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PMC:7441788 / 5971-7424 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T19 71-76 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 243-248 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 267-271 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 751-755 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 816-821 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 1011-1016 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 1316-1320 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T51 41-49 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 114-122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 223-231 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 309-318 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 355-363 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 656-664 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 785-793 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 796-805 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 980-988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 991-1000 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T61 1188-1196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 1433-1441 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T59 14-22 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T60 64-76 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T61 243-248 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62 267-276 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T63 667-675 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T64 751-755 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 809-821 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T66 933-935 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T67 1004-1016 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T68 1128-1130 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T69 1148-1150 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T70 1199-1207 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T71 1316-1320 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T72 1444-1452 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T71 26-28 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T72 97-99 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T73 103-105 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T74 170-172 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T75 380-382 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T76 504-506 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T77 510-512 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T78 679-681 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T79 843-845 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T80 1034-1036 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T81 1211-1213 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T82 1409-1411 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T3 1321-1328 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T48 26-28 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T49 103-105 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T50 170-172 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T51 380-382 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T52 510-512 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T53 679-681 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T54 843-845 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T55 1034-1036 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T56 1211-1213 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T57 1409-1411 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T58 41-51 Species denotes SARS-CoV-2 NCBItxid:2697049
T59 114-124 Species denotes SARS-CoV-2 NCBItxid:2697049
T60 223-233 Species denotes SARS-CoV-2 NCBItxid:2697049
T61 355-365 Species denotes SARS-CoV-2 NCBItxid:2697049
T62 656-666 Species denotes SARS-CoV-2 NCBItxid:2697049
T63 785-795 Species denotes SARS-CoV-2 NCBItxid:2697049
T64 980-990 Species denotes SARS-CoV-2 NCBItxid:2697049
T65 1188-1198 Species denotes SARS-CoV-2 NCBItxid:2697049
T66 1433-1443 Species denotes SARS-CoV-2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T47 0-2 Sentence denotes 3.
T48 4-60 Sentence denotes Antiviral activity of CQ/HCQ against SARS-CoV-2 in vitro
T49 61-169 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 170-254 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 255-485 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 486-618 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 619-724 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 725-1152 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 1153-1242 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 1243-1365 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 1366-1453 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
242 26-32 Gene denotes CQ/HCQ
243 41-51 Species denotes SARS-CoV-2 Tax:2697049
278 135-137 Gene denotes μM Gene:56925
279 411-413 Gene denotes μM Gene:56925
280 481-483 Gene denotes μM Gene:56925
281 869-871 Gene denotes μM Gene:56925
282 1060-1062 Gene denotes μM Gene:56925
283 919-921 Gene denotes μM Gene:56925
284 1409-1415 Gene denotes CQ/HCQ
285 1114-1116 Gene denotes μM Gene:56925
286 1102-1104 Gene denotes μM Gene:56925
287 1047-1049 Gene denotes μM Gene:56925
288 907-909 Gene denotes μM Gene:56925
289 857-859 Gene denotes μM Gene:56925
290 114-124 Species denotes SARS-CoV-2 Tax:2697049
291 355-365 Species denotes SARS-CoV-2 Tax:2697049
292 656-666 Species denotes SARS-CoV-2 Tax:2697049
293 1188-1198 Species denotes SARS-CoV-2 Tax:2697049
294 1433-1443 Species denotes SARS-CoV-2 Tax:2697049
295 103-105 Chemical denotes CQ MESH:D002738
296 170-172 Chemical denotes CQ MESH:D002738
297 380-382 Chemical denotes CQ MESH:D002738
298 447-450 Chemical denotes HCQ MESH:D006886
299 510-512 Chemical denotes CQ MESH:D002738
300 580-583 Chemical denotes HCQ MESH:D006886
301 679-681 Chemical denotes CQ MESH:D002738
302 711-714 Chemical denotes HCQ MESH:D006886
303 1211-1213 Chemical denotes CQ MESH:D002738
304 1229-1232 Chemical denotes HCQ MESH:D006886
305 223-242 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 309-318 Disease denotes infection MESH:D007239
307 790-805 Disease denotes CoV-2 infection MESH:C000657245
308 980-1000 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 64-70 CellLine denotes VeroE6 CVCL:0574
310 809-815 CellLine denotes VeroE6 CVCL:0574
311 1004-1010 CellLine denotes VeroE6 CVCL:0574

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T44 4-13 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T45 71-76 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 173-183 http://purl.obolibrary.org/obo/BFO_0000034 denotes functioned
T47 234-242 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T48 243-248 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 267-271 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T50 309-318 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T51 751-755 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T52 796-805 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T53 816-821 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T54 991-1000 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T55 1011-1016 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 1316-1320 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T19 71-76 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 243-248 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 267-271 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 751-755 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 816-821 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 1011-1016 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 1316-1320 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T44 41-51 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T45 114-124 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T46 223-233 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T47 309-318 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T48 355-365 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T49 656-666 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T50 785-795 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T51 796-805 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 980-990 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T53 991-1000 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 1188-1198 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T55 1433-1443 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
242 26-32 Gene denotes CQ/HCQ
243 41-51 Species denotes SARS-CoV-2 Tax:2697049
278 135-137 Gene denotes μM Gene:56925
279 411-413 Gene denotes μM Gene:56925
280 481-483 Gene denotes μM Gene:56925
281 869-871 Gene denotes μM Gene:56925
282 1060-1062 Gene denotes μM Gene:56925
283 919-921 Gene denotes μM Gene:56925
284 1409-1415 Gene denotes CQ/HCQ
285 1114-1116 Gene denotes μM Gene:56925
286 1102-1104 Gene denotes μM Gene:56925
287 1047-1049 Gene denotes μM Gene:56925
288 907-909 Gene denotes μM Gene:56925
289 857-859 Gene denotes μM Gene:56925
290 114-124 Species denotes SARS-CoV-2 Tax:2697049
291 355-365 Species denotes SARS-CoV-2 Tax:2697049
292 656-666 Species denotes SARS-CoV-2 Tax:2697049
293 1188-1198 Species denotes SARS-CoV-2 Tax:2697049
294 1433-1443 Species denotes SARS-CoV-2 Tax:2697049
295 103-105 Chemical denotes CQ MESH:D002738
296 170-172 Chemical denotes CQ MESH:D002738
297 380-382 Chemical denotes CQ MESH:D002738
298 447-450 Chemical denotes HCQ MESH:D006886
299 510-512 Chemical denotes CQ MESH:D002738
300 580-583 Chemical denotes HCQ MESH:D006886
301 679-681 Chemical denotes CQ MESH:D002738
302 711-714 Chemical denotes HCQ MESH:D006886
303 1211-1213 Chemical denotes CQ MESH:D002738
304 1229-1232 Chemical denotes HCQ MESH:D006886
305 223-242 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 309-318 Disease denotes infection MESH:D007239
307 790-805 Disease denotes CoV-2 infection MESH:C000657245
308 980-1000 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 64-70 CellLine denotes VeroE6 CVCL:0574
310 809-815 CellLine denotes VeroE6 CVCL:0574
311 1004-1010 CellLine denotes VeroE6 CVCL:0574

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T47 0-2 Sentence denotes 3.
T48 4-60 Sentence denotes Antiviral activity of CQ/HCQ against SARS-CoV-2 in vitro
T49 61-169 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 170-254 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 255-485 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 486-618 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 619-724 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 725-1152 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 1153-1242 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 1243-1365 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 1366-1453 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.

2_test

Id Subject Object Predicate Lexical cue
32496926-32020029-132195664 250-252 32020029 denotes 16
32496926-32194981-132195665 614-616 32194981 denotes 17