PMC:7441788 / 352-740 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7441788","sourcedb":"PMC","sourceid":"7441788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7441788","text":"ugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect ","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":30,"end":39},"obj":"Body_part"},{"id":"T2","span":{"begin":212,"end":220},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma46831"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67180"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T9","span":{"begin":126,"end":134},"obj":"Disease"}],"attributes":[{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":258,"end":266},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T2","span":{"begin":304,"end":312},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T3","span":{"begin":367,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T6","span":{"begin":41,"end":52},"obj":"Chemical"},{"id":"T7","span":{"begin":54,"end":56},"obj":"Chemical"},{"id":"T8","span":{"begin":62,"end":80},"obj":"Chemical"},{"id":"T9","span":{"begin":136,"end":138},"obj":"Chemical"}],"attributes":[{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T1","span":{"begin":10,"end":23},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A1","pred":"meddra_id","subj":"T1","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"subj":"T1","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T3","span":{"begin":41,"end":52},"obj":"Chemical"},{"id":"T4","span":{"begin":54,"end":56},"obj":"Chemical"},{"id":"T5","span":{"begin":62,"end":80},"obj":"Chemical"},{"id":"T6","span":{"begin":136,"end":138},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"subj":"T3","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-sample-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T7","span":{"begin":126,"end":134},"obj":"Species"}],"attributes":[{"id":"A7","pred":"ncbi_taxonomy_id","subj":"T7","obj":"NCBItxid:2697049"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T10","span":{"begin":136,"end":313},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"43","span":{"begin":189,"end":202},"obj":"Species"},{"id":"48","span":{"begin":41,"end":52},"obj":"Chemical"},{"id":"49","span":{"begin":54,"end":56},"obj":"Chemical"},{"id":"50","span":{"begin":62,"end":80},"obj":"Chemical"},{"id":"51","span":{"begin":82,"end":85},"obj":"Chemical"},{"id":"66","span":{"begin":126,"end":134},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"pubann:denotes","subj":"43","obj":"Tax:11118"},{"id":"A48","pred":"pubann:denotes","subj":"48","obj":"MESH:D002738"},{"id":"A49","pred":"pubann:denotes","subj":"49","obj":"MESH:D002738"},{"id":"A50","pred":"pubann:denotes","subj":"50","obj":"MESH:D006886"},{"id":"A51","pred":"pubann:denotes","subj":"51","obj":"MESH:D006886"},{"id":"A66","pred":"pubann:denotes","subj":"66","obj":"MESH:C000657245"},{"subj":"43","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"48","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"49","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"50","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"51","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"66","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T1","span":{"begin":30,"end":39},"obj":"Body_part"},{"id":"T2","span":{"begin":212,"end":220},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma46831"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67180"},{"subj":"T1","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T2","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T1","span":{"begin":221,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":258,"end":273},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T2","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T7","span":{"begin":126,"end":134},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T7","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T1","span":{"begin":221,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":258,"end":273},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":221,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0045851"},{"id":"T2","span":{"begin":258,"end":273},"obj":"http://purl.obolibrary.org/obo/GO_0061025"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"43","span":{"begin":189,"end":202},"obj":"Species"},{"id":"48","span":{"begin":41,"end":52},"obj":"Chemical"},{"id":"49","span":{"begin":54,"end":56},"obj":"Chemical"},{"id":"50","span":{"begin":62,"end":80},"obj":"Chemical"},{"id":"51","span":{"begin":82,"end":85},"obj":"Chemical"},{"id":"66","span":{"begin":126,"end":134},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Tax:11118"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"MESH:D002738"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D002738"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"MESH:D006886"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"MESH:D006886"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:C000657245"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"},{"subj":"50","pred":"source","obj":"LitCovid-PubTator"},{"subj":"51","pred":"source","obj":"LitCovid-PubTator"},{"subj":"66","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":136,"end":313},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecd4","default":true},{"id":"LitCovid-PD-MONDO","color":"#ecba93"},{"id":"LitCovid-PD-CLO","color":"#a093ec"},{"id":"LitCovid-PD-CHEBI","color":"#9fec93"},{"id":"LitCovid-sample-MedDRA","color":"#ec93b9"},{"id":"LitCovid-sample-CHEBI","color":"#93d3ec"},{"id":"LitCovid-sample-PD-NCBITaxon","color":"#ecea93"},{"id":"LitCovid-sample-sentences","color":"#d093ec"},{"id":"LitCovid-sample-Pubtator","color":"#93ecb6"},{"id":"LitCovid-sample-PD-FMA","color":"#ec9c93"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#93a3ec"},{"id":"LitCovid-sample-PD-MONDO","color":"#bdec93"},{"id":"LitCovid-sample-GO-BP","color":"#ec93d7"},{"id":"LitCovid-PD-GO-BP","color":"#93ece7"},{"id":"LitCovid-PubTator","color":"#eccd93"},{"id":"LitCovid-sentences","color":"#b393ec"}]}]}}