PMC:7441788 / 6577-7035 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7441788","sourcedb":"PMC","sourceid":"7441788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7441788","text":"19.25) [17]. These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro. However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were \u003e100 μM and 18.01 μM, ","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T22","span":{"begin":145,"end":149},"obj":"Body_part"},{"id":"T23","span":{"begin":210,"end":215},"obj":"Body_part"},{"id":"T24","span":{"begin":405,"end":410},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T56","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"T57","span":{"begin":179,"end":187},"obj":"Disease"},{"id":"T58","span":{"begin":190,"end":199},"obj":"Disease"},{"id":"T59","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"T60","span":{"begin":385,"end":394},"obj":"Disease"}],"attributes":[{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T63","span":{"begin":61,"end":69},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T64","span":{"begin":145,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T65","span":{"begin":203,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T66","span":{"begin":327,"end":329},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T67","span":{"begin":398,"end":410},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"attributes":[{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T78","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"T79","span":{"begin":237,"end":239},"obj":"Chemical"},{"id":"T80","span":{"begin":428,"end":430},"obj":"Chemical"}],"attributes":[{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T53","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"T54","span":{"begin":237,"end":239},"obj":"Chemical"},{"id":"T55","span":{"begin":428,"end":430},"obj":"Chemical"}],"attributes":[{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T53","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T54","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T55","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T62","span":{"begin":50,"end":60},"obj":"Species"},{"id":"T63","span":{"begin":179,"end":189},"obj":"Species"},{"id":"T64","span":{"begin":374,"end":384},"obj":"Species"}],"attributes":[{"id":"A62","pred":"ncbi_taxonomy_id","subj":"T62","obj":"NCBItxid:2697049"},{"id":"A63","pred":"ncbi_taxonomy_id","subj":"T63","obj":"NCBItxid:2697049"},{"id":"A64","pred":"ncbi_taxonomy_id","subj":"T64","obj":"NCBItxid:2697049"},{"subj":"T62","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T63","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T64","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T53","span":{"begin":13,"end":118},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T53","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"281","span":{"begin":263,"end":265},"obj":"Gene"},{"id":"282","span":{"begin":454,"end":456},"obj":"Gene"},{"id":"283","span":{"begin":313,"end":315},"obj":"Gene"},{"id":"287","span":{"begin":441,"end":443},"obj":"Gene"},{"id":"288","span":{"begin":301,"end":303},"obj":"Gene"},{"id":"289","span":{"begin":251,"end":253},"obj":"Gene"},{"id":"292","span":{"begin":50,"end":60},"obj":"Species"},{"id":"301","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"302","span":{"begin":105,"end":108},"obj":"Chemical"},{"id":"307","span":{"begin":184,"end":199},"obj":"Disease"},{"id":"308","span":{"begin":374,"end":394},"obj":"Disease"},{"id":"310","span":{"begin":203,"end":209},"obj":"CellLine"},{"id":"311","span":{"begin":398,"end":404},"obj":"CellLine"}],"attributes":[{"id":"A287","pred":"pubann:denotes","subj":"287","obj":"Gene:56925"},{"id":"A310","pred":"pubann:denotes","subj":"310","obj":"CVCL:0574"},{"id":"A292","pred":"pubann:denotes","subj":"292","obj":"Tax:2697049"},{"id":"A288","pred":"pubann:denotes","subj":"288","obj":"Gene:56925"},{"id":"A311","pred":"pubann:denotes","subj":"311","obj":"CVCL:0574"},{"id":"A307","pred":"pubann:denotes","subj":"307","obj":"MESH:C000657245"},{"id":"A301","pred":"pubann:denotes","subj":"301","obj":"MESH:D002738"},{"id":"A281","pred":"pubann:denotes","subj":"281","obj":"Gene:56925"},{"id":"A283","pred":"pubann:denotes","subj":"283","obj":"Gene:56925"},{"id":"A282","pred":"pubann:denotes","subj":"282","obj":"Gene:56925"},{"id":"A302","pred":"pubann:denotes","subj":"302","obj":"MESH:D006886"},{"id":"A289","pred":"pubann:denotes","subj":"289","obj":"Gene:56925"},{"id":"A308","pred":"pubann:denotes","subj":"308","obj":"MESH:C000657245"},{"subj":"281","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"282","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"283","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"287","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"288","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"289","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"292","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"301","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"302","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"307","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"308","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"310","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"311","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T51","span":{"begin":145,"end":149},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T52","span":{"begin":190,"end":199},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T53","span":{"begin":210,"end":215},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T54","span":{"begin":385,"end":394},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T55","span":{"begin":405,"end":410},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"attributes":[{"subj":"T51","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T52","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T53","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T54","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T55","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T22","span":{"begin":145,"end":149},"obj":"Body_part"},{"id":"T23","span":{"begin":210,"end":215},"obj":"Body_part"},{"id":"T24","span":{"begin":405,"end":410},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T22","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T23","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T24","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T49","span":{"begin":50,"end":60},"obj":"Disease"},{"id":"T50","span":{"begin":179,"end":189},"obj":"Disease"},{"id":"T51","span":{"begin":190,"end":199},"obj":"Disease"},{"id":"T52","span":{"begin":374,"end":384},"obj":"Disease"},{"id":"T53","span":{"begin":385,"end":394},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T49","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"281","span":{"begin":263,"end":265},"obj":"Gene"},{"id":"282","span":{"begin":454,"end":456},"obj":"Gene"},{"id":"283","span":{"begin":313,"end":315},"obj":"Gene"},{"id":"287","span":{"begin":441,"end":443},"obj":"Gene"},{"id":"288","span":{"begin":301,"end":303},"obj":"Gene"},{"id":"289","span":{"begin":251,"end":253},"obj":"Gene"},{"id":"292","span":{"begin":50,"end":60},"obj":"Species"},{"id":"301","span":{"begin":73,"end":75},"obj":"Chemical"},{"id":"302","span":{"begin":105,"end":108},"obj":"Chemical"},{"id":"307","span":{"begin":184,"end":199},"obj":"Disease"},{"id":"308","span":{"begin":374,"end":394},"obj":"Disease"},{"id":"310","span":{"begin":203,"end":209},"obj":"CellLine"},{"id":"311","span":{"begin":398,"end":404},"obj":"CellLine"}],"attributes":[{"id":"A281","pred":"tao:has_database_id","subj":"281","obj":"Gene:56925"},{"id":"A282","pred":"tao:has_database_id","subj":"282","obj":"Gene:56925"},{"id":"A283","pred":"tao:has_database_id","subj":"283","obj":"Gene:56925"},{"id":"A287","pred":"tao:has_database_id","subj":"287","obj":"Gene:56925"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"Gene:56925"},{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:56925"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"Tax:2697049"},{"id":"A301","pred":"tao:has_database_id","subj":"301","obj":"MESH:D002738"},{"id":"A302","pred":"tao:has_database_id","subj":"302","obj":"MESH:D006886"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"MESH:C000657245"},{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"MESH:C000657245"},{"id":"A310","pred":"tao:has_database_id","subj":"310","obj":"CVCL:0574"},{"id":"A311","pred":"tao:has_database_id","subj":"311","obj":"CVCL:0574"},{"subj":"281","pred":"source","obj":"LitCovid-PubTator"},{"subj":"282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"287","pred":"source","obj":"LitCovid-PubTator"},{"subj":"288","pred":"source","obj":"LitCovid-PubTator"},{"subj":"289","pred":"source","obj":"LitCovid-PubTator"},{"subj":"292","pred":"source","obj":"LitCovid-PubTator"},{"subj":"301","pred":"source","obj":"LitCovid-PubTator"},{"subj":"302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"307","pred":"source","obj":"LitCovid-PubTator"},{"subj":"308","pred":"source","obj":"LitCovid-PubTator"},{"subj":"310","pred":"source","obj":"LitCovid-PubTator"},{"subj":"311","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":13,"end":118},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T53","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32496926-32194981-132195665","span":{"begin":8,"end":10},"obj":"32194981"}],"attributes":[{"subj":"32496926-32194981-132195665","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#af93ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ec95"},{"id":"LitCovid-PD-CLO","color":"#ec93ab"},{"id":"LitCovid-PD-CHEBI","color":"#93c5ec"},{"id":"LitCovid-sample-CHEBI","color":"#dfec93"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#df93ec"},{"id":"LitCovid-sample-sentences","color":"#93ecc5"},{"id":"LitCovid-sample-Pubtator","color":"#ecab93"},{"id":"LitCovid-sample-PD-IDO","color":"#9394ec"},{"id":"LitCovid-sample-PD-FMA","color":"#aeec93"},{"id":"LitCovid-sample-PD-MONDO","color":"#ec93c8"},{"id":"LitCovid-PubTator","color":"#93e2ec"},{"id":"LitCovid-sentences","color":"#ecdb93"},{"id":"2_test","color":"#c193ec"}]}]}}