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PMC:7441788 / 6032-7424 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T19 10-15 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 182-187 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 206-210 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 690-694 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 755-760 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 950-955 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 1255-1259 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T52 53-61 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 162-170 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 248-257 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 294-302 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 595-603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 724-732 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 735-744 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 919-927 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 930-939 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T61 1127-1135 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 1372-1380 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T60 3-15 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T61 182-187 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62 206-215 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T63 606-614 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T64 690-694 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 748-760 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T66 872-874 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T67 943-955 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T68 1067-1069 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T69 1087-1089 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T70 1138-1146 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T71 1255-1259 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T72 1383-1391 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T72 36-38 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T73 42-44 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T74 109-111 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T75 319-321 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T76 443-445 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T77 449-451 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T78 618-620 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T79 782-784 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T80 973-975 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T81 1150-1152 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T82 1348-1350 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T3 1260-1267 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T49 42-44 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T50 109-111 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T51 319-321 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T52 449-451 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T53 618-620 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T54 782-784 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T55 973-975 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T56 1150-1152 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T57 1348-1350 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T59 53-63 Species denotes SARS-CoV-2 NCBItxid:2697049
T60 162-172 Species denotes SARS-CoV-2 NCBItxid:2697049
T61 294-304 Species denotes SARS-CoV-2 NCBItxid:2697049
T62 595-605 Species denotes SARS-CoV-2 NCBItxid:2697049
T63 724-734 Species denotes SARS-CoV-2 NCBItxid:2697049
T64 919-929 Species denotes SARS-CoV-2 NCBItxid:2697049
T65 1127-1137 Species denotes SARS-CoV-2 NCBItxid:2697049
T66 1372-1382 Species denotes SARS-CoV-2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T49 0-108 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 109-193 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 194-424 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 425-557 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 558-663 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 664-1091 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 1092-1181 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 1182-1304 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 1305-1392 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
278 74-76 Gene denotes μM Gene:56925
279 350-352 Gene denotes μM Gene:56925
280 420-422 Gene denotes μM Gene:56925
281 808-810 Gene denotes μM Gene:56925
282 999-1001 Gene denotes μM Gene:56925
283 858-860 Gene denotes μM Gene:56925
284 1348-1354 Gene denotes CQ/HCQ
285 1053-1055 Gene denotes μM Gene:56925
286 1041-1043 Gene denotes μM Gene:56925
287 986-988 Gene denotes μM Gene:56925
288 846-848 Gene denotes μM Gene:56925
289 796-798 Gene denotes μM Gene:56925
290 53-63 Species denotes SARS-CoV-2 Tax:2697049
291 294-304 Species denotes SARS-CoV-2 Tax:2697049
292 595-605 Species denotes SARS-CoV-2 Tax:2697049
293 1127-1137 Species denotes SARS-CoV-2 Tax:2697049
294 1372-1382 Species denotes SARS-CoV-2 Tax:2697049
295 42-44 Chemical denotes CQ MESH:D002738
296 109-111 Chemical denotes CQ MESH:D002738
297 319-321 Chemical denotes CQ MESH:D002738
298 386-389 Chemical denotes HCQ MESH:D006886
299 449-451 Chemical denotes CQ MESH:D002738
300 519-522 Chemical denotes HCQ MESH:D006886
301 618-620 Chemical denotes CQ MESH:D002738
302 650-653 Chemical denotes HCQ MESH:D006886
303 1150-1152 Chemical denotes CQ MESH:D002738
304 1168-1171 Chemical denotes HCQ MESH:D006886
305 162-181 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 248-257 Disease denotes infection MESH:D007239
307 729-744 Disease denotes CoV-2 infection MESH:C000657245
308 919-939 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 3-9 CellLine denotes VeroE6 CVCL:0574
310 748-754 CellLine denotes VeroE6 CVCL:0574
311 943-949 CellLine denotes VeroE6 CVCL:0574

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T45 10-15 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 112-122 http://purl.obolibrary.org/obo/BFO_0000034 denotes functioned
T47 173-181 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T48 182-187 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 206-210 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T50 248-257 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T51 690-694 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T52 735-744 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T53 755-760 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T54 930-939 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T55 950-955 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 1255-1259 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T19 10-15 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 182-187 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 206-210 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 690-694 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 755-760 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 950-955 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 1255-1259 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T45 53-63 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T46 162-172 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T47 248-257 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T48 294-304 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T49 595-605 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T50 724-734 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T51 735-744 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 919-929 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T53 930-939 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 1127-1137 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T55 1372-1382 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
278 74-76 Gene denotes μM Gene:56925
279 350-352 Gene denotes μM Gene:56925
280 420-422 Gene denotes μM Gene:56925
281 808-810 Gene denotes μM Gene:56925
282 999-1001 Gene denotes μM Gene:56925
283 858-860 Gene denotes μM Gene:56925
284 1348-1354 Gene denotes CQ/HCQ
285 1053-1055 Gene denotes μM Gene:56925
286 1041-1043 Gene denotes μM Gene:56925
287 986-988 Gene denotes μM Gene:56925
288 846-848 Gene denotes μM Gene:56925
289 796-798 Gene denotes μM Gene:56925
290 53-63 Species denotes SARS-CoV-2 Tax:2697049
291 294-304 Species denotes SARS-CoV-2 Tax:2697049
292 595-605 Species denotes SARS-CoV-2 Tax:2697049
293 1127-1137 Species denotes SARS-CoV-2 Tax:2697049
294 1372-1382 Species denotes SARS-CoV-2 Tax:2697049
295 42-44 Chemical denotes CQ MESH:D002738
296 109-111 Chemical denotes CQ MESH:D002738
297 319-321 Chemical denotes CQ MESH:D002738
298 386-389 Chemical denotes HCQ MESH:D006886
299 449-451 Chemical denotes CQ MESH:D002738
300 519-522 Chemical denotes HCQ MESH:D006886
301 618-620 Chemical denotes CQ MESH:D002738
302 650-653 Chemical denotes HCQ MESH:D006886
303 1150-1152 Chemical denotes CQ MESH:D002738
304 1168-1171 Chemical denotes HCQ MESH:D006886
305 162-181 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 248-257 Disease denotes infection MESH:D007239
307 729-744 Disease denotes CoV-2 infection MESH:C000657245
308 919-939 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 3-9 CellLine denotes VeroE6 CVCL:0574
310 748-754 CellLine denotes VeroE6 CVCL:0574
311 943-949 CellLine denotes VeroE6 CVCL:0574

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T49 0-108 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 109-193 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 194-424 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 425-557 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 558-663 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 664-1091 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 1092-1181 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 1182-1304 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 1305-1392 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.

2_test

Id Subject Object Predicate Lexical cue
32496926-32020029-132195664 189-191 32020029 denotes 16
32496926-32194981-132195665 553-555 32194981 denotes 17