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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T128 367-375 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T129 1105-1109 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 2372-2376 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T23 2372-2376 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T159 16-24 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 244-252 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T161 541-549 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 657-665 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T163 693-701 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 796-804 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T165 903-911 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 1081-1086 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T167 1229-1240 Disease denotes chikungunya http://purl.obolibrary.org/obo/MONDO_0017941
T168 1296-1305 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T169 1443-1451 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 1489-1497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 1867-1875 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 2143-2151 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T173 2457-2465 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 2468-2477 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T175 2857-2865 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 2992-3000 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 3116-3124 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T285 188-198 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T286 408-416 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T287 454-462 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T288 517-518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 551-552 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T290 708-710 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T291 769-777 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T292 1087-1092 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T293 1093-1109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity in cell
T294 1153-1159 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T295 1192-1195 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T296 1241-1246 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T297 1264-1270 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T298 1832-1834 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T299 1837-1838 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T300 2267-2268 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T301 2324-2332 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T302 2395-2401 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T303 2626-2631 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T304 2766-2767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T409 157-159 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T410 310-312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T411 599-601 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T412 781-783 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T413 857-859 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T414 1069-1071 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T415 1189-1191 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T416 1466-1468 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T417 2196-2198 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T418 2294-2296 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T419 2419-2421 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T420 2595-2607 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T421 2730-2732 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T422 2768-2777 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T423 2968-2970 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T424 3048-3059 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T425 3063-3065 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T426 3106-3111 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T22 1110-1117 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447
T23 2525-2537 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T240 157-159 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T241 310-312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T242 599-601 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T243 781-783 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T244 857-859 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T245 1069-1071 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T246 1189-1191 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T247 1466-1468 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T248 2196-2198 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T249 2294-2296 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T250 2419-2421 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T251 2595-2607 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T252 2730-2732 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T253 2768-2777 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T254 2968-2970 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T255 3063-3065 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T139 16-24 Species denotes COVID-19 NCBItxid:2697049
T140 244-254 Species denotes SARS-CoV-2 NCBItxid:2697049
T141 541-549 Species denotes COVID-19 NCBItxid:2697049
T142 657-665 Species denotes SARS-CoV NCBItxid:694009
T143 675-683 Species denotes MERS-CoV NCBItxid:1335626
T144 693-703 Species denotes SARS-CoV-2 NCBItxid:2697049
T145 796-806 Species denotes SARS-CoV-2 NCBItxid:2697049
T146 903-911 Species denotes COVID-19 NCBItxid:2697049
T147 1081-1092 Species denotes Ebola virus NCBItxid:1570291
T148 1229-1246 Species denotes chikungunya virus NCBItxid:37124
T149 1443-1451 Species denotes COVID-19 NCBItxid:2697049
T150 1489-1497 Species denotes COVID-19 NCBItxid:2697049
T151 1867-1875 Species denotes COVID-19 NCBItxid:2697049
T152 2143-2151 Species denotes COVID-19 NCBItxid:2697049
T153 2269-2275 Species denotes rodent NCBItxid:9989
T154 2314-2323 Species denotes HCoV-OC43 NCBItxid:31631
T155 2395-2401 Species denotes humans NCBItxid:9605
T156 2457-2467 Species denotes SARS-CoV-2 NCBItxid:2697049
T157 2857-2865 Species denotes COVID-19 NCBItxid:2697049
T158 2992-3000 Species denotes COVID-19 NCBItxid:2697049
T159 3116-3124 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T267 0-58 Sentence denotes At present, the COVID-19 pandemic is continuing worldwide.
T268 59-156 Sentence denotes It is still an urgent need to find effective therapies and vaccines for treatment and prevention.
T269 157-283 Sentence denotes CQ/HCQ have diverse biological activities, and their mechanisms against CoVs including SARS-CoV-2 are not yet fully clarified.
T270 284-463 Sentence denotes Current studies show that CQ/HCQ can prevent receptor recognition by CoVs, inhibit endosome acidification, which interferes membrane fusion, and exhibit immunomodulatory activity.
T271 464-550 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T272 551-712 Sentence denotes A number of in vitro studies have revealed that CQ/HCQ have inhibitory effects on various CoVs, including SARS-CoV [12,13], MERS-CoV [10] and SARS-CoV-2 [16–18].
T273 713-815 Sentence denotes However, conflicting results also exist on the in vitro activity of CQ/HCQ against SARS-CoV-2 [17,18].
T274 816-1030 Sentence denotes Several clinical studies have shown that CQ/HCQ may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay the progression of the disease, with less serious adverse effects [48,50,57,58,].
T275 1031-1175 Sentence denotes However, previous studies showed that CQ had anti-Ebola virus activity in cell culture, but it had conflicting results in animal models [71,72].
T276 1176-1340 Sentence denotes In addition, CQ has shown beneficial results against chikungunya virus in vitro, but in animal models it aggravates the infection and lacks therapeutic effect [73].
T277 1341-1586 Sentence denotes More importantly, in recent studies the use of HCQ did not show any favorable effect on patients with COVID-19 and high-dose CQ treatment of severe COVID-19 patients may even increase the risks of mortality and QTc interval prolongation [49,55].
T278 1587-1674 Sentence denotes In addition, the optimal daily dose and duration of treatment course are not yet clear.
T279 1675-1836 Sentence denotes One study suggested that the dose of HCQ should be 400 mg/2 times for 1 day, 200 mg/2 times/day for 4 days based on the physiological pharmacokinetic model [18].
T280 1837-2173 Sentence denotes A prospective study of HCQ on COVID-19 patients (13 cases) admitted to the ICU in France showed that the first daily dose of 800 mg/1 time for 1 day, and 200 mg/2 times/day for 7 days was recommended to maintain the HCQ treatment level (1–2 mg/l) based on physiologically pharmacokinetic (PBPK) models for COVID-19 patients in ICU [67].
T281 2174-2266 Sentence denotes Whether the dosage of CQ or HCQ should be varied according disease severity is also unclear.
T282 2267-2382 Sentence denotes A rodent study showed that CQ could exert anti-HCoV-OC43 activity transplacentally or by way of maternal milk [14].
T283 2383-2538 Sentence denotes However, in humans, the efficacy of CQ in the prevention and treatment of SARS-CoV-2 infection to both the mother and the child remains to be investigated.
T284 2539-2716 Sentence denotes Clinical trials in France showed that HCQ combined with azithromycin could enhance the virus clearance [50], but the subsequent reports did not support this combination [59,61].
T285 2717-2887 Sentence denotes Furthermore, CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69].
T286 2888-3231 Sentence denotes Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ, alone or in combination with other drugs, in COVID-19 before the conclusive findings are obtained by well-designed, multicenter, randomized, controlled studies.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 2372-2376 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1478 857-863 Gene denotes CQ/HCQ
1479 781-787 Gene denotes CQ/HCQ
1480 229-233 Species denotes CoVs Tax:11118
1481 244-254 Species denotes SARS-CoV-2 Tax:2697049
1482 353-357 Species denotes CoVs Tax:11118
1483 641-645 Species denotes CoVs Tax:11118
1484 657-665 Species denotes SARS-CoV Tax:694009
1487 796-806 Species denotes SARS-CoV-2 Tax:2697049
1488 1229-1246 Species denotes chikungunya virus Tax:37124
1489 1429-1437 Species denotes patients Tax:9606
1490 1498-1506 Species denotes patients Tax:9606
1491 1876-1884 Species denotes patients Tax:9606
1492 2152-2160 Species denotes patients Tax:9606
1493 2395-2401 Species denotes humans Tax:9606
1494 2505-2510 Species denotes child Tax:9606
1495 1081-1086 Species denotes Ebola Tax:1570291
1496 2314-2323 Species denotes HCoV-OC43 Tax:31631
1497 157-163 Chemical denotes CQ/HCQ
1498 310-316 Chemical denotes CQ/HCQ
1499 599-601 Chemical denotes CQ MESH:D002738
1500 602-605 Chemical denotes HCQ MESH:D006886
1501 1069-1071 Chemical denotes CQ MESH:D002738
1502 1189-1191 Chemical denotes CQ MESH:D002738
1503 1388-1391 Chemical denotes HCQ MESH:D006886
1504 1466-1468 Chemical denotes CQ MESH:D002738
1505 1712-1715 Chemical denotes HCQ MESH:D006886
1506 1860-1863 Chemical denotes HCQ MESH:D006886
1507 2053-2056 Chemical denotes HCQ MESH:D006886
1508 2196-2198 Chemical denotes CQ MESH:D002738
1509 2202-2205 Chemical denotes HCQ MESH:D006886
1510 2294-2296 Chemical denotes CQ MESH:D002738
1511 2419-2421 Chemical denotes CQ MESH:D002738
1512 2577-2580 Chemical denotes HCQ MESH:D006886
1513 2595-2607 Chemical denotes azithromycin MESH:D017963
1514 2730-2736 Chemical denotes CQ/HCQ
1515 2768-2777 Chemical denotes macrolide MESH:D018942
1516 2968-2970 Chemical denotes CQ MESH:D002738
1517 2971-2974 Chemical denotes HCQ MESH:D006886
1518 3063-3065 Chemical denotes CQ MESH:D002738
1519 3066-3069 Chemical denotes HCQ MESH:D006886
1520 16-24 Disease denotes COVID-19 MESH:C000657245
1521 541-549 Disease denotes COVID-19 MESH:C000657245
1522 903-911 Disease denotes COVID-19 MESH:C000657245
1523 1296-1305 Disease denotes infection MESH:D007239
1524 1443-1451 Disease denotes COVID-19 MESH:C000657245
1525 1489-1497 Disease denotes COVID-19 MESH:C000657245
1526 1538-1547 Disease denotes mortality MESH:D003643
1527 1552-1577 Disease denotes QTc interval prolongation MESH:D008133
1528 1867-1875 Disease denotes COVID-19 MESH:C000657245
1529 2143-2151 Disease denotes COVID-19 MESH:C000657245
1530 2457-2477 Disease denotes SARS-CoV-2 infection MESH:C000657245
1531 2857-2865 Disease denotes COVID-19 MESH:C000657245
1532 2992-3000 Disease denotes COVID-19 MESH:C000657245
1533 3116-3124 Disease denotes COVID-19 MESH:C000657245
690 2733-2736 Chemical denotes HCQ MESH:D006886
695 2971-2974 Chemical denotes HCQ MESH:D006886
719 3116-3124 Disease denotes COVID-19 MESH:C000657245

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T147 891-899 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T148 972-979 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T149 1087-1092 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T150 1105-1109 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T151 1241-1246 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T152 1296-1305 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T153 2233-2240 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T154 2468-2477 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T155 2626-2631 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T127 367-375 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T128 1105-1109 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 2372-2376 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T77 376-389 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T78 408-423 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T151 16-24 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 244-254 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 541-549 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T154 657-665 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 693-703 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T156 796-806 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 903-911 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T158 1081-1086 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T159 1229-1240 Disease denotes chikungunya http://purl.obolibrary.org/obo/MONDO_0017941
T160 1296-1305 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T161 1443-1451 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 1489-1497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 1867-1875 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 2143-2151 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 2457-2467 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T166 2468-2477 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T167 2857-2865 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 2992-3000 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T169 3116-3124 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T68 376-389 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T69 408-423 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T64 376-389 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T65 408-423 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
690 2733-2736 Chemical denotes HCQ MESH:D006886
1478 857-863 Gene denotes CQ/HCQ
1479 781-787 Gene denotes CQ/HCQ
1480 229-233 Species denotes CoVs Tax:11118
1481 244-254 Species denotes SARS-CoV-2 Tax:2697049
1482 353-357 Species denotes CoVs Tax:11118
1483 641-645 Species denotes CoVs Tax:11118
1484 657-665 Species denotes SARS-CoV Tax:694009
1485 675-683 Species denotes MERS-CoV Tax:1335626
1486 693-703 Species denotes SARS-CoV-2 Tax:2697049
1487 796-806 Species denotes SARS-CoV-2 Tax:2697049
1488 1229-1246 Species denotes chikungunya virus Tax:37124
1489 1429-1437 Species denotes patients Tax:9606
1490 1498-1506 Species denotes patients Tax:9606
1491 1876-1884 Species denotes patients Tax:9606
1492 2152-2160 Species denotes patients Tax:9606
1493 2395-2401 Species denotes humans Tax:9606
1494 2505-2510 Species denotes child Tax:9606
1495 1081-1086 Species denotes Ebola Tax:1570291
1496 2314-2323 Species denotes HCoV-OC43 Tax:31631
1497 157-163 Chemical denotes CQ/HCQ
1498 310-316 Chemical denotes CQ/HCQ
1499 599-601 Chemical denotes CQ MESH:D002738
1500 602-605 Chemical denotes HCQ MESH:D006886
1501 1069-1071 Chemical denotes CQ MESH:D002738
1502 1189-1191 Chemical denotes CQ MESH:D002738
1503 1388-1391 Chemical denotes HCQ MESH:D006886
1504 1466-1468 Chemical denotes CQ MESH:D002738
1505 1712-1715 Chemical denotes HCQ MESH:D006886
1506 1860-1863 Chemical denotes HCQ MESH:D006886
1507 2053-2056 Chemical denotes HCQ MESH:D006886
1508 2196-2198 Chemical denotes CQ MESH:D002738
1509 2202-2205 Chemical denotes HCQ MESH:D006886
1510 2294-2296 Chemical denotes CQ MESH:D002738
1511 2419-2421 Chemical denotes CQ MESH:D002738
1512 2577-2580 Chemical denotes HCQ MESH:D006886
1513 2595-2607 Chemical denotes azithromycin MESH:D017963
1514 2730-3069 Chemical denotes CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69]. Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ
1515 2779-2788 Chemical denotes nduced hi MESH:D018942
1516 2968-2970 Chemical denotes CQ MESH:D002738
1517 2971-2974 Chemical denotes HCQ MESH:D006886
1518 3063-3065 Chemical denotes CQ MESH:D002738
1519 3066-3069 Chemical denotes HCQ MESH:D006886
1520 16-24 Disease denotes COVID-19 MESH:C000657245
1521 541-549 Disease denotes COVID-19 MESH:C000657245
1522 903-911 Disease denotes COVID-19 MESH:C000657245
1523 1296-1305 Disease denotes infection MESH:D007239
1524 1443-1451 Disease denotes COVID-19 MESH:C000657245
1525 1489-1497 Disease denotes COVID-19 MESH:C000657245
1526 1538-1547 Disease denotes mortality MESH:D003643
1527 1552-1577 Disease denotes QTc interval prolongation MESH:D008133
1528 1867-1875 Disease denotes COVID-19 MESH:C000657245
1529 2143-2151 Disease denotes COVID-19 MESH:C000657245
1530 2457-2477 Disease denotes SARS-CoV-2 infection MESH:C000657245
1531 2868-2876 Disease denotes eatment MESH:C000657245
1532 2992-3000 Disease denotes COVID-19 MESH:C000657245
1533 3116-3124 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T267 0-58 Sentence denotes At present, the COVID-19 pandemic is continuing worldwide.
T268 59-156 Sentence denotes It is still an urgent need to find effective therapies and vaccines for treatment and prevention.
T269 157-283 Sentence denotes CQ/HCQ have diverse biological activities, and their mechanisms against CoVs including SARS-CoV-2 are not yet fully clarified.
T270 284-463 Sentence denotes Current studies show that CQ/HCQ can prevent receptor recognition by CoVs, inhibit endosome acidification, which interferes membrane fusion, and exhibit immunomodulatory activity.
T271 464-550 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T272 551-712 Sentence denotes A number of in vitro studies have revealed that CQ/HCQ have inhibitory effects on various CoVs, including SARS-CoV [12,13], MERS-CoV [10] and SARS-CoV-2 [16–18].
T273 713-815 Sentence denotes However, conflicting results also exist on the in vitro activity of CQ/HCQ against SARS-CoV-2 [17,18].
T274 816-1030 Sentence denotes Several clinical studies have shown that CQ/HCQ may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay the progression of the disease, with less serious adverse effects [48,50,57,58,].
T275 1031-1175 Sentence denotes However, previous studies showed that CQ had anti-Ebola virus activity in cell culture, but it had conflicting results in animal models [71,72].
T276 1176-1340 Sentence denotes In addition, CQ has shown beneficial results against chikungunya virus in vitro, but in animal models it aggravates the infection and lacks therapeutic effect [73].
T277 1341-1586 Sentence denotes More importantly, in recent studies the use of HCQ did not show any favorable effect on patients with COVID-19 and high-dose CQ treatment of severe COVID-19 patients may even increase the risks of mortality and QTc interval prolongation [49,55].
T278 1587-1674 Sentence denotes In addition, the optimal daily dose and duration of treatment course are not yet clear.
T279 1675-1836 Sentence denotes One study suggested that the dose of HCQ should be 400 mg/2 times for 1 day, 200 mg/2 times/day for 4 days based on the physiological pharmacokinetic model [18].
T280 1837-2173 Sentence denotes A prospective study of HCQ on COVID-19 patients (13 cases) admitted to the ICU in France showed that the first daily dose of 800 mg/1 time for 1 day, and 200 mg/2 times/day for 7 days was recommended to maintain the HCQ treatment level (1–2 mg/l) based on physiologically pharmacokinetic (PBPK) models for COVID-19 patients in ICU [67].
T281 2174-2266 Sentence denotes Whether the dosage of CQ or HCQ should be varied according disease severity is also unclear.
T282 2267-2382 Sentence denotes A rodent study showed that CQ could exert anti-HCoV-OC43 activity transplacentally or by way of maternal milk [14].
T283 2383-2538 Sentence denotes However, in humans, the efficacy of CQ in the prevention and treatment of SARS-CoV-2 infection to both the mother and the child remains to be investigated.
T284 2539-2716 Sentence denotes Clinical trials in France showed that HCQ combined with azithromycin could enhance the virus clearance [50], but the subsequent reports did not support this combination [59,61].
T285 2717-2887 Sentence denotes Furthermore, CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69].
T286 2888-3231 Sentence denotes Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ, alone or in combination with other drugs, in COVID-19 before the conclusive findings are obtained by well-designed, multicenter, randomized, controlled studies.

2_test

Id Subject Object Predicate Lexical cue
32496926-15351731-132195715 667-669 15351731 denotes 12
32496926-16115318-132195716 670-672 16115318 denotes 13
32496926-24841269-132195717 685-687 24841269 denotes 10
32496926-32020029-132195718 705-707 32020029 denotes 16
32496926-32194981-132195718 705-707 32194981 denotes 16
32496926-32194981-132195719 808-810 32194981 denotes 17
32496926-23577127-132195720 1168-1170 23577127 denotes 71
32496926-26459826-132195721 1171-1173 26459826 denotes 72
32496926-19506054-132195722 2378-2380 19506054 denotes 14