PMC:7441788 / 4622-5112 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T47","span":{"begin":86,"end":104},"obj":"Disease"},{"id":"T48","span":{"begin":95,"end":104},"obj":"Disease"},{"id":"T49","span":{"begin":287,"end":296},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T40","span":{"begin":15,"end":21},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T41","span":{"begin":234,"end":239},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T42","span":{"begin":261,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0001751"},{"id":"T43","span":{"begin":313,"end":315},"obj":"http://purl.obolibrary.org/obo/CLO_0001527"},{"id":"T44","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T45","span":{"begin":445,"end":446},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T56","span":{"begin":48,"end":50},"obj":"Chemical"},{"id":"T57","span":{"begin":138,"end":140},"obj":"Chemical"},{"id":"T58","span":{"begin":203,"end":205},"obj":"Chemical"},{"id":"T59","span":{"begin":330,"end":332},"obj":"Chemical"},{"id":"T60","span":{"begin":427,"end":436},"obj":"Chemical"},{"id":"T61","span":{"begin":471,"end":473},"obj":"Chemical"}],"attributes":[{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T36","span":{"begin":48,"end":50},"obj":"Chemical"},{"id":"T37","span":{"begin":138,"end":140},"obj":"Chemical"},{"id":"T38","span":{"begin":203,"end":205},"obj":"Chemical"},{"id":"T39","span":{"begin":330,"end":332},"obj":"Chemical"},{"id":"T40","span":{"begin":471,"end":473},"obj":"Chemical"}],"attributes":[{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T46","span":{"begin":86,"end":94},"obj":"Species"}],"attributes":[{"id":"A46","pred":"ncbi_taxonomy_id","subj":"T46","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T40","span":{"begin":0,"end":490},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"212","span":{"begin":86,"end":104},"obj":"Disease"},{"id":"213","span":{"begin":287,"end":296},"obj":"Disease"}],"attributes":[{"id":"A212","pred":"pubann:denotes","subj":"212","obj":"MESH:C000657245"},{"id":"A213","pred":"pubann:denotes","subj":"213","obj":"MESH:D007239"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T34","span":{"begin":95,"end":104},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T35","span":{"begin":149,"end":160},"obj":"http://purl.obolibrary.org/obo/IDO_0000464"},{"id":"T36","span":{"begin":234,"end":239},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T37","span":{"begin":287,"end":296},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T38","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T39","span":{"begin":427,"end":436},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T41","span":{"begin":86,"end":104},"obj":"Disease"},{"id":"T42","span":{"begin":287,"end":296},"obj":"Disease"}],"attributes":[{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"212","span":{"begin":86,"end":104},"obj":"Disease"},{"id":"213","span":{"begin":287,"end":296},"obj":"Disease"}],"attributes":[{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"MESH:C000657245"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T40","span":{"begin":0,"end":490},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}

{"project":"2_test","denotations":[{"id":"32496926-16115318-132195660","span":{"begin":486,"end":488},"obj":"16115318"}],"text":"Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13]."}