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PMC:7441788 / 4210-5259 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T13 10-15 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 913-918 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T43 58-66 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 188-196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 254-263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 315-323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 498-516 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T48 507-516 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 699-708 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T32 3-15 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T33 31-39 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T34 100-102 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T35 297-300 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T36 324-332 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T37 359-362 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T38 368-369 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 387-388 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 427-433 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T41 646-651 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T42 673-679 http://purl.obolibrary.org/obo/CLO_0001751 denotes and 33
T43 725-727 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T44 761-766 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T45 857-858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 906-918 http://purl.obolibrary.org/obo/CLO_0051972 denotes HRT-18 cells
T47 906-918 http://purl.obolibrary.org/obo/CLO_0051973 denotes HRT-18 cells
T48 906-912 http://purl.obolibrary.org/obo/CLO_0003836 denotes HRT-18
T49 934-942 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T49 21-30 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T50 43-45 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T51 146-148 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T52 160-162 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T53 239-241 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T54 294-296 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T55 356-358 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T56 460-462 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T57 550-552 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T58 615-617 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T59 742-744 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T60 839-848 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T61 883-885 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T62 924-933 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T63 946-948 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T64 1032-1034 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T32 43-45 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T33 239-241 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T34 294-296 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T35 356-358 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T36 460-462 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T37 550-552 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T38 615-617 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T39 742-744 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T40 883-885 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T41 946-948 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T43 58-66 Species denotes SARS-CoV NCBItxid:694009
T44 188-196 Species denotes SARS-CoV NCBItxid:694009
T45 315-323 Species denotes SARS-CoV NCBItxid:694009
T46 498-506 Species denotes SARS-CoV NCBItxid:694009
T47 957-966 Species denotes HCoV-OC43 NCBItxid:31631

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T36 0-187 Sentence denotes In VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of >128 μM and CC50 > 100 and SI of >31 and SI>3, respectively [10,11].
T37 188-269 Sentence denotes SARS-CoV replication was inhibited by 99% at 16 μM CQ 3 days post-infection [12].
T38 270-342 Sentence denotes The data indicates that CQ has stronger anti-SARS-CoV activity than HCQ.
T39 343-411 Sentence denotes In addition, CQ has both a prophylactic and a therapeutic advantage.
T40 412-902 Sentence denotes Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13].
T41 903-1049 Sentence denotes In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
194 107-109 Gene denotes μM Gene:56925
195 997-999 Gene denotes μM Gene:56925
196 1024-1026 Gene denotes μM Gene:56925
197 236-238 Gene denotes μM Gene:56925
198 124-126 Gene denotes μM Gene:56925
199 93-95 Gene denotes μM Gene:56925
200 58-66 Species denotes SARS-CoV Tax:694009
201 188-196 Species denotes SARS-CoV Tax:694009
202 957-966 Species denotes HCoV-OC43 Tax:31631
203 315-323 Species denotes SARS-CoV Tax:694009
204 43-45 Chemical denotes CQ MESH:D002738
205 46-49 Chemical denotes HCQ MESH:D006886
206 239-241 Chemical denotes CQ MESH:D002738
207 294-296 Chemical denotes CQ MESH:D002738
208 338-341 Chemical denotes HCQ MESH:D006886
209 356-358 Chemical denotes CQ MESH:D002738
210 946-948 Chemical denotes CQ MESH:D002738
211 254-263 Disease denotes infection MESH:D007239
212 498-516 Disease denotes SARS-CoV infection MESH:C000657245
213 699-708 Disease denotes infection MESH:D007239
214 3-9 CellLine denotes VeroE6 CVCL:0574
215 906-912 CellLine denotes HRT-18 CVCL:2514

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T30 10-15 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T31 21-30 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T32 197-208 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T33 254-263 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T34 507-516 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T35 561-572 http://purl.obolibrary.org/obo/IDO_0000464 denotes infectivity
T36 646-651 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T37 699-708 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T38 761-766 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T39 839-848 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T40 913-918 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T41 924-933 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T13 10-15 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 913-918 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T37 58-66 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 188-196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 254-263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 315-323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 498-516 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T42 699-708 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
194 107-109 Gene denotes μM Gene:56925
195 997-999 Gene denotes μM Gene:56925
196 1024-1026 Gene denotes μM Gene:56925
197 236-238 Gene denotes μM Gene:56925
198 124-126 Gene denotes μM Gene:56925
199 93-95 Gene denotes μM Gene:56925
200 58-66 Species denotes SARS-CoV Tax:694009
201 188-196 Species denotes SARS-CoV Tax:694009
202 957-966 Species denotes HCoV-OC43 Tax:31631
203 315-323 Species denotes SARS-CoV Tax:694009
204 43-45 Chemical denotes CQ MESH:D002738
205 46-49 Chemical denotes HCQ MESH:D006886
206 239-241 Chemical denotes CQ MESH:D002738
207 294-296 Chemical denotes CQ MESH:D002738
208 338-341 Chemical denotes HCQ MESH:D006886
209 356-358 Chemical denotes CQ MESH:D002738
210 946-948 Chemical denotes CQ MESH:D002738
211 254-263 Disease denotes infection MESH:D007239
212 498-516 Disease denotes SARS-CoV infection MESH:C000657245
213 699-708 Disease denotes infection MESH:D007239
214 3-9 CellLine denotes VeroE6 CVCL:0574
215 906-912 CellLine denotes HRT-18 CVCL:2514

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T36 0-187 Sentence denotes In VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of >128 μM and CC50 > 100 and SI of >31 and SI>3, respectively [10,11].
T37 188-269 Sentence denotes SARS-CoV replication was inhibited by 99% at 16 μM CQ 3 days post-infection [12].
T38 270-342 Sentence denotes The data indicates that CQ has stronger anti-SARS-CoV activity than HCQ.
T39 343-411 Sentence denotes In addition, CQ has both a prophylactic and a therapeutic advantage.
T40 412-902 Sentence denotes Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13].
T41 903-1049 Sentence denotes In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].

2_test

Id Subject Object Predicate Lexical cue
32496926-24841269-132195657 180-182 24841269 denotes 10
32496926-16640347-132195658 183-185 16640347 denotes 11
32496926-15351731-132195659 265-267 15351731 denotes 12
32496926-16115318-132195660 898-900 16115318 denotes 13
32496926-19506054-132195661 1045-1047 19506054 denotes 14