PMC:7441788 / 5009-5436 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T14","span":{"begin":114,"end":119},"obj":"Body_part"},{"id":"T15","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62100"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T45","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T46","span":{"begin":107,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0051972"},{"id":"T47","span":{"begin":107,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0051973"},{"id":"T48","span":{"begin":107,"end":113},"obj":"http://purl.obolibrary.org/obo/CLO_0003836"},{"id":"T49","span":{"begin":135,"end":143},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T50","span":{"begin":309,"end":317},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T51","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T60","span":{"begin":40,"end":49},"obj":"Chemical"},{"id":"T61","span":{"begin":84,"end":86},"obj":"Chemical"},{"id":"T62","span":{"begin":125,"end":134},"obj":"Chemical"},{"id":"T63","span":{"begin":147,"end":149},"obj":"Chemical"},{"id":"T64","span":{"begin":233,"end":235},"obj":"Chemical"},{"id":"T65","span":{"begin":279,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_90326"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T40","span":{"begin":84,"end":86},"obj":"Chemical"},{"id":"T41","span":{"begin":147,"end":149},"obj":"Chemical"},{"id":"T42","span":{"begin":279,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T47","span":{"begin":158,"end":167},"obj":"Species"},{"id":"T48","span":{"begin":299,"end":308},"obj":"Species"},{"id":"T49","span":{"begin":371,"end":376},"obj":"Species"}],"attributes":[{"id":"A47","pred":"ncbi_taxonomy_id","subj":"T47","obj":"NCBItxid:31631"},{"id":"A48","pred":"ncbi_taxonomy_id","subj":"T48","obj":"NCBItxid:31631"},{"id":"A49","pred":"ncbi_taxonomy_id","subj":"T49","obj":"NCBItxid:10090"},{"id":"A50","pred":"ncbi_taxonomy_id","subj":"T49","obj":"NCBItxid:10088"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T41","span":{"begin":104,"end":250},"obj":"Sentence"},{"id":"T42","span":{"begin":251,"end":356},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T1","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001913"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"195","span":{"begin":198,"end":200},"obj":"Gene"},{"id":"196","span":{"begin":225,"end":227},"obj":"Gene"},{"id":"202","span":{"begin":158,"end":167},"obj":"Species"},{"id":"210","span":{"begin":147,"end":149},"obj":"Chemical"},{"id":"215","span":{"begin":107,"end":113},"obj":"CellLine"},{"id":"228","span":{"begin":371,"end":376},"obj":"Species"},{"id":"233","span":{"begin":299,"end":308},"obj":"Species"},{"id":"234","span":{"begin":279,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A228","pred":"pubann:denotes","subj":"228","obj":"Tax:10090"},{"id":"A233","pred":"pubann:denotes","subj":"233","obj":"Tax:31631"},{"id":"A202","pred":"pubann:denotes","subj":"202","obj":"Tax:31631"},{"id":"A195","pred":"pubann:denotes","subj":"195","obj":"Gene:56925"},{"id":"A215","pred":"pubann:denotes","subj":"215","obj":"CVCL:2514"},{"id":"A234","pred":"pubann:denotes","subj":"234","obj":"MESH:D002738"},{"id":"A196","pred":"pubann:denotes","subj":"196","obj":"Gene:56925"},{"id":"A210","pred":"pubann:denotes","subj":"210","obj":"MESH:D002738"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T39","span":{"begin":40,"end":49},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"},{"id":"T40","span":{"begin":114,"end":119},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T41","span":{"begin":125,"end":134},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T14","span":{"begin":114,"end":119},"obj":"Body_part"},{"id":"T15","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma62100"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-PubTator","denotations":[{"id":"195","span":{"begin":198,"end":200},"obj":"Gene"},{"id":"196","span":{"begin":225,"end":227},"obj":"Gene"},{"id":"202","span":{"begin":158,"end":167},"obj":"Species"},{"id":"210","span":{"begin":147,"end":149},"obj":"Chemical"},{"id":"215","span":{"begin":107,"end":113},"obj":"CellLine"},{"id":"228","span":{"begin":371,"end":376},"obj":"Species"},{"id":"233","span":{"begin":299,"end":308},"obj":"Species"},{"id":"234","span":{"begin":279,"end":281},"obj":"Chemical"}],"attributes":[{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Gene:56925"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Gene:56925"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Tax:31631"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"MESH:D002738"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"CVCL:2514"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Tax:10090"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Tax:31631"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"LitCovid-sentences","denotations":[{"id":"T41","span":{"begin":104,"end":250},"obj":"Sentence"},{"id":"T42","span":{"begin":251,"end":356},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}

{"project":"2_test","denotations":[{"id":"32496926-16115318-132195660","span":{"begin":99,"end":101},"obj":"16115318"},{"id":"32496926-19506054-132195661","span":{"begin":246,"end":248},"obj":"19506054"}],"text":"ly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]. In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].\nAn in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. The data from mouse models showed that 98.6% of the pups survived when"}