PMC:7441788 / 4044-4393 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T13","span":{"begin":176,"end":181},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":45,"end":54},"obj":"Disease"},{"id":"T43","span":{"begin":224,"end":232},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T31","span":{"begin":110,"end":115},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T32","span":{"begin":169,"end":181},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T33","span":{"begin":197,"end":205},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T34","span":{"begin":266,"end":268},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T47","span":{"begin":12,"end":14},"obj":"Chemical"},{"id":"T48","span":{"begin":90,"end":92},"obj":"Chemical"},{"id":"T49","span":{"begin":187,"end":196},"obj":"Chemical"},{"id":"T50","span":{"begin":209,"end":211},"obj":"Chemical"},{"id":"T51","span":{"begin":312,"end":314},"obj":"Chemical"},{"id":"T52","span":{"begin":326,"end":328},"obj":"Chemical"}],"attributes":[{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_90326"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_90326"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T30","span":{"begin":12,"end":14},"obj":"Chemical"},{"id":"T31","span":{"begin":90,"end":92},"obj":"Chemical"},{"id":"T32","span":{"begin":209,"end":211},"obj":"Chemical"}],"attributes":[{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T42","span":{"begin":36,"end":44},"obj":"Species"},{"id":"T43","span":{"begin":224,"end":232},"obj":"Species"}],"attributes":[{"id":"A42","pred":"ncbi_taxonomy_id","subj":"T42","obj":"NCBItxid:1335626"},{"id":"A43","pred":"ncbi_taxonomy_id","subj":"T43","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"156","span":{"begin":69,"end":71},"obj":"Gene"},{"id":"157","span":{"begin":59,"end":61},"obj":"Gene"},{"id":"165","span":{"begin":12,"end":14},"obj":"Chemical"},{"id":"166","span":{"begin":90,"end":92},"obj":"Chemical"},{"id":"169","span":{"begin":41,"end":54},"obj":"Disease"},{"id":"194","span":{"begin":273,"end":275},"obj":"Gene"},{"id":"198","span":{"begin":290,"end":292},"obj":"Gene"},{"id":"199","span":{"begin":259,"end":261},"obj":"Gene"},{"id":"200","span":{"begin":224,"end":232},"obj":"Species"},{"id":"204","span":{"begin":209,"end":211},"obj":"Chemical"},{"id":"205","span":{"begin":212,"end":215},"obj":"Chemical"},{"id":"214","span":{"begin":169,"end":175},"obj":"CellLine"}],"attributes":[{"id":"A194","pred":"pubann:denotes","subj":"194","obj":"Gene:56925"},{"id":"A214","pred":"pubann:denotes","subj":"214","obj":"CVCL:0574"},{"id":"A198","pred":"pubann:denotes","subj":"198","obj":"Gene:56925"},{"id":"A199","pred":"pubann:denotes","subj":"199","obj":"Gene:56925"},{"id":"A157","pred":"pubann:denotes","subj":"157","obj":"Gene:56925"},{"id":"A156","pred":"pubann:denotes","subj":"156","obj":"Gene:56925"},{"id":"A169","pred":"pubann:denotes","subj":"169","obj":"MESH:D018352"},{"id":"A205","pred":"pubann:denotes","subj":"205","obj":"MESH:D006886"},{"id":"A200","pred":"pubann:denotes","subj":"200","obj":"Tax:694009"},{"id":"A204","pred":"pubann:denotes","subj":"204","obj":"MESH:D002738"},{"id":"A165","pred":"pubann:denotes","subj":"165","obj":"MESH:D002738"},{"id":"A166","pred":"pubann:denotes","subj":"166","obj":"MESH:D002738"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T27","span":{"begin":45,"end":54},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T28","span":{"begin":110,"end":115},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T29","span":{"begin":116,"end":126},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T30","span":{"begin":176,"end":181},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T31","span":{"begin":187,"end":196},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T13","span":{"begin":176,"end":181},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T36","span":{"begin":45,"end":54},"obj":"Disease"},{"id":"T37","span":{"begin":224,"end":232},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"LitCovid-PubTator","denotations":[{"id":"156","span":{"begin":69,"end":71},"obj":"Gene"},{"id":"157","span":{"begin":59,"end":61},"obj":"Gene"},{"id":"165","span":{"begin":12,"end":14},"obj":"Chemical"},{"id":"166","span":{"begin":90,"end":92},"obj":"Chemical"},{"id":"169","span":{"begin":41,"end":54},"obj":"Disease"},{"id":"194","span":{"begin":273,"end":275},"obj":"Gene"},{"id":"198","span":{"begin":290,"end":292},"obj":"Gene"},{"id":"199","span":{"begin":259,"end":261},"obj":"Gene"},{"id":"200","span":{"begin":224,"end":232},"obj":"Species"},{"id":"204","span":{"begin":209,"end":211},"obj":"Chemical"},{"id":"205","span":{"begin":212,"end":215},"obj":"Chemical"},{"id":"214","span":{"begin":169,"end":175},"obj":"CellLine"}],"attributes":[{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:56925"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Gene:56925"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:D002738"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"MESH:D002738"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"MESH:D018352"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Gene:56925"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Gene:56925"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Gene:56925"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Tax:694009"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D002738"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"MESH:D006886"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"CVCL:0574"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}

{"project":"2_test","denotations":[{"id":"32496926-24841269-132195656","span":{"begin":161,"end":163},"obj":"24841269"},{"id":"32496926-24841269-132195657","span":{"begin":346,"end":348},"obj":"24841269"}],"text":"wever, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].\nIn VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of \u003e128 μM and CC50 \u003e 100 and SI of \u003e31 and SI\u003e3, respectively [10,"}