PMC:7441788 / 18010-18682 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7441788","sourcedb":"PMC","sourceid":"7441788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7441788","text":"Lack of a placebo control group; Design introduces the possibility of biased investigator determined assessment and unbalanced dosage adjustment; Randomization of sequential envelopes may be biased. The antiviral efficacy of HCQ was not assessed at an earlier stage; Most patients are mild to severe, and the effect of HCQ on disease progression or regression could not be provided. The trial terminated early due to the difficulty to recruit enough patients. Some secondary endpoints could not be analyzed by the cutoff date; Viral RNA specimens are mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T108","span":{"begin":533,"end":536},"obj":"Body_part"},{"id":"T109","span":{"begin":567,"end":590},"obj":"Body_part"}],"attributes":[{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma45661"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":567,"end":590},"obj":"Body_part"},{"id":"T9","span":{"begin":573,"end":590},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001557"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T181","span":{"begin":8,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T181","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T229","span":{"begin":26,"end":31},"obj":"Chemical"},{"id":"T230","span":{"begin":203,"end":212},"obj":"Chemical"}],"attributes":[{"id":"A229","pred":"chebi_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A230","pred":"chebi_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T9","span":{"begin":77,"end":89},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T10","span":{"begin":603,"end":625},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A9","pred":"meddra_id","subj":"T9","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"id":"A10","pred":"meddra_id","subj":"T10","obj":"http://purl.bioontology.org/ontology/MEDDRA/10049413"},{"subj":"T9","pred":"source","obj":"LitCovid-sample-MedDRA"},{"subj":"T10","pred":"source","obj":"LitCovid-sample-MedDRA"}]},{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T136","span":{"begin":533,"end":536},"obj":"Chemical"}],"attributes":[{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"},{"subj":"T136","pred":"source","obj":"LitCovid-sample-CHEBI"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T135","span":{"begin":0,"end":198},"obj":"Sentence"},{"id":"T136","span":{"begin":199,"end":382},"obj":"Sentence"},{"id":"T137","span":{"begin":383,"end":459},"obj":"Sentence"},{"id":"T138","span":{"begin":460,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T135","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T136","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T137","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T138","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T8","span":{"begin":567,"end":590},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001557"},{"subj":"T8","pred":"source","obj":"LitCovid-sample-PD-UBERON"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"645","span":{"begin":272,"end":280},"obj":"Species"},{"id":"646","span":{"begin":450,"end":458},"obj":"Species"},{"id":"674","span":{"begin":225,"end":228},"obj":"Chemical"},{"id":"675","span":{"begin":319,"end":322},"obj":"Chemical"}],"attributes":[{"id":"A645","pred":"pubann:denotes","subj":"645","obj":"Tax:9606"},{"id":"A646","pred":"pubann:denotes","subj":"646","obj":"Tax:9606"},{"id":"A674","pred":"pubann:denotes","subj":"674","obj":"MESH:D006886"},{"id":"A675","pred":"pubann:denotes","subj":"675","obj":"MESH:D006886"},{"subj":"645","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"646","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"674","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"675","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T120","span":{"begin":203,"end":212},"obj":"http://purl.obolibrary.org/obo/IDO_0000559"},{"id":"T121","span":{"begin":326,"end":333},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"attributes":[{"subj":"T120","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T121","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T107","span":{"begin":533,"end":536},"obj":"Body_part"},{"id":"T108","span":{"begin":567,"end":590},"obj":"Body_part"}],"attributes":[{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma45661"},{"subj":"T107","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T108","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T60","span":{"begin":649,"end":654},"obj":"http://purl.obolibrary.org/obo/GO_0071878"},{"id":"T61","span":{"begin":649,"end":654},"obj":"http://purl.obolibrary.org/obo/GO_0071877"}],"attributes":[{"subj":"T60","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T61","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"645","span":{"begin":272,"end":280},"obj":"Species"},{"id":"646","span":{"begin":450,"end":458},"obj":"Species"},{"id":"674","span":{"begin":225,"end":228},"obj":"Chemical"},{"id":"675","span":{"begin":319,"end":322},"obj":"Chemical"}],"attributes":[{"id":"A645","pred":"tao:has_database_id","subj":"645","obj":"Tax:9606"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"Tax:9606"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"MESH:D006886"},{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"MESH:D006886"},{"subj":"645","pred":"source","obj":"LitCovid-PubTator"},{"subj":"646","pred":"source","obj":"LitCovid-PubTator"},{"subj":"674","pred":"source","obj":"LitCovid-PubTator"},{"subj":"675","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T135","span":{"begin":0,"end":198},"obj":"Sentence"},{"id":"T136","span":{"begin":199,"end":382},"obj":"Sentence"},{"id":"T137","span":{"begin":383,"end":459},"obj":"Sentence"},{"id":"T138","span":{"begin":460,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T135","pred":"source","obj":"LitCovid-sentences"},{"subj":"T136","pred":"source","obj":"LitCovid-sentences"},{"subj":"T137","pred":"source","obj":"LitCovid-sentences"},{"subj":"T138","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9b93","default":true},{"id":"LitCovid-PD-UBERON","color":"#93a4ec"},{"id":"LitCovid-PD-CLO","color":"#beec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93d8"},{"id":"LitCovid-sample-MedDRA","color":"#93ece5"},{"id":"LitCovid-sample-CHEBI","color":"#eccb93"},{"id":"LitCovid-sample-sentences","color":"#b193ec"},{"id":"LitCovid-sample-PD-UBERON","color":"#93ec97"},{"id":"LitCovid-sample-Pubtator","color":"#ec93a8"},{"id":"LitCovid-sample-PD-IDO","color":"#93c2ec"},{"id":"LitCovid-sample-PD-FMA","color":"#dcec93"},{"id":"LitCovid-sample-GO-BP","color":"#e193ec"},{"id":"LitCovid-PubTator","color":"#93ecc7"},{"id":"LitCovid-sentences","color":"#ecad93"}]}]}}