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PMC:7441788 / 35326-39123 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T118 498-501 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T119 503-524 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T120 530-535 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T121 1042-1064 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T122 1084-1089 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 1094-1100 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T124 1155-1160 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T125 1165-1171 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T126 3139-3144 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T127 3497-3504 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T15 498-501 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T16 503-524 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T17 530-535 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 1084-1089 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 1094-1100 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 1155-1160 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T21 1165-1171 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 3139-3144 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T137 33-40 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T138 322-330 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T139 565-573 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T140 575-594 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T141 595-609 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T142 615-625 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T143 948-959 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T144 1347-1355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 1637-1672 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T146 1650-1672 Disease denotes atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000465
T147 1896-1904 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 2000-2009 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T149 2026-2034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 2193-2201 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T151 2736-2746 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T152 2763-2771 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T153 3139-3152 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T154 3532-3536 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T155 3586-3602 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T156 3596-3602 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T157 3667-3682 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T158 3760-3775 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T247 46-47 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 498-501 http://www.ebi.ac.uk/efo/EFO_0000826 denotes ear
T249 503-524 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T250 503-524 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T251 530-535 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T252 530-535 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T253 695-698 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T254 769-775 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T255 1042-1064 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T256 1084-1089 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T257 1084-1089 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T258 1094-1100 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T259 1094-1100 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T260 1094-1100 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T261 1106-1107 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 1155-1160 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T263 1155-1160 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T264 1165-1171 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T265 1165-1171 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T266 1165-1171 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T267 1567-1568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 1605-1607 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T269 1635-1636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 1696-1697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 1920-1921 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T272 2356-2358 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T273 2378-2379 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 2432-2434 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T275 2493-2495 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T276 2569-2571 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T277 2612-2613 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 2642-2643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 2889-2890 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 3139-3144 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T281 3139-3144 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T282 3139-3144 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T283 3139-3144 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T284 3459-3468 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T373 0-2 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T374 131-133 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T375 259-261 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T376 451-453 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T377 687-689 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T378 818-820 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T379 966-968 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T380 1225-1227 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T381 1507-1510 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T382 2102-2114 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T383 2312-2324 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T384 2471-2483 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T385 2600-2602 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T386 2604-2606 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T387 2614-2623 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T388 2644-2653 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T389 2866-2868 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T390 2891-2900 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T391 2907-2909 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T392 3002-3010 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T393 3075-3077 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T394 3192-3197 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T395 3222-3227 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T396 3229-3243 Chemical denotes antihistamines http://purl.obolibrary.org/obo/CHEBI_37956
T397 3249-3261 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T398 3350-3355 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T399 3364-3369 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T400 3453-3455 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T401 3497-3504 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T403 3507-3516 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T407 3688-3690 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T408 3794-3796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T20 2924-2941 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes electrocardiogram http://purl.bioontology.org/ontology/MEDDRA/10014362
T21 3497-3530 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes glucose 6-phosphate dehydrogenase http://purl.bioontology.org/ontology/MEDDRA/10059900

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T210 0-2 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T211 131-133 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T212 259-261 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T213 451-453 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T214 687-689 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T215 818-820 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T216 966-968 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T217 1225-1227 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T218 1507-1510 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T219 2102-2114 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T220 2312-2324 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T221 2471-2483 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T222 2600-2602 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T223 2604-2606 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T224 2614-2623 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T225 2644-2653 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T226 2866-2868 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T227 2891-2900 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T228 2907-2909 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T229 3075-3077 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T230 3249-3261 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T231 3453-3455 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T232 3497-3504 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T234 3507-3516 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T238 3688-3690 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T239 3794-3796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T133 1347-1355 Species denotes COVID-19 NCBItxid:2697049
T134 1896-1904 Species denotes COVID-19 NCBItxid:2697049
T135 2026-2034 Species denotes COVID-19 NCBItxid:2697049
T136 2193-2201 Species denotes COVID-19 NCBItxid:2697049
T137 2763-2771 Species denotes COVID-19 NCBItxid:2697049
T138 3596-3602 Species denotes anemia NCBItxid:12939

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T241 0-95 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 96-216 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 217-345 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 346-417 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 418-674 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 675-765 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 766-826 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 827-965 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 966-1143 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 1144-1214 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 1215-1391 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 1392-1539 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 1540-1692 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 1693-1832 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 1833-1919 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 1920-2169 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 2170-2588 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 2589-2786 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 2787-2901 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 2902-3074 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 3075-3280 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 3281-3439 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 3440-3608 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 3609-3797 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T13 498-501 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T14 503-524 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T15 530-535 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 1084-1089 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T17 1094-1100 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T18 1155-1160 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 1165-1171 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 3139-3144 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1339 1333-1341 Species denotes patients Tax:9606
1340 1436-1444 Species denotes patients Tax:9606
1341 1472-1480 Species denotes patients Tax:9606
1342 1554-1562 Species denotes patients Tax:9606
1343 1617-1624 Species denotes patient Tax:9606
1344 1748-1756 Species denotes patients Tax:9606
1345 1905-1913 Species denotes patients Tax:9606
1346 1953-1961 Species denotes patients Tax:9606
1347 2202-2210 Species denotes patients Tax:9606
1348 2273-2281 Species denotes patients Tax:9606
1349 2363-2371 Species denotes patients Tax:9606
1350 2441-2449 Species denotes patients Tax:9606
1351 2772-2780 Species denotes patients Tax:9606
1352 3116-3124 Species denotes patients Tax:9606
1353 3483-3491 Species denotes patients Tax:9606
1354 3653-3661 Species denotes patients Tax:9606
1355 0-6 Chemical denotes CQ/HCQ
1356 131-133 Chemical denotes CQ MESH:D002738
1357 259-261 Chemical denotes CQ MESH:D002738
1358 451-453 Chemical denotes CQ MESH:D002738
1359 687-689 Chemical denotes CQ MESH:D002738
1360 691-694 Chemical denotes HCQ MESH:D006886
1361 784-787 Chemical denotes HCQ MESH:D006886
1362 818-820 Chemical denotes CQ MESH:D002738
1363 934-937 Chemical denotes HCQ MESH:D006886
1364 966-968 Chemical denotes CQ MESH:D002738
1365 969-972 Chemical denotes HCQ MESH:D006886
1366 1225-1227 Chemical denotes CQ MESH:D002738
1367 1455-1458 Chemical denotes HCQ MESH:D006886
1368 1494-1497 Chemical denotes HCQ MESH:D006886
1369 1767-1770 Chemical denotes HCQ MESH:D006886
1370 1868-1871 Chemical denotes HCQ MESH:D006886
1371 1975-1978 Chemical denotes HCQ MESH:D006886
1372 2102-2114 Chemical denotes azithromycin MESH:D017963
1373 2292-2295 Chemical denotes HCQ MESH:D006886
1374 2312-2324 Chemical denotes azithromycin MESH:D017963
1375 2463-2466 Chemical denotes HCQ MESH:D006886
1376 2471-2483 Chemical denotes azithromycin MESH:D017963
1377 2523-2526 Chemical denotes HCQ MESH:D006886
1378 2600-2602 Chemical denotes CQ MESH:D002738
1379 2604-2606 Chemical denotes CQ MESH:D002738
1380 2614-2623 Chemical denotes macrolide MESH:D018942
1381 2625-2628 Chemical denotes HCQ MESH:D006886
1382 2633-2636 Chemical denotes HCQ MESH:D006886
1383 2644-2653 Chemical denotes macrolide MESH:D018942
1384 2866-2872 Chemical denotes CQ/HCQ
1385 2891-2900 Chemical denotes macrolide MESH:D018942
1386 2907-2913 Chemical denotes CQ/HCQ
1387 3075-3081 Chemical denotes CQ/HCQ
1388 3249-3261 Chemical denotes moxifloxacin MESH:D000077266
1389 3453-3455 Chemical denotes CQ MESH:D002738
1390 3688-3690 Chemical denotes CQ MESH:D002738
1391 3794-3796 Chemical denotes CQ MESH:D002738
1392 33-40 Disease denotes malaria MESH:D008288
1393 304-310 Disease denotes nausea MESH:D009325
1394 312-320 Disease denotes vomiting MESH:D014839
1395 322-330 Disease denotes diarrhea MESH:D003967
1396 336-344 Disease denotes anorexia MESH:D000855
1397 503-524 Disease denotes cardiovascular system MESH:D002318
1398 552-573 Disease denotes neurological deafness MESH:D009422
1399 575-609 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 615-625 Disease denotes leukopenia MESH:D007970
1401 756-764 Disease denotes toxicity MESH:D064420
1402 948-959 Disease denotes retinopathy MESH:D012164
1403 1155-1183 Disease denotes liver and kidney dysfunction MESH:D051437
1404 1279-1314 Disease denotes increased QTc interval prolongation MESH:D008133
1405 1318-1332 Disease denotes critically ill MESH:D016638
1406 1347-1355 Disease denotes COVID-19 MESH:C000657245
1407 1650-1672 Disease denotes atrioventricular block MESH:D054537
1408 1808-1816 Disease denotes headache MESH:D006261
1409 1821-1825 Disease denotes rash MESH:D005076
1410 1896-1904 Disease denotes COVID-19 MESH:C000657245
1411 2000-2009 Disease denotes pneumonia MESH:D011014
1412 2026-2034 Disease denotes COVID-19 MESH:C000657245
1413 2056-2072 Disease denotes QTc prolongation MESH:D008133
1414 2193-2201 Disease denotes COVID-19 MESH:C000657245
1415 2724-2746 Disease denotes ventricular arrhythmia MESH:D001145
1416 2763-2771 Disease denotes COVID-19 MESH:C000657245
1417 3139-3152 Disease denotes heart disease MESH:D006331
1418 3497-3548 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 3586-3602 Disease denotes hemolytic anemia MESH:D000743
1420 3667-3682 Disease denotes G6PD deficiency MESH:D005955
1421 3760-3775 Disease denotes G6PD deficiency MESH:D005955

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1302 3497-3530 Protein denotes glucose 6-phosphate dehydrogenase https://www.uniprot.org/uniprot/R4GMU1|https://www.uniprot.org/uniprot/Q8CFX1|https://www.uniprot.org/uniprot/Q8BLH1|https://www.uniprot.org/uniprot/Q68DT3|https://www.uniprot.org/uniprot/Q66I35|https://www.uniprot.org/uniprot/Q4TT33|https://www.uniprot.org/uniprot/P56201|https://www.uniprot.org/uniprot/O95479|https://www.uniprot.org/uniprot/G1SE36|https://www.uniprot.org/uniprot/B2KGW7|https://www.uniprot.org/uniprot/A2A7A9
T1313 3532-3536 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1345 3667-3671 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1377 3760-3764 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T141 53-60 http://purl.obolibrary.org/obo/BFO_0000182 denotes history
T142 352-360 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T143 530-535 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T144 586-594 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorder
T145 3145-3152 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T146 3328-3336 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T117 498-501 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T118 503-524 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T119 530-535 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T120 1042-1064 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T121 1084-1089 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T122 1094-1100 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T123 1155-1160 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T124 1165-1171 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T125 3139-3144 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T126 3497-3504 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T9 498-501 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T10 498-501 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T11 498-501 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T12 503-524 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T13 530-535 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T14 530-535 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T15 1084-1089 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T16 1094-1100 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T17 1155-1160 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T18 1165-1171 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T19 3139-3144 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T76 1071-1080 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T130 33-40 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T131 322-330 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T132 565-573 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T133 575-594 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T134 595-609 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T135 615-625 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T136 948-959 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T137 1347-1355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 1637-1672 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T139 1821-1825 Disease denotes rash http://purl.obolibrary.org/obo/MONDO_0006547
T140 1896-1904 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T141 2000-2009 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T142 2026-2034 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T143 2193-2201 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T144 2736-2746 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T145 2763-2771 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 3139-3152 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T147 3532-3536 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T148 3586-3602 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T149 3667-3682 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T150 3760-3775 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 304-320 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T25 322-330 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T26 336-344 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T27 565-573 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T28 595-609 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T29 615-625 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T30 948-959 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T31 1569-1591 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T32 1637-1672 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T33 1808-1816 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T34 1821-1825 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T35 1833-1854 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T36 2000-2009 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 2724-2746 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T38 3586-3602 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T67 1071-1080 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T63 1071-1080 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1339 1333-1341 Species denotes patients Tax:9606
1340 1436-1444 Species denotes patients Tax:9606
1341 1472-1480 Species denotes patients Tax:9606
1342 1554-1562 Species denotes patients Tax:9606
1343 1617-1624 Species denotes patient Tax:9606
1344 1748-1756 Species denotes patients Tax:9606
1345 1905-1913 Species denotes patients Tax:9606
1346 1953-1961 Species denotes patients Tax:9606
1347 2202-2210 Species denotes patients Tax:9606
1348 2273-2281 Species denotes patients Tax:9606
1349 2363-2371 Species denotes patients Tax:9606
1350 2441-2449 Species denotes patients Tax:9606
1351 2772-2780 Species denotes patients Tax:9606
1352 3116-3124 Species denotes patients Tax:9606
1353 3483-3491 Species denotes patients Tax:9606
1354 3653-3661 Species denotes patients Tax:9606
1355 0-6 Chemical denotes CQ/HCQ
1356 131-133 Chemical denotes CQ MESH:D002738
1357 259-261 Chemical denotes CQ MESH:D002738
1358 451-453 Chemical denotes CQ MESH:D002738
1359 687-689 Chemical denotes CQ MESH:D002738
1360 691-694 Chemical denotes HCQ MESH:D006886
1361 784-787 Chemical denotes HCQ MESH:D006886
1362 818-820 Chemical denotes CQ MESH:D002738
1363 934-937 Chemical denotes HCQ MESH:D006886
1364 966-968 Chemical denotes CQ MESH:D002738
1365 969-972 Chemical denotes HCQ MESH:D006886
1366 1225-1227 Chemical denotes CQ MESH:D002738
1367 1455-1458 Chemical denotes HCQ MESH:D006886
1368 1494-1497 Chemical denotes HCQ MESH:D006886
1369 1767-1770 Chemical denotes HCQ MESH:D006886
1370 1868-1871 Chemical denotes HCQ MESH:D006886
1371 1975-1978 Chemical denotes HCQ MESH:D006886
1372 2102-2114 Chemical denotes azithromycin MESH:D017963
1373 2292-2295 Chemical denotes HCQ MESH:D006886
1374 2312-2324 Chemical denotes azithromycin MESH:D017963
1375 2463-2466 Chemical denotes HCQ MESH:D006886
1376 2471-2483 Chemical denotes azithromycin MESH:D017963
1377 2523-2526 Chemical denotes HCQ MESH:D006886
1378 2600-2602 Chemical denotes CQ MESH:D002738
1379 2604-2606 Chemical denotes CQ MESH:D002738
1380 2614-2623 Chemical denotes macrolide MESH:D018942
1381 2625-2628 Chemical denotes HCQ MESH:D006886
1382 2633-2636 Chemical denotes HCQ MESH:D006886
1383 2644-2653 Chemical denotes macrolide MESH:D018942
1384 2866-2872 Chemical denotes CQ/HCQ
1385 2891-2900 Chemical denotes macrolide MESH:D018942
1386 2907-2913 Chemical denotes CQ/HCQ
1387 3075-3081 Chemical denotes CQ/HCQ
1388 3249-3261 Chemical denotes moxifloxacin MESH:D000077266
1389 3453-3455 Chemical denotes CQ MESH:D002738
1390 3688-3690 Chemical denotes CQ MESH:D002738
1391 3794-3796 Chemical denotes CQ MESH:D002738
1392 33-40 Disease denotes malaria MESH:D008288
1393 304-310 Disease denotes nausea MESH:D009325
1394 312-320 Disease denotes vomiting MESH:D014839
1395 322-330 Disease denotes diarrhea MESH:D003967
1396 336-344 Disease denotes anorexia MESH:D000855
1397 503-524 Disease denotes cardiovascular system MESH:D002318
1398 552-573 Disease denotes neurological deafness MESH:D009422
1399 575-609 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 615-625 Disease denotes leukopenia MESH:D007970
1401 756-764 Disease denotes toxicity MESH:D064420
1402 948-959 Disease denotes retinopathy MESH:D012164
1403 1155-1183 Disease denotes liver and kidney dysfunction MESH:D051437
1404 1279-1314 Disease denotes increased QTc interval prolongation MESH:D008133
1405 1318-1332 Disease denotes critically ill MESH:D016638
1406 1347-1355 Disease denotes COVID-19 MESH:C000657245
1407 1650-1672 Disease denotes atrioventricular block MESH:D054537
1408 1808-1816 Disease denotes headache MESH:D006261
1409 1821-1825 Disease denotes rash MESH:D005076
1410 1896-1904 Disease denotes COVID-19 MESH:C000657245
1411 2000-2009 Disease denotes pneumonia MESH:D011014
1412 2026-2034 Disease denotes COVID-19 MESH:C000657245
1413 2056-2072 Disease denotes QTc prolongation MESH:D008133
1414 2193-2201 Disease denotes COVID-19 MESH:C000657245
1415 2724-2746 Disease denotes ventricular arrhythmia MESH:D001145
1416 2763-2771 Disease denotes COVID-19 MESH:C000657245
1417 3139-3152 Disease denotes heart disease MESH:D006331
1418 3497-3548 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 3586-3602 Disease denotes hemolytic anemia MESH:D000743
1420 3667-3682 Disease denotes G6PD deficiency MESH:D005955
1421 3760-3775 Disease denotes G6PD deficiency MESH:D005955

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T241 0-95 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 96-216 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 217-345 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 346-417 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 418-674 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 675-765 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 766-826 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 827-965 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 966-1143 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 1144-1214 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 1215-1391 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 1392-1539 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 1540-1692 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 1693-1832 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 1833-1919 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 1920-2169 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 2170-2588 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 2589-2786 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 2787-2901 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 2902-3074 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 3075-3280 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 3281-3439 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 3440-3608 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 3609-3797 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T25 304-320 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T26 322-330 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T27 336-344 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T28 565-573 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T29 595-609 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T30 615-625 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T31 948-959 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T32 1569-1591 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T33 1637-1672 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T34 1808-1816 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T35 1821-1825 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T36 1833-1854 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T37 2000-2009 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T38 2724-2746 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T39 3586-3602 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 3497-3504 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose

2_test

Id Subject Object Predicate Lexical cue
32496926-25693996-132195705 89-90 25693996 denotes 3
32496926-20513543-132195706 91-93 20513543 denotes 62
32496926-7040501-132195707 212-214 7040501 denotes 63
32496926-25693996-132195708 414-415 25693996 denotes 3
32496926-25693996-132195709 671-672 25693996 denotes 3
32496926-6408923-132195710 822-824 6408923 denotes 64
32496926-30401979-132195711 961-963 30401979 denotes 65
32496926-25693996-132195712 1137-1138 25693996 denotes 3
32496926-22009248-132195713 1139-1141 22009248 denotes 66
32496926-31701865-132195714 3604-3606 31701865 denotes 70