span":{"begin":403,"end":416},"obj":"Disease"}],"attributes":[{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Tax:11118"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Tax:2697049"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:D002738"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:D006886"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"MESH:D018942"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:C000657245"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"MESH:C000657245"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D003141"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"},{"subj":"52","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"67","pred":"source","obj":"LitCovid-PubTator"},{"subj":"68","pred":"source","obj":"LitCovid-PubTator"},{"subj":"69","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T11","span":{"begin":2,"end":88},"obj":"Sentence"},{"id":"T12","span":{"begin":89,"end":238},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-MONDO","color":"#93eceb","default":true},{"id":"LitCovid-PD-CLO","color":"#ecd193"},{"id":"LitCovid-PD-CHEBI","color":"#b793ec"},{"id":"LitCovid-sample-CHEBI","color":"#93ec9d"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#ec93a2"},{"id":"LitCovid-sample-sentences","color":"#93bcec"},{"id":"LitCovid-sample-Pubtator","color":"#d7ec93"},{"id":"LitCovid-sample-PD-IDO","color":"#e793ec"},{"id":"LitCovid-sample-PD-MONDO","color":"#93eccd"},{"id":"LitCovid-PubTator","color":"#ecb393"},{"id":"LitCovid-sentences","color":"#9993ec"}]}]}}