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PMC:7441788 / 1687-42371 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T3 967-981 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T4 967-971 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 1007-1017 Body_part denotes organelles http://purl.org/sig/ont/fma/fma63832
T6 1027-1036 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T7 1038-1059 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T8 1477-1480 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T9 1498-1501 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T10 1556-1559 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T11 1923-1927 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 2287-2292 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13 2533-2538 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 3436-3441 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 3673-3677 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T16 3989-3993 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T17 4106-4111 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T18 4162-4173 Body_part denotes spinal cord http://purl.org/sig/ont/fma/fma7647
T19 4355-4360 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 4527-4532 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 4551-4555 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 5035-5039 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 5100-5105 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 5295-5300 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 5600-5604 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 5868-5875 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 5987-5999 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T28 5987-5991 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 6118-6131 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T30 6118-6122 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 6194-6199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 6325-6332 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 6410-6422 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T34 6410-6414 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 6742-6749 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 7137-7144 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 7183-7194 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T38 7362-7365 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T39 7439-7443 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 7494-7503 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T41 7543-7548 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T42 7555-7560 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 7724-7731 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 7740-7743 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T45 7748-7780 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T46 7864-7866 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T47 7868-7879 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T48 7928-7935 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 7936-7954 Body_part denotes membrane receptors http://purl.org/sig/ont/fma/fma0326969
T50 7974-7979 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 8027-8040 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 8045-8057 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T53 8331-8343 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T54 8356-8368 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T55 8356-8360 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T56 8428-8440 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T57 8509-8516 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 8520-8532 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T59 8775-8786 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T60 8871-8874 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T61 8894-8898 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 9015-9024 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T63 9025-9036 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T64 9268-9274 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T65 9326-9333 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 9509-9517 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 9674-9679 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 9769-9776 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 9918-9933 Body_part denotes early endosomes http://purl.org/sig/ont/fma/fma67463
T70 9973-9978 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 10106-10115 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T72 10240-10248 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T73 10295-10304 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T74 10417-10421 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 10489-10496 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 10546-10558 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 10546-10550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 10702-10706 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 10707-10723 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 10718-10723 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T81 11299-11303 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 11319-11327 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T83 11490-11499 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T84 11541-11573 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T85 11575-11578 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T86 11655-11659 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 11727-11732 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 11755-11764 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89 11773-11784 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T90 11785-11791 Body_part denotes (IL)-1 http://purl.org/sig/ont/fma/fma86583
T91 11786-11788 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T92 11793-11795 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T93 11848-11853 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94 11860-11865 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 11901-11910 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T96 12047-12056 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T97 12148-12157 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T98 12158-12161 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T99 12263-12265 Body_part denotes A2 http://purl.org/sig/ont/fma/fma66595
T100 12425-12434 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T101 12472-12474 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T102 12481-12483 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T103 12507-12513 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T104 12591-12599 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T105 13124-13128 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T106 14546-14550 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T107 15413-15417 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T108 16856-16859 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T109 16890-16913 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T110 17849-17851 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T111 18709-18720 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T112 18796-18807 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T113 24609-24612 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T114 24644-24667 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T115 25869-25877 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T116 25878-25880 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T117 28245-28256 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T118 34137-34140 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T119 34142-34163 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T120 34169-34174 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T121 34681-34703 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T122 34723-34728 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 34733-34739 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T124 34794-34799 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T125 34804-34810 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T126 36778-36783 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T127 37136-37143 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T128 37820-37828 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T129 38558-38562 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 39825-39829 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3673-3677 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T2 3989-3993 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T3 4106-4111 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T4 4162-4173 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T5 10702-10706 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 13124-13128 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 14546-14550 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 16890-16913 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T9 16896-16913 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T10 18709-18720 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T11 18796-18807 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T12 24644-24667 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T13 24650-24667 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T14 28245-28256 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T15 34137-34140 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T16 34142-34163 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T17 34169-34174 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 34723-34728 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 34733-34739 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 34794-34799 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T21 34804-34810 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 36778-36783 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T23 39825-39829 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T17 41-49 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 61-108 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T19 61-94 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T20 110-118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 240-248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 329-337 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 586-594 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 1112-1119 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T25 1179-1198 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T26 1207-1235 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T27 1216-1235 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T28 1237-1240 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T29 1246-1266 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T30 1257-1266 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T31 1268-1270 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383
T33 1507-1513 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T34 1528-1533 Disease denotes polio http://purl.obolibrary.org/obo/MONDO_0017373
T35 1582-1593 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T36 1582-1591 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T37 1608-1622 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T38 1692-1700 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 1737-1745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 1914-1922 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256
T41 2312-2321 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 2402-2411 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 2581-2589 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 2711-2719 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 2777-2786 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 2838-2846 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 3021-3039 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T48 3030-3039 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 3222-3231 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50 4130-4139 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 4325-4333 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 4398-4406 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 4507-4515 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 4593-4602 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 4639-4647 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 4940-4948 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 5069-5077 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 5080-5089 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 5264-5272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 5275-5284 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T61 5472-5480 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 5717-5725 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 5776-5784 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 5879-5887 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 6227-6235 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 6351-6359 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 6731-6735 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T68 7005-7013 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 7601-7609 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T70 7611-7635 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T71 7888-7893 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T72 7956-7965 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T73 8124-8133 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T74 8159-8167 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 8249-8257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T76 9532-9540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 9588-9597 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T78 9646-9654 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 9756-9764 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 9861-9869 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 9902-9910 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 10041-10049 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 10590-10599 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 10629-10637 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 11080-11086 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T86 11802-11807 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T87 12555-12563 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 12618-12621 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T90 12733-12736 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T92 12766-12774 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 12840-12848 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 12920-12928 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 13004-13012 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 13103-13112 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T97 13534-13542 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 14156-14164 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 14280-14288 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 14511-14520 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T101 15125-15133 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 16284-16292 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 17811-17819 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 19204-19212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 21180-21188 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 21367-21377 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T107 21667-21675 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 21757-21765 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T109 22116-22125 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T110 22569-22577 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 22852-22860 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 23135-23143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 23387-23391 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T114 23641-23649 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 23666-23675 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T116 23990-23998 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 24435-24443 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 24963-24971 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 25540-25548 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 26219-26227 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 26449-26457 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 26530-26538 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T123 26708-26716 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 26949-26957 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 27924-27932 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 29276-29284 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 29707-29715 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 30811-30819 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 31605-31615 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T130 31822-31833 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T131 32373-32383 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T132 32481-32489 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T133 32714-32722 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T134 32935-32943 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T135 33439-33447 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T136 33617-33625 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 33672-33679 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T138 33961-33969 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T139 34204-34212 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T140 34214-34233 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T141 34234-34248 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T142 34254-34264 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T143 34587-34598 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T144 34986-34994 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 35276-35311 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T146 35289-35311 Disease denotes atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000465
T147 35535-35543 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 35639-35648 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T149 35665-35673 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 35832-35840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T151 36375-36385 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T152 36402-36410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T153 36778-36791 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T154 37171-37175 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T155 37225-37241 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T156 37235-37241 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T157 37306-37321 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T158 37399-37414 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T159 37469-37477 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 37697-37705 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T161 37994-38002 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 38110-38118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T163 38146-38154 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 38249-38257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T165 38356-38364 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 38534-38539 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T167 38682-38693 Disease denotes chikungunya http://purl.obolibrary.org/obo/MONDO_0017941
T168 38749-38758 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T169 38896-38904 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 38942-38950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 39320-39328 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 39596-39604 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T173 39910-39918 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 39921-39930 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T175 40310-40318 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 40445-40453 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 40569-40577 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T7 261-262 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 810-811 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 967-971 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10 972-981 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T11 1027-1036 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T12 1157-1165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T13 1304-1312 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T14 1386-1396 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T15 1460-1468 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T16 1481-1488 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T17 1514-1519 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T18 1534-1539 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T19 1560-1567 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T20 1592-1593 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T21 1594-1599 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T22 1623-1628 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T23 1762-1770 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T24 1789-1794 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T25 1842-1850 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T26 1908-1913 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T27 1923-1932 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T28 1934-1939 http://purl.obolibrary.org/obo/CLO_0051864 denotes Huh-7
T29 2280-2292 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T30 2337-2342 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T31 2467-2472 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T32 2526-2538 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T33 2554-2562 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T34 2623-2625 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T35 2820-2823 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T36 2847-2855 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T37 2882-2885 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T38 2891-2892 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 2910-2911 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 2950-2956 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T41 3169-3174 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T42 3196-3202 http://purl.obolibrary.org/obo/CLO_0001751 denotes and 33
T43 3248-3250 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T44 3284-3289 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T45 3380-3381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3429-3441 http://purl.obolibrary.org/obo/CLO_0051972 denotes HRT-18 cells
T47 3429-3441 http://purl.obolibrary.org/obo/CLO_0051973 denotes HRT-18 cells
T48 3429-3435 http://purl.obolibrary.org/obo/CLO_0003836 denotes HRT-18
T49 3457-3465 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T50 3631-3639 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T51 3693-3698 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T52 3830-3831 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 4041-4046 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T54 4106-4111 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T55 4106-4111 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T56 4162-4173 http://purl.obolibrary.org/obo/UBERON_0002240 denotes spinal cord
T57 4225-4226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 4252-4260 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T59 4298-4306 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T60 4348-4360 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T61 4527-4532 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T62 4551-4560 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T63 4951-4959 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T64 5035-5039 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 5093-5105 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T66 5217-5219 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T67 5288-5300 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T68 5412-5414 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T69 5432-5434 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T70 5483-5491 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T71 5600-5604 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T72 5728-5736 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T73 5802-5810 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T74 5938-5940 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T75 5945-5947 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T76 5945-5947 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T77 5958-5960 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T78 5987-5991 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T79 6052-6057 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T80 6078-6080 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T81 6078-6080 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T82 6099-6104 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T83 6118-6122 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T84 6123-6131 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T85 6187-6199 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T86 6410-6414 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T87 6564-6572 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T88 7211-7219 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T89 7298-7308 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T90 7431-7434 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T91 7437-7443 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T92 7453-7462 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T93 7527-7537 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T94 7541-7548 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T95 7553-7560 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T96 7714-7723 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T97 7936-7944 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T98 7974-7979 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T99 8077-8078 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 8094-8101 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T101 8199-8200 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T102 8282-8283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 8356-8360 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T104 8680-8688 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T105 8828-8836 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T106 8875-8882 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T107 8894-8898 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T108 8923-8924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 8980-8988 http://purl.obolibrary.org/obo/UBERON_0000158 denotes Membrane
T110 9128-9138 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T111 9334-9344 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T112 9363-9371 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T113 9476-9486 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T114 9490-9491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 9582-9587 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T116 9598-9603 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T117 9620-9621 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T118 9664-9667 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T119 9664-9667 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T120 9664-9667 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T121 9664-9667 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T122 9664-9667 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T123 9664-9667 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T124 9664-9667 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T125 9674-9679 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 9783-9784 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T127 9966-9978 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T128 10187-10195 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T129 10295-10304 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T130 10352-10357 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T131 10367-10376 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T132 10417-10421 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T133 10422-10431 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T134 10479-10488 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T135 10529-10536 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T136 10546-10550 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T137 10621-10623 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T138 10686-10691 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 10702-10723 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T140 10725-10729 http://purl.obolibrary.org/obo/CLO_0007158 denotes L132
T141 10755-10765 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T142 10914-10924 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T143 11036-11045 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T144 11087-11092 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 11093-11101 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T146 11157-11165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T147 11185-11195 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T148 11297-11303 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T149 11304-11314 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T150 11490-11499 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T151 11500-11508 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T152 11611-11621 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T153 11653-11659 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T154 11660-11670 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T155 11719-11722 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T156 11725-11732 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T157 11734-11736 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T158 11846-11853 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T159 11858-11865 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T160 11958-11967 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T161 12018-12028 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T162 12125-12133 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T163 12180-12197 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T164 12263-12265 http://purl.obolibrary.org/obo/CLO_0001562 denotes A2
T165 12359-12361 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T166 12507-12513 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T167 13124-13128 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T168 13124-13128 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T169 13264-13266 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T170 13416-13417 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 13591-13593 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T172 13981-13983 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T173 14035-14037 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T174 14383-14385 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T175 14546-14550 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T176 14546-14550 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T177 14857-14859 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T178 15183-15184 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 15705-15706 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T180 16010-16015 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T181 16331-16332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 17133-17134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 17592-17594 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T184 17883-17884 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 18058-18063 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T186 18286-18291 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T187 18295-18298 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T188 18320-18325 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T189 19321-19322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 19445-19446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 19897-19898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 19909-19910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 20034-20035 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 20046-20047 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 20237-20238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 20913-20914 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 20947-20948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 21029-21030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 21065-21066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 21092-21093 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T201 21690-21691 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 22210-22212 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T203 22251-22253 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T204 22268-22270 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T205 23049-23050 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T206 23105-23108 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T207 23221-23223 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T208 23814-23815 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 23897-23898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 24548-24549 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 25064-25065 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 25095-25097 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T213 25665-25667 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T214 25948-25950 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T215 26005-26007 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T216 26114-26122 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T217 26409-26410 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 26917-26918 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 27038-27040 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T220 27299-27304 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T221 27308-27311 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T222 27354-27359 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T223 27579-27580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T224 27874-27875 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 28451-28456 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 28706-28707 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T227 29055-29056 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 29644-29645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 29688-29689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 30656-30657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 30839-30840 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T232 30945-30946 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 31003-31004 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 31207-31208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 31275-31276 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 31466-31467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 31522-31523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 31582-31583 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 31710-31711 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 31855-31856 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 31897-31898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 32042-32049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 32264-32267 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T244 32296-32297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 32459-32460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 33237-33239 http://purl.obolibrary.org/obo/CLO_0037161 denotes en
T247 33685-33686 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 34137-34140 http://www.ebi.ac.uk/efo/EFO_0000826 denotes ear
T249 34142-34163 http://purl.obolibrary.org/obo/UBERON_0004535 denotes cardiovascular system
T250 34142-34163 http://www.ebi.ac.uk/efo/EFO_0000791 denotes cardiovascular system
T251 34169-34174 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T252 34169-34174 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T253 34334-34337 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T254 34408-34414 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T255 34681-34703 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T256 34723-34728 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T257 34723-34728 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T258 34733-34739 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T259 34733-34739 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T260 34733-34739 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T261 34745-34746 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 34794-34799 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T263 34794-34799 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T264 34804-34810 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T265 34804-34810 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T266 34804-34810 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T267 35206-35207 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 35244-35246 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T269 35274-35275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 35335-35336 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 35559-35560 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T272 35995-35997 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T273 36017-36018 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 36071-36073 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T275 36132-36134 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T276 36208-36210 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T277 36251-36252 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 36281-36282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 36528-36529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 36778-36783 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T281 36778-36783 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T282 36778-36783 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T283 36778-36783 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T284 37098-37107 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T285 37641-37651 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T286 37861-37869 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T287 37907-37915 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T288 37970-37971 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 38004-38005 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T290 38161-38163 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T291 38222-38230 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T292 38540-38545 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T293 38546-38562 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity in cell
T294 38606-38612 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T295 38645-38648 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T296 38694-38699 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T297 38717-38723 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T298 39285-39287 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T299 39290-39291 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T300 39720-39721 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T301 39777-39785 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T302 39848-39854 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T303 40079-40084 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T304 40219-40220 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T19 371-386 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T20 371-380 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T21 381-386 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T22 533-538 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T23 614-619 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T24 669-674 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T25 675-686 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T26 688-690 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T27 707-725 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T28 763-768 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T29 867-869 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T30 895-909 Chemical denotes aminoquinoline http://purl.obolibrary.org/obo/CHEBI_36709
T31 936-941 Chemical denotes bases http://purl.obolibrary.org/obo/CHEBI_22695
T32 1075-1077 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T33 1268-1270 Chemical denotes RA http://purl.obolibrary.org/obo/CHEBI_73810
T34 1331-1333 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T35 1361-1371 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T36 1376-1385 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T37 1435-1437 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T38 1450-1459 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T39 1556-1559 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T40 1677-1679 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T41 1774-1776 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T42 1832-1841 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T43 1854-1856 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T44 2129-2131 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T45 2196-2198 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T46 2274-2276 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T47 2369-2371 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T48 2447-2449 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T49 2544-2553 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T50 2566-2568 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T51 2669-2671 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T52 2683-2685 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T53 2762-2764 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T54 2817-2819 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T55 2879-2881 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T56 2983-2985 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T57 3073-3075 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T58 3138-3140 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T59 3265-3267 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T60 3362-3371 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T61 3406-3408 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T62 3447-3456 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T63 3469-3471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T64 3555-3557 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T65 3601-3603 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T66 3794-3796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T67 3919-3921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T68 4021-4023 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T69 4054-4056 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T70 4213-4215 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T71 4310-4312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T72 4381-4383 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T73 4387-4389 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T74 4454-4456 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T75 4664-4666 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T76 4788-4790 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T77 4794-4796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T78 4963-4965 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T79 5127-5129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T80 5318-5320 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T81 5495-5497 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T82 5693-5695 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T83 5757-5759 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T84 5868-5875 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 5945-5947 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T86 6009-6020 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T87 6078-6080 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T88 6173-6175 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T89 6256-6258 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T90 6325-6332 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 6443-6445 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T92 6576-6578 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T93 6742-6749 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 6866-6868 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T95 6930-6932 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T96 6963-6972 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97 7137-7144 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98 7167-7178 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T99 7174-7178 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T100 7183-7194 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T101 7372-7374 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T102 7568-7579 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T103 7637-7639 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T104 7641-7652 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T105 7659-7677 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T106 7706-7713 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T107 7724-7731 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T108 7744-7746 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T109 7787-7789 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T110 7822-7836 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T111 7829-7832 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T113 7833-7836 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T116 7852-7862 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T117 7864-7866 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T119 7928-7935 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T120 8004-8015 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T121 8011-8015 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T122 8027-8040 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T123 8045-8057 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T124 8331-8343 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T125 8377-8388 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T126 8384-8388 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T127 8398-8400 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T128 8411-8423 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T129 8418-8423 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T130 8428-8440 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T131 8509-8516 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T132 8520-8532 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T133 8539-8541 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T134 8567-8574 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T135 8625-8637 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T136 8632-8637 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T137 8692-8694 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T138 8759-8770 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T139 8766-8770 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T140 8775-8786 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T141 9221-9223 Chemical denotes PC http://purl.obolibrary.org/obo/CHEBI_16110|http://purl.obolibrary.org/obo/CHEBI_49183|http://purl.obolibrary.org/obo/CHEBI_53201|http://purl.obolibrary.org/obo/CHEBI_55395|http://purl.obolibrary.org/obo/CHEBI_57643|http://purl.obolibrary.org/obo/CHEBI_61433
T147 9268-9274 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T148 9326-9333 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 9509-9517 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T150 9769-9776 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 9840-9842 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T152 10008-10010 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T153 10085-10087 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T154 10199-10201 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T155 10471-10478 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T156 10489-10496 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T157 10566-10573 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T158 10644-10646 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T159 10847-10870 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T160 10856-10862 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T161 10872-10875 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T162 11026-11035 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T163 11119-11121 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T164 11147-11156 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T165 11339-11341 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T166 11424-11440 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T167 11474-11476 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T168 11521-11528 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T169 11586-11588 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T170 11739-11741 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T171 11786-11788 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T173 11793-11795 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T175 12063-12065 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T176 12086-12100 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T177 12093-12096 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T179 12097-12100 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T182 12158-12161 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T183 12187-12197 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T184 12225-12227 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T185 12294-12310 Chemical denotes arachidonic acid http://purl.obolibrary.org/obo/CHEBI_15843
T186 12306-12310 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T187 12343-12357 Chemical denotes prostaglandins http://purl.obolibrary.org/obo/CHEBI_26333
T188 12472-12474 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T190 12481-12483 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T192 12698-12700 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T193 12813-12815 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T194 12914-12916 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T195 12964-12966 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T196 13030-13032 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T197 13061-13066 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T198 13622-13624 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T199 13691-13693 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T200 13802-13807 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T201 13846-13851 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T202 13887-13892 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T203 14023-14028 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T204 14087-14089 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T205 14217-14228 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T206 14230-14232 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T207 14234-14252 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T208 14431-14433 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T209 14469-14471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T210 14818-14820 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T211 14821-14826 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T212 14844-14846 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T213 14870-14872 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T214 14915-14917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T215 15010-15015 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T216 15054-15059 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T217 15093-15095 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T218 15304-15309 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T219 15327-15332 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T220 15381-15386 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T221 15462-15467 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T222 15613-15618 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T223 15636-15641 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T224 15698-15703 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T225 15803-15808 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T226 16010-16015 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T227 16049-16054 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T228 16072-16077 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T229 16349-16354 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T230 16526-16535 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T231 17040-17045 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T232 17063-17068 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T233 17581-17586 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T234 17603-17608 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T235 17683-17688 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T236 17725-17730 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T237 17849-17851 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T239 18008-18013 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T240 18058-18063 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T241 18092-18097 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T242 18111-18123 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T243 18124-18129 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T244 18146-18151 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T245 18230-18242 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T246 18457-18461 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T247 18561-18566 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T248 18637-18649 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T249 18862-18867 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T250 19015-19027 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T251 19111-19123 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T252 19793-19805 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T253 19997-19999 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T254 20086-20098 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T255 20659-20671 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T256 20832-20837 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T257 20867-20869 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T258 20879-20881 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T259 20905-20907 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T260 20915-20924 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T261 20949-20958 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T262 21021-21023 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T263 21031-21040 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T264 21067-21076 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T265 21112-21114 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T266 21141-21150 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T267 21467-21471 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T268 21572-21576 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T269 21905-21910 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T270 21950-21955 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T271 22030-22035 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T272 22053-22058 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T273 22137-22142 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T274 22171-22176 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T275 22241-22246 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T276 22286-22291 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T277 22965-22970 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T278 23158-23164 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T279 23248-23253 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T280 23278-23283 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T281 23453-23458 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T282 23470-23475 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T283 23503-23508 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T284 24280-24285 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T285 24328-24333 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T286 24487-24496 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T287 24569-24578 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T288 25772-25777 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T289 25814-25819 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T290 25878-25880 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T292 25894-25899 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T293 26887-26889 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T294 26919-26928 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T295 27122-27134 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T296 27203-27208 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T297 27243-27255 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T298 27397-27409 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T299 27527-27538 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T300 27542-27554 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T301 27687-27692 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T302 27768-27773 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T303 28025-28037 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T304 28336-28348 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T305 28344-28348 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T306 28543-28548 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T307 28692-28704 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T308 28806-28818 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T309 28920-28932 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T310 29005-29010 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T311 29031-29043 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T312 29044-29049 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T313 29108-29113 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T314 29189-29201 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T315 29575-29587 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T316 29806-29818 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T317 29857-29869 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T318 29901-29905 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T319 29914-29926 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T320 30007-30019 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T321 30052-30064 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T322 30093-30097 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T323 30195-30199 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T324 30292-30304 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T325 30320-30332 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T326 30703-30705 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T327 30740-30750 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T328 30761-30773 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T329 30778-30792 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T330 30919-30921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T331 30937-30939 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T332 30947-30956 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T333 31005-31014 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T334 31044-31049 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T335 31165-31170 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T336 31179-31181 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T337 31182-31187 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T338 31199-31201 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T339 31209-31218 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T340 31219-31224 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T341 31240-31245 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T342 31264-31269 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T343 31277-31286 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T344 31303-31308 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T345 31427-31432 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T346 31441-31443 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T347 31444-31449 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T348 31458-31460 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T349 31468-31477 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T350 31478-31483 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T351 31496-31501 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T352 31524-31533 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T353 31534-31539 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T354 31668-31670 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T355 31712-31721 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T356 31989-32001 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T357 32213-32215 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T358 32220-32230 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T359 32232-32244 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T360 32248-32262 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T361 32432-32434 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T362 32616-32618 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T363 32774-32776 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T364 32781-32791 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T365 32793-32805 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T366 32809-32823 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T367 32915-32917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T368 33237-33239 Chemical denotes en http://purl.obolibrary.org/obo/CHEBI_30347
T369 33306-33308 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T370 33344-33346 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T371 33380-33390 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T372 33574-33579 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T373 33639-33641 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T374 33770-33772 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T375 33898-33900 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T376 34090-34092 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T377 34326-34328 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T378 34457-34459 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T379 34605-34607 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T380 34864-34866 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T381 35146-35149 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T382 35741-35753 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T383 35951-35963 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T384 36110-36122 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T385 36239-36241 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T386 36243-36245 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T387 36253-36262 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T388 36283-36292 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T389 36505-36507 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T390 36530-36539 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T391 36546-36548 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T392 36641-36649 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T393 36714-36716 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T394 36831-36836 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T395 36861-36866 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T396 36868-36882 Chemical denotes antihistamines http://purl.obolibrary.org/obo/CHEBI_37956
T397 36888-36900 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T398 36989-36994 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T399 37003-37008 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T400 37092-37094 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T401 37136-37143 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T403 37146-37155 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T407 37327-37329 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T408 37433-37435 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T409 37610-37612 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T410 37763-37765 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T411 38052-38054 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T412 38234-38236 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T413 38310-38312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T414 38522-38524 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T415 38642-38644 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T416 38919-38921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T417 39649-39651 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T418 39747-39749 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T419 39872-39874 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T420 40048-40060 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T421 40183-40185 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T422 40221-40230 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T423 40421-40423 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T424 40501-40512 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T425 40516-40518 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T426 40559-40564 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T2 626-639 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigation http://purl.bioontology.org/ontology/MEDDRA/10062026
T3 5605-5612 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447
T4 6009-6038 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T5 6142-6155 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigation http://purl.bioontology.org/ontology/MEDDRA/10062026
T6 7568-7597 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T7 9791-9803 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T8 15413-15429 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes body temperature http://purl.bioontology.org/ontology/MEDDRA/10005906
T9 16400-16412 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigator http://purl.bioontology.org/ontology/MEDDRA/10062026
T10 16926-16948 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes bronchoalveolar lavage http://purl.bioontology.org/ontology/MEDDRA/10049413
T11 17387-17396 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes weighting http://purl.bioontology.org/ontology/MEDDRA/10047890
T12 18721-18731 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T13 18808-18818 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T14 23540-23557 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes electrocardiogram http://purl.bioontology.org/ontology/MEDDRA/10014362
T15 24680-24702 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes bronchoalveolar lavage http://purl.bioontology.org/ontology/MEDDRA/10049413
T16 26858-26870 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 27851-27861 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T18 28257-28267 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T19 28457-28464 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447
T20 36563-36580 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes electrocardiogram http://purl.bioontology.org/ontology/MEDDRA/10014362
T21 37136-37169 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes glucose 6-phosphate dehydrogenase http://purl.bioontology.org/ontology/MEDDRA/10059900
T22 38563-38570 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447
T23 39978-39990 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15 675-686 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T16 688-690 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T17 707-725 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T18 867-869 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T19 895-909 Chemical denotes aminoquinoline http://purl.obolibrary.org/obo/CHEBI_36709
T20 1075-1077 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T21 1331-1333 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T22 1435-1437 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T23 1477-1480 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T24 1556-1559 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T25 1677-1679 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T26 1774-1776 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T27 1854-1856 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T28 2196-2198 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T29 2274-2276 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T30 2369-2371 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T31 2447-2449 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T32 2566-2568 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T33 2762-2764 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T34 2817-2819 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T35 2879-2881 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T36 2983-2985 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T37 3073-3075 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T38 3138-3140 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T39 3265-3267 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T40 3406-3408 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T41 3469-3471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T42 3601-3603 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T43 3794-3796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T44 3919-3921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T45 4021-4023 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T46 4054-4056 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T47 4213-4215 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T48 4310-4312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T49 4387-4389 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T50 4454-4456 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T51 4664-4666 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T52 4794-4796 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T53 4963-4965 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T54 5127-5129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T55 5318-5320 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T56 5495-5497 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T57 5693-5695 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T58 5757-5759 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T59 5868-5875 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T60 6009-6020 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T61 6173-6175 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T62 6256-6258 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T63 6325-6332 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T64 6443-6445 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T65 6576-6578 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T66 6742-6749 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T67 6866-6868 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T68 6930-6932 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T69 7137-7144 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 7167-7178 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T71 7183-7194 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T72 7568-7579 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T73 7637-7639 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T74 7641-7652 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T75 7659-7677 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T76 7724-7731 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 7822-7836 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T78 7928-7935 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 8004-8015 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T80 8027-8040 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T81 8045-8057 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T82 8331-8343 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T83 8377-8388 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T84 8398-8400 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T85 8411-8423 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T86 8428-8440 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T87 8509-8516 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 8520-8532 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T89 8539-8541 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T90 8567-8574 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T91 8625-8637 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T92 8692-8694 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T93 8759-8770 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T94 8775-8786 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T95 8871-8874 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T96 9268-9274 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T97 9326-9333 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98 9509-9517 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T99 9769-9776 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 9840-9842 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T101 10008-10010 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T102 10085-10087 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T103 10199-10201 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T104 10489-10496 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 10644-10646 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T106 10847-10870 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T107 10872-10875 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T108 11119-11121 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T109 11339-11341 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T110 11474-11476 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T111 11739-11741 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T112 12063-12065 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T113 12086-12100 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T114 12158-12161 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T115 12225-12227 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T116 12294-12310 Chemical denotes arachidonic acid http://purl.obolibrary.org/obo/CHEBI_15843
T117 12343-12357 Chemical denotes prostaglandins http://purl.obolibrary.org/obo/CHEBI_26333
T118 12698-12700 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T119 12813-12815 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T120 12914-12916 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T121 12964-12966 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T122 13030-13032 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T123 13622-13624 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T124 13691-13693 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T125 14087-14089 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T126 14217-14228 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T127 14230-14232 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T128 14234-14252 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T129 14431-14433 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T130 14469-14471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T131 14818-14820 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T132 14844-14846 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T133 14870-14872 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T134 14915-14917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T135 15093-15095 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T136 16856-16859 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T137 18111-18123 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T138 18230-18242 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T139 18637-18649 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T140 19015-19027 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T141 19111-19123 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T142 19793-19805 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T143 20086-20098 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T144 20659-20671 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T145 20867-20869 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T146 20905-20907 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T147 20915-20924 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T148 20949-20958 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T149 21021-21023 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T150 21031-21040 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T151 21067-21076 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T152 21112-21114 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T153 21141-21150 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T154 23158-23164 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T155 24609-24612 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T156 26887-26889 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T157 26919-26928 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T158 27122-27134 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T159 27243-27255 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T160 27397-27409 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T161 27542-27554 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T162 28025-28037 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T163 28336-28348 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T164 28692-28704 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T165 28806-28818 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T166 28920-28932 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T167 29031-29043 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T168 29189-29201 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T169 29575-29587 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T170 29806-29818 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T171 29857-29869 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T172 29914-29926 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T173 30007-30019 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T174 30052-30064 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T175 30292-30304 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T176 30320-30332 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T177 30703-30705 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T178 30740-30750 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T179 30761-30773 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T180 30778-30792 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T181 30919-30921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T182 30937-30939 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T183 30947-30956 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T184 31005-31014 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T185 31179-31181 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T186 31199-31201 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T187 31209-31218 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T188 31277-31286 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T189 31441-31443 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T190 31458-31460 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T191 31468-31477 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T192 31524-31533 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T193 31668-31670 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T194 31712-31721 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T195 31989-32001 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T196 32213-32215 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T197 32220-32230 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T198 32232-32244 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T199 32248-32262 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T200 32432-32434 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T201 32616-32618 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T202 32774-32776 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T203 32781-32791 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T204 32793-32805 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T205 32809-32823 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T206 32915-32917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T207 33306-33308 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T208 33344-33346 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T209 33380-33390 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T210 33639-33641 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T211 33770-33772 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T212 33898-33900 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T213 34090-34092 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T214 34326-34328 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T215 34457-34459 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T216 34605-34607 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T217 34864-34866 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T218 35146-35149 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T219 35741-35753 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T220 35951-35963 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T221 36110-36122 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T222 36239-36241 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T223 36243-36245 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T224 36253-36262 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T225 36283-36292 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T226 36505-36507 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T227 36530-36539 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T228 36546-36548 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T229 36714-36716 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T230 36888-36900 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T231 37092-37094 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T232 37136-37143 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T234 37146-37155 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T238 37327-37329 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T239 37433-37435 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T240 37610-37612 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T241 37763-37765 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T242 38052-38054 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T243 38234-38236 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T244 38310-38312 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T245 38522-38524 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T246 38642-38644 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T247 38919-38921 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T248 39649-39651 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T249 39747-39749 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T250 39872-39874 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T251 40048-40060 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T252 40183-40185 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T253 40221-40230 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T254 40421-40423 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T255 40516-40518 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T15 41-49 Species denotes COVID-19 NCBItxid:2697049
T16 61-108 Species denotes severe acute respiratory syndrome coronavirus 2 NCBItxid:2697049
T17 110-120 Species denotes SARS-CoV-2 NCBItxid:2697049
T18 240-248 Species denotes COVID-19 NCBItxid:2697049
T19 329-337 Species denotes COVID-19 NCBItxid:2697049
T20 586-594 Species denotes COVID-19 NCBItxid:2697049
T21 1146-1156 Species denotes plasmodium NCBItxid:5820|NCBItxid:418103
T23 1477-1488 Species denotes RNA viruses NCBItxid:2559587
T24 1498-1501 Species denotes HIV NCBItxid:57667|NCBItxid:35274|NCBItxid:12721|NCBItxid:11709|NCBItxid:11676
T29 1507-1519 Species denotes rabies virus NCBItxid:11292
T30 1528-1539 Species denotes polio virus NCBItxid:138950
T31 1556-1567 Species denotes DNA viruses NCBItxid:2080735
T32 1582-1599 Species denotes hepatitis B virus NCBItxid:10407
T33 1615-1628 Species denotes simplex virus NCBItxid:10294
T34 1692-1702 Species denotes SARS-CoV-2 NCBItxid:2697049
T35 1737-1745 Species denotes COVID-19 NCBItxid:2697049
T36 1789-1806 Species denotes human coronavirus NCBItxid:694448
T37 1865-1873 Species denotes MERS-CoV NCBItxid:1335626
T38 1878-1887 Species denotes HCoV-229E NCBItxid:11137
T39 1908-1913 Species denotes human NCBItxid:9606
T40 2234-2242 Species denotes MERS-CoV NCBItxid:1335626
T41 2303-2311 Species denotes MERS-CoV NCBItxid:1335626
T42 2393-2401 Species denotes MERS-CoV NCBItxid:1335626
T43 2581-2589 Species denotes SARS-CoV NCBItxid:694009
T44 2711-2719 Species denotes SARS-CoV NCBItxid:694009
T45 2838-2846 Species denotes SARS-CoV NCBItxid:694009
T46 3021-3029 Species denotes SARS-CoV NCBItxid:694009
T47 3480-3489 Species denotes HCoV-OC43 NCBItxid:31631
T48 3621-3630 Species denotes HCoV-OC43 NCBItxid:31631
T49 3693-3698 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T51 3759-3763 Species denotes mice NCBItxid:10095|NCBItxid:10088
T53 3971-3975 Species denotes mice NCBItxid:10095|NCBItxid:10088
T55 4041-4046 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T57 4077-4086 Species denotes HCoV-OC43 NCBItxid:31631
T58 4325-4335 Species denotes SARS-CoV-2 NCBItxid:2697049
T59 4398-4408 Species denotes SARS-CoV-2 NCBItxid:2697049
T60 4507-4517 Species denotes SARS-CoV-2 NCBItxid:2697049
T61 4639-4649 Species denotes SARS-CoV-2 NCBItxid:2697049
T62 4940-4950 Species denotes SARS-CoV-2 NCBItxid:2697049
T63 5069-5079 Species denotes SARS-CoV-2 NCBItxid:2697049
T64 5264-5274 Species denotes SARS-CoV-2 NCBItxid:2697049
T65 5472-5482 Species denotes SARS-CoV-2 NCBItxid:2697049
T66 5717-5727 Species denotes SARS-CoV-2 NCBItxid:2697049
T67 5776-5784 Species denotes COVID-19 NCBItxid:2697049
T68 5879-5889 Species denotes SARS-CoV-2 NCBItxid:2697049
T69 6227-6237 Species denotes SARS-CoV-2 NCBItxid:2697049
T70 6351-6359 Species denotes SARS-CoV NCBItxid:694009
T71 6731-6735 Species denotes SARS NCBItxid:694009
T72 7005-7013 Species denotes COVID-19 NCBItxid:2697049
T73 7601-7609 Species denotes COVID-19 NCBItxid:2697049
T74 7611-7635 Species denotes coronavirus disease 2019 NCBItxid:2697049
T75 8094-8101 Species denotes viruses NCBItxid:10239
T76 8159-8167 Species denotes SARS-CoV NCBItxid:694009
T77 8177-8186 Species denotes HCoV-OC43 NCBItxid:31631
T78 8249-8259 Species denotes SARS-CoV-2 NCBItxid:2697049
T79 8871-8882 Species denotes RNA viruses NCBItxid:2559587
T80 9532-9540 Species denotes SARS-CoV NCBItxid:694009
T81 9547-9555 Species denotes MERS-CoV NCBItxid:1335626
T82 9562-9571 Species denotes HCoV-229E NCBItxid:11137
T83 9582-9605 Species denotes mouse hepatitis virus 2 NCBItxid:76344
T84 9607-9610 Species denotes MHV NCBItxid:11138
T85 9646-9656 Species denotes SARS-CoV-2 NCBItxid:2697049
T86 9756-9766 Species denotes SARS-CoV-2 NCBItxid:2697049
T87 9861-9871 Species denotes SARS-CoV-2 NCBItxid:2697049
T88 9902-9912 Species denotes SARS-CoV-2 NCBItxid:2697049
T89 10041-10051 Species denotes SARS-CoV-2 NCBItxid:2697049
T90 10616-10619 Species denotes MHV NCBItxid:11138
T91 10629-10637 Species denotes SARS-CoV NCBItxid:694009
T92 10661-10670 Species denotes HCoV-229E NCBItxid:11137
T93 10686-10691 Species denotes human NCBItxid:9606
T94 11080-11092 Species denotes dengue virus NCBItxid:12637
T95 12555-12565 Species denotes SARS-CoV-2 NCBItxid:2697049
T96 12766-12774 Species denotes COVID-19 NCBItxid:2697049
T97 12840-12848 Species denotes COVID-19 NCBItxid:2697049
T98 12920-12928 Species denotes COVID-19 NCBItxid:2697049
T99 13004-13012 Species denotes COVID-19 NCBItxid:2697049
T100 13534-13542 Species denotes COVID-19 NCBItxid:2697049
T101 14156-14164 Species denotes COVID-19 NCBItxid:2697049
T102 14280-14288 Species denotes COVID-19 NCBItxid:2697049
T103 15125-15133 Species denotes COVID-19 NCBItxid:2697049
T104 16284-16292 Species denotes COVID-19 NCBItxid:2697049
T105 17811-17819 Species denotes COVID-19 NCBItxid:2697049
T106 19204-19212 Species denotes COVID-19 NCBItxid:2697049
T107 21180-21188 Species denotes COVID-19 NCBItxid:2697049
T108 21667-21675 Species denotes COVID-19 NCBItxid:2697049
T109 21757-21765 Species denotes COVID-19 NCBItxid:2697049
T110 22569-22577 Species denotes COVID-19 NCBItxid:2697049
T111 22852-22860 Species denotes COVID-19 NCBItxid:2697049
T112 23135-23143 Species denotes COVID-19 NCBItxid:2697049
T113 23641-23649 Species denotes COVID-19 NCBItxid:2697049
T114 23990-23998 Species denotes COVID-19 NCBItxid:2697049
T115 24435-24443 Species denotes COVID-19 NCBItxid:2697049
T116 24963-24971 Species denotes COVID-19 NCBItxid:2697049
T117 25540-25548 Species denotes COVID-19 NCBItxid:2697049
T118 26219-26227 Species denotes COVID-19 NCBItxid:2697049
T119 26449-26457 Species denotes COVID-19 NCBItxid:2697049
T120 26530-26538 Species denotes COVID-19 NCBItxid:2697049
T121 26708-26716 Species denotes COVID-19 NCBItxid:2697049
T122 26949-26957 Species denotes COVID-19 NCBItxid:2697049
T123 27924-27932 Species denotes COVID-19 NCBItxid:2697049
T124 29276-29284 Species denotes COVID-19 NCBItxid:2697049
T125 29707-29715 Species denotes COVID-19 NCBItxid:2697049
T126 30811-30819 Species denotes COVID-19 NCBItxid:2697049
T127 32042-32049 Species denotes viruses NCBItxid:10239
T128 32481-32489 Species denotes COVID-19 NCBItxid:2697049
T129 32714-32722 Species denotes COVID-19 NCBItxid:2697049
T130 32935-32943 Species denotes COVID-19 NCBItxid:2697049
T131 33439-33447 Species denotes COVID-19 NCBItxid:2697049
T132 33617-33625 Species denotes COVID-19 NCBItxid:2697049
T133 34986-34994 Species denotes COVID-19 NCBItxid:2697049
T134 35535-35543 Species denotes COVID-19 NCBItxid:2697049
T135 35665-35673 Species denotes COVID-19 NCBItxid:2697049
T136 35832-35840 Species denotes COVID-19 NCBItxid:2697049
T137 36402-36410 Species denotes COVID-19 NCBItxid:2697049
T138 37235-37241 Species denotes anemia NCBItxid:12939
T139 37469-37477 Species denotes COVID-19 NCBItxid:2697049
T140 37697-37707 Species denotes SARS-CoV-2 NCBItxid:2697049
T141 37994-38002 Species denotes COVID-19 NCBItxid:2697049
T142 38110-38118 Species denotes SARS-CoV NCBItxid:694009
T143 38128-38136 Species denotes MERS-CoV NCBItxid:1335626
T144 38146-38156 Species denotes SARS-CoV-2 NCBItxid:2697049
T145 38249-38259 Species denotes SARS-CoV-2 NCBItxid:2697049
T146 38356-38364 Species denotes COVID-19 NCBItxid:2697049
T147 38534-38545 Species denotes Ebola virus NCBItxid:1570291
T148 38682-38699 Species denotes chikungunya virus NCBItxid:37124
T149 38896-38904 Species denotes COVID-19 NCBItxid:2697049
T150 38942-38950 Species denotes COVID-19 NCBItxid:2697049
T151 39320-39328 Species denotes COVID-19 NCBItxid:2697049
T152 39596-39604 Species denotes COVID-19 NCBItxid:2697049
T153 39722-39728 Species denotes rodent NCBItxid:9989
T154 39767-39776 Species denotes HCoV-OC43 NCBItxid:31631
T155 39848-39854 Species denotes humans NCBItxid:9605
T156 39910-39920 Species denotes SARS-CoV-2 NCBItxid:2697049
T157 40310-40318 Species denotes COVID-19 NCBItxid:2697049
T158 40445-40453 Species denotes COVID-19 NCBItxid:2697049
T159 40569-40577 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T17 0-2 Sentence denotes 1.
T18 4-16 Sentence denotes Introduction
T19 17-223 Sentence denotes Coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide, resulting in the third outbreak of coronaviruses in the 21st century.
T20 224-301 Sentence denotes The pandemic of COVID-19 constitutes a serious threat to the whole world [1].
T21 302-509 Sentence denotes To control the pandemic of COVID-19, effective and easily accessible antiviral drugs and vaccines are urgently needed, in addition to the implementation of epidemiological measures such as strict quarantine.
T22 510-595 Sentence denotes However, until now, no drugs have been demonstrated to be effective against COVID-19.
T23 596-866 Sentence denotes Among the various drugs under investigation are repurposed anti-malarial drugs chloroquine (CQ) and its analog hydroxychloroquine (HCQ), which are among the most used drugs because they are easy to obtain and have a proven favorable safety record at relatively low cost.
T24 867-910 Sentence denotes CQ/HCQ are derivatives of 4-aminoquinoline.
T25 911-1074 Sentence denotes They are lipophilic weak bases that quickly pass across cell membranes and accumulate in acidic organelles, such as lysosomes, endoplasmic reticulum and Golgi [2].
T26 1075-1317 Sentence denotes CQ/HCQ are used to treat and prevent malaria attacks due to their anti-plasmodium activity and to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) owing to their immunomodulatory activity [3].
T27 1318-1401 Sentence denotes In addition, CQ/HCQ display antibacterial, antifungal and antiviral activities [4].
T28 1402-1633 Sentence denotes In vitro studies have shown that CQ/HCQ possess antiviral activity against RNA viruses, such as HIV [5], rabies virus [6] and polio virus [7] and various DNA viruses as diverse as hepatitis B virus [8] and herpes simplex virus [9].
T29 1634-1746 Sentence denotes This article reviews the current status of CQ/HCQ against SARS-CoV-2 and their use in the treatment of COVID-19.
T30 1748-1750 Sentence denotes 2.
T31 1752-1827 Sentence denotes Antiviral activity of CQ/HCQ against human coronavirus in vitro and in vivo
T32 1828-2195 Sentence denotes The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and >50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and >15, respectively [10].
T33 2196-2261 Sentence denotes CQ could inhibit an early step in the MERS-CoV replication cycle.
T34 2262-2354 Sentence denotes Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production.
T35 2355-2522 Sentence denotes However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].
T36 2523-2710 Sentence denotes In VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of >128 μM and CC50 > 100 and SI of >31 and SI>3, respectively [10,11].
T37 2711-2792 Sentence denotes SARS-CoV replication was inhibited by 99% at 16 μM CQ 3 days post-infection [12].
T38 2793-2865 Sentence denotes The data indicates that CQ has stronger anti-SARS-CoV activity than HCQ.
T39 2866-2934 Sentence denotes In addition, CQ has both a prophylactic and a therapeutic advantage.
T40 2935-3425 Sentence denotes Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13].
T41 3426-3572 Sentence denotes In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].
T42 3573-3678 Sentence denotes An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk.
T43 3679-3941 Sentence denotes The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14].
T44 3942-4029 Sentence denotes The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14].
T45 4030-4179 Sentence denotes In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15].
T46 4180-4282 Sentence denotes The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo.
T47 4284-4286 Sentence denotes 3.
T48 4288-4344 Sentence denotes Antiviral activity of CQ/HCQ against SARS-CoV-2 in vitro
T49 4345-4453 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 4454-4538 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 4539-4769 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 4770-4902 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 4903-5008 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 5009-5436 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 5437-5526 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 5527-5649 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 5650-5737 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.
T58 5739-5741 Sentence denotes 4.
T59 5743-5784 Sentence denotes Mechanisms of CQ/HCQ in treating COVID-19
T60 5786-5790 Sentence denotes 4.1.
T61 5792-5810 Sentence denotes Antiviral activity
T62 5812-5818 Sentence denotes 4.1.1.
T63 5820-5861 Sentence denotes Hindrance of receptor recognition process
T64 5862-5953 Sentence denotes The S protein of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19].
T65 5954-6137 Sentence denotes The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19].
T66 6138-6526 Sentence denotes The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective anti-SARS-CoV-2 concentrations of CQ had no significant effect on the synthesis and glycosylation of S protein on the surface of SARS-CoV, and although it had no significant effect on the cell surface expression of ACE2, CQ could destroy the glycosylation at the terminal glycosylation site of ACE2 [13].
T67 6527-6800 Sentence denotes Therefore, the mechanism of anti-CoV activity of CQ/HCQ may be at least partly related to the impairment of terminal glycosylation of ACE2, which may result in reduced binding affinities between ACE2 and SARS CoV S protein, thereby blocking receptor recognition (Figure 1).
T68 6801-6810 Sentence denotes Figure 1.
T69 6811-6929 Sentence denotes Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response.
T70 6930-7561 Sentence denotes CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells.
T71 7562-7912 Sentence denotes ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α.
T72 7913-8198 Sentence denotes In addition to protein membrane receptors, infection of host cells by HCoVs also relies on sialic acid-containing glycoproteins and gangliosides, which are used by a broad range of viruses as receptors, such as influenza [20] and HCoVs including SARS-CoV [21] and HCoV-OC43 [13,22,23].
T73 8199-8397 Sentence denotes A recent molecular structure analysis showed that SARS-CoV-2 not only uses ACE2 as a receptor, but also recognizes highly conserved gangliosides on the host cell surface through sialic acid [24,25].
T74 8398-8538 Sentence denotes CQ/HCQ binds sialic acids and gangliosides with high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25].
T75 8539-8646 Sentence denotes CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27].
T76 8647-8798 Sentence denotes Hence, the mechanism of anti-CoV activity of CQ/HCQ may also be related to hindering the recognition process of sialic acid and ganglioside (Figure 1).
T77 8800-8806 Sentence denotes 4.1.2.
T78 8808-8851 Sentence denotes Interference of the membrane fusion process
T79 8852-8979 Sentence denotes CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28].
T80 8980-9144 Sentence denotes Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29].
T81 9145-9384 Sentence denotes Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30].
T82 9385-9619 Sentence denotes Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33].
T83 9620-9782 Sentence denotes A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24].
T84 9783-10132 Sentence denotes A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17].
T85 10133-10396 Sentence denotes These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1).
T86 10398-10404 Sentence denotes 4.1.3.
T87 10406-10466 Sentence denotes Effects on cell signaling pathway and host defense machinery
T88 10467-10643 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 10644-10783 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 10784-10949 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 10950-11107 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 11108-11268 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).
T93 11270-11274 Sentence denotes 4.2.
T94 11276-11338 Sentence denotes Inhibitory effect on T cell activation and cytokine production
T95 11339-11441 Sentence denotes CQ/HCQ regulate the release of various pro-inflammatory factors, which are important immunomodulators.
T96 11442-11627 Sentence denotes Intracellular alkalinization by CQ/HCQ inhibits lysosomal activity, preventing antigen processing, major histocompatibility complex (MHC) class II expression and immune activation [40].
T97 11628-11738 Sentence denotes This process can inhibit T cell activation and block expression of CD154 on the surface of CD4 + T cells [41].
T98 11739-11871 Sentence denotes CQ also reduces cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α) produced by T cells and B cells [42].
T99 11872-12062 Sentence denotes At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43].
T100 12063-12214 Sentence denotes CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44].
T101 12215-12363 Sentence denotes In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of prostaglandins [45].
T102 12364-12659 Sentence denotes Some clinical studies have found that high concentrations of cytokines and pro-inflammatory factors such as IL-6 and IL-10 are elevated in the plasma of critically ill patients infected with SARS-CoV-2 [46,47], suggesting that cytokine release syndrome (CRS) is associated with disease severity.
T103 12660-12786 Sentence denotes In the aspect of immune response, HCQ/CQ therefore are likely to inhibit CRS, delaying the progression of COVID-19 (Figure 1).
T104 12788-12790 Sentence denotes 5.
T105 12792-12848 Sentence denotes Clinical efficacy of CQ/HCQ in the treatment of COVID-19
T106 12849-12948 Sentence denotes Only two published clinical reports have studied the efficacy of CQ in COVID-19 patients (Table 1).
T107 12949-13202 Sentence denotes One study used CQ to treat more than 100 patients with COVID-19 and claimed that CQ was superior to the control group in suppressing the deterioration of pneumonia, improving lung imaging, promoting viral conversion and shortening the course of disease.
T108 13203-13268 Sentence denotes Serious adverse effects were not observed in these patients [48].
T109 13269-13405 Sentence denotes However, this report did not provide any details about the study design and patient data, thus it is difficult to evaluate the validity.
T110 13406-13508 Sentence denotes Recently, a parallel, double-blind, randomized, phase IIB clinical trial was performed in Brazil [49].
T111 13509-13590 Sentence denotes In this study, 81 severe COVID-19 patients were randomly divided into two groups:
T112 13591-13758 Sentence denotes 41 patients received high-dose CQ (600 mg/2 times/day for 10 day) and 40 patients received low-dose CQ (450 mg/2 times on day 1 and then 450 mg/1 time/day for 4 days).
T113 13759-13870 Sentence denotes The 13-day mortality rate in the high-dose group was more than double that in low-dose group (39.0% vs. 16.0%).
T114 13871-14047 Sentence denotes The high-dosage group exhibited more instance of corrected QT (QTc) interval prolongation (>500 milliseconds (ms); 7 of 37 [18.9%]) than the low-dosage group (4 of 36 [11.1%]).
T115 14048-14170 Sentence denotes These findings suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 [49].
T116 14171-14179 Sentence denotes Table 1.
T117 14180-14289 Sentence denotes Outcomes and advantage/limitation of chloroquine (CQ)/hydroxychloroquine (HCQ) clinical studies for COVID-19.
T118 14290-14371 Sentence denotes Author (Reference) Study design Patients Treatment Outcomes Advantage Limitations
T119 14372-14387 Sentence denotes Gao et al [48].
T120 14388-14617 Sentence denotes Rough and simple description Not mentioned CQ (No specific dosage was mentioned) CQ was superior to control in suppressing pneumonia deterioration, improving lung imaging, promoting viral conversion and shortening disease course.
T121 14618-14634 Sentence denotes Not significant.
T122 14635-14761 Sentence denotes No study design and the specific number of patients and controls were provided and thus the result appears to be unconvincing.
T123 14762-14779 Sentence denotes Borba et al [49].
T124 14780-15266 Sentence denotes Randomized controlled trial High-dose CQ group: n = 40;Low-dose CQ group:n = 41 high-dose CQ (600 mg/2 times/day, for 10 day);low-dose CQ (450 mg/2 times/day for 5 days, double dose on 1st day) The mortality rate in the high-dose group was more than double that in low-dose group Double-blind study; 2 dosages of CQ for the first time in severe COVID-19 Small sample size; single-center design; Lack of a placebo control; Lack of exclusion criteria based on the QTc interval at baseline
T125 15267-15485 Sentence denotes Chen et al.[50] Randomized trial HCQ group: n = 31; control group: n = 30 HCQ (200 mg/2 times/day for 5 days) HCQ group have small improvement in body temperature and cough compered with control group Randomized trial.
T126 15486-15570 Sentence denotes Small sample size; Single-center design; Small improvement in temperature and cough.
T127 15571-15590 Sentence denotes Mahévas et al [53].
T128 15591-15809 Sentence denotes Comparative study HCQ group: n = 84; control group: n = 97 HCQ 600 mg/day for 7 days Compared with control group, a reduction of admissions to ICU or death 7 days after hospital admission was not observed in HCQ group.
T129 15810-15876 Sentence denotes Relatively larger sample size in HCQ treatment and control groups.
T130 15877-15987 Sentence denotes Nonrandomized design; In propensity score model, four possible important prognostic variables were unbalanced.
T131 15988-16004 Sentence denotes Tang et al [54].
T132 16005-16086 Sentence denotes Open label, randomized controlled trial HCQ group: n = 70; control group: n = 80.
T133 16087-16293 Sentence denotes HCQ 1200 mg daily for 3 days, 800 mg daily for 2 weeks (mild to moderate disease)/3 weeks(severe disease) HCQ did not show additional benefits of vial elimination in patients with mild to moderate COVID-19.
T134 16294-16322 Sentence denotes Randomized controlled study.
T135 16323-16521 Sentence denotes Lack of a placebo control group; Design introduces the possibility of biased investigator determined assessment and unbalanced dosage adjustment; Randomization of sequential envelopes may be biased.
T136 16522-16705 Sentence denotes The antiviral efficacy of HCQ was not assessed at an earlier stage; Most patients are mild to severe, and the effect of HCQ on disease progression or regression could not be provided.
T137 16706-16782 Sentence denotes The trial terminated early due to the difficulty to recruit enough patients.
T138 16783-16995 Sentence denotes Some secondary endpoints could not be analyzed by the cutoff date; Viral RNA specimens are mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T139 16996-17015 Sentence denotes Geleris et al [55].
T140 17016-17259 Sentence denotes Observational study HCQ group: n = 811; no-HCQ group: n = 565 HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) No correlation between the HCQ use and significant higher or lower risk of intubation or death was observed.
T141 17260-17431 Sentence denotes Large sample size; Minimization of the unmeasured confusion and error through multivariable Cox model with inverse probability weighting according to the propensity score.
T142 17432-17541 Sentence denotes Single-center design; missing of some variables; Potential for inaccuracies in the electronic health records.
T143 17542-17556 Sentence denotes Yu et al [56].
T144 17557-17731 Sentence denotes Retrospective study HCQ group: n = 48; no-HCQ group: n = 502 HCQ (200 mg/2 times/day, for 7 to 10 days) The fatalities of HCQ group was significantly lower than no-HCQ group.
T145 17732-17860 Sentence denotes HCQ treatment was related to significantly reduced mortality in critically ill COVID-19 patients and greatly lowered IL-6 level.
T146 17861-17951 Sentence denotes Mortality was used as a measure of outcome and the study included critically ill patients.
T147 17952-18033 Sentence denotes Retrospective design of the study and the number of HCQ group patients was small.
T148 18034-18304 Sentence denotes Gautret et al.[57] Open label, nonrandom cohort study HCQ group: n = 12; HCQ+azithromycin group: n = 6; control group: n = 12 HCQ (200 mg/3 times/day for 10 days) HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T149 18305-18366 Sentence denotes Nasopharyngeal virus determination was used as main endpoint.
T150 18367-18516 Sentence denotes Small sample size; Six patients dropped out due to critical illness or intolerance to the drug; Lack of clinical outcomes; Limited follow-up results.
T151 18517-18536 Sentence denotes Gautret et al [58].
T152 18537-18780 Sentence denotes Observational study HCQ group: n = 80; no control HCQ, 200 mg/3 times/day for 10 days combined with azithromycin 500 mg on the 1st day, 250 mg/day afterward for 5 days The nasopharynx viral load in most patients received HCQ decreased rapidly.
T153 18781-18819 Sentence denotes Observation of nasopharynx viral load.
T154 18820-18904 Sentence denotes Observational study design and no control group; No clinical outcomes were analyzed.
T155 18905-18952 Sentence denotes Possible confounding factors were not adjusted.
T156 18953-18974 Sentence denotes Magagnoli et al [59].
T157 18975-19071 Sentence denotes Retrospective study HCQ group:n = 97HCQ+azithromycin: n = 113No HCQ group:n = 158 Not specified.
T158 19072-19294 Sentence denotes The use of HCQ, either with or without azithromycin, didn’t reduce the risk of mechanical ventilation in patients hospitalized with COVID-19; Patients treated with HCQ alone was associated with increased overall mortality.
T159 19295-19516 Sentence denotes The study data comes from a comprehensive electronic medical record; Strictly defined covariates and outcomes; Using propensity scores adjustment for a large number of relevant confounders to make results more persuasive.
T160 19517-19710 Sentence denotes Retrospective nature of the study; The subjects included only men and most of them were black; Despite adjustments to many possible confounding factors, there may still be undiscovered factors.
T161 19711-20217 Sentence denotes Rosenberg et al[60] Retrospective multicenter cohort study HCQ group:n = 271;HCQ +azithromycin group:n = 735control group:n = 221 HCQ:200 mg/400 mg/600 mg/other/unknown, frequency: once a day/twice a day/other/unknownazithromycin:200 mg/250 mg/400 mg/500 mg/other/unknown, methods:Oral/IV/unknown,frequency: only once/once a day/twice a day/other/unknown Treatment with HCQ, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality.
T162 20218-20300 Sentence denotes This study include a large, random sample from 25 metropolitan New York hospitals.
T163 20301-20465 Sentence denotes The sample was drawnearly in the epidemic to include patients with long, complicated, and ongoing hospital stays; In-hospital mortality was used as primary outcome.
T164 20466-20607 Sentence denotes Retrospective study design; There may be missing information; Mortality was limited to in-hospital death; There may be potential confounders.
T165 20608-20687 Sentence denotes The dosing in the doses and frequencies of HCQ and azithromycin varied greatly.
T166 20688-20747 Sentence denotes The confidence intervals for some of the findings are wide.
T167 20748-21206 Sentence denotes Mehraet al[61] Multinational real-world analysis Teatment groups: n = 14,888Control group: n = 81,144 Mean daily dose: CQ 765 mg, (SD 308); HCQ 596 mg(126); CQ with a macrolide 790 mg(320); HCQ with a macrolide 597 mg(128).mean duration:CQ 6.6 days(2.4); HCQ 4.2 days(1.9);CQ with a macrolide 6.8 days(2.5); HCQ with a macrolide 4.3 days (2.0) A benefit of HCQ or CQ, when used alone or witha macrolide, on in-hospital outcomes for COVID-19 was not observed.
T168 21207-21281 Sentence denotes Large multinational real-world data and large number of study populations.
T169 21282-21600 Sentence denotes There may be potential confounders; It did not measure QT intervals and stratify the arrhythmia pattern; It did not determine whether the increased risk of death in-hospital and use of drug treatment regimens were directly related to cardiovascular risk; It did not observe the risk of the drug dose-response analysis.
T170 21601-21686 Sentence denotes Several trials evaluated the efficacy of HCQ for the treatment of COVID-19 (Table 1).
T171 21687-21839 Sentence denotes In a randomized clinical trial from Wuhan about HCQ treatment of mild COVID-19 [50], 31 out of 62 patients received HCQ (200 mg/2 times/day for 5 days).
T172 21840-22195 Sentence denotes The results showed that the temperature recovery time in the HCQ group was improved compared with the control group (average days, 2.2 vs. 3.2); the cough relief time was shorter in the HCQ group than the control group (average days, 2.4 vs. 3.1); and the improvement rate of pneumonia in the HCQ group was higher than the control group (80.6% vs. 54.8%).
T173 22196-22358 Sentence denotes However, only 48% of patients (15/31) in HCQ group and 71% of patients (22/31) in control group had cough at baseline and the duration of cough was not described.
T174 22359-22435 Sentence denotes Improvement of symptoms were small and the trial was terminated prematurely.
T175 22436-22530 Sentence denotes These factors and the low sample size compromise the reliability of the results of this study.
T176 22531-22737 Sentence denotes Importantly, evaluation of HCQ in the COVID-19 pandemic areas have shown that HCQ can help patients with mild symptoms, and may potentially reduce transmission in areas lacking isolation facilities [51,52].
T177 22738-22922 Sentence denotes However, in areas with strict isolation standards, the use of HCQ to reduce transmission or for treatment of mild COVID-19 cases may not be beneficial in risk-benefit analysis [51,52].
T178 22923-23048 Sentence denotes Nevertheless, there is an urgent need for drugs and therapeutics in severe cases, which require randomized controlled trials.
T179 23049-23175 Sentence denotes A study from four French tertiary care centers included 181 patients hospitalized for COVID-19 and requiring oxygen (2 L/min):
T180 23176-23290 Sentence denotes 84 patients received HCQ (600 mg/day) within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group) [53].
T181 23291-23476 Sentence denotes The results showed that the patients transferred to the ICU or died within 7 days and developed ARDS within 7 days had no significant differences between the HCQ group and no-HCQ group.
T182 23477-23570 Sentence denotes Eight patients in the HCQ group (9.5%) discontinued HCQ due to electrocardiogram alterations.
T183 23571-23685 Sentence denotes These results do not support the use of HCQ for treating hospitalized COVID-19-related hypoxic pneumonia patients.
T184 23686-23893 Sentence denotes It is worth noting that in the study’s propensity score model, four possible important prognostic variables were unbalanced and a center effect was not considered, which all can cause bias for study results.
T185 23894-24188 Sentence denotes In a multicenter, randomized, parallel trial about HCQ in patients with mainly mild to moderate COVID-19 [54], 80 patients received ‘standard care’ and 70 patients received HCQ (1200 mg daily for 3 days, and then 800 mg daily for 2 weeks [mild to moderate disease] or 3 weeks [severe disease]).
T186 24189-24342 Sentence denotes The results showed that the 28-days negative conversion probability in ‘standard care’+HCQ group was 85.4%, similar to the ‘standard care’ group (81.2%).
T187 24343-24444 Sentence denotes HCQ did not show additional benefits of viral elimination in patients with mild to moderate COVID-19.
T188 24445-24589 Sentence denotes However, the study could not evaluate the antiviral effect of HCQ at early stages of disease, which is a critical period of antiviral treatment.
T189 24590-24749 Sentence denotes In addition, viral RNA specimens were mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T190 24750-24901 Sentence denotes Due to the small number of severe patients, this study could not provide evidence regarding the effect of HCQ on the disease progression or regression.
T191 24902-25138 Sentence denotes In another large observational study involving 1376 cases of COVID-19 from New York, 811 patients received HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) within 24 or 48 hours of admission and 565 did not [55].
T192 25139-25249 Sentence denotes This study found no correlation between HCQ use and significantly higher or lower risk of intubation or death.
T193 25250-25425 Sentence denotes However, in this study, even after the propensity score-matching, the diseases in patients receiving HCQ were more severe at baseline than those in the patients not receiving.
T194 25426-25575 Sentence denotes Notably, according to another recent study [56], low dose of HCQ reduced fatality of critically ill patients with COVID-19 without apparent toxicity.
T195 25576-25745 Sentence denotes This retrospective study included 550 patients who need mechanical ventilation, of which 48 received HCQ treatment (200 mg/2 times/day for 7 to 10 days) and 502 did not.
T196 25746-26036 Sentence denotes The fatalities of the HCQ group was significantly lower than no-HCQ group (18.8% vs 47.4%, P < 0.05), and the inflammatory cytokine IL-6 in the HCQ group decreased significantly from 22.2 (8.3 to 118.9 pg/mL) at the beginning of treatment to 5.2 (3.0 to 23.4 pg/mL) at the end of treatment.
T197 26037-26228 Sentence denotes The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19.
T198 26229-26341 Sentence denotes Yet, this study is flawed due to its retrospective nature and the small number of HCQ treated patients included.
T199 26342-26606 Sentence denotes In short, some initial studies have shown that HCQ appears to have a curative effect on patients with mild COVID-19, but subsequent studies indicate that HCQ had no significant benefit in COVID-19 patients with viral conversion and the risk of intubation or death.
T200 26607-26821 Sentence denotes Although some recent studies show that low-dose HCQ could potentially reduce the mortality of severe COVID-19 patients, there are other studies showing that the HCQ use had no effect on risk of intubation or death.
T201 26822-26968 Sentence denotes There are also several reports that investigated the efficacy of CQ or HCQ in combination with a macrolide in the treatment of COVID-19 (Table 1).
T202 26969-27152 Sentence denotes In an open nonrandom clinical trial conducted in France [57], of the 36 participants, 20 patients were given HCQ (200 mg/3 times) with 6 receiving added azithromycin, and 16 controls.
T203 27153-27317 Sentence denotes The results showed that compared with the control group, HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T204 27318-27487 Sentence denotes On the 6th day after treatment, the virus clearance rates of HCQ combined with azithromycin, HCQ alone and controls were 100%, 57.1% and 12.5%, respectively (P < 0.001).
T205 27488-27600 Sentence denotes This study indicated that the combined application of azithromycin and HCQ appears to have a synergistic effect.
T206 27601-27810 Sentence denotes However, the trial design and the results were unreliable, as six patients in the HCQ group discontinued treatment early due to critical illness or intolerance to the drugs and were excluded from the analysis.
T207 27811-27894 Sentence denotes The assessment of efficacy was based on viral load rather than a clinical endpoint.
T208 27895-28240 Sentence denotes An observational study in 80 COVID-19 patients evaluated the efficacy of HCQ (200 mg/3 times/day for 10 days) in combination with azithromycin (500 mg on the first day, 250 mg/day afterward for 5 days) and showed that all patients’ clinical symptoms were improved, except for one patient aged over 86 years who died due to critical illness [58].
T209 28241-28413 Sentence denotes The nasopharynx viral load in most patients decreased rapidly, and the negative rates of viral nucleic acid conversion on days 7 and 8 were about 83% and 93%, respectively.
T210 28414-28507 Sentence denotes About 97.5% of patients had negative virus culture in respiratory specimens on the fifth day.
T211 28508-28600 Sentence denotes However, this study had no control group, thus the results were difficult to interpret [58].
T212 28601-28705 Sentence denotes Some recent studies have yielded different results about the efficacy of HCQ combined with azithromycin.
T213 28706-28982 Sentence denotes A retrospective study including 368 patients (97 patients received HCQ, 113 patients received HCQ + azithromycin and 158 patients received no HCQ) from USA [59] showed that the rates of ventilation in the HCQ, HCQ+azithromycin and no HCQ groups had no significant differences.
T214 28983-29114 Sentence denotes Unfortunately, theHCQ group (but not in the HCQ+azithromycin group) had a higher risk of death from any case than the no HCQ group.
T215 29115-29285 Sentence denotes This study showed no evidence that the use of HCQ, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19.
T216 29286-29400 Sentence denotes Noticeably, in patients treated with HCQ alone, an association with increased overall mortality was observed [59].
T217 29401-29528 Sentence denotes In this study, the subjects included were only men and most of them were black, which may affect the generality of the results.
T218 29529-29640 Sentence denotes In addition, the patients who received HCQ or azithromycin were more severe, which may also affect the results.
T219 29641-29928 Sentence denotes In a retrospective multicenter cohort study of a random sample of COVID-19 patients from 25 hospitals in New York [60], totaling 1438 patients, 735 received HCQ and azithromycin, 271 received HCQ alone, 211 received azithromycin alone and 221 received neither drug (HCQ or azithromycin).
T220 29929-30108 Sentence denotes The results showed that the hospital mortality rate of patients receiving HCQ+azithromycin was 25.7%, HCQ alone was 19.9%, azithromycin alone was 10.0% and neither drug was 12.7%.
T221 30109-30339 Sentence denotes In adjusted Cox proportional hazards models, compared with patients receiving neither drug, there were no significant differences in hospital mortality rate for patients receiving HC+azithromycin, HCQ alone, or azithromycin alone.
T222 30340-30454 Sentence denotes In this study, the sample size is large and includes patients with long-term, complex and ongoing hospitalization.
T223 30455-30645 Sentence denotes However, the mortality rate of this study was limited to in-hospital deaths, and patients discharged during the study period were considered alive, which may underestimate the morality rate.
T224 30646-30838 Sentence denotes Recently, a multinational registry analysis about HCQ or CQ with or without second-generation macrolides (especial azithromycin and clarithromycin) for treatment of COVID-19 was reported [61].
T225 30839-30894 Sentence denotes A total of 96,032 patients were included in this study.
T226 30895-31050 Sentence denotes Of these, 1868 received CQ, 3783 received CQ with a macrolide, 3016 received HCQ and 6221 received HCQ with a macrolide and 8114 patients as control group.
T227 31051-31383 Sentence denotes After controlling various confounding factors related to disease, when compared with the mortality in the control group (9.3%), CQ group was 16.4%, CQ with a macrolide group was 22.2%, HCQ group was 18.0% and HCQ group with a macrolide was 23.8%; each group was associated with an increased risk of hospital mortality independently.
T228 31384-31644 Sentence denotes Apart from this, compared with the control group (0.3%), CQ group (4.3%), CQ with a macrolide group (6.5%), HCQ group (6.1%) and HCQ with a macrolide group (8.1%) were independently associated with a risk for ventricular arrhythmia during hospitalization [61].
T229 31645-31834 Sentence denotes This study showed that CQ or HCQ (used alone or combination with a macrolide) was associated with an increased hazard for in-hospital death and an increased risk of ventricular arrhythmias.
T230 31835-31925 Sentence denotes This study included a large number of patients, but it is not a randomized clinical trial.
T231 31926-32143 Sentence denotes In short, some small studies have shown that HCQ combined with azithromycin could quickly and effectively eliminate viruses, but the design of these studies was flawed in many aspects, making the results unconvincing.
T232 32144-32410 Sentence denotes Several subsequent studies have shown that the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) has no obvious correlation with a reduced risk for mechanical ventilation, and may even increase the risk of arrhythmia and in-hospital mortality.
T233 32411-32732 Sentence denotes In summary, although CQ/HCQ appeared to exhibit a favorable effect on COVID-19 patients in some initial studies of small numbers of patients, the most recent studies with larger sample sizes revealed that CQ/HCQ exhibited no significant improvement of disease but even an increased overall mortality in COVID-19 patients.
T234 32733-32858 Sentence denotes The studies on the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) also showed conflicting findings.
T235 32859-33049 Sentence denotes Therefore, caution should be taken regarding the use of CQ/HCQ treatment in COVID-19 due to the uncertainty of efficacy, the potential adverse effects and the various defects in the studies.
T236 33050-33313 Sentence denotes According to the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org.cn/index.aspx) and the International Clinical Trials Registry Platform (ICTRP) (https://www.who.int/ictrp/en/), currently, there are more than 200 ongoing clinical trials for CQ/HCQ.
T237 33314-33476 Sentence denotes Current findings suggest that CQ/HCQ alone or in combination with macrolides should not be recommended for widespread use in COVID-19 (except in clinical trials).
T238 33477-33626 Sentence denotes Results from these ongoing prospective, randomized, controlled studies are required before these drugs are recommended for the treatment of COVID-19.
T239 33628-33630 Sentence denotes 6.
T240 33632-33638 Sentence denotes Safety
T241 33639-33734 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 33735-33855 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 33856-33984 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 33985-34056 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 34057-34313 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 34314-34404 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 34405-34465 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 34466-34604 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 34605-34782 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 34783-34853 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 34854-35030 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 35031-35178 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 35179-35331 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 35332-35471 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 35472-35558 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 35559-35808 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 35809-36227 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 36228-36425 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 36426-36540 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 36541-36713 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 36714-36919 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 36920-37078 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 37079-37247 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 37248-37436 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.
T265 37438-37440 Sentence denotes 7.
T266 37442-37452 Sentence denotes Discussion
T267 37453-37511 Sentence denotes At present, the COVID-19 pandemic is continuing worldwide.
T268 37512-37609 Sentence denotes It is still an urgent need to find effective therapies and vaccines for treatment and prevention.
T269 37610-37736 Sentence denotes CQ/HCQ have diverse biological activities, and their mechanisms against CoVs including SARS-CoV-2 are not yet fully clarified.
T270 37737-37916 Sentence denotes Current studies show that CQ/HCQ can prevent receptor recognition by CoVs, inhibit endosome acidification, which interferes membrane fusion, and exhibit immunomodulatory activity.
T271 37917-38003 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T272 38004-38165 Sentence denotes A number of in vitro studies have revealed that CQ/HCQ have inhibitory effects on various CoVs, including SARS-CoV [12,13], MERS-CoV [10] and SARS-CoV-2 [16–18].
T273 38166-38268 Sentence denotes However, conflicting results also exist on the in vitro activity of CQ/HCQ against SARS-CoV-2 [17,18].
T274 38269-38483 Sentence denotes Several clinical studies have shown that CQ/HCQ may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay the progression of the disease, with less serious adverse effects [48,50,57,58,].
T275 38484-38628 Sentence denotes However, previous studies showed that CQ had anti-Ebola virus activity in cell culture, but it had conflicting results in animal models [71,72].
T276 38629-38793 Sentence denotes In addition, CQ has shown beneficial results against chikungunya virus in vitro, but in animal models it aggravates the infection and lacks therapeutic effect [73].
T277 38794-39039 Sentence denotes More importantly, in recent studies the use of HCQ did not show any favorable effect on patients with COVID-19 and high-dose CQ treatment of severe COVID-19 patients may even increase the risks of mortality and QTc interval prolongation [49,55].
T278 39040-39127 Sentence denotes In addition, the optimal daily dose and duration of treatment course are not yet clear.
T279 39128-39289 Sentence denotes One study suggested that the dose of HCQ should be 400 mg/2 times for 1 day, 200 mg/2 times/day for 4 days based on the physiological pharmacokinetic model [18].
T280 39290-39626 Sentence denotes A prospective study of HCQ on COVID-19 patients (13 cases) admitted to the ICU in France showed that the first daily dose of 800 mg/1 time for 1 day, and 200 mg/2 times/day for 7 days was recommended to maintain the HCQ treatment level (1–2 mg/l) based on physiologically pharmacokinetic (PBPK) models for COVID-19 patients in ICU [67].
T281 39627-39719 Sentence denotes Whether the dosage of CQ or HCQ should be varied according disease severity is also unclear.
T282 39720-39835 Sentence denotes A rodent study showed that CQ could exert anti-HCoV-OC43 activity transplacentally or by way of maternal milk [14].
T283 39836-39991 Sentence denotes However, in humans, the efficacy of CQ in the prevention and treatment of SARS-CoV-2 infection to both the mother and the child remains to be investigated.
T284 39992-40169 Sentence denotes Clinical trials in France showed that HCQ combined with azithromycin could enhance the virus clearance [50], but the subsequent reports did not support this combination [59,61].
T285 40170-40340 Sentence denotes Furthermore, CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69].
T286 40341-40684 Sentence denotes Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ, alone or in combination with other drugs, in COVID-19 before the conclusive findings are obtained by well-designed, multicenter, randomized, controlled studies.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3673-3677 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T2 3989-3993 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T3 4106-4111 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T4 4162-4173 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T5 10702-10706 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 13124-13128 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 14546-14550 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 16890-16913 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T9 18709-18720 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T10 18796-18807 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T11 24644-24667 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T12 28245-28256 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T13 34137-34140 Body_part denotes ear http://purl.obolibrary.org/obo/UBERON_0001690
T14 34142-34163 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T15 34169-34174 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 34723-34728 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T17 34733-34739 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T18 34794-34799 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 34804-34810 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T20 36778-36783 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T21 39825-39829 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
103 1677-1683 Gene denotes CQ/HCQ
104 1435-1441 Gene denotes CQ/HCQ
105 61-108 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
106 110-120 Species denotes SARS-CoV-2 Tax:2697049
107 189-202 Species denotes coronaviruses Tax:11118
108 1507-1519 Species denotes rabies virus Tax:11292
1086 27041-27053 Species denotes participants Tax:9606
1087 27058-27066 Species denotes patients Tax:9606
1088 27667-27675 Species denotes patients Tax:9606
1089 27933-27941 Species denotes patients Tax:9606
109 1556-1567 Species denotes DNA viruses Tax:2080735
1090 28117-28125 Species denotes patients Tax:9606
1091 28175-28182 Species denotes patient Tax:9606
1092 28276-28284 Species denotes patients Tax:9606
1093 28429-28437 Species denotes patients Tax:9606
1094 28742-28750 Species denotes patients Tax:9606
1095 28755-28763 Species denotes patients Tax:9606
1096 28782-28790 Species denotes patients Tax:9606
1097 28827-28835 Species denotes patients Tax:9606
1098 29249-29257 Species denotes patients Tax:9606
1099 29301-29309 Species denotes patients Tax:9606
110 1692-1702 Species denotes SARS-CoV-2 Tax:2697049
1100 29448-29451 Species denotes men Tax:9606
1101 29546-29554 Species denotes patients Tax:9606
1102 29716-29724 Species denotes patients Tax:9606
1103 29775-29783 Species denotes patients Tax:9606
1104 29984-29992 Species denotes patients Tax:9606
1105 30168-30176 Species denotes patients Tax:9606
1106 30270-30278 Species denotes patients Tax:9606
1107 30393-30401 Species denotes patients Tax:9606
1108 30536-30544 Species denotes patients Tax:9606
1109 30857-30865 Species denotes patients Tax:9606
111 675-686 Chemical denotes chloroquine MESH:D002738
1110 31024-31032 Species denotes patients Tax:9606
1111 31873-31881 Species denotes patients Tax:9606
1112 26887-26889 Chemical denotes CQ MESH:D002738
1113 26893-26896 Chemical denotes HCQ MESH:D006886
1114 26919-26928 Chemical denotes macrolide MESH:D018942
1115 27078-27081 Chemical denotes HCQ MESH:D006886
1116 27122-27134 Chemical denotes azithromycin MESH:D017963
1117 27210-27213 Chemical denotes HCQ MESH:D006886
1118 27243-27255 Chemical denotes azithromycin MESH:D017963
1119 27379-27382 Chemical denotes HCQ MESH:D006886
112 688-690 Chemical denotes CQ MESH:D002738
1120 27397-27409 Chemical denotes azithromycin MESH:D017963
1121 27411-27414 Chemical denotes HCQ MESH:D006886
1122 27542-27554 Chemical denotes azithromycin MESH:D017963
1123 27559-27562 Chemical denotes HCQ MESH:D006886
1124 27683-27686 Chemical denotes HCQ MESH:D006886
1125 27968-27971 Chemical denotes HCQ MESH:D006886
1126 28025-28037 Chemical denotes azithromycin MESH:D017963
1127 28674-28677 Chemical denotes HCQ MESH:D006886
1128 28692-28704 Chemical denotes azithromycin MESH:D017963
1129 28773-28776 Chemical denotes HCQ MESH:D006886
113 707-725 Chemical denotes hydroxychloroquine MESH:D006886
1130 28800-28803 Chemical denotes HCQ MESH:D006886
1131 28806-28818 Chemical denotes azithromycin MESH:D017963
1132 28848-28851 Chemical denotes HCQ MESH:D006886
1133 28911-28914 Chemical denotes HCQ MESH:D006886
1134 28916-28919 Chemical denotes HCQ MESH:D006886
1135 28920-28932 Chemical denotes azithromycin MESH:D017963
1136 28940-28943 Chemical denotes HCQ MESH:D006886
1137 28998-29004 Chemical denotes theHCQ
1138 29027-29030 Chemical denotes HCQ MESH:D006886
1139 29031-29043 Chemical denotes azithromycin MESH:D017963
114 727-730 Chemical denotes HCQ MESH:D006886
1140 29104-29107 Chemical denotes HCQ MESH:D006886
1141 29161-29164 Chemical denotes HCQ MESH:D006886
1142 29189-29201 Chemical denotes azithromycin MESH:D017963
1143 29323-29326 Chemical denotes HCQ MESH:D006886
1144 29568-29571 Chemical denotes HCQ MESH:D006886
1145 29575-29587 Chemical denotes azithromycin MESH:D017963
1146 29798-29801 Chemical denotes HCQ MESH:D006886
1147 29806-29818 Chemical denotes azithromycin MESH:D017963
1148 29833-29836 Chemical denotes HCQ MESH:D006886
1149 29857-29869 Chemical denotes azithromycin MESH:D017963
115 867-873 Chemical denotes CQ/HCQ
1150 29907-29910 Chemical denotes HCQ MESH:D006886
1151 29914-29926 Chemical denotes azithromycin MESH:D017963
1152 30003-30007 Chemical denotes HCQ+ MESH:D006886
1153 30007-30019 Chemical denotes azithromycin MESH:D017963
1154 30031-30034 Chemical denotes HCQ MESH:D006886
1155 30052-30064 Chemical denotes azithromycin MESH:D017963
1156 30292-30304 Chemical denotes azithromycin MESH:D017963
1157 30306-30309 Chemical denotes HCQ MESH:D006886
1158 30320-30332 Chemical denotes azithromycin MESH:D017963
1159 30696-30699 Chemical denotes HCQ MESH:D006886
116 893-909 Chemical denotes 4-aminoquinoline MESH:C001920
1160 30740-30750 Chemical denotes macrolides MESH:D018942
1161 30761-30773 Chemical denotes azithromycin MESH:D017963
1162 30778-30792 Chemical denotes clarithromycin MESH:D017291
1163 30919-30921 Chemical denotes CQ MESH:D002738
1164 30937-30939 Chemical denotes CQ MESH:D002738
1165 30947-30956 Chemical denotes macrolide MESH:D018942
1166 30972-30975 Chemical denotes HCQ MESH:D006886
1167 30994-30997 Chemical denotes HCQ MESH:D006886
1168 31005-31014 Chemical denotes macrolide MESH:D018942
1169 31179-31181 Chemical denotes CQ MESH:D002738
117 1075-1081 Chemical denotes CQ/HCQ
1170 31199-31201 Chemical denotes CQ MESH:D002738
1171 31209-31218 Chemical denotes macrolide MESH:D018942
1172 31236-31239 Chemical denotes HCQ MESH:D006886
1173 31260-31263 Chemical denotes HCQ MESH:D006886
1174 31277-31286 Chemical denotes macrolide MESH:D018942
1175 31441-31443 Chemical denotes CQ MESH:D002738
1176 31458-31460 Chemical denotes CQ MESH:D002738
1177 31468-31477 Chemical denotes macrolide MESH:D018942
1178 31492-31495 Chemical denotes HCQ MESH:D006886
1179 31513-31516 Chemical denotes HCQ MESH:D006886
118 1331-1337 Chemical denotes CQ/HCQ
1180 31524-31533 Chemical denotes macrolide MESH:D018942
1181 31668-31670 Chemical denotes CQ MESH:D002738
1182 31674-31677 Chemical denotes HCQ MESH:D006886
1183 31712-31721 Chemical denotes macrolide MESH:D018942
1184 31971-31974 Chemical denotes HCQ MESH:D006886
1185 31989-32001 Chemical denotes azithromycin MESH:D017963
1186 32206-32209 Chemical denotes HCQ MESH:D006886
1187 32213-32215 Chemical denotes CQ MESH:D002738
1188 32220-32230 Chemical denotes macrolides MESH:D018942
1189 32232-32244 Chemical denotes azithromycin MESH:D017963
1190 32248-32262 Chemical denotes clarithromycin MESH:D017291
1191 26949-26957 Disease denotes COVID-19 MESH:C000657245
1192 27729-27745 Disease denotes critical illness MESH:D016638
1193 27924-27932 Disease denotes COVID-19 MESH:C000657245
1194 28206-28210 Disease denotes died MESH:D003643
1195 28218-28234 Disease denotes critical illness MESH:D016638
1196 29072-29077 Disease denotes death MESH:D003643
1197 29276-29284 Disease denotes COVID-19 MESH:C000657245
1198 29372-29381 Disease denotes mortality MESH:D003643
1199 29707-29715 Disease denotes COVID-19 MESH:C000657245
120 41-49 Disease denotes COVID-19 MESH:C000657245
1200 29966-29975 Disease denotes mortality MESH:D003643
1201 30251-30260 Disease denotes mortality MESH:D003643
1202 30468-30477 Disease denotes mortality MESH:D003643
1203 30524-30530 Disease denotes deaths MESH:D003643
1204 30811-30819 Disease denotes COVID-19 MESH:C000657245
1205 31140-31149 Disease denotes mortality MESH:D003643
1206 31359-31368 Disease denotes mortality MESH:D003643
1207 31593-31615 Disease denotes ventricular arrhythmia MESH:D001145
1208 31779-31784 Disease denotes death MESH:D003643
1209 31810-31833 Disease denotes ventricular arrhythmias MESH:D001145
121 240-248 Disease denotes COVID-19 MESH:C000657245
1210 32373-32383 Disease denotes arrhythmia MESH:D001145
1211 32400-32409 Disease denotes mortality MESH:D003643
122 329-337 Disease denotes COVID-19 MESH:C000657245
123 586-594 Disease denotes COVID-19 MESH:C000657245
1234 32490-32498 Species denotes patients Tax:9606
1235 32543-32551 Species denotes patients Tax:9606
1236 32723-32731 Species denotes patients Tax:9606
1237 32432-32438 Chemical denotes CQ/HCQ
1238 32616-32622 Chemical denotes CQ/HCQ
1239 32767-32770 Chemical denotes HCQ MESH:D006886
124 1112-1119 Disease denotes malaria MESH:D008288
1240 32774-32776 Chemical denotes CQ MESH:D002738
1241 32781-32791 Chemical denotes macrolides MESH:D018942
1242 32793-32805 Chemical denotes azithromycin MESH:D017963
1243 32809-32823 Chemical denotes clarithromycin MESH:D017291
1244 32915-32917 Chemical denotes CQ MESH:D002738
1245 32918-32921 Chemical denotes HCQ MESH:D006886
1246 33306-33308 Chemical denotes CQ MESH:D002738
1247 33309-33312 Chemical denotes HCQ MESH:D006886
1248 33344-33350 Chemical denotes CQ/HCQ
1249 33380-33390 Chemical denotes macrolides MESH:D018942
125 1179-1198 Disease denotes autoimmune diseases MESH:D001327
1250 32481-32489 Disease denotes COVID-19 MESH:C000657245
1251 32701-32710 Disease denotes mortality MESH:D003643
1252 32714-32722 Disease denotes COVID-19 MESH:C000657245
1253 32935-32943 Disease denotes COVID-19 MESH:C000657245
1254 33439-33447 Disease denotes COVID-19 MESH:C000657245
1255 33617-33625 Disease denotes COVID-19 MESH:C000657245
126 1207-1235 Disease denotes systemic lupus erythematosus MESH:D008180
127 1237-1240 Disease denotes SLE MESH:D008180
128 1246-1266 Disease denotes rheumatoid arthritis MESH:D001172
129 1268-1270 Disease denotes RA MESH:D001172
130 1498-1501 Disease denotes HIV MESH:D015658
131 1737-1745 Disease denotes COVID-19 MESH:C000657245
1339 34972-34980 Species denotes patients Tax:9606
134 1774-1780 Gene denotes CQ/HCQ
1340 35075-35083 Species denotes patients Tax:9606
1341 35111-35119 Species denotes patients Tax:9606
1342 35193-35201 Species denotes patients Tax:9606
1343 35256-35263 Species denotes patient Tax:9606
1344 35387-35395 Species denotes patients Tax:9606
1345 35544-35552 Species denotes patients Tax:9606
1346 35592-35600 Species denotes patients Tax:9606
1347 35841-35849 Species denotes patients Tax:9606
1348 35912-35920 Species denotes patients Tax:9606
1349 36002-36010 Species denotes patients Tax:9606
135 1789-1806 Species denotes human coronavirus Tax:694448
1350 36080-36088 Species denotes patients Tax:9606
1351 36411-36419 Species denotes patients Tax:9606
1352 36755-36763 Species denotes patients Tax:9606
1353 37122-37130 Species denotes patients Tax:9606
1354 37292-37300 Species denotes patients Tax:9606
1355 33639-33645 Chemical denotes CQ/HCQ
1356 33770-33772 Chemical denotes CQ MESH:D002738
1357 33898-33900 Chemical denotes CQ MESH:D002738
1358 34090-34092 Chemical denotes CQ MESH:D002738
1359 34326-34328 Chemical denotes CQ MESH:D002738
1360 34330-34333 Chemical denotes HCQ MESH:D006886
1361 34423-34426 Chemical denotes HCQ MESH:D006886
1362 34457-34459 Chemical denotes CQ MESH:D002738
1363 34573-34576 Chemical denotes HCQ MESH:D006886
1364 34605-34607 Chemical denotes CQ MESH:D002738
1365 34608-34611 Chemical denotes HCQ MESH:D006886
1366 34864-34866 Chemical denotes CQ MESH:D002738
1367 35094-35097 Chemical denotes HCQ MESH:D006886
1368 35133-35136 Chemical denotes HCQ MESH:D006886
1369 35406-35409 Chemical denotes HCQ MESH:D006886
1370 35507-35510 Chemical denotes HCQ MESH:D006886
1371 35614-35617 Chemical denotes HCQ MESH:D006886
1372 35741-35753 Chemical denotes azithromycin MESH:D017963
1373 35931-35934 Chemical denotes HCQ MESH:D006886
1374 35951-35963 Chemical denotes azithromycin MESH:D017963
1375 36102-36105 Chemical denotes HCQ MESH:D006886
1376 36110-36122 Chemical denotes azithromycin MESH:D017963
1377 36162-36165 Chemical denotes HCQ MESH:D006886
1378 36239-36241 Chemical denotes CQ MESH:D002738
1379 36243-36245 Chemical denotes CQ MESH:D002738
1380 36253-36262 Chemical denotes macrolide MESH:D018942
1381 36264-36267 Chemical denotes HCQ MESH:D006886
1382 36272-36275 Chemical denotes HCQ MESH:D006886
1383 36283-36292 Chemical denotes macrolide MESH:D018942
1384 36505-36511 Chemical denotes CQ/HCQ
1385 36530-36539 Chemical denotes macrolide MESH:D018942
1386 36546-36552 Chemical denotes CQ/HCQ
1387 36714-36720 Chemical denotes CQ/HCQ
1388 36888-36900 Chemical denotes moxifloxacin MESH:D000077266
1389 37092-37094 Chemical denotes CQ MESH:D002738
1390 37327-37329 Chemical denotes CQ MESH:D002738
1391 37433-37435 Chemical denotes CQ MESH:D002738
1392 33672-33679 Disease denotes malaria MESH:D008288
1393 33943-33949 Disease denotes nausea MESH:D009325
1394 33951-33959 Disease denotes vomiting MESH:D014839
1395 33961-33969 Disease denotes diarrhea MESH:D003967
1396 33975-33983 Disease denotes anorexia MESH:D000855
1397 34142-34163 Disease denotes cardiovascular system MESH:D002318
1398 34191-34212 Disease denotes neurological deafness MESH:D009422
1399 34214-34248 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 34254-34264 Disease denotes leukopenia MESH:D007970
1401 34395-34403 Disease denotes toxicity MESH:D064420
1402 34587-34598 Disease denotes retinopathy MESH:D012164
1403 34794-34822 Disease denotes liver and kidney dysfunction MESH:D051437
1404 34918-34953 Disease denotes increased QTc interval prolongation MESH:D008133
1405 34957-34971 Disease denotes critically ill MESH:D016638
1406 34986-34994 Disease denotes COVID-19 MESH:C000657245
1407 35289-35311 Disease denotes atrioventricular block MESH:D054537
1408 35447-35455 Disease denotes headache MESH:D006261
1409 35460-35464 Disease denotes rash MESH:D005076
1410 35535-35543 Disease denotes COVID-19 MESH:C000657245
1411 35639-35648 Disease denotes pneumonia MESH:D011014
1412 35665-35673 Disease denotes COVID-19 MESH:C000657245
1413 35695-35711 Disease denotes QTc prolongation MESH:D008133
1414 35832-35840 Disease denotes COVID-19 MESH:C000657245
1415 36363-36385 Disease denotes ventricular arrhythmia MESH:D001145
1416 36402-36410 Disease denotes COVID-19 MESH:C000657245
1417 36778-36791 Disease denotes heart disease MESH:D006331
1418 37136-37187 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 37225-37241 Disease denotes hemolytic anemia MESH:D000743
1420 37306-37321 Disease denotes G6PD deficiency MESH:D005955
1421 37399-37414 Disease denotes G6PD deficiency MESH:D005955
1478 38310-38316 Gene denotes CQ/HCQ
1479 38234-38240 Gene denotes CQ/HCQ
1480 37682-37686 Species denotes CoVs Tax:11118
1481 37697-37707 Species denotes SARS-CoV-2 Tax:2697049
1482 37806-37810 Species denotes CoVs Tax:11118
1483 38094-38098 Species denotes CoVs Tax:11118
1484 38110-38118 Species denotes SARS-CoV Tax:694009
1487 38249-38259 Species denotes SARS-CoV-2 Tax:2697049
1488 38682-38699 Species denotes chikungunya virus Tax:37124
1489 38882-38890 Species denotes patients Tax:9606
1490 38951-38959 Species denotes patients Tax:9606
1491 39329-39337 Species denotes patients Tax:9606
1492 39605-39613 Species denotes patients Tax:9606
1493 39848-39854 Species denotes humans Tax:9606
1494 39958-39963 Species denotes child Tax:9606
1495 38534-38539 Species denotes Ebola Tax:1570291
1496 39767-39776 Species denotes HCoV-OC43 Tax:31631
1497 37610-37616 Chemical denotes CQ/HCQ
1498 37763-37769 Chemical denotes CQ/HCQ
1499 38052-38054 Chemical denotes CQ MESH:D002738
1500 38055-38058 Chemical denotes HCQ MESH:D006886
1501 38522-38524 Chemical denotes CQ MESH:D002738
1502 38642-38644 Chemical denotes CQ MESH:D002738
1503 38841-38844 Chemical denotes HCQ MESH:D006886
1504 38919-38921 Chemical denotes CQ MESH:D002738
1505 39165-39168 Chemical denotes HCQ MESH:D006886
1506 39313-39316 Chemical denotes HCQ MESH:D006886
1507 39506-39509 Chemical denotes HCQ MESH:D006886
1508 39649-39651 Chemical denotes CQ MESH:D002738
1509 39655-39658 Chemical denotes HCQ MESH:D006886
1510 39747-39749 Chemical denotes CQ MESH:D002738
1511 39872-39874 Chemical denotes CQ MESH:D002738
1512 40030-40033 Chemical denotes HCQ MESH:D006886
1513 40048-40060 Chemical denotes azithromycin MESH:D017963
1514 40183-40189 Chemical denotes CQ/HCQ
1515 40221-40230 Chemical denotes macrolide MESH:D018942
1516 40421-40423 Chemical denotes CQ MESH:D002738
1517 40424-40427 Chemical denotes HCQ MESH:D006886
1518 40516-40518 Chemical denotes CQ MESH:D002738
1519 40519-40522 Chemical denotes HCQ MESH:D006886
1520 37469-37477 Disease denotes COVID-19 MESH:C000657245
1521 37994-38002 Disease denotes COVID-19 MESH:C000657245
1522 38356-38364 Disease denotes COVID-19 MESH:C000657245
1523 38749-38758 Disease denotes infection MESH:D007239
1524 38896-38904 Disease denotes COVID-19 MESH:C000657245
1525 38942-38950 Disease denotes COVID-19 MESH:C000657245
1526 38991-39000 Disease denotes mortality MESH:D003643
1527 39005-39030 Disease denotes QTc interval prolongation MESH:D008133
1528 39320-39328 Disease denotes COVID-19 MESH:C000657245
1529 39596-39604 Disease denotes COVID-19 MESH:C000657245
1530 39910-39930 Disease denotes SARS-CoV-2 infection MESH:C000657245
1531 40310-40318 Disease denotes COVID-19 MESH:C000657245
1532 40445-40453 Disease denotes COVID-19 MESH:C000657245
1533 40569-40577 Disease denotes COVID-19 MESH:C000657245
154 2028-2030 Gene denotes μM Gene:56925
155 2088-2090 Gene denotes μM Gene:56925
156 2426-2428 Gene denotes μM Gene:56925
157 2416-2418 Gene denotes μm Gene:56925
158 2011-2013 Gene denotes μM Gene:56925
159 1865-1873 Species denotes MERS-CoV Tax:1335626
160 1878-1887 Species denotes HCoV-229E Tax:11137
161 1908-1913 Species denotes human Tax:9606
162 2234-2242 Species denotes MERS-CoV Tax:1335626
163 2196-2198 Chemical denotes CQ MESH:D002738
164 2274-2276 Chemical denotes CQ MESH:D002738
165 2369-2371 Chemical denotes CQ MESH:D002738
166 2447-2449 Chemical denotes CQ MESH:D002738
167 1914-1922 Disease denotes hepatoma MESH:D006528
168 2303-2321 Disease denotes MERS-CoV infection MESH:D018352
169 2398-2411 Disease denotes CoV infection MESH:D018352
170 1934-1939 CellLine denotes Huh-7 CVCL:0336
171 2280-2286 CellLine denotes VeroE6 CVCL:0574
194 2630-2632 Gene denotes μM Gene:56925
195 3520-3522 Gene denotes μM Gene:56925
196 3547-3549 Gene denotes μM Gene:56925
197 2759-2761 Gene denotes μM Gene:56925
198 2647-2649 Gene denotes μM Gene:56925
199 2616-2618 Gene denotes μM Gene:56925
200 2581-2589 Species denotes SARS-CoV Tax:694009
201 2711-2719 Species denotes SARS-CoV Tax:694009
202 3480-3489 Species denotes HCoV-OC43 Tax:31631
203 2838-2846 Species denotes SARS-CoV Tax:694009
204 2566-2568 Chemical denotes CQ MESH:D002738
205 2569-2572 Chemical denotes HCQ MESH:D006886
206 2762-2764 Chemical denotes CQ MESH:D002738
207 2817-2819 Chemical denotes CQ MESH:D002738
208 2861-2864 Chemical denotes HCQ MESH:D006886
209 2879-2881 Chemical denotes CQ MESH:D002738
210 3469-3471 Chemical denotes CQ MESH:D002738
211 2777-2786 Disease denotes infection MESH:D007239
212 3021-3039 Disease denotes SARS-CoV infection MESH:C000657245
213 3222-3231 Disease denotes infection MESH:D007239
214 2526-2532 CellLine denotes VeroE6 CVCL:0574
215 3429-3435 CellLine denotes HRT-18 CVCL:2514
228 3693-3698 Species denotes mouse Tax:10090
229 3759-3763 Species denotes mice Tax:10090
230 3971-3975 Species denotes mice Tax:10090
231 4041-4046 Species denotes mouse Tax:10090
232 4077-4086 Species denotes HCoV-OC43 Tax:31631
233 3621-3630 Species denotes HCoV-OC43 Tax:31631
234 3601-3603 Chemical denotes CQ MESH:D002738
235 3794-3796 Chemical denotes CQ MESH:D002738
236 3919-3921 Chemical denotes CQ MESH:D002738
237 4021-4023 Chemical denotes CQ MESH:D002738
238 4054-4056 Chemical denotes CQ MESH:D002738
239 4130-4139 Disease denotes infection MESH:D007239
242 4310-4316 Gene denotes CQ/HCQ
243 4325-4335 Species denotes SARS-CoV-2 Tax:2697049
278 4419-4421 Gene denotes μM Gene:56925
279 4695-4697 Gene denotes μM Gene:56925
280 4765-4767 Gene denotes μM Gene:56925
281 5153-5155 Gene denotes μM Gene:56925
282 5344-5346 Gene denotes μM Gene:56925
283 5203-5205 Gene denotes μM Gene:56925
284 5693-5699 Gene denotes CQ/HCQ
285 5398-5400 Gene denotes μM Gene:56925
286 5386-5388 Gene denotes μM Gene:56925
287 5331-5333 Gene denotes μM Gene:56925
288 5191-5193 Gene denotes μM Gene:56925
289 5141-5143 Gene denotes μM Gene:56925
290 4398-4408 Species denotes SARS-CoV-2 Tax:2697049
291 4639-4649 Species denotes SARS-CoV-2 Tax:2697049
292 4940-4950 Species denotes SARS-CoV-2 Tax:2697049
293 5472-5482 Species denotes SARS-CoV-2 Tax:2697049
294 5717-5727 Species denotes SARS-CoV-2 Tax:2697049
295 4387-4389 Chemical denotes CQ MESH:D002738
296 4454-4456 Chemical denotes CQ MESH:D002738
297 4664-4666 Chemical denotes CQ MESH:D002738
298 4731-4734 Chemical denotes HCQ MESH:D006886
299 4794-4796 Chemical denotes CQ MESH:D002738
300 4864-4867 Chemical denotes HCQ MESH:D006886
301 4963-4965 Chemical denotes CQ MESH:D002738
302 4995-4998 Chemical denotes HCQ MESH:D006886
303 5495-5497 Chemical denotes CQ MESH:D002738
304 5513-5516 Chemical denotes HCQ MESH:D006886
305 4507-4526 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 4593-4602 Disease denotes infection MESH:D007239
307 5074-5089 Disease denotes CoV-2 infection MESH:C000657245
308 5264-5284 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 4348-4354 CellLine denotes VeroE6 CVCL:0574
310 5093-5099 CellLine denotes VeroE6 CVCL:0574
311 5288-5294 CellLine denotes VeroE6 CVCL:0574
313 5776-5784 Disease denotes COVID-19 MESH:C000657245
322 7126-7130 Gene denotes ACE2 Gene:59272
323 7294-7297 Gene denotes p38 Gene:1432
324 7407-7412 Gene denotes CD154 Gene:959
325 7431-7434 Gene denotes CD4 Gene:920
326 6881-6885 Species denotes CoVs Tax:11118
327 6866-6868 Chemical denotes CQ MESH:D002738
328 6869-6872 Chemical denotes HCQ MESH:D006886
329 7005-7013 Disease denotes COVID-19 MESH:C000657245
350 6009-6040 Gene denotes angiotensin-converting enzyme 2 Gene:59272
351 6042-6046 Gene denotes ACE2 Gene:59272
352 6179-6183 Gene denotes ACE2 Gene:103231639
353 6437-6441 Gene denotes ACE2 Gene:59272
354 6516-6520 Gene denotes ACE2 Gene:59272
355 6661-6665 Gene denotes ACE2 Gene:59272
356 6722-6726 Gene denotes ACE2 Gene:59272
357 6323-6324 Gene denotes S Gene:43740568
358 5866-5867 Gene denotes S Gene:43740568
359 5879-5889 Species denotes SARS-CoV-2 Tax:2697049
360 6351-6359 Species denotes SARS-CoV Tax:694009
361 6731-6739 Species denotes SARS CoV Tax:694009
362 6227-6237 Species denotes SARS-CoV-2 Tax:2697049
363 6560-6563 Species denotes CoV Tax:11118
364 6173-6175 Chemical denotes CQ MESH:D002738
365 6256-6258 Chemical denotes CQ MESH:D002738
366 6443-6445 Chemical denotes CQ MESH:D002738
367 6576-6578 Chemical denotes CQ MESH:D002738
368 6579-6582 Chemical denotes HCQ MESH:D006886
369 6187-6193 CellLine denotes VeroE6 CVCL:0574
394 8274-8278 Gene denotes ACE2 Gene:59272
395 8567-8586 Gene denotes quinone reductase 2 Gene:4835
396 8588-8591 Gene denotes QR2 Gene:4835
397 8398-8404 Gene denotes CQ/HCQ
398 8159-8167 Species denotes SARS-CoV Tax:694009
400 8249-8259 Species denotes SARS-CoV-2 Tax:2697049
401 8124-8133 Species denotes influenza Tax:11320
402 8497-8504 Species denotes SARSCoV Tax:694009
403 8676-8679 Species denotes CoV Tax:11118
404 8004-8015 Chemical denotes sialic acid MESH:D019158
405 8045-8057 Chemical denotes gangliosides MESH:D005732
406 8331-8343 Chemical denotes gangliosides MESH:D005732
407 8377-8388 Chemical denotes sialic acid MESH:D019158
408 8411-8423 Chemical denotes sialic acids MESH:D012794
409 8428-8440 Chemical denotes gangliosides MESH:D005732
410 8520-8532 Chemical denotes gangliosides MESH:D005732
411 8539-8541 Chemical denotes CQ MESH:D002738
412 8625-8637 Chemical denotes sialic acids MESH:D012794
413 8692-8694 Chemical denotes CQ MESH:D002738
414 8695-8698 Chemical denotes HCQ MESH:D006886
415 8759-8770 Chemical denotes sialic acid MESH:D019158
416 8775-8786 Chemical denotes ganglioside MESH:D005732
417 7956-7965 Disease denotes infection MESH:D007239
442 9191-9196 Gene denotes furin Gene:5045
443 9397-9408 Gene denotes cathepsin L Gene:1514
444 9717-9728 Gene denotes cathepsin L Gene:1514
445 10085-10091 Gene denotes CQ/HCQ
446 9840-9846 Gene denotes CQ/HCQ
447 9767-9768 Gene denotes S Gene:43740568
448 8852-8856 Species denotes CoVs Tax:11118
452 9582-9603 Species denotes mouse hepatitis virus Tax:11138
453 9646-9656 Species denotes SARS-CoV-2 Tax:2697049
454 9756-9766 Species denotes SARS-CoV-2 Tax:2697049
455 9861-9871 Species denotes SARS-CoV-2 Tax:2697049
456 9902-9912 Species denotes SARS-CoV-2 Tax:2697049
457 10041-10051 Species denotes SARS-CoV-2 Tax:2697049
458 9607-9612 Species denotes MHV-2 Tax:502106
459 10183-10186 Species denotes CoV Tax:11118
460 9268-9274 Chemical denotes serine MESH:D012694
461 10008-10010 Chemical denotes CQ MESH:D002738
462 10199-10201 Chemical denotes CQ MESH:D002738
463 10202-10205 Chemical denotes HCQ MESH:D006886
464 9503-9517 Disease denotes CoV S proteins MESH:C000657245
465 9966-9972 CellLine denotes VeroE6 CVCL:0574
478 11012-11045 Gene denotes mitochondrial antiviral signaling Gene:57506
479 11047-11051 Gene denotes MAVS Gene:57506
480 10603-10607 Species denotes CoVs Tax:11118
482 10661-10670 Species denotes HCoV-229E Tax:11137
483 10686-10691 Species denotes human Tax:9606
484 10794-10797 Chemical denotes HCQ MESH:D006886
485 10847-10870 Chemical denotes reactive oxygen species MESH:D017382
486 10872-10875 Chemical denotes ROS MESH:D017382
487 10950-10953 Chemical denotes HCQ MESH:D006886
488 11119-11125 Chemical denotes CQ/HCQ
489 10590-10599 Disease denotes infection MESH:D007239
520 11695-11700 Gene denotes CD154 Gene:959
521 11719-11722 Gene denotes CD4 Gene:920
522 11773-11791 Gene denotes interleukin (IL)-1 Gene:3552
523 11793-11797 Gene denotes IL-6 Gene:3569
524 11802-11825 Gene denotes tumor necrosis factor-α Gene:7124
525 11827-11832 Gene denotes TNF-α Gene:7124
526 11977-11981 Gene denotes TLR7 Gene:51284
527 11986-11990 Gene denotes TLR9 Gene:54106
528 12086-12117 Gene denotes cyclic GMP-AMP (cGAMP) synthase Gene:115004
529 12119-12123 Gene denotes cGAS Gene:115004
530 12249-12265 Gene denotes phospholipase A2 Gene:5319
531 12472-12476 Gene denotes IL-6 Gene:3569
532 12481-12486 Gene denotes IL-10 Gene:3586
533 12532-12540 Species denotes patients Tax:9606
534 12555-12565 Species denotes SARS-CoV-2 Tax:2697049
535 11474-11476 Chemical denotes CQ MESH:D002738
536 11477-11480 Chemical denotes HCQ MESH:D006886
537 11739-11741 Chemical denotes CQ MESH:D002738
538 12063-12066 Chemical denotes CQ/ MESH:D002738
539 12066-12069 Chemical denotes HCQ MESH:D006886
540 12225-12231 Chemical denotes CQ/HCQ
541 12294-12310 Chemical denotes arachidonic acid MESH:D016718
542 12343-12357 Chemical denotes prostaglandins MESH:D011453
543 12694-12697 Chemical denotes HCQ MESH:D006886
544 12698-12700 Chemical denotes CQ MESH:D002738
545 12517-12531 Disease denotes critically ill MESH:D016638
546 12541-12549 Disease denotes infected MESH:D007239
547 12618-12621 Disease denotes CRS MESH:D003398
548 12733-12736 Disease denotes CRS MESH:D003398
549 12766-12774 Disease denotes COVID-19 MESH:C000657245
552 12813-12819 Chemical denotes CQ/HCQ
553 12840-12848 Disease denotes COVID-19 MESH:C000657245
641 17849-17853 Gene denotes IL-6 Gene:3569
642 14322-14330 Species denotes Patients Tax:9606
643 14678-14686 Species denotes patients Tax:9606
644 16253-16261 Species denotes patients Tax:9606
645 16595-16603 Species denotes patients Tax:9606
646 16773-16781 Species denotes patients Tax:9606
647 17820-17828 Species denotes patients Tax:9606
648 17942-17950 Species denotes patients Tax:9606
649 18014-18022 Species denotes patients Tax:9606
657 14431-14433 Chemical denotes CQ MESH:D002738
658 14469-14471 Chemical denotes CQ MESH:D002738
659 14818-14820 Chemical denotes CQ MESH:D002738
660 14844-14846 Chemical denotes CQ MESH:D002738
661 14870-14872 Chemical denotes CQ MESH:D002738
662 14915-14917 Chemical denotes CQ MESH:D002738
663 15093-15095 Chemical denotes CQ MESH:D002738
664 15300-15303 Chemical denotes HCQ MESH:D006886
665 15341-15344 Chemical denotes HCQ MESH:D006886
666 15377-15380 Chemical denotes HCQ MESH:D006886
667 15609-15612 Chemical denotes HCQ MESH:D006886
668 15650-15653 Chemical denotes HCQ MESH:D006886
669 15799-15802 Chemical denotes HCQ MESH:D006886
670 15843-15846 Chemical denotes HCQ MESH:D006886
671 16045-16048 Chemical denotes HCQ MESH:D006886
672 16087-16090 Chemical denotes HCQ MESH:D006886
673 16193-16196 Chemical denotes HCQ MESH:D006886
674 16548-16551 Chemical denotes HCQ MESH:D006886
675 16642-16645 Chemical denotes HCQ MESH:D006886
676 17036-17039 Chemical denotes HCQ MESH:D006886
677 17059-17062 Chemical denotes HCQ MESH:D006886
678 17078-17081 Chemical denotes HCQ MESH:D006886
679 17178-17181 Chemical denotes HCQ MESH:D006886
680 17577-17580 Chemical denotes HCQ MESH:D006886
681 17599-17602 Chemical denotes HCQ MESH:D006886
682 17618-17621 Chemical denotes HCQ MESH:D006886
683 17679-17682 Chemical denotes HCQ MESH:D006886
684 17721-17724 Chemical denotes HCQ MESH:D006886
685 17732-17735 Chemical denotes HCQ MESH:D006886
686 18088-18091 Chemical denotes HCQ MESH:D006886
687 18107-18110 Chemical denotes HCQ MESH:D006886
688 29031-29043 Chemical denotes azithromycin MESH:D017963
689 33309-33312 Chemical denotes HCQ MESH:D006886
690 40186-40189 Chemical denotes HCQ MESH:D006886
695 40424-40427 Chemical denotes HCQ MESH:D006886
705 14511-14520 Disease denotes pneumonia MESH:D011014
706 14978-14987 Disease denotes mortality MESH:D003643
707 15125-15133 Disease denotes COVID-19 MESH:C000657245
708 15434-15439 Disease denotes cough MESH:D003371
709 15564-15569 Disease denotes cough MESH:D003371
710 15741-15746 Disease denotes death MESH:D003643
711 16284-16292 Disease denotes COVID-19 MESH:C000657245
712 17240-17245 Disease denotes death MESH:D003643
713 17783-17792 Disease denotes mortality MESH:D003643
714 17796-17810 Disease denotes critically ill MESH:D016638
715 17811-17819 Disease denotes COVID-19 MESH:C000657245
716 17861-17870 Disease denotes Mortality MESH:D003643
717 17927-17941 Disease denotes critically ill MESH:D016638
719 40569-40577 Disease denotes COVID-19 MESH:C000657245
733 14217-14228 Chemical denotes chloroquine MESH:D002738
734 14230-14232 Chemical denotes CQ MESH:D002738
735 14234-14252 Chemical denotes hydroxychloroquine MESH:D006886
736 14254-14257 Chemical denotes HCQ MESH:D006886
737 14280-14288 Disease denotes COVID-19 MESH:C000657245
760 12929-12937 Species denotes patients Tax:9606
761 12990-12998 Species denotes patients Tax:9606
762 13254-13262 Species denotes patients Tax:9606
763 13345-13352 Species denotes patient Tax:9606
764 13543-13551 Species denotes patients Tax:9606
765 13594-13602 Species denotes patients Tax:9606
766 13664-13672 Species denotes patients Tax:9606
767 14142-14150 Species denotes patients Tax:9606
768 12914-12916 Chemical denotes CQ MESH:D002738
769 12964-12966 Chemical denotes CQ MESH:D002738
770 13030-13032 Chemical denotes CQ MESH:D002738
771 13622-13624 Chemical denotes CQ MESH:D002738
772 13691-13693 Chemical denotes CQ MESH:D002738
773 14087-14089 Chemical denotes CQ MESH:D002738
774 12920-12928 Disease denotes COVID-19 MESH:C000657245
775 13004-13012 Disease denotes COVID-19 MESH:C000657245
776 13086-13112 Disease denotes deterioration of pneumonia MESH:D011014
777 13534-13542 Disease denotes COVID-19 MESH:C000657245
778 13770-13779 Disease denotes mortality MESH:D003643
779 13930-13960 Disease denotes QT (QTc) interval prolongation MESH:D008133
780 14127-14141 Disease denotes critically ill MESH:D016638
781 14156-14164 Disease denotes COVID-19 MESH:C000657245
871 25878-25882 Gene denotes IL-6 Gene:3569
872 21785-21793 Species denotes patients Tax:9606
873 22217-22225 Species denotes patients Tax:9606
912 23611-23614 Chemical denotes HCQ MESH:D006886
874 22258-22266 Species denotes patients Tax:9606
875 22622-22630 Species denotes patients Tax:9606
876 23109-23117 Species denotes patients Tax:9606
877 23179-23187 Species denotes patients Tax:9606
878 23319-23327 Species denotes patients Tax:9606
879 23483-23491 Species denotes patients Tax:9606
880 23676-23684 Species denotes patients Tax:9606
881 23952-23960 Species denotes patients Tax:9606
882 24008-24016 Species denotes patients Tax:9606
883 24049-24057 Species denotes patients Tax:9606
884 24404-24412 Species denotes patients Tax:9606
885 24784-24792 Species denotes patients Tax:9606
886 24991-24999 Species denotes patients Tax:9606
887 25332-25340 Species denotes patients Tax:9606
888 25402-25410 Species denotes patients Tax:9606
889 25526-25534 Species denotes patients Tax:9606
890 25614-25622 Species denotes patients Tax:9606
891 26205-26213 Species denotes patients Tax:9606
892 26323-26331 Species denotes patients Tax:9606
893 26430-26438 Species denotes patients Tax:9606
894 26539-26547 Species denotes patients Tax:9606
895 26717-26725 Species denotes patients Tax:9606
896 21642-21645 Chemical denotes HCQ MESH:D006886
897 21735-21738 Chemical denotes HCQ MESH:D006886
898 21803-21806 Chemical denotes HCQ MESH:D006886
899 21901-21904 Chemical denotes HCQ MESH:D006886
900 22026-22029 Chemical denotes HCQ MESH:D006886
901 22133-22136 Chemical denotes HCQ MESH:D006886
902 22237-22240 Chemical denotes HCQ MESH:D006886
903 22800-22803 Chemical denotes HCQ MESH:D006886
904 23158-23164 Chemical denotes oxygen MESH:D010100
905 23197-23200 Chemical denotes HCQ MESH:D006886
906 23244-23247 Chemical denotes HCQ MESH:D006886
907 23274-23277 Chemical denotes HCQ MESH:D006886
908 23449-23452 Chemical denotes HCQ MESH:D006886
909 23466-23469 Chemical denotes HCQ MESH:D006886
910 23499-23502 Chemical denotes HCQ MESH:D006886
911 23529-23532 Chemical denotes HCQ MESH:D006886
913 23945-23948 Chemical denotes HCQ MESH:D006886
914 24067-24070 Chemical denotes HCQ MESH:D006886
915 24343-24346 Chemical denotes HCQ MESH:D006886
916 24507-24510 Chemical denotes HCQ MESH:D006886
917 24856-24859 Chemical denotes HCQ MESH:D006886
918 25009-25012 Chemical denotes HCQ MESH:D006886
919 25179-25182 Chemical denotes HCQ MESH:D006886
920 25351-25354 Chemical denotes HCQ MESH:D006886
921 25487-25490 Chemical denotes HCQ MESH:D006886
922 25677-25680 Chemical denotes HCQ MESH:D006886
923 25768-25771 Chemical denotes HCQ MESH:D006886
924 25810-25813 Chemical denotes HCQ MESH:D006886
925 25890-25893 Chemical denotes HCQ MESH:D006886
926 26102-26105 Chemical denotes HCQ MESH:D006886
927 26311-26314 Chemical denotes HCQ MESH:D006886
928 26389-26392 Chemical denotes HCQ MESH:D006886
929 26496-26499 Chemical denotes HCQ MESH:D006886
930 26655-26658 Chemical denotes HCQ MESH:D006886
931 26768-26771 Chemical denotes HCQ MESH:D006886
932 21667-21675 Disease denotes COVID-19 MESH:C000657245
933 21757-21765 Disease denotes COVID-19 MESH:C000657245
934 21989-21994 Disease denotes cough MESH:D003371
935 22116-22125 Disease denotes pneumonia MESH:D011014
936 22296-22301 Disease denotes cough MESH:D003371
937 22334-22339 Disease denotes cough MESH:D003371
938 22569-22577 Disease denotes COVID-19 MESH:C000657245
939 22852-22860 Disease denotes COVID-19 MESH:C000657245
940 23135-23143 Disease denotes COVID-19 MESH:C000657245
941 23354-23358 Disease denotes died MESH:D003643
942 23387-23391 Disease denotes ARDS MESH:D012128
943 23641-23649 Disease denotes COVID-19 MESH:C000657245
944 23658-23675 Disease denotes hypoxic pneumonia MESH:D011014
945 23990-23998 Disease denotes COVID-19 MESH:C000657245
946 24435-24443 Disease denotes COVID-19 MESH:C000657245
947 24963-24971 Disease denotes COVID-19 MESH:C000657245
948 25243-25248 Disease denotes death MESH:D003643
949 25511-25525 Disease denotes critically ill MESH:D016638
950 25540-25548 Disease denotes COVID-19 MESH:C000657245
951 25566-25574 Disease denotes toxicity MESH:D064420
952 26190-26204 Disease denotes critically ill MESH:D016638
953 26219-26227 Disease denotes COVID-19 MESH:C000657245
954 26449-26457 Disease denotes COVID-19 MESH:C000657245
955 26530-26538 Disease denotes COVID-19 MESH:C000657245
956 26600-26605 Disease denotes death MESH:D003643
957 26688-26697 Disease denotes mortality MESH:D003643
958 26708-26716 Disease denotes COVID-19 MESH:C000657245
959 26815-26820 Disease denotes death MESH:D003643

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1 5866-5875 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T34 6009-6040 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T49 6042-6046 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T50 6179-6183 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T51 6323-6332 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T84 6437-6441 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T85 6516-6520 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T86 6661-6665 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T87 6722-6726 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T88 6740-6749 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T121 7126-7130 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T122 7135-7144 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T155 7294-7297 Protein denotes p38 https://www.uniprot.org/uniprot/Q9Y4Y1|https://www.uniprot.org/uniprot/Q9Y2S7|https://www.uniprot.org/uniprot/Q9UFX6|https://www.uniprot.org/uniprot/Q9UFG0|https://www.uniprot.org/uniprot/Q9Q6X7|https://www.uniprot.org/uniprot/Q9PY95|https://www.uniprot.org/uniprot/Q9P060|https://www.uniprot.org/uniprot/Q9NV58|https://www.uniprot.org/uniprot/Q9H8M8|https://www.uniprot.org/uniprot/Q9H5H9|https://www.uniprot.org/uniprot/Q96JE4|https://www.uniprot.org/uniprot/Q96IL6|https://www.uniprot.org/uniprot/Q96HJ0|https://www.uniprot.org/uniprot/Q96GA9|https://www.uniprot.org/uniprot/Q7TD18|https://www.uniprot.org/uniprot/Q64010|https://www.uniprot.org/uniprot/Q63768|https://www.uniprot.org/uniprot/Q52LG1|https://www.uniprot.org/uniprot/Q04929|https://www.uniprot.org/uniprot/Q01552|https://www.uniprot.org/uniprot/P46108|https://www.uniprot.org/uniprot/P34717|https://www.uniprot.org/uniprot/P27586|https://www.uniprot.org/uniprot/P0C797|https://www.uniprot.org/uniprot/P0C796|https://www.uniprot.org/uniprot/P06663|https://www.uniprot.org/uniprot/P04383|https://www.uniprot.org/uniprot/O97628|https://www.uniprot.org/uniprot/O95433|https://www.uniprot.org/uniprot/D3DTH6|https://www.uniprot.org/uniprot/B4DUR9|https://www.uniprot.org/uniprot/B2R9L2|https://www.uniprot.org/uniprot/B2R846|https://www.uniprot.org/uniprot/B0LPE8|https://www.uniprot.org/uniprot/A8MWE8|https://www.uniprot.org/uniprot/A3KCU9
T191 7407-7412 Protein denotes CD154 https://www.uniprot.org/uniprot/Q9Z2V2|https://www.uniprot.org/uniprot/Q9R254|https://www.uniprot.org/uniprot/Q9BDN3|https://www.uniprot.org/uniprot/Q9BDM7|https://www.uniprot.org/uniprot/Q9BDM3|https://www.uniprot.org/uniprot/Q9BDC7|https://www.uniprot.org/uniprot/Q95MQ5|https://www.uniprot.org/uniprot/P63305|https://www.uniprot.org/uniprot/P63304|https://www.uniprot.org/uniprot/P51749|https://www.uniprot.org/uniprot/P29965|https://www.uniprot.org/uniprot/P27548|https://www.uniprot.org/uniprot/O97626|https://www.uniprot.org/uniprot/O97605
T205 7431-7434 Protein denotes CD4 https://www.uniprot.org/uniprot/Q9XS78|https://www.uniprot.org/uniprot/Q9UDE5|https://www.uniprot.org/uniprot/Q5U066|https://www.uniprot.org/uniprot/Q4ZGK2|https://www.uniprot.org/uniprot/Q29617|https://www.uniprot.org/uniprot/Q29037|https://www.uniprot.org/uniprot/Q28217|https://www.uniprot.org/uniprot/Q08340|https://www.uniprot.org/uniprot/Q08339|https://www.uniprot.org/uniprot/Q08338|https://www.uniprot.org/uniprot/Q08336|https://www.uniprot.org/uniprot/P79196|https://www.uniprot.org/uniprot/P79185|https://www.uniprot.org/uniprot/P79184|https://www.uniprot.org/uniprot/P46630|https://www.uniprot.org/uniprot/P33705|https://www.uniprot.org/uniprot/P16004|https://www.uniprot.org/uniprot/P16003|https://www.uniprot.org/uniprot/P06332|https://www.uniprot.org/uniprot/P05542|https://www.uniprot.org/uniprot/P05540|https://www.uniprot.org/uniprot/P01730|https://www.uniprot.org/uniprot/O77593|https://www.uniprot.org/uniprot/O02805|https://www.uniprot.org/uniprot/D3DUS5|https://www.uniprot.org/uniprot/B2R737
T231 7562-7566 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T232 7568-7599 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T247 7816-7820 Protein denotes cGAS https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T259 7822-7845 Protein denotes cyclic GMP-AMP synthase https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T271 7852-7862 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T273 7888-7909 Protein denotes tumor necrosis factor https://www.uniprot.org/uniprot/Q9UIV3|https://www.uniprot.org/uniprot/Q9TTJ3|https://www.uniprot.org/uniprot/Q9P1Q2|https://www.uniprot.org/uniprot/Q9MYZ2|https://www.uniprot.org/uniprot/Q9JI27|https://www.uniprot.org/uniprot/Q9JI26|https://www.uniprot.org/uniprot/Q9BEA1|https://www.uniprot.org/uniprot/Q91VF3|https://www.uniprot.org/uniprot/Q8WNR1|https://www.uniprot.org/uniprot/Q8MKG8|https://www.uniprot.org/uniprot/Q8JFG3|https://www.uniprot.org/uniprot/Q8HZD9|https://www.uniprot.org/uniprot/Q8HZD6|https://www.uniprot.org/uniprot/Q8HYM0|https://www.uniprot.org/uniprot/Q75N23|https://www.uniprot.org/uniprot/Q6EE11|https://www.uniprot.org/uniprot/Q62326|https://www.uniprot.org/uniprot/Q5TM21|https://www.uniprot.org/uniprot/Q539C2|https://www.uniprot.org/uniprot/Q2MH05|https://www.uniprot.org/uniprot/P29553|https://www.uniprot.org/uniprot/P23563|https://www.uniprot.org/uniprot/P23383|https://www.uniprot.org/uniprot/P19101|https://www.uniprot.org/uniprot/P16599|https://www.uniprot.org/uniprot/P13296|https://www.uniprot.org/uniprot/P06804|https://www.uniprot.org/uniprot/P04924|https://www.uniprot.org/uniprot/P01375|https://www.uniprot.org/uniprot/O77764|https://www.uniprot.org/uniprot/O77510|https://www.uniprot.org/uniprot/O43647|https://www.uniprot.org/uniprot/O35853|https://www.uniprot.org/uniprot/O35734|https://www.uniprot.org/uniprot/O18779|https://www.uniprot.org/uniprot/A9QWR7|https://www.uniprot.org/uniprot/A5D9N8|https://www.uniprot.org/uniprot/A4IFT5|https://www.uniprot.org/uniprot/Q28339|https://www.uniprot.org/uniprot/Q28320|https://www.uniprot.org/uniprot/Q27978|https://www.uniprot.org/uniprot/Q1XHZ6|https://www.uniprot.org/uniprot/Q1WM27|https://www.uniprot.org/uniprot/Q1G1A2|https://www.uniprot.org/uniprot/Q19LH4|https://www.uniprot.org/uniprot/Q06599|https://www.uniprot.org/uniprot/Q006K5|https://www.uniprot.org/uniprot/P79374|https://www.uniprot.org/uniprot/P79337|https://www.uniprot.org/uniprot/P59695|https://www.uniprot.org/uniprot/P59694|https://www.uniprot.org/uniprot/P59693|https://www.uniprot.org/uniprot/P59684|https://www.uniprot.org/uniprot/P51743|https://www.uniprot.org/uniprot/P51742|https://www.uniprot.org/uniprot/P51435|https://www.uniprot.org/uniprot/P48094|https://www.uniprot.org/uniprot/P36939|https://www.uniprot.org/uniprot/P33620
T332 8027-8040 Protein denotes glycoproteins https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T417 8274-8278 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T418 8507-8516 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T451 8567-8586 Protein denotes quinone reductase 2 https://www.uniprot.org/uniprot/Q9JI75|https://www.uniprot.org/uniprot/Q6AY80|https://www.uniprot.org/uniprot/Q5TD04|https://www.uniprot.org/uniprot/Q5RBB9|https://www.uniprot.org/uniprot/P16083|https://www.uniprot.org/uniprot/B2R492
T457 8588-8591 Protein denotes QR2 https://www.uniprot.org/uniprot/Q9JI75|https://www.uniprot.org/uniprot/Q6AY80|https://www.uniprot.org/uniprot/Q5TD04|https://www.uniprot.org/uniprot/Q5RBB9|https://www.uniprot.org/uniprot/P16083|https://www.uniprot.org/uniprot/B2R492
T463 9182-9189 Protein denotes trypsin https://www.uniprot.org/uniprot/P83348|https://www.uniprot.org/uniprot/P81524|https://www.uniprot.org/uniprot/P81071|https://www.uniprot.org/uniprot/P70059|https://www.uniprot.org/uniprot/P51588|https://www.uniprot.org/uniprot/P35051|https://www.uniprot.org/uniprot/P35050|https://www.uniprot.org/uniprot/P35048|https://www.uniprot.org/uniprot/P35034|https://www.uniprot.org/uniprot/P19799|https://www.uniprot.org/uniprot/P00764|https://www.uniprot.org/uniprot/P00761|https://www.uniprot.org/uniprot/O97399
T476 9191-9196 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T484 9259-9267 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T728 9298-9306 Protein denotes elastase https://www.uniprot.org/uniprot/P32197
T729 9324-9333 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T762 9397-9408 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T784 9507-9517 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T817 9717-9728 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T839 9767-9776 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T872 10692-10701 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T873 10769-10777 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0
T877 11047-11051 Protein denotes MAVS https://www.uniprot.org/uniprot/Q9ULE9|https://www.uniprot.org/uniprot/Q9H8D3|https://www.uniprot.org/uniprot/Q9H4Y1|https://www.uniprot.org/uniprot/Q9H1H3|https://www.uniprot.org/uniprot/Q8VCF0|https://www.uniprot.org/uniprot/Q86VY7|https://www.uniprot.org/uniprot/Q7Z434|https://www.uniprot.org/uniprot/Q66HG9|https://www.uniprot.org/uniprot/Q5T7I6|https://www.uniprot.org/uniprot/Q3I0Y2|https://www.uniprot.org/uniprot/Q2HWT5|https://www.uniprot.org/uniprot/M1P2Z0|https://www.uniprot.org/uniprot/F5H6C8|https://www.uniprot.org/uniprot/B2BD34|https://www.uniprot.org/uniprot/B2BD33|https://www.uniprot.org/uniprot/A8K6X0
T893 11199-11207 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0
T897 11695-11700 Protein denotes CD154 https://www.uniprot.org/uniprot/Q9Z2V2|https://www.uniprot.org/uniprot/Q9R254|https://www.uniprot.org/uniprot/Q9BDN3|https://www.uniprot.org/uniprot/Q9BDM7|https://www.uniprot.org/uniprot/Q9BDM3|https://www.uniprot.org/uniprot/Q9BDC7|https://www.uniprot.org/uniprot/Q95MQ5|https://www.uniprot.org/uniprot/P63305|https://www.uniprot.org/uniprot/P63304|https://www.uniprot.org/uniprot/P51749|https://www.uniprot.org/uniprot/P29965|https://www.uniprot.org/uniprot/P27548|https://www.uniprot.org/uniprot/O97626|https://www.uniprot.org/uniprot/O97605
T911 11719-11722 Protein denotes CD4 https://www.uniprot.org/uniprot/Q9XS78|https://www.uniprot.org/uniprot/Q9UDE5|https://www.uniprot.org/uniprot/Q5U066|https://www.uniprot.org/uniprot/Q4ZGK2|https://www.uniprot.org/uniprot/Q29617|https://www.uniprot.org/uniprot/Q29037|https://www.uniprot.org/uniprot/Q28217|https://www.uniprot.org/uniprot/Q08340|https://www.uniprot.org/uniprot/Q08339|https://www.uniprot.org/uniprot/Q08338|https://www.uniprot.org/uniprot/Q08336|https://www.uniprot.org/uniprot/P79196|https://www.uniprot.org/uniprot/P79185|https://www.uniprot.org/uniprot/P79184|https://www.uniprot.org/uniprot/P46630|https://www.uniprot.org/uniprot/P33705|https://www.uniprot.org/uniprot/P16004|https://www.uniprot.org/uniprot/P16003|https://www.uniprot.org/uniprot/P06332|https://www.uniprot.org/uniprot/P05542|https://www.uniprot.org/uniprot/P05540|https://www.uniprot.org/uniprot/P01730|https://www.uniprot.org/uniprot/O77593|https://www.uniprot.org/uniprot/O02805|https://www.uniprot.org/uniprot/D3DUS5|https://www.uniprot.org/uniprot/B2R737
T937 11793-11797 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T981 11802-11823 Protein denotes tumor necrosis factor https://www.uniprot.org/uniprot/Q9UIV3|https://www.uniprot.org/uniprot/Q9TTJ3|https://www.uniprot.org/uniprot/Q9P1Q2|https://www.uniprot.org/uniprot/Q9MYZ2|https://www.uniprot.org/uniprot/Q9JI27|https://www.uniprot.org/uniprot/Q9JI26|https://www.uniprot.org/uniprot/Q9BEA1|https://www.uniprot.org/uniprot/Q91VF3|https://www.uniprot.org/uniprot/Q8WNR1|https://www.uniprot.org/uniprot/Q8MKG8|https://www.uniprot.org/uniprot/Q8JFG3|https://www.uniprot.org/uniprot/Q8HZD9|https://www.uniprot.org/uniprot/Q8HZD6|https://www.uniprot.org/uniprot/Q8HYM0|https://www.uniprot.org/uniprot/Q75N23|https://www.uniprot.org/uniprot/Q6EE11|https://www.uniprot.org/uniprot/Q62326|https://www.uniprot.org/uniprot/Q5TM21|https://www.uniprot.org/uniprot/Q539C2|https://www.uniprot.org/uniprot/Q2MH05|https://www.uniprot.org/uniprot/P29553|https://www.uniprot.org/uniprot/P23563|https://www.uniprot.org/uniprot/P23383|https://www.uniprot.org/uniprot/P19101|https://www.uniprot.org/uniprot/P16599|https://www.uniprot.org/uniprot/P13296|https://www.uniprot.org/uniprot/P06804|https://www.uniprot.org/uniprot/P04924|https://www.uniprot.org/uniprot/P01375|https://www.uniprot.org/uniprot/O77764|https://www.uniprot.org/uniprot/O77510|https://www.uniprot.org/uniprot/O43647|https://www.uniprot.org/uniprot/O35853|https://www.uniprot.org/uniprot/O35734|https://www.uniprot.org/uniprot/O18779|https://www.uniprot.org/uniprot/A9QWR7|https://www.uniprot.org/uniprot/A5D9N8|https://www.uniprot.org/uniprot/A4IFT5|https://www.uniprot.org/uniprot/Q28339|https://www.uniprot.org/uniprot/Q28320|https://www.uniprot.org/uniprot/Q27978|https://www.uniprot.org/uniprot/Q1XHZ6|https://www.uniprot.org/uniprot/Q1WM27|https://www.uniprot.org/uniprot/Q1G1A2|https://www.uniprot.org/uniprot/Q19LH4|https://www.uniprot.org/uniprot/Q06599|https://www.uniprot.org/uniprot/Q006K5|https://www.uniprot.org/uniprot/P79374|https://www.uniprot.org/uniprot/P79337|https://www.uniprot.org/uniprot/P59695|https://www.uniprot.org/uniprot/P59694|https://www.uniprot.org/uniprot/P59693|https://www.uniprot.org/uniprot/P59684|https://www.uniprot.org/uniprot/P51743|https://www.uniprot.org/uniprot/P51742|https://www.uniprot.org/uniprot/P51435|https://www.uniprot.org/uniprot/P48094|https://www.uniprot.org/uniprot/P36939|https://www.uniprot.org/uniprot/P33620
T1040 12101-12117 Protein denotes (cGAMP) synthase https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T1052 12119-12123 Protein denotes cGAS https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T1064 12187-12197 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T1066 12249-12265 Protein denotes phospholipase A2 https://www.uniprot.org/uniprot/Q05017|https://www.uniprot.org/uniprot/P86780|https://www.uniprot.org/uniprot/P86517|https://www.uniprot.org/uniprot/P86043|https://www.uniprot.org/uniprot/P82971|https://www.uniprot.org/uniprot/P59066|https://www.uniprot.org/uniprot/P50393|https://www.uniprot.org/uniprot/P50392|https://www.uniprot.org/uniprot/P49147|https://www.uniprot.org/uniprot/P47713|https://www.uniprot.org/uniprot/P47712|https://www.uniprot.org/uniprot/P43434|https://www.uniprot.org/uniprot/P18999|https://www.uniprot.org/uniprot/P14419|https://www.uniprot.org/uniprot/P0DPT8|https://www.uniprot.org/uniprot/P0DP54|https://www.uniprot.org/uniprot/P0CV89|https://www.uniprot.org/uniprot/P0C8L9|https://www.uniprot.org/uniprot/P06596|https://www.uniprot.org/uniprot/P04362|https://www.uniprot.org/uniprot/P04055|https://www.uniprot.org/uniprot/P04054|https://www.uniprot.org/uniprot/P00630|https://www.uniprot.org/uniprot/P00594|https://www.uniprot.org/uniprot/P00593|https://www.uniprot.org/uniprot/O77793|https://www.uniprot.org/uniprot/O70320|https://www.uniprot.org/uniprot/O54728|https://www.uniprot.org/uniprot/F5CPF0|https://www.uniprot.org/uniprot/C0HLL2|https://www.uniprot.org/uniprot/C0HLB8|https://www.uniprot.org/uniprot/B3EWQ8|https://www.uniprot.org/uniprot/B3EWP6|https://www.uniprot.org/uniprot/B2R4H5|https://www.uniprot.org/uniprot/B1WAZ6|https://www.uniprot.org/uniprot/B1AKG4|https://www.uniprot.org/uniprot/A8KAX2|https://www.uniprot.org/uniprot/A6H6K5|https://www.uniprot.org/uniprot/A5JGM7|https://www.uniprot.org/uniprot/A4IFJ5|https://www.uniprot.org/uniprot/A0A5C2A2T2|https://www.uniprot.org/uniprot/A0A5C1ZXT8|https://www.uniprot.org/uniprot/A0A5C1ZW08|https://www.uniprot.org/uniprot/Q9Z0Y2|https://www.uniprot.org/uniprot/Q9TWL9|https://www.uniprot.org/uniprot/Q9TT38|https://www.uniprot.org/uniprot/Q9PRZ0|https://www.uniprot.org/uniprot/Q9D884|https://www.uniprot.org/uniprot/Q9D7E2|https://www.uniprot.org/uniprot/Q9D4Y6|https://www.uniprot.org/uniprot/Q9BMK4|https://www.uniprot.org/uniprot/Q96DP9|https://www.uniprot.org/uniprot/Q8WPH5|https://www.uniprot.org/uniprot/Q8IUP7|https://www.uniprot.org/uniprot/Q7T0T9|https://www.uniprot.org/uniprot/Q7M4I6|https://www.uniprot.org/uniprot/Q7M4I5|https://www.uniprot.org/uniprot/Q7M3V3|https://www.uniprot.org/uniprot/Q7M334|https://www.uniprot.org/uniprot/Q7LZG3|https://www.uniprot.org/uniprot/Q6T178|https://www.uniprot.org/uniprot/Q6P1J6|https://www.uniprot.org/uniprot/Q5R8A5|https://www.uniprot.org/uniprot/Q53S03|https://www.uniprot.org/uniprot/Q3TTY0|https://www.uniprot.org/uniprot/Q3KPI1|https://www.uniprot.org/uniprot/Q29R80|https://www.uniprot.org/uniprot/Q1XD55|https://www.uniprot.org/uniprot/Q0VEX7|https://www.uniprot.org/uniprot/Q06HQ7
T1136 12472-12476 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T1180 12481-12486 Protein denotes IL-10 https://www.uniprot.org/uniprot/Q9Z1Y5|https://www.uniprot.org/uniprot/Q9TSJ7|https://www.uniprot.org/uniprot/Q9TSJ4|https://www.uniprot.org/uniprot/Q9JHK7|https://www.uniprot.org/uniprot/Q8MKG9|https://www.uniprot.org/uniprot/Q865X4|https://www.uniprot.org/uniprot/Q6A2H5|https://www.uniprot.org/uniprot/Q6A2H4|https://www.uniprot.org/uniprot/Q63263|https://www.uniprot.org/uniprot/Q5Q0V6|https://www.uniprot.org/uniprot/Q2PE73|https://www.uniprot.org/uniprot/Q29408|https://www.uniprot.org/uniprot/Q29055|https://www.uniprot.org/uniprot/Q28374|https://www.uniprot.org/uniprot/Q25BC1|https://www.uniprot.org/uniprot/Q1W5D6|https://www.uniprot.org/uniprot/Q0Z972|https://www.uniprot.org/uniprot/Q0VBJ1|https://www.uniprot.org/uniprot/P79338|https://www.uniprot.org/uniprot/P55029|https://www.uniprot.org/uniprot/P51746|https://www.uniprot.org/uniprot/P51497|https://www.uniprot.org/uniprot/P51496|https://www.uniprot.org/uniprot/P48411|https://www.uniprot.org/uniprot/P47965|https://www.uniprot.org/uniprot/P46651|https://www.uniprot.org/uniprot/P43480|https://www.uniprot.org/uniprot/P29456|https://www.uniprot.org/uniprot/P22301|https://www.uniprot.org/uniprot/P18893|https://www.uniprot.org/uniprot/O97798|https://www.uniprot.org/uniprot/O46673|https://www.uniprot.org/uniprot/A9QWR2|https://www.uniprot.org/uniprot/A2T6Z6
T1214 17849-17853 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T1258 25878-25882 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T1302 37136-37169 Protein denotes glucose 6-phosphate dehydrogenase https://www.uniprot.org/uniprot/R4GMU1|https://www.uniprot.org/uniprot/Q8CFX1|https://www.uniprot.org/uniprot/Q8BLH1|https://www.uniprot.org/uniprot/Q68DT3|https://www.uniprot.org/uniprot/Q66I35|https://www.uniprot.org/uniprot/Q4TT33|https://www.uniprot.org/uniprot/P56201|https://www.uniprot.org/uniprot/O95479|https://www.uniprot.org/uniprot/G1SE36|https://www.uniprot.org/uniprot/B2KGW7|https://www.uniprot.org/uniprot/A2A7A9
T1313 37171-37175 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1345 37306-37310 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1
T1377 37399-37403 Protein denotes G6PD https://www.uniprot.org/uniprot/Q9VWE3|https://www.uniprot.org/uniprot/Q9VWE2|https://www.uniprot.org/uniprot/Q96PQ2|https://www.uniprot.org/uniprot/Q8IUA6|https://www.uniprot.org/uniprot/Q8IU88|https://www.uniprot.org/uniprot/Q8IU70|https://www.uniprot.org/uniprot/Q7YS37|https://www.uniprot.org/uniprot/Q29492|https://www.uniprot.org/uniprot/Q27881|https://www.uniprot.org/uniprot/Q27879|https://www.uniprot.org/uniprot/Q27872|https://www.uniprot.org/uniprot/Q27638|https://www.uniprot.org/uniprot/Q27574|https://www.uniprot.org/uniprot/Q27464|https://www.uniprot.org/uniprot/Q25537|https://www.uniprot.org/uniprot/Q25019|https://www.uniprot.org/uniprot/Q24625|https://www.uniprot.org/uniprot/Q23711|https://www.uniprot.org/uniprot/Q16765|https://www.uniprot.org/uniprot/Q16000|https://www.uniprot.org/uniprot/Q0VB18|https://www.uniprot.org/uniprot/Q00612|https://www.uniprot.org/uniprot/P97324|https://www.uniprot.org/uniprot/P54996|https://www.uniprot.org/uniprot/P41571|https://www.uniprot.org/uniprot/P15588|https://www.uniprot.org/uniprot/P12646|https://www.uniprot.org/uniprot/P11413|https://www.uniprot.org/uniprot/P05370|https://www.uniprot.org/uniprot/O55044|https://www.uniprot.org/uniprot/D3DWX9|https://www.uniprot.org/uniprot/R4GMU1

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T5 29-36 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T6 371-380 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T7 967-971 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T8 1190-1198 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T9 1346-1359 http://purl.obolibrary.org/obo/IDO_0000562 denotes antibacterial
T10 1361-1371 http://purl.obolibrary.org/obo/IDO_0000560 denotes antifungal
T11 1376-1385 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T12 1450-1459 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T13 1481-1488 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T14 1514-1519 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 1534-1539 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T16 1560-1567 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T17 1594-1599 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T18 1623-1628 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T19 1752-1761 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T20 1832-1841 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T21 1923-1927 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T22 2243-2254 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T23 2287-2292 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T24 2312-2321 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T25 2337-2342 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 2343-2353 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T27 2402-2411 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T28 2467-2472 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T29 2473-2483 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T30 2533-2538 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T31 2544-2553 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T32 2720-2731 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T33 2777-2786 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T34 3030-3039 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T35 3084-3095 http://purl.obolibrary.org/obo/IDO_0000464 denotes infectivity
T36 3169-3174 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T37 3222-3231 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T38 3284-3289 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T39 3362-3371 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T40 3436-3441 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T41 3447-3456 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T42 4087-4098 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T43 4130-4139 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T44 4288-4297 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T45 4355-4360 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 4457-4467 http://purl.obolibrary.org/obo/BFO_0000034 denotes functioned
T47 4518-4526 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T48 4527-4532 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 4551-4555 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T50 4593-4602 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T51 5035-5039 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T52 5080-5089 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T53 5100-5105 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T54 5275-5284 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T55 5295-5300 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 5600-5604 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T57 5792-5801 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T58 5904-5908 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T59 5982-5986 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T60 5987-5991 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T61 6052-6057 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T62 6099-6104 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T63 6113-6117 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T64 6118-6122 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T65 6194-6199 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 6410-6414 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 6508-6512 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T68 6886-6897 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T69 6913-6928 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T70 6963-6972 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T71 7323-7327 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T72 7439-7443 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T73 7480-7490 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T74 7543-7548 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T75 7555-7560 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T76 7623-7630 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T77 7956-7965 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T78 7969-7973 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T79 7974-7979 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T80 8094-8101 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T81 8351-8355 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T82 8356-8360 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T83 8875-8882 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T84 8894-8898 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T85 9598-9603 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T86 9674-9679 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T87 9973-9978 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T88 10352-10357 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T89 10362-10366 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T90 10417-10421 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T91 10444-10448 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T92 10546-10550 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T93 10590-10599 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T94 10671-10682 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T95 10718-10723 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T96 10824-10834 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T97 10977-10981 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T98 11026-11035 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T99 11087-11092 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T100 11147-11156 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T101 11234-11238 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T102 11299-11303 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T103 11328-11338 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T104 11655-11659 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T105 11727-11732 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T106 11834-11847 http://purl.obolibrary.org/obo/IDO_0000607 denotes produced by T
T107 11848-11853 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T108 11860-11865 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T109 12033-12043 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T110 12198-12208 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T111 12329-12339 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T112 12541-12549 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T113 12642-12649 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T114 12677-12692 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T115 13194-13201 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T116 14602-14616 http://purl.obolibrary.org/obo/OGMS_0000063 denotes disease course
T117 14602-14609 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T118 16160-16167 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T119 16184-16191 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T120 16526-16535 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T121 16649-16656 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T122 18286-18291 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T123 18320-18325 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T124 22374-22382 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T125 22641-22649 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T126 24150-24157 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T127 24178-24185 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T128 24487-24496 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T129 24530-24537 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T130 24569-24578 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T131 24867-24874 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T132 25320-25328 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T133 26143-26154 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T134 27299-27304 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T135 27354-27359 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T136 28136-28144 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T137 28451-28456 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T138 31108-31115 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T139 32042-32049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T140 32663-32670 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T141 33692-33699 http://purl.obolibrary.org/obo/BFO_0000182 denotes history
T142 33991-33999 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T143 34169-34174 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T144 34225-34233 http://purl.obolibrary.org/obo/OGMS_0000045 denotes disorder
T145 36784-36791 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T146 36967-36975 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T147 38344-38352 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T148 38425-38432 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T149 38540-38545 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T150 38558-38562 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T151 38694-38699 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T152 38749-38758 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T153 39686-39693 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T154 39921-39930 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T155 40079-40084 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T3 967-981 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T4 967-971 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 1007-1017 Body_part denotes organelles http://purl.org/sig/ont/fma/fma63832
T6 1027-1036 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T7 1038-1059 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T8 1477-1480 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T9 1498-1501 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T10 1556-1559 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T11 1923-1927 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 2287-2292 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13 2533-2538 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 3436-3441 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 3673-3677 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T16 3989-3993 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T17 4106-4111 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T18 4162-4173 Body_part denotes spinal cord http://purl.org/sig/ont/fma/fma7647
T19 4355-4360 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 4527-4532 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 4551-4555 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 5035-5039 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 5100-5105 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 5295-5300 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 5600-5604 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 5868-5875 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 5987-5999 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T28 5987-5991 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T29 6118-6131 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T30 6118-6122 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T31 6194-6199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 6325-6332 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 6410-6422 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T34 6410-6414 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 6742-6749 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T36 7137-7144 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 7183-7194 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T38 7362-7365 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T39 7439-7443 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 7494-7503 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T41 7543-7548 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T42 7555-7560 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T43 7724-7731 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 7740-7743 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T45 7748-7780 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T46 7864-7866 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T47 7868-7879 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T48 7928-7935 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 7936-7954 Body_part denotes membrane receptors http://purl.org/sig/ont/fma/fma0326969
T50 7974-7979 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 8027-8040 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T52 8045-8057 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T53 8331-8343 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T54 8356-8368 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T55 8356-8360 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T56 8428-8440 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T57 8509-8516 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 8520-8532 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T59 8775-8786 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T60 8871-8874 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T61 8894-8898 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 9015-9024 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T63 9025-9036 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T64 9268-9274 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T65 9326-9333 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 9509-9517 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 9674-9679 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 9769-9776 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 9918-9933 Body_part denotes early endosomes http://purl.org/sig/ont/fma/fma67463
T70 9973-9978 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 10106-10115 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T72 10240-10248 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T73 10295-10304 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T74 10417-10421 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T75 10489-10496 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 10546-10558 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 10546-10550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 10702-10706 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 10707-10723 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 10718-10723 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T81 11299-11303 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 11319-11327 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T83 11490-11499 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T84 11541-11573 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T85 11575-11578 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T86 11655-11659 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 11727-11732 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 11755-11764 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89 11773-11784 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T90 11785-11791 Body_part denotes (IL)-1 http://purl.org/sig/ont/fma/fma86583
T91 11786-11788 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T92 11793-11795 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T93 11848-11853 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94 11860-11865 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 11901-11910 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T96 12047-12056 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T97 12148-12157 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T98 12158-12161 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T99 12425-12434 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T100 12472-12474 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T101 12481-12483 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T102 12507-12513 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T103 12591-12599 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T104 13124-13128 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T105 14546-14550 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T106 15413-15417 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T107 16856-16859 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T108 16890-16913 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T109 17849-17851 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T110 18709-18720 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T111 18796-18807 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T112 24609-24612 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T113 24644-24667 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T114 25869-25877 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T115 25878-25880 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T116 28245-28256 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T117 34137-34140 Body_part denotes ear http://purl.org/sig/ont/fma/fma52780
T118 34142-34163 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T119 34169-34174 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T120 34681-34703 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T121 34723-34728 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T122 34733-34739 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T123 34794-34799 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T124 34804-34810 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T125 36778-36783 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T126 37136-37143 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T127 37820-37828 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T128 38558-38562 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 39825-39829 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T1 4106-4111 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 4162-4173 http://purl.obolibrary.org/obo/MAT_0000183 denotes spinal cord
T3 10702-10706 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T4 13124-13128 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T5 14546-14550 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T6 18709-18720 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx
T7 18796-18807 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx
T8 28245-28256 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx
T9 34137-34140 http://purl.obolibrary.org/obo/MAT_0000317 denotes ear
T10 34137-34140 http://purl.obolibrary.org/obo/MAT_0000233 denotes ear
T11 34137-34140 http://purl.obolibrary.org/obo/MAT_0000138 denotes ear
T12 34142-34163 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T13 34169-34174 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T14 34169-34174 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T15 34723-34728 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T16 34733-34739 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T17 34794-34799 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T18 34804-34810 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T19 36778-36783 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T3 6292-6301 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 6306-6319 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 6464-6477 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 6485-6507 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 6494-6507 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 6635-6657 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 6644-6657 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 6913-6928 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 7211-7226 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 7263-7276 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 7294-7297 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T14 7362-7365 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T15 7453-7462 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T16 7700-7704 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T17 7740-7743 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T18 7748-7780 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T19 7894-7902 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T20 7894-7902 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 7894-7902 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T22 7894-7902 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T23 8609-8621 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T24 8828-8843 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T25 8944-8973 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T26 8962-8973 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T27 8980-8995 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T28 9043-9054 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T29 9099-9112 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T30 9363-9378 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T31 9695-9706 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T32 9886-9898 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T33 10028-10037 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T34 10249-10262 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T35 10422-10439 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T36 10422-10431 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T37 10505-10509 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 10769-10772 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T39 10773-10777 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T40 10928-10943 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T41 11036-11045 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T42 11199-11202 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T43 11203-11207 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T44 11297-11314 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T45 11299-11314 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T46 11319-11338 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T47 11442-11470 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T48 11521-11539 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T49 11541-11573 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T50 11575-11578 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T51 11645-11670 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T52 11653-11670 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T53 11655-11670 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T54 11808-11816 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 11808-11816 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T56 11808-11816 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T57 11808-11816 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T58 11958-11967 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T59 12180-12208 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T60 12187-12208 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T61 12249-12262 http://purl.obolibrary.org/obo/GO_0004623 denotes phospholipase
T62 12280-12290 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T63 12677-12692 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T64 15741-15746 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T65 17240-17245 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T66 20565-20570 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T67 21438-21443 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T68 25243-25248 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T69 26126-26154 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T70 26137-26154 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T71 26137-26154 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T72 26600-26605 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T73 26815-26820 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T74 29072-29077 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T75 31779-31784 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T76 34710-34719 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T77 37829-37842 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T78 37861-37876 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T15 17-39 Disease denotes Coronavirus disease-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 41-49 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 61-108 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T18 110-120 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T19 240-248 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 329-337 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 586-594 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 1112-1119 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T23 1179-1198 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T24 1207-1235 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T25 1237-1240 Disease denotes SLE http://purl.obolibrary.org/obo/MONDO_0007915
T26 1246-1266 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T27 1268-1270 Disease denotes RA http://purl.obolibrary.org/obo/MONDO_0008383
T28 1507-1513 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T29 1528-1533 Disease denotes polio http://purl.obolibrary.org/obo/MONDO_0017373
T30 1582-1593 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T31 1608-1622 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T32 1692-1702 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T33 1737-1745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 1914-1922 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256
T35 2312-2321 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36 2402-2411 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 2581-2589 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 2711-2719 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 2777-2786 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 2838-2846 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 3021-3039 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T42 3222-3231 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 4130-4139 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 4325-4335 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T45 4398-4408 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T46 4507-4517 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T47 4593-4602 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T48 4639-4649 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T49 4940-4950 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T50 5069-5079 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T51 5080-5089 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 5264-5274 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T53 5275-5284 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 5472-5482 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T55 5717-5727 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T56 5776-5784 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 5879-5889 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T58 6227-6237 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T59 6351-6359 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 6731-6735 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T61 7005-7013 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 7601-7609 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 7611-7635 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T64 7888-7893 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T65 7956-7965 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 8124-8133 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T67 8159-8167 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 8249-8259 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T69 9532-9540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 9588-9597 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T71 9646-9656 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T72 9756-9766 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T73 9861-9871 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T74 9902-9912 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T75 10041-10051 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T76 10590-10599 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 10629-10637 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 11080-11086 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T79 11802-11807 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T80 12555-12565 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T81 12618-12621 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T83 12733-12736 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T85 12766-12774 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 12840-12848 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 12920-12928 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T88 13004-13012 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 13103-13112 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T90 13534-13542 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 14156-14164 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 14280-14288 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 14511-14520 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T94 15125-15133 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 16284-16292 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 17811-17819 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T97 19204-19212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 21180-21188 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 21367-21377 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T100 21667-21675 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T101 21757-21765 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 22116-22125 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T103 22569-22577 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 22852-22860 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 23135-23143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 23387-23391 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T107 23641-23649 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 23666-23675 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T109 23990-23998 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 24435-24443 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 24963-24971 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 25540-25548 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 26219-26227 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 26449-26457 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 26530-26538 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 26708-26716 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 26949-26957 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 27924-27932 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 29276-29284 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 29707-29715 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 30811-30819 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 31605-31615 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T123 31822-31833 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T124 32373-32383 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T125 32481-32489 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 32714-32722 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 32935-32943 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 33439-33447 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 33617-33625 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T130 33672-33679 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T131 33961-33969 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T132 34204-34212 Disease denotes deafness http://purl.obolibrary.org/obo/MONDO_0005365
T133 34214-34233 Disease denotes conduction disorder http://purl.obolibrary.org/obo/MONDO_0007264
T134 34234-34248 Disease denotes cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0004994
T135 34254-34264 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T136 34587-34598 Disease denotes retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T137 34986-34994 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 35276-35311 Disease denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/MONDO_0000466
T139 35460-35464 Disease denotes rash http://purl.obolibrary.org/obo/MONDO_0006547
T140 35535-35543 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T141 35639-35648 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T142 35665-35673 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T143 35832-35840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T144 36375-36385 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T145 36402-36410 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 36778-36791 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T147 37171-37175 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T148 37225-37241 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T149 37306-37321 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T150 37399-37414 Disease denotes G6PD deficiency http://purl.obolibrary.org/obo/MONDO_0005775
T151 37469-37477 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 37697-37707 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 37994-38002 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T154 38110-38118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 38146-38156 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T156 38249-38259 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 38356-38364 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T158 38534-38539 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T159 38682-38693 Disease denotes chikungunya http://purl.obolibrary.org/obo/MONDO_0017941
T160 38749-38758 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T161 38896-38904 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 38942-38950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 39320-39328 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 39596-39604 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 39910-39920 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T166 39921-39930 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T167 40310-40318 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 40445-40453 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T169 40569-40577 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 1179-1198 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T3 1207-1235 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T4 1237-1240 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T5 1246-1266 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T6 1268-1270 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T7 1582-1591 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T8 7888-7893 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T9 9588-9597 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T10 11802-11807 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T11 13103-13112 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T12 14511-14520 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 15434-15439 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T14 15564-15569 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T15 21367-21377 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T16 21989-21994 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T17 22116-22125 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 22296-22301 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T19 22334-22339 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T20 23666-23675 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T21 31593-31615 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T22 31810-31833 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T23 32373-32383 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T24 33943-33959 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T25 33961-33969 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T26 33975-33983 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T27 34204-34212 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T28 34234-34248 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T29 34254-34264 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T30 34587-34598 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T31 35208-35230 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T32 35276-35311 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T33 35447-35455 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T34 35460-35464 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T35 35472-35493 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T36 35639-35648 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 36363-36385 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T38 37225-37241 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T3 6292-6301 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 6306-6319 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 6464-6477 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 6485-6507 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 6494-6507 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 6635-6657 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 6644-6657 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 6913-6928 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 7211-7226 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 7263-7276 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 7362-7365 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T14 7453-7462 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 7700-7704 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T16 7740-7743 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T17 7748-7780 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T18 7894-7902 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T19 7894-7902 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20 7894-7902 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 7894-7902 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T22 8609-8621 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T23 8828-8843 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T24 8944-8973 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T25 8962-8973 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T26 8980-8995 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T27 9043-9054 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T28 9099-9112 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T29 9363-9378 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T30 9695-9706 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T31 9886-9898 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T32 10028-10037 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T33 10249-10262 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T34 10422-10439 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T35 10422-10431 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T36 10505-10509 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 10773-10777 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 10928-10943 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 11036-11045 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 11203-11207 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T41 11297-11314 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T42 11299-11314 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T43 11319-11338 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T44 11442-11470 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T45 11521-11539 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T46 11541-11573 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T47 11575-11578 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T48 11645-11670 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T49 11653-11670 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T50 11655-11670 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T51 11808-11816 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T52 11808-11816 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T53 11808-11816 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T54 11808-11816 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 11958-11967 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 12180-12208 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T57 12187-12208 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T58 12280-12290 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T59 12677-12692 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T60 16972-16977 http://purl.obolibrary.org/obo/GO_0071878 denotes false
T61 16972-16977 http://purl.obolibrary.org/obo/GO_0071877 denotes false
T62 24726-24731 http://purl.obolibrary.org/obo/GO_0071878 denotes false
T63 24726-24731 http://purl.obolibrary.org/obo/GO_0071877 denotes false
T64 26126-26154 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T65 26137-26154 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T66 26137-26154 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T67 34710-34719 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T68 37829-37842 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T69 37861-37876 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 6292-6301 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 6306-6319 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 6464-6477 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 6485-6507 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T7 6494-6507 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 6635-6657 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T9 6644-6657 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T10 6913-6928 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11 7211-7226 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T12 7263-7276 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T13 7362-7365 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T14 7453-7462 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 7700-7704 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T16 7740-7743 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T17 7748-7780 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T18 7894-7902 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T19 7894-7902 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20 7894-7902 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21 7894-7902 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T22 8609-8621 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T23 8828-8843 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T24 8944-8973 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T25 8962-8973 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T26 8980-8995 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T27 9043-9054 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T28 9099-9112 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T29 9363-9378 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T30 9695-9706 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T31 9886-9898 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T32 10028-10037 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T33 10249-10262 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T34 10422-10439 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T35 10422-10431 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T36 10505-10509 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 10773-10777 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 10928-10943 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 11036-11045 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 11203-11207 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T41 11297-11314 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T42 11299-11314 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T43 11319-11338 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T44 11442-11470 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T45 11521-11539 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T46 11541-11573 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T47 11575-11578 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T48 11645-11670 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T49 11653-11670 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T50 11655-11670 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T51 11808-11816 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T52 11808-11816 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T53 11808-11816 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T54 11808-11816 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 11958-11967 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 12180-12208 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T57 12187-12208 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T58 12280-12290 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T59 12677-12692 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T60 26126-26154 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T61 26137-26154 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T62 26137-26154 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T63 34710-34719 http://purl.obolibrary.org/obo/GO_0007588 denotes excretion
T64 37829-37842 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T65 37861-37876 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
103 1677-1683 Gene denotes CQ/HCQ
104 1435-1441 Gene denotes CQ/HCQ
105 61-108 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
106 110-120 Species denotes SARS-CoV-2 Tax:2697049
107 189-202 Species denotes coronaviruses Tax:11118
108 1507-1519 Species denotes rabies virus Tax:11292
109 1556-1567 Species denotes DNA viruses Tax:2080735
110 1692-1702 Species denotes SARS-CoV-2 Tax:2697049
111 675-686 Chemical denotes chloroquine MESH:D002738
112 688-690 Chemical denotes CQ MESH:D002738
113 707-725 Chemical denotes hydroxychloroquine MESH:D006886
114 727-730 Chemical denotes HCQ MESH:D006886
115 867-873 Chemical denotes CQ/HCQ
116 893-909 Chemical denotes 4-aminoquinoline MESH:C001920
117 1075-1081 Chemical denotes CQ/HCQ
118 1331-1337 Chemical denotes CQ/HCQ
119 17-39 Disease denotes Coronavirus disease-19 MESH:C000657245
120 41-49 Disease denotes COVID-19 MESH:C000657245
121 240-248 Disease denotes COVID-19 MESH:C000657245
122 329-337 Disease denotes COVID-19 MESH:C000657245
123 586-594 Disease denotes COVID-19 MESH:C000657245
124 1112-1119 Disease denotes malaria MESH:D008288
125 1179-1198 Disease denotes autoimmune diseases MESH:D001327
126 1207-1235 Disease denotes systemic lupus erythematosus MESH:D008180
127 1237-1240 Disease denotes SLE MESH:D008180
128 1246-1266 Disease denotes rheumatoid arthritis MESH:D001172
129 1268-1270 Disease denotes RA MESH:D001172
130 1498-1501 Disease denotes HIV MESH:D015658
131 1737-1745 Disease denotes COVID-19 MESH:C000657245
134 1774-1780 Gene denotes CQ/HCQ
135 1789-1806 Species denotes human coronavirus Tax:694448
154 2028-2030 Gene denotes μM Gene:56925
155 2088-2090 Gene denotes μM Gene:56925
156 2426-2428 Gene denotes μM Gene:56925
157 2416-2418 Gene denotes μm Gene:56925
158 2011-2013 Gene denotes μM Gene:56925
159 1865-1873 Species denotes MERS-CoV Tax:1335626
160 1878-1887 Species denotes HCoV-229E Tax:11137
161 1908-1913 Species denotes human Tax:9606
162 2234-2242 Species denotes MERS-CoV Tax:1335626
163 2196-2198 Chemical denotes CQ MESH:D002738
164 2274-2276 Chemical denotes CQ MESH:D002738
165 2369-2371 Chemical denotes CQ MESH:D002738
166 2447-2449 Chemical denotes CQ MESH:D002738
167 1914-1922 Disease denotes hepatoma MESH:D006528
168 2303-2321 Disease denotes MERS-CoV infection MESH:D018352
169 2398-2411 Disease denotes CoV infection MESH:D018352
170 1934-1939 CellLine denotes Huh-7 CVCL:0336
171 2280-2286 CellLine denotes VeroE6 CVCL:0574
194 2630-2632 Gene denotes μM Gene:56925
195 3520-3522 Gene denotes μM Gene:56925
196 3547-3549 Gene denotes μM Gene:56925
197 2759-2761 Gene denotes μM Gene:56925
198 2647-2649 Gene denotes μM Gene:56925
199 2616-2618 Gene denotes μM Gene:56925
200 2581-2589 Species denotes SARS-CoV Tax:694009
201 2711-2719 Species denotes SARS-CoV Tax:694009
202 3480-3489 Species denotes HCoV-OC43 Tax:31631
203 2838-2846 Species denotes SARS-CoV Tax:694009
204 2566-2568 Chemical denotes CQ MESH:D002738
205 2569-2572 Chemical denotes HCQ MESH:D006886
206 2762-2764 Chemical denotes CQ MESH:D002738
207 2817-2819 Chemical denotes CQ MESH:D002738
208 2861-2864 Chemical denotes HCQ MESH:D006886
209 2879-2881 Chemical denotes CQ MESH:D002738
210 3469-3471 Chemical denotes CQ MESH:D002738
211 2777-2786 Disease denotes infection MESH:D007239
212 3021-3039 Disease denotes SARS-CoV infection MESH:C000657245
213 3222-3231 Disease denotes infection MESH:D007239
214 2526-2532 CellLine denotes VeroE6 CVCL:0574
215 3429-3435 CellLine denotes HRT-18 CVCL:2514
228 3693-3698 Species denotes mouse Tax:10090
229 3759-3763 Species denotes mice Tax:10090
230 3971-3975 Species denotes mice Tax:10090
231 4041-4046 Species denotes mouse Tax:10090
232 4077-4086 Species denotes HCoV-OC43 Tax:31631
233 3621-3630 Species denotes HCoV-OC43 Tax:31631
234 3601-3603 Chemical denotes CQ MESH:D002738
235 3794-3796 Chemical denotes CQ MESH:D002738
236 3919-3921 Chemical denotes CQ MESH:D002738
237 4021-4023 Chemical denotes CQ MESH:D002738
238 4054-4056 Chemical denotes CQ MESH:D002738
239 4130-4139 Disease denotes infection MESH:D007239
242 4310-4316 Gene denotes CQ/HCQ
243 4325-4335 Species denotes SARS-CoV-2 Tax:2697049
278 4419-4421 Gene denotes μM Gene:56925
279 4695-4697 Gene denotes μM Gene:56925
280 4765-4767 Gene denotes μM Gene:56925
281 5153-5155 Gene denotes μM Gene:56925
282 5344-5346 Gene denotes μM Gene:56925
283 5203-5205 Gene denotes μM Gene:56925
284 5693-5699 Gene denotes CQ/HCQ
285 5398-5400 Gene denotes μM Gene:56925
286 5386-5388 Gene denotes μM Gene:56925
287 5331-5333 Gene denotes μM Gene:56925
288 5191-5193 Gene denotes μM Gene:56925
289 5141-5143 Gene denotes μM Gene:56925
290 4398-4408 Species denotes SARS-CoV-2 Tax:2697049
291 4639-4649 Species denotes SARS-CoV-2 Tax:2697049
292 4940-4950 Species denotes SARS-CoV-2 Tax:2697049
293 5472-5482 Species denotes SARS-CoV-2 Tax:2697049
294 5717-5727 Species denotes SARS-CoV-2 Tax:2697049
295 4387-4389 Chemical denotes CQ MESH:D002738
296 4454-4456 Chemical denotes CQ MESH:D002738
297 4664-4666 Chemical denotes CQ MESH:D002738
298 4731-4734 Chemical denotes HCQ MESH:D006886
299 4794-4796 Chemical denotes CQ MESH:D002738
300 4864-4867 Chemical denotes HCQ MESH:D006886
301 4963-4965 Chemical denotes CQ MESH:D002738
302 4995-4998 Chemical denotes HCQ MESH:D006886
303 5495-5497 Chemical denotes CQ MESH:D002738
304 5513-5516 Chemical denotes HCQ MESH:D006886
305 4507-4526 Disease denotes SARS-CoV-2 infected MESH:C000657245
306 4593-4602 Disease denotes infection MESH:D007239
307 5074-5089 Disease denotes CoV-2 infection MESH:C000657245
308 5264-5284 Disease denotes SARS-CoV-2 infection MESH:C000657245
309 4348-4354 CellLine denotes VeroE6 CVCL:0574
310 5093-5099 CellLine denotes VeroE6 CVCL:0574
311 5288-5294 CellLine denotes VeroE6 CVCL:0574
313 5776-5784 Disease denotes COVID-19 MESH:C000657245
322 7126-7130 Gene denotes ACE2 Gene:59272
323 7294-7297 Gene denotes p38 Gene:1432
324 7407-7412 Gene denotes CD154 Gene:959
325 7431-7434 Gene denotes CD4 Gene:920
326 6881-6885 Species denotes CoVs Tax:11118
327 6866-6868 Chemical denotes CQ MESH:D002738
328 6869-6872 Chemical denotes HCQ MESH:D006886
329 7005-7013 Disease denotes COVID-19 MESH:C000657245
350 6009-6040 Gene denotes angiotensin-converting enzyme 2 Gene:59272
351 6042-6046 Gene denotes ACE2 Gene:59272
352 6179-6183 Gene denotes ACE2 Gene:103231639
353 6437-6441 Gene denotes ACE2 Gene:59272
354 6516-6520 Gene denotes ACE2 Gene:59272
355 6661-6665 Gene denotes ACE2 Gene:59272
356 6722-6726 Gene denotes ACE2 Gene:59272
357 6323-6324 Gene denotes S Gene:43740568
358 5866-5867 Gene denotes S Gene:43740568
359 5879-5889 Species denotes SARS-CoV-2 Tax:2697049
360 6351-6359 Species denotes SARS-CoV Tax:694009
361 6731-6739 Species denotes SARS CoV Tax:694009
362 6227-6237 Species denotes SARS-CoV-2 Tax:2697049
363 6560-6563 Species denotes CoV Tax:11118
364 6173-6175 Chemical denotes CQ MESH:D002738
365 6256-6258 Chemical denotes CQ MESH:D002738
366 6443-6445 Chemical denotes CQ MESH:D002738
367 6576-6578 Chemical denotes CQ MESH:D002738
368 6579-6582 Chemical denotes HCQ MESH:D006886
369 6187-6193 CellLine denotes VeroE6 CVCL:0574
394 8274-8278 Gene denotes ACE2 Gene:59272
395 8567-8586 Gene denotes quinone reductase 2 Gene:4835
396 8588-8591 Gene denotes QR2 Gene:4835
397 8398-8404 Gene denotes CQ/HCQ
398 8159-8167 Species denotes SARS-CoV Tax:694009
399 8177-8186 Species denotes HCoV-OC43 Tax:31631
400 8249-8259 Species denotes SARS-CoV-2 Tax:2697049
401 8124-8133 Species denotes influenza Tax:11320
402 8497-8504 Species denotes SARSCoV Tax:694009
403 8676-8679 Species denotes CoV Tax:11118
404 8004-8015 Chemical denotes sialic acid MESH:D019158
405 8045-8057 Chemical denotes gangliosides MESH:D005732
406 8331-8343 Chemical denotes gangliosides MESH:D005732
407 8377-8388 Chemical denotes sialic acid MESH:D019158
408 8411-8423 Chemical denotes sialic acids MESH:D012794
409 8428-8440 Chemical denotes gangliosides MESH:D005732
410 8520-8532 Chemical denotes gangliosides MESH:D005732
411 8539-8541 Chemical denotes CQ MESH:D002738
412 8625-8637 Chemical denotes sialic acids MESH:D012794
413 8692-8694 Chemical denotes CQ MESH:D002738
414 8695-8698 Chemical denotes HCQ MESH:D006886
415 8759-8770 Chemical denotes sialic acid MESH:D019158
416 8775-8786 Chemical denotes ganglioside MESH:D005732
417 7956-7965 Disease denotes infection MESH:D007239
442 9191-9196 Gene denotes furin Gene:5045
443 9397-9408 Gene denotes cathepsin L Gene:1514
444 9717-9728 Gene denotes cathepsin L Gene:1514
445 10085-10091 Gene denotes CQ/HCQ
446 9840-9846 Gene denotes CQ/HCQ
447 9767-9768 Gene denotes S Gene:43740568
448 8852-8856 Species denotes CoVs Tax:11118
452 9582-9603 Species denotes mouse hepatitis virus Tax:11138
453 9646-9656 Species denotes SARS-CoV-2 Tax:2697049
454 9756-9766 Species denotes SARS-CoV-2 Tax:2697049
455 9861-9871 Species denotes SARS-CoV-2 Tax:2697049
456 9902-9912 Species denotes SARS-CoV-2 Tax:2697049
457 10041-10051 Species denotes SARS-CoV-2 Tax:2697049
458 9607-9612 Species denotes MHV-2 Tax:502106
459 10183-10186 Species denotes CoV Tax:11118
460 9268-9274 Chemical denotes serine MESH:D012694
461 10008-10010 Chemical denotes CQ MESH:D002738
462 10199-10201 Chemical denotes CQ MESH:D002738
463 10202-10205 Chemical denotes HCQ MESH:D006886
464 9503-9517 Disease denotes CoV S proteins MESH:C000657245
465 9966-9972 CellLine denotes VeroE6 CVCL:0574
478 11012-11045 Gene denotes mitochondrial antiviral signaling Gene:57506
479 11047-11051 Gene denotes MAVS Gene:57506
480 10603-10607 Species denotes CoVs Tax:11118
481 10629-10637 Species denotes SARS-CoV Tax:694009
482 10661-10670 Species denotes HCoV-229E Tax:11137
483 10686-10691 Species denotes human Tax:9606
484 10794-10797 Chemical denotes HCQ MESH:D006886
485 10847-10870 Chemical denotes reactive oxygen species MESH:D017382
486 10872-10875 Chemical denotes ROS MESH:D017382
487 10950-10953 Chemical denotes HCQ MESH:D006886
488 11119-11125 Chemical denotes CQ/HCQ
489 10590-10599 Disease denotes infection MESH:D007239
520 11695-11700 Gene denotes CD154 Gene:959
521 11719-11722 Gene denotes CD4 Gene:920
522 11773-11791 Gene denotes interleukin (IL)-1 Gene:3552
523 11793-11797 Gene denotes IL-6 Gene:3569
524 11802-11825 Gene denotes tumor necrosis factor-α Gene:7124
525 11827-11832 Gene denotes TNF-α Gene:7124
526 11977-11981 Gene denotes TLR7 Gene:51284
527 11986-11990 Gene denotes TLR9 Gene:54106
528 12086-12117 Gene denotes cyclic GMP-AMP (cGAMP) synthase Gene:115004
529 12119-12123 Gene denotes cGAS Gene:115004
530 12249-12265 Gene denotes phospholipase A2 Gene:5319
531 12472-12476 Gene denotes IL-6 Gene:3569
532 12481-12486 Gene denotes IL-10 Gene:3586
533 12532-12540 Species denotes patients Tax:9606
534 12555-12565 Species denotes SARS-CoV-2 Tax:2697049
535 11474-11476 Chemical denotes CQ MESH:D002738
536 11477-11480 Chemical denotes HCQ MESH:D006886
537 11739-11741 Chemical denotes CQ MESH:D002738
538 12063-12066 Chemical denotes CQ/ MESH:D002738
539 12066-12069 Chemical denotes HCQ MESH:D006886
540 12225-12231 Chemical denotes CQ/HCQ
541 12294-12310 Chemical denotes arachidonic acid MESH:D016718
542 12343-12357 Chemical denotes prostaglandins MESH:D011453
543 12694-12697 Chemical denotes HCQ MESH:D006886
544 12698-12700 Chemical denotes CQ MESH:D002738
545 12517-12531 Disease denotes critically ill MESH:D016638
546 12541-12549 Disease denotes infected MESH:D007239
547 12618-12621 Disease denotes CRS MESH:D003398
548 12733-12736 Disease denotes CRS MESH:D003398
549 12766-12774 Disease denotes COVID-19 MESH:C000657245
552 12813-12819 Chemical denotes CQ/HCQ
553 12840-12848 Disease denotes COVID-19 MESH:C000657245
641 17849-17853 Gene denotes IL-6 Gene:3569
642 14322-14330 Species denotes Patients Tax:9606
643 14678-14686 Species denotes patients Tax:9606
644 16253-16261 Species denotes patients Tax:9606
645 16595-16603 Species denotes patients Tax:9606
646 16773-16781 Species denotes patients Tax:9606
647 17820-17828 Species denotes patients Tax:9606
648 17942-17950 Species denotes patients Tax:9606
649 18014-18022 Species denotes patients Tax:9606
657 14431-14433 Chemical denotes CQ MESH:D002738
658 14469-14471 Chemical denotes CQ MESH:D002738
659 14818-14820 Chemical denotes CQ MESH:D002738
660 14844-14846 Chemical denotes CQ MESH:D002738
661 14870-14872 Chemical denotes CQ MESH:D002738
662 14915-14917 Chemical denotes CQ MESH:D002738
663 15093-15095 Chemical denotes CQ MESH:D002738
664 15300-15303 Chemical denotes HCQ MESH:D006886
665 15341-15344 Chemical denotes HCQ MESH:D006886
666 15377-15380 Chemical denotes HCQ MESH:D006886
667 15609-15612 Chemical denotes HCQ MESH:D006886
668 15650-15653 Chemical denotes HCQ MESH:D006886
669 15799-15802 Chemical denotes HCQ MESH:D006886
670 15843-15846 Chemical denotes HCQ MESH:D006886
671 16045-16048 Chemical denotes HCQ MESH:D006886
672 16087-16090 Chemical denotes HCQ MESH:D006886
673 16193-16196 Chemical denotes HCQ MESH:D006886
674 16548-16551 Chemical denotes HCQ MESH:D006886
675 16642-16645 Chemical denotes HCQ MESH:D006886
676 17036-17039 Chemical denotes HCQ MESH:D006886
677 17059-17062 Chemical denotes HCQ MESH:D006886
678 17078-17081 Chemical denotes HCQ MESH:D006886
679 17178-17181 Chemical denotes HCQ MESH:D006886
680 17577-17580 Chemical denotes HCQ MESH:D006886
681 17599-17602 Chemical denotes HCQ MESH:D006886
682 17618-17621 Chemical denotes HCQ MESH:D006886
683 17679-17682 Chemical denotes HCQ MESH:D006886
684 17721-17724 Chemical denotes HCQ MESH:D006886
685 17732-17735 Chemical denotes HCQ MESH:D006886
686 18088-18091 Chemical denotes HCQ MESH:D006886
687 18107-18110 Chemical denotes HCQ MESH:D006886
688 29031-29043 Chemical denotes azithromycin MESH:D017963
690 40186-40189 Chemical denotes HCQ MESH:D006886
705 14511-14520 Disease denotes pneumonia MESH:D011014
706 14978-14987 Disease denotes mortality MESH:D003643
707 15125-15133 Disease denotes COVID-19 MESH:C000657245
708 15434-15439 Disease denotes cough MESH:D003371
709 15564-15569 Disease denotes cough MESH:D003371
710 15741-15746 Disease denotes death MESH:D003643
711 16284-16292 Disease denotes COVID-19 MESH:C000657245
712 17240-17245 Disease denotes death MESH:D003643
713 17783-17792 Disease denotes mortality MESH:D003643
714 17796-17810 Disease denotes critically ill MESH:D016638
715 17811-17819 Disease denotes COVID-19 MESH:C000657245
716 17861-17870 Disease denotes Mortality MESH:D003643
717 17927-17941 Disease denotes critically ill MESH:D016638
733 14217-14228 Chemical denotes chloroquine MESH:D002738
734 14230-14232 Chemical denotes CQ MESH:D002738
735 14234-14252 Chemical denotes hydroxychloroquine MESH:D006886
736 14254-14257 Chemical denotes HCQ MESH:D006886
737 14280-14288 Disease denotes COVID-19 MESH:C000657245
760 12929-12937 Species denotes patients Tax:9606
761 12990-12998 Species denotes patients Tax:9606
762 13254-13262 Species denotes patients Tax:9606
763 13345-13352 Species denotes patient Tax:9606
764 13543-13551 Species denotes patients Tax:9606
765 13594-13602 Species denotes patients Tax:9606
766 13664-13672 Species denotes patients Tax:9606
767 14142-14150 Species denotes patients Tax:9606
768 12914-12916 Chemical denotes CQ MESH:D002738
769 12964-12966 Chemical denotes CQ MESH:D002738
770 13030-13032 Chemical denotes CQ MESH:D002738
771 13622-13624 Chemical denotes CQ MESH:D002738
772 13691-13693 Chemical denotes CQ MESH:D002738
773 14087-14089 Chemical denotes CQ MESH:D002738
774 12920-12928 Disease denotes COVID-19 MESH:C000657245
775 13004-13012 Disease denotes COVID-19 MESH:C000657245
776 13086-13112 Disease denotes deterioration of pneumonia MESH:D011014
777 13534-13542 Disease denotes COVID-19 MESH:C000657245
778 13770-13779 Disease denotes mortality MESH:D003643
779 13930-13960 Disease denotes QT (QTc) interval prolongation MESH:D008133
780 14127-14141 Disease denotes critically ill MESH:D016638
781 14156-14164 Disease denotes COVID-19 MESH:C000657245
871 25878-25882 Gene denotes IL-6 Gene:3569
872 21785-21793 Species denotes patients Tax:9606
873 22217-22225 Species denotes patients Tax:9606
874 22258-22266 Species denotes patients Tax:9606
875 22622-22630 Species denotes patients Tax:9606
876 23109-23117 Species denotes patients Tax:9606
877 23179-23187 Species denotes patients Tax:9606
878 23319-23327 Species denotes patients Tax:9606
879 23483-23491 Species denotes patients Tax:9606
880 23676-23684 Species denotes patients Tax:9606
881 23952-23960 Species denotes patients Tax:9606
882 24008-24016 Species denotes patients Tax:9606
883 24049-24057 Species denotes patients Tax:9606
884 24404-24412 Species denotes patients Tax:9606
885 24784-24792 Species denotes patients Tax:9606
886 24991-24999 Species denotes patients Tax:9606
887 25332-25340 Species denotes patients Tax:9606
888 25402-25410 Species denotes patients Tax:9606
889 25526-25534 Species denotes patients Tax:9606
890 25614-25622 Species denotes patients Tax:9606
891 26205-26213 Species denotes patients Tax:9606
892 26323-26331 Species denotes patients Tax:9606
893 26430-26438 Species denotes patients Tax:9606
894 26539-26547 Species denotes patients Tax:9606
895 26717-26725 Species denotes patients Tax:9606
896 21642-21645 Chemical denotes HCQ MESH:D006886
897 21735-21738 Chemical denotes HCQ MESH:D006886
898 21803-21806 Chemical denotes HCQ MESH:D006886
899 21901-21904 Chemical denotes HCQ MESH:D006886
900 22026-22029 Chemical denotes HCQ MESH:D006886
901 22133-22136 Chemical denotes HCQ MESH:D006886
902 22237-22240 Chemical denotes HCQ MESH:D006886
903 22800-22803 Chemical denotes HCQ MESH:D006886
904 23158-23164 Chemical denotes oxygen MESH:D010100
905 23197-23200 Chemical denotes HCQ MESH:D006886
906 23244-23247 Chemical denotes HCQ MESH:D006886
907 23274-23277 Chemical denotes HCQ MESH:D006886
908 23449-23452 Chemical denotes HCQ MESH:D006886
909 23466-23469 Chemical denotes HCQ MESH:D006886
910 23499-23502 Chemical denotes HCQ MESH:D006886
911 23529-23532 Chemical denotes HCQ MESH:D006886
912 23611-23614 Chemical denotes HCQ MESH:D006886
913 23945-23948 Chemical denotes HCQ MESH:D006886
914 24067-24070 Chemical denotes HCQ MESH:D006886
915 24343-24346 Chemical denotes HCQ MESH:D006886
916 24507-24510 Chemical denotes HCQ MESH:D006886
917 24856-24859 Chemical denotes HCQ MESH:D006886
918 25009-25012 Chemical denotes HCQ MESH:D006886
919 25179-25182 Chemical denotes HCQ MESH:D006886
920 25351-25354 Chemical denotes HCQ MESH:D006886
921 25487-25490 Chemical denotes HCQ MESH:D006886
922 25677-25680 Chemical denotes HCQ MESH:D006886
923 25768-25771 Chemical denotes HCQ MESH:D006886
924 25810-25813 Chemical denotes HCQ MESH:D006886
925 25890-25893 Chemical denotes HCQ MESH:D006886
926 26102-26105 Chemical denotes HCQ MESH:D006886
927 26311-26314 Chemical denotes HCQ MESH:D006886
928 26389-26392 Chemical denotes HCQ MESH:D006886
929 26496-26499 Chemical denotes HCQ MESH:D006886
930 26655-26658 Chemical denotes HCQ MESH:D006886
931 26768-26771 Chemical denotes HCQ MESH:D006886
932 21667-21675 Disease denotes COVID-19 MESH:C000657245
933 21757-21765 Disease denotes COVID-19 MESH:C000657245
934 21989-21994 Disease denotes cough MESH:D003371
935 22116-22125 Disease denotes pneumonia MESH:D011014
936 22296-22301 Disease denotes cough MESH:D003371
937 22334-22339 Disease denotes cough MESH:D003371
938 22569-22577 Disease denotes COVID-19 MESH:C000657245
939 22852-22860 Disease denotes COVID-19 MESH:C000657245
940 23135-23143 Disease denotes COVID-19 MESH:C000657245
941 23354-23358 Disease denotes died MESH:D003643
942 23387-23391 Disease denotes ARDS MESH:D012128
943 23641-23649 Disease denotes COVID-19 MESH:C000657245
944 23658-23675 Disease denotes hypoxic pneumonia MESH:D011014
945 23990-23998 Disease denotes COVID-19 MESH:C000657245
946 24435-24443 Disease denotes COVID-19 MESH:C000657245
947 24963-24971 Disease denotes COVID-19 MESH:C000657245
948 25243-25248 Disease denotes death MESH:D003643
949 25511-25525 Disease denotes critically ill MESH:D016638
950 25540-25548 Disease denotes COVID-19 MESH:C000657245
951 25566-25574 Disease denotes toxicity MESH:D064420
952 26190-26204 Disease denotes critically ill MESH:D016638
953 26219-26227 Disease denotes COVID-19 MESH:C000657245
954 26449-26457 Disease denotes COVID-19 MESH:C000657245
955 26530-26538 Disease denotes COVID-19 MESH:C000657245
956 26600-26605 Disease denotes death MESH:D003643
957 26688-26697 Disease denotes mortality MESH:D003643
958 26708-26716 Disease denotes COVID-19 MESH:C000657245
959 26815-26820 Disease denotes death MESH:D003643
1086 27041-27053 Species denotes participants Tax:9606
1087 27058-27066 Species denotes patients Tax:9606
1088 27667-27675 Species denotes patients Tax:9606
1089 27933-27941 Species denotes patients Tax:9606
1090 28117-28125 Species denotes patients Tax:9606
1091 28175-28182 Species denotes patient Tax:9606
1092 28276-28284 Species denotes patients Tax:9606
1093 28429-28437 Species denotes patients Tax:9606
1094 28742-28750 Species denotes patients Tax:9606
1095 28755-28763 Species denotes patients Tax:9606
1096 28782-28790 Species denotes patients Tax:9606
1097 28827-28835 Species denotes patients Tax:9606
1098 29249-29257 Species denotes patients Tax:9606
1099 29301-29309 Species denotes patients Tax:9606
1100 29448-29451 Species denotes men Tax:9606
1101 29546-29554 Species denotes patients Tax:9606
1102 29716-29724 Species denotes patients Tax:9606
1103 29775-29783 Species denotes patients Tax:9606
1104 29984-29992 Species denotes patients Tax:9606
1105 30168-30176 Species denotes patients Tax:9606
1106 30270-30278 Species denotes patients Tax:9606
1107 30393-30401 Species denotes patients Tax:9606
1108 30536-30544 Species denotes patients Tax:9606
1109 30857-30865 Species denotes patients Tax:9606
1110 31024-31032 Species denotes patients Tax:9606
1111 31873-31881 Species denotes patients Tax:9606
1112 26887-26889 Chemical denotes CQ MESH:D002738
1113 26893-26896 Chemical denotes HCQ MESH:D006886
1114 26919-26928 Chemical denotes macrolide MESH:D018942
1115 27078-27081 Chemical denotes HCQ MESH:D006886
1116 27122-27134 Chemical denotes azithromycin MESH:D017963
1117 27210-27213 Chemical denotes HCQ MESH:D006886
1118 27243-27255 Chemical denotes azithromycin MESH:D017963
1119 27379-27382 Chemical denotes HCQ MESH:D006886
1120 27397-27409 Chemical denotes azithromycin MESH:D017963
1121 27411-27414 Chemical denotes HCQ MESH:D006886
1122 27542-27554 Chemical denotes azithromycin MESH:D017963
1123 27559-27562 Chemical denotes HCQ MESH:D006886
1124 27683-27686 Chemical denotes HCQ MESH:D006886
1125 27968-27971 Chemical denotes HCQ MESH:D006886
1126 28025-28037 Chemical denotes azithromycin MESH:D017963
1127 28674-28677 Chemical denotes HCQ MESH:D006886
1128 28692-28704 Chemical denotes azithromycin MESH:D017963
1129 28773-28776 Chemical denotes HCQ MESH:D006886
1130 28800-28803 Chemical denotes HCQ MESH:D006886
1131 28806-28818 Chemical denotes azithromycin MESH:D017963
1132 28848-28851 Chemical denotes HCQ MESH:D006886
1133 28911-28914 Chemical denotes HCQ MESH:D006886
1134 28916-28919 Chemical denotes HCQ MESH:D006886
1135 28920-28932 Chemical denotes azithromycin MESH:D017963
1136 28940-28943 Chemical denotes HCQ MESH:D006886
1137 28998-29004 Chemical denotes theHCQ
1138 29027-29030 Chemical denotes HCQ MESH:D006886
1140 29104-29107 Chemical denotes HCQ MESH:D006886
1141 29161-29164 Chemical denotes HCQ MESH:D006886
1142 29189-29201 Chemical denotes azithromycin MESH:D017963
1143 29323-29326 Chemical denotes HCQ MESH:D006886
1144 29568-29571 Chemical denotes HCQ MESH:D006886
1145 29575-29587 Chemical denotes azithromycin MESH:D017963
1146 29798-29801 Chemical denotes HCQ MESH:D006886
1147 29806-29818 Chemical denotes azithromycin MESH:D017963
1148 29833-29836 Chemical denotes HCQ MESH:D006886
1149 29857-29869 Chemical denotes azithromycin MESH:D017963
1150 29907-29910 Chemical denotes HCQ MESH:D006886
1151 29914-29926 Chemical denotes azithromycin MESH:D017963
1152 30003-30007 Chemical denotes HCQ+ MESH:D006886
1153 30007-30019 Chemical denotes azithromycin MESH:D017963
1154 30031-30034 Chemical denotes HCQ MESH:D006886
1155 30052-30064 Chemical denotes azithromycin MESH:D017963
1156 30292-30304 Chemical denotes azithromycin MESH:D017963
1157 30306-30309 Chemical denotes HCQ MESH:D006886
1158 30320-30332 Chemical denotes azithromycin MESH:D017963
1159 30696-30699 Chemical denotes HCQ MESH:D006886
1160 30740-30750 Chemical denotes macrolides MESH:D018942
1161 30761-30773 Chemical denotes azithromycin MESH:D017963
1162 30778-30792 Chemical denotes clarithromycin MESH:D017291
1163 30919-30921 Chemical denotes CQ MESH:D002738
1164 30937-30939 Chemical denotes CQ MESH:D002738
1165 30947-30956 Chemical denotes macrolide MESH:D018942
1166 30972-30975 Chemical denotes HCQ MESH:D006886
1167 30994-30997 Chemical denotes HCQ MESH:D006886
1168 31005-31014 Chemical denotes macrolide MESH:D018942
1169 31179-31181 Chemical denotes CQ MESH:D002738
1170 31199-31201 Chemical denotes CQ MESH:D002738
1171 31209-31218 Chemical denotes macrolide MESH:D018942
1172 31236-31239 Chemical denotes HCQ MESH:D006886
1173 31260-31263 Chemical denotes HCQ MESH:D006886
1174 31277-31286 Chemical denotes macrolide MESH:D018942
1175 31441-31443 Chemical denotes CQ MESH:D002738
1176 31458-31460 Chemical denotes CQ MESH:D002738
1177 31468-31477 Chemical denotes macrolide MESH:D018942
1178 31492-31495 Chemical denotes HCQ MESH:D006886
1179 31513-31516 Chemical denotes HCQ MESH:D006886
1180 31524-31533 Chemical denotes macrolide MESH:D018942
1181 31668-31670 Chemical denotes CQ MESH:D002738
1182 31674-31677 Chemical denotes HCQ MESH:D006886
1183 31712-31721 Chemical denotes macrolide MESH:D018942
1184 31971-31974 Chemical denotes HCQ MESH:D006886
1185 31989-32001 Chemical denotes azithromycin MESH:D017963
1186 32206-32209 Chemical denotes HCQ MESH:D006886
1187 32213-32215 Chemical denotes CQ MESH:D002738
1188 32220-32230 Chemical denotes macrolides MESH:D018942
1189 32232-32244 Chemical denotes azithromycin MESH:D017963
1190 32248-32262 Chemical denotes clarithromycin MESH:D017291
1191 26949-26957 Disease denotes COVID-19 MESH:C000657245
1192 27729-27745 Disease denotes critical illness MESH:D016638
1193 27924-27932 Disease denotes COVID-19 MESH:C000657245
1194 28206-28210 Disease denotes died MESH:D003643
1195 28218-28234 Disease denotes critical illness MESH:D016638
1196 29072-29077 Disease denotes death MESH:D003643
1197 29276-29284 Disease denotes COVID-19 MESH:C000657245
1198 29372-29381 Disease denotes mortality MESH:D003643
1199 29707-29715 Disease denotes COVID-19 MESH:C000657245
1200 29966-29975 Disease denotes mortality MESH:D003643
1201 30251-30260 Disease denotes mortality MESH:D003643
1202 30468-30477 Disease denotes mortality MESH:D003643
1203 30524-30530 Disease denotes deaths MESH:D003643
1204 30811-30819 Disease denotes COVID-19 MESH:C000657245
1205 31140-31149 Disease denotes mortality MESH:D003643
1206 31359-31368 Disease denotes mortality MESH:D003643
1207 31593-31615 Disease denotes ventricular arrhythmia MESH:D001145
1208 31779-31784 Disease denotes death MESH:D003643
1209 31810-31833 Disease denotes ventricular arrhythmias MESH:D001145
1210 32373-32383 Disease denotes arrhythmia MESH:D001145
1211 32400-32409 Disease denotes mortality MESH:D003643
1234 32490-32498 Species denotes patients Tax:9606
1235 32543-32551 Species denotes patients Tax:9606
1236 32723-32731 Species denotes patients Tax:9606
1237 32432-32438 Chemical denotes CQ/HCQ
1238 32616-32622 Chemical denotes CQ/HCQ
1239 32767-32770 Chemical denotes HCQ MESH:D006886
1240 32774-32776 Chemical denotes CQ MESH:D002738
1241 32781-32791 Chemical denotes macrolides MESH:D018942
1242 32793-32805 Chemical denotes azithromycin MESH:D017963
1243 32809-32823 Chemical denotes clarithromycin MESH:D017291
1244 32915-32917 Chemical denotes CQ MESH:D002738
1245 32918-32921 Chemical denotes HCQ MESH:D006886
1246 33306-33308 Chemical denotes CQ MESH:D002738
1247 33309-33312 Chemical denotes HCQ MESH:D006886
1248 33344-33350 Chemical denotes CQ/HCQ
1249 33380-33390 Chemical denotes macrolides MESH:D018942
1250 32481-32489 Disease denotes COVID-19 MESH:C000657245
1251 32701-32710 Disease denotes mortality MESH:D003643
1252 32714-32722 Disease denotes COVID-19 MESH:C000657245
1253 32935-32943 Disease denotes COVID-19 MESH:C000657245
1254 33439-33447 Disease denotes COVID-19 MESH:C000657245
1255 33617-33625 Disease denotes COVID-19 MESH:C000657245
1339 34972-34980 Species denotes patients Tax:9606
1340 35075-35083 Species denotes patients Tax:9606
1341 35111-35119 Species denotes patients Tax:9606
1342 35193-35201 Species denotes patients Tax:9606
1343 35256-35263 Species denotes patient Tax:9606
1344 35387-35395 Species denotes patients Tax:9606
1345 35544-35552 Species denotes patients Tax:9606
1346 35592-35600 Species denotes patients Tax:9606
1347 35841-35849 Species denotes patients Tax:9606
1348 35912-35920 Species denotes patients Tax:9606
1349 36002-36010 Species denotes patients Tax:9606
1350 36080-36088 Species denotes patients Tax:9606
1351 36411-36419 Species denotes patients Tax:9606
1352 36755-36763 Species denotes patients Tax:9606
1353 37122-37130 Species denotes patients Tax:9606
1354 37292-37300 Species denotes patients Tax:9606
1355 33639-33645 Chemical denotes CQ/HCQ
1356 33770-33772 Chemical denotes CQ MESH:D002738
1357 33898-33900 Chemical denotes CQ MESH:D002738
1358 34090-34092 Chemical denotes CQ MESH:D002738
1359 34326-34328 Chemical denotes CQ MESH:D002738
1360 34330-34333 Chemical denotes HCQ MESH:D006886
1361 34423-34426 Chemical denotes HCQ MESH:D006886
1362 34457-34459 Chemical denotes CQ MESH:D002738
1363 34573-34576 Chemical denotes HCQ MESH:D006886
1364 34605-34607 Chemical denotes CQ MESH:D002738
1365 34608-34611 Chemical denotes HCQ MESH:D006886
1366 34864-34866 Chemical denotes CQ MESH:D002738
1367 35094-35097 Chemical denotes HCQ MESH:D006886
1368 35133-35136 Chemical denotes HCQ MESH:D006886
1369 35406-35409 Chemical denotes HCQ MESH:D006886
1370 35507-35510 Chemical denotes HCQ MESH:D006886
1371 35614-35617 Chemical denotes HCQ MESH:D006886
1372 35741-35753 Chemical denotes azithromycin MESH:D017963
1373 35931-35934 Chemical denotes HCQ MESH:D006886
1374 35951-35963 Chemical denotes azithromycin MESH:D017963
1375 36102-36105 Chemical denotes HCQ MESH:D006886
1376 36110-36122 Chemical denotes azithromycin MESH:D017963
1377 36162-36165 Chemical denotes HCQ MESH:D006886
1378 36239-36241 Chemical denotes CQ MESH:D002738
1379 36243-36245 Chemical denotes CQ MESH:D002738
1380 36253-36262 Chemical denotes macrolide MESH:D018942
1381 36264-36267 Chemical denotes HCQ MESH:D006886
1382 36272-36275 Chemical denotes HCQ MESH:D006886
1383 36283-36292 Chemical denotes macrolide MESH:D018942
1384 36505-36511 Chemical denotes CQ/HCQ
1385 36530-36539 Chemical denotes macrolide MESH:D018942
1386 36546-36552 Chemical denotes CQ/HCQ
1387 36714-36720 Chemical denotes CQ/HCQ
1388 36888-36900 Chemical denotes moxifloxacin MESH:D000077266
1389 37092-37094 Chemical denotes CQ MESH:D002738
1390 37327-37329 Chemical denotes CQ MESH:D002738
1391 37433-37435 Chemical denotes CQ MESH:D002738
1392 33672-33679 Disease denotes malaria MESH:D008288
1393 33943-33949 Disease denotes nausea MESH:D009325
1394 33951-33959 Disease denotes vomiting MESH:D014839
1395 33961-33969 Disease denotes diarrhea MESH:D003967
1396 33975-33983 Disease denotes anorexia MESH:D000855
1397 34142-34163 Disease denotes cardiovascular system MESH:D002318
1398 34191-34212 Disease denotes neurological deafness MESH:D009422
1399 34214-34248 Disease denotes conduction disorder cardiomyopathy MESH:C563384
1400 34254-34264 Disease denotes leukopenia MESH:D007970
1401 34395-34403 Disease denotes toxicity MESH:D064420
1402 34587-34598 Disease denotes retinopathy MESH:D012164
1403 34794-34822 Disease denotes liver and kidney dysfunction MESH:D051437
1404 34918-34953 Disease denotes increased QTc interval prolongation MESH:D008133
1405 34957-34971 Disease denotes critically ill MESH:D016638
1406 34986-34994 Disease denotes COVID-19 MESH:C000657245
1407 35289-35311 Disease denotes atrioventricular block MESH:D054537
1408 35447-35455 Disease denotes headache MESH:D006261
1409 35460-35464 Disease denotes rash MESH:D005076
1410 35535-35543 Disease denotes COVID-19 MESH:C000657245
1411 35639-35648 Disease denotes pneumonia MESH:D011014
1412 35665-35673 Disease denotes COVID-19 MESH:C000657245
1413 35695-35711 Disease denotes QTc prolongation MESH:D008133
1414 35832-35840 Disease denotes COVID-19 MESH:C000657245
1415 36363-36385 Disease denotes ventricular arrhythmia MESH:D001145
1416 36402-36410 Disease denotes COVID-19 MESH:C000657245
1417 36778-36791 Disease denotes heart disease MESH:D006331
1418 37136-37187 Disease denotes glucose 6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
1419 37225-37241 Disease denotes hemolytic anemia MESH:D000743
1420 37306-37321 Disease denotes G6PD deficiency MESH:D005955
1421 37399-37414 Disease denotes G6PD deficiency MESH:D005955
1478 38310-38316 Gene denotes CQ/HCQ
1479 38234-38240 Gene denotes CQ/HCQ
1480 37682-37686 Species denotes CoVs Tax:11118
1481 37697-37707 Species denotes SARS-CoV-2 Tax:2697049
1482 37806-37810 Species denotes CoVs Tax:11118
1483 38094-38098 Species denotes CoVs Tax:11118
1484 38110-38118 Species denotes SARS-CoV Tax:694009
1485 38128-38136 Species denotes MERS-CoV Tax:1335626
1486 38146-38156 Species denotes SARS-CoV-2 Tax:2697049
1487 38249-38259 Species denotes SARS-CoV-2 Tax:2697049
1488 38682-38699 Species denotes chikungunya virus Tax:37124
1489 38882-38890 Species denotes patients Tax:9606
1490 38951-38959 Species denotes patients Tax:9606
1491 39329-39337 Species denotes patients Tax:9606
1492 39605-39613 Species denotes patients Tax:9606
1493 39848-39854 Species denotes humans Tax:9606
1494 39958-39963 Species denotes child Tax:9606
1495 38534-38539 Species denotes Ebola Tax:1570291
1496 39767-39776 Species denotes HCoV-OC43 Tax:31631
1497 37610-37616 Chemical denotes CQ/HCQ
1498 37763-37769 Chemical denotes CQ/HCQ
1499 38052-38054 Chemical denotes CQ MESH:D002738
1500 38055-38058 Chemical denotes HCQ MESH:D006886
1501 38522-38524 Chemical denotes CQ MESH:D002738
1502 38642-38644 Chemical denotes CQ MESH:D002738
1503 38841-38844 Chemical denotes HCQ MESH:D006886
1504 38919-38921 Chemical denotes CQ MESH:D002738
1505 39165-39168 Chemical denotes HCQ MESH:D006886
1506 39313-39316 Chemical denotes HCQ MESH:D006886
1507 39506-39509 Chemical denotes HCQ MESH:D006886
1508 39649-39651 Chemical denotes CQ MESH:D002738
1509 39655-39658 Chemical denotes HCQ MESH:D006886
1510 39747-39749 Chemical denotes CQ MESH:D002738
1511 39872-39874 Chemical denotes CQ MESH:D002738
1512 40030-40033 Chemical denotes HCQ MESH:D006886
1513 40048-40060 Chemical denotes azithromycin MESH:D017963
1514 40183-40522 Chemical denotes CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69]. Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ
1515 40232-40241 Chemical denotes nduced hi MESH:D018942
1516 40421-40423 Chemical denotes CQ MESH:D002738
1517 40424-40427 Chemical denotes HCQ MESH:D006886
1518 40516-40518 Chemical denotes CQ MESH:D002738
1519 40519-40522 Chemical denotes HCQ MESH:D006886
1520 37469-37477 Disease denotes COVID-19 MESH:C000657245
1521 37994-38002 Disease denotes COVID-19 MESH:C000657245
1522 38356-38364 Disease denotes COVID-19 MESH:C000657245
1523 38749-38758 Disease denotes infection MESH:D007239
1524 38896-38904 Disease denotes COVID-19 MESH:C000657245
1525 38942-38950 Disease denotes COVID-19 MESH:C000657245
1526 38991-39000 Disease denotes mortality MESH:D003643
1527 39005-39030 Disease denotes QTc interval prolongation MESH:D008133
1528 39320-39328 Disease denotes COVID-19 MESH:C000657245
1529 39596-39604 Disease denotes COVID-19 MESH:C000657245
1530 39910-39930 Disease denotes SARS-CoV-2 infection MESH:C000657245
1531 40321-40329 Disease denotes eatment MESH:C000657245
1532 40445-40453 Disease denotes COVID-19 MESH:C000657245
1533 40569-40577 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T17 0-2 Sentence denotes 1.
T18 4-16 Sentence denotes Introduction
T19 17-223 Sentence denotes Coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide, resulting in the third outbreak of coronaviruses in the 21st century.
T20 224-301 Sentence denotes The pandemic of COVID-19 constitutes a serious threat to the whole world [1].
T21 302-509 Sentence denotes To control the pandemic of COVID-19, effective and easily accessible antiviral drugs and vaccines are urgently needed, in addition to the implementation of epidemiological measures such as strict quarantine.
T22 510-595 Sentence denotes However, until now, no drugs have been demonstrated to be effective against COVID-19.
T23 596-866 Sentence denotes Among the various drugs under investigation are repurposed anti-malarial drugs chloroquine (CQ) and its analog hydroxychloroquine (HCQ), which are among the most used drugs because they are easy to obtain and have a proven favorable safety record at relatively low cost.
T24 867-910 Sentence denotes CQ/HCQ are derivatives of 4-aminoquinoline.
T25 911-1074 Sentence denotes They are lipophilic weak bases that quickly pass across cell membranes and accumulate in acidic organelles, such as lysosomes, endoplasmic reticulum and Golgi [2].
T26 1075-1317 Sentence denotes CQ/HCQ are used to treat and prevent malaria attacks due to their anti-plasmodium activity and to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) owing to their immunomodulatory activity [3].
T27 1318-1401 Sentence denotes In addition, CQ/HCQ display antibacterial, antifungal and antiviral activities [4].
T28 1402-1633 Sentence denotes In vitro studies have shown that CQ/HCQ possess antiviral activity against RNA viruses, such as HIV [5], rabies virus [6] and polio virus [7] and various DNA viruses as diverse as hepatitis B virus [8] and herpes simplex virus [9].
T29 1634-1746 Sentence denotes This article reviews the current status of CQ/HCQ against SARS-CoV-2 and their use in the treatment of COVID-19.
T30 1748-1750 Sentence denotes 2.
T31 1752-1827 Sentence denotes Antiviral activity of CQ/HCQ against human coronavirus in vitro and in vivo
T32 1828-2195 Sentence denotes The antiviral activity of CQ against MERS-CoV and HCoV-229E was assessed in the human hepatoma cell line (Huh-7) and found that the 50% effective concentrations (EC50) were 3.0(±1.1) μM and 3.3(±1.2) μM, the 50% cytotoxic concentrations (CC50) were 58.1(±1.1) μM and >50, and the selectivity indexes (SI; calculated as CC50/EC50) were 19.4 and >15, respectively [10].
T33 2196-2261 Sentence denotes CQ could inhibit an early step in the MERS-CoV replication cycle.
T34 2262-2354 Sentence denotes Addition of CQ to VeroE6 cells 1 h after MERS-CoV infection did not affect virus production.
T35 2355-2522 Sentence denotes However, when CQ was added 1 h before MERS-CoV infection, 16 μm and 32 μM concentrations of CQ could reduce the virus production of 1-log and 2-log, respectively [10].
T36 2523-2710 Sentence denotes In VeroE6 cells, the antiviral activity of CQ/HCQ against SARS-CoV had an EC50 of 4.1 (±1.0) μM and 34(±5) μM, CC50 of >128 μM and CC50 > 100 and SI of >31 and SI>3, respectively [10,11].
T37 2711-2792 Sentence denotes SARS-CoV replication was inhibited by 99% at 16 μM CQ 3 days post-infection [12].
T38 2793-2865 Sentence denotes The data indicates that CQ has stronger anti-SARS-CoV activity than HCQ.
T39 2866-2934 Sentence denotes In addition, CQ has both a prophylactic and a therapeutic advantage.
T40 2935-3425 Sentence denotes Vincent et al. tested various concentrations of CQ (0.1–10 µM) added 20–24 h prior to SARS-CoV infection and found that 0.1, 1, and 10 µM CQ reduced infectivity by 28%, 53%, and 100%, respectively; when CQ was added immediately after virus adsorption, 0.1–1 µM and 33–100 µM reduced the infection by 50% up to 90–94%; addition of CQ 3 and 5 h after virus adsorption was still significantly effective, yet to achieve equivalent antiviral effect, a higher concentration of CQ was needed [13].
T41 3426-3572 Sentence denotes In HRT-18 cells, the antiviral activity of CQ against HCoV-OC43 had an EC50 of 0.306 (±0.091) μM, CC50 of 419.0 (±192.5) μM, and SI of 1.369 [14].
T42 3573-3678 Sentence denotes An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk.
T43 3679-3941 Sentence denotes The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14].
T44 3942-4029 Sentence denotes The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14].
T45 4030-4179 Sentence denotes In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15].
T46 4180-4282 Sentence denotes The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo.
T47 4284-4286 Sentence denotes 3.
T48 4288-4344 Sentence denotes Antiviral activity of CQ/HCQ against SARS-CoV-2 in vitro
T49 4345-4453 Sentence denotes In VeroE6 cells, the EC50, CC50 and SI of CQ against SARS-CoV-2 were 1.13 μM, >100 and >88.50, respectively.
T50 4454-4538 Sentence denotes CQ functioned at the entry, and post-entry stages of SARS-CoV-2 infected cells [16].
T51 4539-4769 Sentence denotes In the same cell line, at different multiplicities of infection (MOIs, 0.01, 0.02, 0.2, and 0.8) of SARS-CoV-2, the EC50 for CQ (2.71, 3.81, 7.14, and 7.36 μM) was slightly lower than that of HCQ (4.51, 4.06, 17.31, and 12.96 μM).
T52 4770-4902 Sentence denotes Consequently, the SI of CQ (100.81, 71.71, 38.26, and 37.12) was slightly higher than that of HCQ (55.32, 61.45, 14.41, 19.25) [17].
T53 4903-5008 Sentence denotes These results indicate that the anti-SARS-CoV-2 activity of CQ seems to be more potent than HCQ in vitro.
T54 5009-5436 Sentence denotes However, another in vitro cell experiment showed that after SARS-CoV-2 infection of VeroE6 cells, the EC50 values for CQ were 23.90 μM and 5.47 μM, and EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively; When administered prior to SARS-CoV-2 infection of VeroE6 cells, EC50 values for CQ were >100 μM and 18.01 μM, and the EC50 values for HCQ were 6.14 μM and 0.72 μM, at 24 and 48 h, respectively [18].
T55 5437-5526 Sentence denotes These results showed that the anti-SARS-CoV-2 activity of CQ was worse than HCQ in vitro.
T56 5527-5649 Sentence denotes The conflicting results of these two studies may be related to different cell culture methods and experimental conditions.
T57 5650-5737 Sentence denotes In short, these in vitro studies show that CQ/HCQ have strong anti-SARS-CoV-2 activity.
T58 5739-5741 Sentence denotes 4.
T59 5743-5784 Sentence denotes Mechanisms of CQ/HCQ in treating COVID-19
T60 5786-5790 Sentence denotes 4.1.
T61 5792-5810 Sentence denotes Antiviral activity
T62 5812-5818 Sentence denotes 4.1.1.
T63 5820-5861 Sentence denotes Hindrance of receptor recognition process
T64 5862-5953 Sentence denotes The S protein of SARS-CoV-2 is cleaved by host proteases into two subunits, S1 and S2 [19].
T65 5954-6137 Sentence denotes The S1 subunit binds to the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) for virus attachment, and the S2 subunit fuses the virus and the host cell membrane [19].
T66 6138-6526 Sentence denotes The investigation of the effect of CQ on ACE2 in VeroE6 cells showed that effective anti-SARS-CoV-2 concentrations of CQ had no significant effect on the synthesis and glycosylation of S protein on the surface of SARS-CoV, and although it had no significant effect on the cell surface expression of ACE2, CQ could destroy the glycosylation at the terminal glycosylation site of ACE2 [13].
T67 6527-6800 Sentence denotes Therefore, the mechanism of anti-CoV activity of CQ/HCQ may be at least partly related to the impairment of terminal glycosylation of ACE2, which may result in reduced binding affinities between ACE2 and SARS CoV S protein, thereby blocking receptor recognition (Figure 1).
T68 6801-6810 Sentence denotes Figure 1.
T69 6811-6929 Sentence denotes Schematic representation of the possible mechanisms of CQ/HCQ against CoVs replication and modulating immune response.
T70 6930-7561 Sentence denotes CQ/HCQ may synergistically exert antiviral and immunomodulatory effects on COVID-19 through multiple mechanisms including hindering the receptor recognition process by influencing the affinity of ACE2 and S protein, and the affinity for sialic acid and ganglioside; inhibiting the membrane fusion process by suppressing endolysosome acidification; suppressing the p38 activation and affecting host defense machinery, and preventing MHC class II expression (block expression of CD154 on the surface of CD4 + T cell) and TLR signaling and reducing the production of cytokines through inhibiting the activation of T cells and B cells.
T71 7562-7912 Sentence denotes ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; CQ, chloroquine; HCQ, hydroxychloroquine; CoVs, coronaviruses; MAPK, mitogen-activated protein kinase; MHC-II, major histocompatibility complex class II; TLR, toll-like receptor; cGAS, cyclic GMP-AMP synthase; IFN, interferon; IL, interleukin; TNF-α, tumor necrosis factor-α.
T72 7913-8198 Sentence denotes In addition to protein membrane receptors, infection of host cells by HCoVs also relies on sialic acid-containing glycoproteins and gangliosides, which are used by a broad range of viruses as receptors, such as influenza [20] and HCoVs including SARS-CoV [21] and HCoV-OC43 [13,22,23].
T73 8199-8397 Sentence denotes A recent molecular structure analysis showed that SARS-CoV-2 not only uses ACE2 as a receptor, but also recognizes highly conserved gangliosides on the host cell surface through sialic acid [24,25].
T74 8398-8538 Sentence denotes CQ/HCQ binds sialic acids and gangliosides with high affinity, which can prevent the attachment of SARSCoV-2 S protein to gangliosides [25].
T75 8539-8646 Sentence denotes CQ had inhibitory effect on quinone reductase 2 (QR2) involved in the biosynthesis of sialic acids [26,27].
T76 8647-8798 Sentence denotes Hence, the mechanism of anti-CoV activity of CQ/HCQ may also be related to hindering the recognition process of sialic acid and ganglioside (Figure 1).
T77 8800-8806 Sentence denotes 4.1.2.
T78 8808-8851 Sentence denotes Interference of the membrane fusion process
T79 8852-8979 Sentence denotes CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28].
T80 8980-9144 Sentence denotes Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29].
T81 9145-9384 Sentence denotes Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30].
T82 9385-9619 Sentence denotes Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33].
T83 9620-9782 Sentence denotes A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24].
T84 9783-10132 Sentence denotes A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17].
T85 10133-10396 Sentence denotes These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1).
T86 10398-10404 Sentence denotes 4.1.3.
T87 10406-10466 Sentence denotes Effects on cell signaling pathway and host defense machinery
T88 10467-10643 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 10644-10783 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 10784-10949 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 10950-11107 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 11108-11268 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).
T93 11270-11274 Sentence denotes 4.2.
T94 11276-11338 Sentence denotes Inhibitory effect on T cell activation and cytokine production
T95 11339-11441 Sentence denotes CQ/HCQ regulate the release of various pro-inflammatory factors, which are important immunomodulators.
T96 11442-11627 Sentence denotes Intracellular alkalinization by CQ/HCQ inhibits lysosomal activity, preventing antigen processing, major histocompatibility complex (MHC) class II expression and immune activation [40].
T97 11628-11738 Sentence denotes This process can inhibit T cell activation and block expression of CD154 on the surface of CD4 + T cells [41].
T98 11739-11871 Sentence denotes CQ also reduces cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α) produced by T cells and B cells [42].
T99 11872-12062 Sentence denotes At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43].
T100 12063-12214 Sentence denotes CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44].
T101 12215-12363 Sentence denotes In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of prostaglandins [45].
T102 12364-12659 Sentence denotes Some clinical studies have found that high concentrations of cytokines and pro-inflammatory factors such as IL-6 and IL-10 are elevated in the plasma of critically ill patients infected with SARS-CoV-2 [46,47], suggesting that cytokine release syndrome (CRS) is associated with disease severity.
T103 12660-12786 Sentence denotes In the aspect of immune response, HCQ/CQ therefore are likely to inhibit CRS, delaying the progression of COVID-19 (Figure 1).
T104 12788-12790 Sentence denotes 5.
T105 12792-12848 Sentence denotes Clinical efficacy of CQ/HCQ in the treatment of COVID-19
T106 12849-12948 Sentence denotes Only two published clinical reports have studied the efficacy of CQ in COVID-19 patients (Table 1).
T107 12949-13202 Sentence denotes One study used CQ to treat more than 100 patients with COVID-19 and claimed that CQ was superior to the control group in suppressing the deterioration of pneumonia, improving lung imaging, promoting viral conversion and shortening the course of disease.
T108 13203-13268 Sentence denotes Serious adverse effects were not observed in these patients [48].
T109 13269-13405 Sentence denotes However, this report did not provide any details about the study design and patient data, thus it is difficult to evaluate the validity.
T110 13406-13508 Sentence denotes Recently, a parallel, double-blind, randomized, phase IIB clinical trial was performed in Brazil [49].
T111 13509-13590 Sentence denotes In this study, 81 severe COVID-19 patients were randomly divided into two groups:
T112 13591-13758 Sentence denotes 41 patients received high-dose CQ (600 mg/2 times/day for 10 day) and 40 patients received low-dose CQ (450 mg/2 times on day 1 and then 450 mg/1 time/day for 4 days).
T113 13759-13870 Sentence denotes The 13-day mortality rate in the high-dose group was more than double that in low-dose group (39.0% vs. 16.0%).
T114 13871-14047 Sentence denotes The high-dosage group exhibited more instance of corrected QT (QTc) interval prolongation (>500 milliseconds (ms); 7 of 37 [18.9%]) than the low-dosage group (4 of 36 [11.1%]).
T115 14048-14170 Sentence denotes These findings suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 [49].
T116 14171-14179 Sentence denotes Table 1.
T117 14180-14289 Sentence denotes Outcomes and advantage/limitation of chloroquine (CQ)/hydroxychloroquine (HCQ) clinical studies for COVID-19.
T118 14290-14371 Sentence denotes Author (Reference) Study design Patients Treatment Outcomes Advantage Limitations
T119 14372-14387 Sentence denotes Gao et al [48].
T120 14388-14617 Sentence denotes Rough and simple description Not mentioned CQ (No specific dosage was mentioned) CQ was superior to control in suppressing pneumonia deterioration, improving lung imaging, promoting viral conversion and shortening disease course.
T121 14618-14634 Sentence denotes Not significant.
T122 14635-14761 Sentence denotes No study design and the specific number of patients and controls were provided and thus the result appears to be unconvincing.
T123 14762-14779 Sentence denotes Borba et al [49].
T124 14780-15266 Sentence denotes Randomized controlled trial High-dose CQ group: n = 40;Low-dose CQ group:n = 41 high-dose CQ (600 mg/2 times/day, for 10 day);low-dose CQ (450 mg/2 times/day for 5 days, double dose on 1st day) The mortality rate in the high-dose group was more than double that in low-dose group Double-blind study; 2 dosages of CQ for the first time in severe COVID-19 Small sample size; single-center design; Lack of a placebo control; Lack of exclusion criteria based on the QTc interval at baseline
T125 15267-15485 Sentence denotes Chen et al.[50] Randomized trial HCQ group: n = 31; control group: n = 30 HCQ (200 mg/2 times/day for 5 days) HCQ group have small improvement in body temperature and cough compered with control group Randomized trial.
T126 15486-15570 Sentence denotes Small sample size; Single-center design; Small improvement in temperature and cough.
T127 15571-15590 Sentence denotes Mahévas et al [53].
T128 15591-15809 Sentence denotes Comparative study HCQ group: n = 84; control group: n = 97 HCQ 600 mg/day for 7 days Compared with control group, a reduction of admissions to ICU or death 7 days after hospital admission was not observed in HCQ group.
T129 15810-15876 Sentence denotes Relatively larger sample size in HCQ treatment and control groups.
T130 15877-15987 Sentence denotes Nonrandomized design; In propensity score model, four possible important prognostic variables were unbalanced.
T131 15988-16004 Sentence denotes Tang et al [54].
T132 16005-16086 Sentence denotes Open label, randomized controlled trial HCQ group: n = 70; control group: n = 80.
T133 16087-16293 Sentence denotes HCQ 1200 mg daily for 3 days, 800 mg daily for 2 weeks (mild to moderate disease)/3 weeks(severe disease) HCQ did not show additional benefits of vial elimination in patients with mild to moderate COVID-19.
T134 16294-16322 Sentence denotes Randomized controlled study.
T135 16323-16521 Sentence denotes Lack of a placebo control group; Design introduces the possibility of biased investigator determined assessment and unbalanced dosage adjustment; Randomization of sequential envelopes may be biased.
T136 16522-16705 Sentence denotes The antiviral efficacy of HCQ was not assessed at an earlier stage; Most patients are mild to severe, and the effect of HCQ on disease progression or regression could not be provided.
T137 16706-16782 Sentence denotes The trial terminated early due to the difficulty to recruit enough patients.
T138 16783-16995 Sentence denotes Some secondary endpoints could not be analyzed by the cutoff date; Viral RNA specimens are mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T139 16996-17015 Sentence denotes Geleris et al [55].
T140 17016-17259 Sentence denotes Observational study HCQ group: n = 811; no-HCQ group: n = 565 HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) No correlation between the HCQ use and significant higher or lower risk of intubation or death was observed.
T141 17260-17431 Sentence denotes Large sample size; Minimization of the unmeasured confusion and error through multivariable Cox model with inverse probability weighting according to the propensity score.
T142 17432-17541 Sentence denotes Single-center design; missing of some variables; Potential for inaccuracies in the electronic health records.
T143 17542-17556 Sentence denotes Yu et al [56].
T144 17557-17731 Sentence denotes Retrospective study HCQ group: n = 48; no-HCQ group: n = 502 HCQ (200 mg/2 times/day, for 7 to 10 days) The fatalities of HCQ group was significantly lower than no-HCQ group.
T145 17732-17860 Sentence denotes HCQ treatment was related to significantly reduced mortality in critically ill COVID-19 patients and greatly lowered IL-6 level.
T146 17861-17951 Sentence denotes Mortality was used as a measure of outcome and the study included critically ill patients.
T147 17952-18033 Sentence denotes Retrospective design of the study and the number of HCQ group patients was small.
T148 18034-18304 Sentence denotes Gautret et al.[57] Open label, nonrandom cohort study HCQ group: n = 12; HCQ+azithromycin group: n = 6; control group: n = 12 HCQ (200 mg/3 times/day for 10 days) HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T149 18305-18366 Sentence denotes Nasopharyngeal virus determination was used as main endpoint.
T150 18367-18516 Sentence denotes Small sample size; Six patients dropped out due to critical illness or intolerance to the drug; Lack of clinical outcomes; Limited follow-up results.
T151 18517-18536 Sentence denotes Gautret et al [58].
T152 18537-18780 Sentence denotes Observational study HCQ group: n = 80; no control HCQ, 200 mg/3 times/day for 10 days combined with azithromycin 500 mg on the 1st day, 250 mg/day afterward for 5 days The nasopharynx viral load in most patients received HCQ decreased rapidly.
T153 18781-18819 Sentence denotes Observation of nasopharynx viral load.
T154 18820-18904 Sentence denotes Observational study design and no control group; No clinical outcomes were analyzed.
T155 18905-18952 Sentence denotes Possible confounding factors were not adjusted.
T156 18953-18974 Sentence denotes Magagnoli et al [59].
T157 18975-19071 Sentence denotes Retrospective study HCQ group:n = 97HCQ+azithromycin: n = 113No HCQ group:n = 158 Not specified.
T158 19072-19294 Sentence denotes The use of HCQ, either with or without azithromycin, didn’t reduce the risk of mechanical ventilation in patients hospitalized with COVID-19; Patients treated with HCQ alone was associated with increased overall mortality.
T159 19295-19516 Sentence denotes The study data comes from a comprehensive electronic medical record; Strictly defined covariates and outcomes; Using propensity scores adjustment for a large number of relevant confounders to make results more persuasive.
T160 19517-19710 Sentence denotes Retrospective nature of the study; The subjects included only men and most of them were black; Despite adjustments to many possible confounding factors, there may still be undiscovered factors.
T161 19711-20217 Sentence denotes Rosenberg et al[60] Retrospective multicenter cohort study HCQ group:n = 271;HCQ +azithromycin group:n = 735control group:n = 221 HCQ:200 mg/400 mg/600 mg/other/unknown, frequency: once a day/twice a day/other/unknownazithromycin:200 mg/250 mg/400 mg/500 mg/other/unknown, methods:Oral/IV/unknown,frequency: only once/once a day/twice a day/other/unknown Treatment with HCQ, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality.
T162 20218-20300 Sentence denotes This study include a large, random sample from 25 metropolitan New York hospitals.
T163 20301-20465 Sentence denotes The sample was drawnearly in the epidemic to include patients with long, complicated, and ongoing hospital stays; In-hospital mortality was used as primary outcome.
T164 20466-20607 Sentence denotes Retrospective study design; There may be missing information; Mortality was limited to in-hospital death; There may be potential confounders.
T165 20608-20687 Sentence denotes The dosing in the doses and frequencies of HCQ and azithromycin varied greatly.
T166 20688-20747 Sentence denotes The confidence intervals for some of the findings are wide.
T167 20748-21206 Sentence denotes Mehraet al[61] Multinational real-world analysis Teatment groups: n = 14,888Control group: n = 81,144 Mean daily dose: CQ 765 mg, (SD 308); HCQ 596 mg(126); CQ with a macrolide 790 mg(320); HCQ with a macrolide 597 mg(128).mean duration:CQ 6.6 days(2.4); HCQ 4.2 days(1.9);CQ with a macrolide 6.8 days(2.5); HCQ with a macrolide 4.3 days (2.0) A benefit of HCQ or CQ, when used alone or witha macrolide, on in-hospital outcomes for COVID-19 was not observed.
T168 21207-21281 Sentence denotes Large multinational real-world data and large number of study populations.
T169 21282-21600 Sentence denotes There may be potential confounders; It did not measure QT intervals and stratify the arrhythmia pattern; It did not determine whether the increased risk of death in-hospital and use of drug treatment regimens were directly related to cardiovascular risk; It did not observe the risk of the drug dose-response analysis.
T170 21601-21686 Sentence denotes Several trials evaluated the efficacy of HCQ for the treatment of COVID-19 (Table 1).
T171 21687-21839 Sentence denotes In a randomized clinical trial from Wuhan about HCQ treatment of mild COVID-19 [50], 31 out of 62 patients received HCQ (200 mg/2 times/day for 5 days).
T172 21840-22195 Sentence denotes The results showed that the temperature recovery time in the HCQ group was improved compared with the control group (average days, 2.2 vs. 3.2); the cough relief time was shorter in the HCQ group than the control group (average days, 2.4 vs. 3.1); and the improvement rate of pneumonia in the HCQ group was higher than the control group (80.6% vs. 54.8%).
T173 22196-22358 Sentence denotes However, only 48% of patients (15/31) in HCQ group and 71% of patients (22/31) in control group had cough at baseline and the duration of cough was not described.
T174 22359-22435 Sentence denotes Improvement of symptoms were small and the trial was terminated prematurely.
T175 22436-22530 Sentence denotes These factors and the low sample size compromise the reliability of the results of this study.
T176 22531-22737 Sentence denotes Importantly, evaluation of HCQ in the COVID-19 pandemic areas have shown that HCQ can help patients with mild symptoms, and may potentially reduce transmission in areas lacking isolation facilities [51,52].
T177 22738-22922 Sentence denotes However, in areas with strict isolation standards, the use of HCQ to reduce transmission or for treatment of mild COVID-19 cases may not be beneficial in risk-benefit analysis [51,52].
T178 22923-23048 Sentence denotes Nevertheless, there is an urgent need for drugs and therapeutics in severe cases, which require randomized controlled trials.
T179 23049-23175 Sentence denotes A study from four French tertiary care centers included 181 patients hospitalized for COVID-19 and requiring oxygen (2 L/min):
T180 23176-23290 Sentence denotes 84 patients received HCQ (600 mg/day) within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group) [53].
T181 23291-23476 Sentence denotes The results showed that the patients transferred to the ICU or died within 7 days and developed ARDS within 7 days had no significant differences between the HCQ group and no-HCQ group.
T182 23477-23570 Sentence denotes Eight patients in the HCQ group (9.5%) discontinued HCQ due to electrocardiogram alterations.
T183 23571-23685 Sentence denotes These results do not support the use of HCQ for treating hospitalized COVID-19-related hypoxic pneumonia patients.
T184 23686-23893 Sentence denotes It is worth noting that in the study’s propensity score model, four possible important prognostic variables were unbalanced and a center effect was not considered, which all can cause bias for study results.
T185 23894-24188 Sentence denotes In a multicenter, randomized, parallel trial about HCQ in patients with mainly mild to moderate COVID-19 [54], 80 patients received ‘standard care’ and 70 patients received HCQ (1200 mg daily for 3 days, and then 800 mg daily for 2 weeks [mild to moderate disease] or 3 weeks [severe disease]).
T186 24189-24342 Sentence denotes The results showed that the 28-days negative conversion probability in ‘standard care’+HCQ group was 85.4%, similar to the ‘standard care’ group (81.2%).
T187 24343-24444 Sentence denotes HCQ did not show additional benefits of viral elimination in patients with mild to moderate COVID-19.
T188 24445-24589 Sentence denotes However, the study could not evaluate the antiviral effect of HCQ at early stages of disease, which is a critical period of antiviral treatment.
T189 24590-24749 Sentence denotes In addition, viral RNA specimens were mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T190 24750-24901 Sentence denotes Due to the small number of severe patients, this study could not provide evidence regarding the effect of HCQ on the disease progression or regression.
T191 24902-25138 Sentence denotes In another large observational study involving 1376 cases of COVID-19 from New York, 811 patients received HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) within 24 or 48 hours of admission and 565 did not [55].
T192 25139-25249 Sentence denotes This study found no correlation between HCQ use and significantly higher or lower risk of intubation or death.
T193 25250-25425 Sentence denotes However, in this study, even after the propensity score-matching, the diseases in patients receiving HCQ were more severe at baseline than those in the patients not receiving.
T194 25426-25575 Sentence denotes Notably, according to another recent study [56], low dose of HCQ reduced fatality of critically ill patients with COVID-19 without apparent toxicity.
T195 25576-25745 Sentence denotes This retrospective study included 550 patients who need mechanical ventilation, of which 48 received HCQ treatment (200 mg/2 times/day for 7 to 10 days) and 502 did not.
T196 25746-26036 Sentence denotes The fatalities of the HCQ group was significantly lower than no-HCQ group (18.8% vs 47.4%, P < 0.05), and the inflammatory cytokine IL-6 in the HCQ group decreased significantly from 22.2 (8.3 to 118.9 pg/mL) at the beginning of treatment to 5.2 (3.0 to 23.4 pg/mL) at the end of treatment.
T197 26037-26228 Sentence denotes The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19.
T198 26229-26341 Sentence denotes Yet, this study is flawed due to its retrospective nature and the small number of HCQ treated patients included.
T199 26342-26606 Sentence denotes In short, some initial studies have shown that HCQ appears to have a curative effect on patients with mild COVID-19, but subsequent studies indicate that HCQ had no significant benefit in COVID-19 patients with viral conversion and the risk of intubation or death.
T200 26607-26821 Sentence denotes Although some recent studies show that low-dose HCQ could potentially reduce the mortality of severe COVID-19 patients, there are other studies showing that the HCQ use had no effect on risk of intubation or death.
T201 26822-26968 Sentence denotes There are also several reports that investigated the efficacy of CQ or HCQ in combination with a macrolide in the treatment of COVID-19 (Table 1).
T202 26969-27152 Sentence denotes In an open nonrandom clinical trial conducted in France [57], of the 36 participants, 20 patients were given HCQ (200 mg/3 times) with 6 receiving added azithromycin, and 16 controls.
T203 27153-27317 Sentence denotes The results showed that compared with the control group, HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T204 27318-27487 Sentence denotes On the 6th day after treatment, the virus clearance rates of HCQ combined with azithromycin, HCQ alone and controls were 100%, 57.1% and 12.5%, respectively (P < 0.001).
T205 27488-27600 Sentence denotes This study indicated that the combined application of azithromycin and HCQ appears to have a synergistic effect.
T206 27601-27810 Sentence denotes However, the trial design and the results were unreliable, as six patients in the HCQ group discontinued treatment early due to critical illness or intolerance to the drugs and were excluded from the analysis.
T207 27811-27894 Sentence denotes The assessment of efficacy was based on viral load rather than a clinical endpoint.
T208 27895-28240 Sentence denotes An observational study in 80 COVID-19 patients evaluated the efficacy of HCQ (200 mg/3 times/day for 10 days) in combination with azithromycin (500 mg on the first day, 250 mg/day afterward for 5 days) and showed that all patients’ clinical symptoms were improved, except for one patient aged over 86 years who died due to critical illness [58].
T209 28241-28413 Sentence denotes The nasopharynx viral load in most patients decreased rapidly, and the negative rates of viral nucleic acid conversion on days 7 and 8 were about 83% and 93%, respectively.
T210 28414-28507 Sentence denotes About 97.5% of patients had negative virus culture in respiratory specimens on the fifth day.
T211 28508-28600 Sentence denotes However, this study had no control group, thus the results were difficult to interpret [58].
T212 28601-28705 Sentence denotes Some recent studies have yielded different results about the efficacy of HCQ combined with azithromycin.
T213 28706-28982 Sentence denotes A retrospective study including 368 patients (97 patients received HCQ, 113 patients received HCQ + azithromycin and 158 patients received no HCQ) from USA [59] showed that the rates of ventilation in the HCQ, HCQ+azithromycin and no HCQ groups had no significant differences.
T214 28983-29114 Sentence denotes Unfortunately, theHCQ group (but not in the HCQ+azithromycin group) had a higher risk of death from any case than the no HCQ group.
T215 29115-29285 Sentence denotes This study showed no evidence that the use of HCQ, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19.
T216 29286-29400 Sentence denotes Noticeably, in patients treated with HCQ alone, an association with increased overall mortality was observed [59].
T217 29401-29528 Sentence denotes In this study, the subjects included were only men and most of them were black, which may affect the generality of the results.
T218 29529-29640 Sentence denotes In addition, the patients who received HCQ or azithromycin were more severe, which may also affect the results.
T219 29641-29928 Sentence denotes In a retrospective multicenter cohort study of a random sample of COVID-19 patients from 25 hospitals in New York [60], totaling 1438 patients, 735 received HCQ and azithromycin, 271 received HCQ alone, 211 received azithromycin alone and 221 received neither drug (HCQ or azithromycin).
T220 29929-30108 Sentence denotes The results showed that the hospital mortality rate of patients receiving HCQ+azithromycin was 25.7%, HCQ alone was 19.9%, azithromycin alone was 10.0% and neither drug was 12.7%.
T221 30109-30339 Sentence denotes In adjusted Cox proportional hazards models, compared with patients receiving neither drug, there were no significant differences in hospital mortality rate for patients receiving HC+azithromycin, HCQ alone, or azithromycin alone.
T222 30340-30454 Sentence denotes In this study, the sample size is large and includes patients with long-term, complex and ongoing hospitalization.
T223 30455-30645 Sentence denotes However, the mortality rate of this study was limited to in-hospital deaths, and patients discharged during the study period were considered alive, which may underestimate the morality rate.
T224 30646-30838 Sentence denotes Recently, a multinational registry analysis about HCQ or CQ with or without second-generation macrolides (especial azithromycin and clarithromycin) for treatment of COVID-19 was reported [61].
T225 30839-30894 Sentence denotes A total of 96,032 patients were included in this study.
T226 30895-31050 Sentence denotes Of these, 1868 received CQ, 3783 received CQ with a macrolide, 3016 received HCQ and 6221 received HCQ with a macrolide and 8114 patients as control group.
T227 31051-31383 Sentence denotes After controlling various confounding factors related to disease, when compared with the mortality in the control group (9.3%), CQ group was 16.4%, CQ with a macrolide group was 22.2%, HCQ group was 18.0% and HCQ group with a macrolide was 23.8%; each group was associated with an increased risk of hospital mortality independently.
T228 31384-31644 Sentence denotes Apart from this, compared with the control group (0.3%), CQ group (4.3%), CQ with a macrolide group (6.5%), HCQ group (6.1%) and HCQ with a macrolide group (8.1%) were independently associated with a risk for ventricular arrhythmia during hospitalization [61].
T229 31645-31834 Sentence denotes This study showed that CQ or HCQ (used alone or combination with a macrolide) was associated with an increased hazard for in-hospital death and an increased risk of ventricular arrhythmias.
T230 31835-31925 Sentence denotes This study included a large number of patients, but it is not a randomized clinical trial.
T231 31926-32143 Sentence denotes In short, some small studies have shown that HCQ combined with azithromycin could quickly and effectively eliminate viruses, but the design of these studies was flawed in many aspects, making the results unconvincing.
T232 32144-32410 Sentence denotes Several subsequent studies have shown that the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) has no obvious correlation with a reduced risk for mechanical ventilation, and may even increase the risk of arrhythmia and in-hospital mortality.
T233 32411-32732 Sentence denotes In summary, although CQ/HCQ appeared to exhibit a favorable effect on COVID-19 patients in some initial studies of small numbers of patients, the most recent studies with larger sample sizes revealed that CQ/HCQ exhibited no significant improvement of disease but even an increased overall mortality in COVID-19 patients.
T234 32733-32858 Sentence denotes The studies on the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) also showed conflicting findings.
T235 32859-33049 Sentence denotes Therefore, caution should be taken regarding the use of CQ/HCQ treatment in COVID-19 due to the uncertainty of efficacy, the potential adverse effects and the various defects in the studies.
T236 33050-33313 Sentence denotes According to the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org.cn/index.aspx) and the International Clinical Trials Registry Platform (ICTRP) (https://www.who.int/ictrp/en/), currently, there are more than 200 ongoing clinical trials for CQ/HCQ.
T237 33314-33476 Sentence denotes Current findings suggest that CQ/HCQ alone or in combination with macrolides should not be recommended for widespread use in COVID-19 (except in clinical trials).
T238 33477-33626 Sentence denotes Results from these ongoing prospective, randomized, controlled studies are required before these drugs are recommended for the treatment of COVID-19.
T239 33628-33630 Sentence denotes 6.
T240 33632-33638 Sentence denotes Safety
T241 33639-33734 Sentence denotes CQ/HCQ are basic medications for malaria with a long history of reliable safety records [3,62].
T242 33735-33855 Sentence denotes However, the therapeutic window of CQ is narrow, and the toxic dose is 3 times higher than the therapeutic dose [55,63].
T243 33856-33984 Sentence denotes The most common adverse effects of taking CQ are gastrointestinal discomforts, such as nausea, vomiting, diarrhea, and anorexia.
T244 33985-34056 Sentence denotes These symptoms are mild and can be controlled by reducing the dose [3].
T245 34057-34313 Sentence denotes However, long-term and high-dose CQ intake can cause irreversible damage to the ear, cardiovascular system, and blood system, such as neurological deafness, conduction disorder cardiomyopathy, and leukopenia, though these adverse effects are very rare [3].
T246 34314-34404 Sentence denotes Compared to CQ, HCQ has fewer adverse effects, which may be related to its lower toxicity.
T247 34405-34465 Sentence denotes In animal models, HCQ was about 40% less toxic than CQ [64].
T248 34466-34604 Sentence denotes Reportedly, only overdoses (average daily dose > 5.0 mg/kg) and long-time (more than 5 years) ingestion of HCQ can cause retinopathy [65].
T249 34605-34782 Sentence denotes CQ/HCQ have similar pharmacokinetic characteristics, fast absorption in the gastrointestinal tract, fast excretion in liver and kidney, and a long half-life (40–50 days) [3,66].
T250 34783-34853 Sentence denotes Therefore, liver and kidney dysfunction may aggravate adverse effects.
T251 34854-35030 Sentence denotes High-dose CQ (600 mg/2 times/day for 10 day) is associated with increased QTc interval prolongation in critically ill patients with COVID-19 [49] and should not be recommended.
T252 35031-35178 Sentence denotes In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days.
T253 35179-35331 Sentence denotes Among them, 7 patients had a prolonged QTc interval more than 60 ms, and one patient developed a first-degree atrioventricular block within 2 days [53].
T254 35332-35471 Sentence denotes In a randomized clinical trial from Wuhan, 2 out of 31 patients receiving HCQ treatment had minor adverse effects (headache and rash) [50].
T255 35472-35558 Sentence denotes Prolonged QT interval after taking HCQ may also develop in ICU COVID-19 patients [67].
T256 35559-35808 Sentence denotes A recent observation showed that patients who received HCQ for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation (19%), and concurrent use of azithromycin was associated with greater changes in QTc (21%) [68].
T257 35809-36227 Sentence denotes Another observation in COVID-19 patients admitted to ICU showed that QTc intervals increased in 93% of patients receiving HCQ with or without azithromycin, prolonged QTc was observed in 36% of patients after a duration of the treatment for 2 to 5 days, and 6 of 18 (33%) patients treated with HCQ and azithromycin and 1 of 22 (5%) of those treated with HCQ alone developed an increase in QTc of 500 ms or greater [69].
T258 36228-36425 Sentence denotes The use of CQ, CQ with a macrolide, HCQ and HCQ with a macrolide were all found to be independently associated with increased risk for ventricular arrhythmia in hospitalized COVID-19 patients [61].
T259 36426-36540 Sentence denotes Therefore, clinicians should carefully weigh risks and benefits if considering CQ/HCQ with or without a macrolide.
T260 36541-36713 Sentence denotes When CQ/HCQ are used, electrocardiogram examination should be routinely performed before taking the medicine, with close monitoring of QTc and concomitant medication usage.
T261 36714-36919 Sentence denotes CQ/HCQ should be more cautiously used in patients with existing heart disease, and the use of QT interval prolonging drugs, such as antiarrhythmic drugs, antihistamines, and moxifloxacin should be avoided.
T262 36920-37078 Sentence denotes In addition, close attention should be paid to symptoms after taking drugs and the drugs should be stopped in time if there are intolerable adverse reactions.
T263 37079-37247 Sentence denotes In addition, CQ is extremely dangerous for patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because of the possible induction of hemolytic anemia [70].
T264 37248-37436 Sentence denotes Therefore, more caution should be given for patients with G6PD deficiency when CQ is considered for the treatment and the best way should be to detect G6PD deficiency before the use of CQ.
T265 37438-37440 Sentence denotes 7.
T266 37442-37452 Sentence denotes Discussion
T267 37453-37511 Sentence denotes At present, the COVID-19 pandemic is continuing worldwide.
T268 37512-37609 Sentence denotes It is still an urgent need to find effective therapies and vaccines for treatment and prevention.
T269 37610-37736 Sentence denotes CQ/HCQ have diverse biological activities, and their mechanisms against CoVs including SARS-CoV-2 are not yet fully clarified.
T270 37737-37916 Sentence denotes Current studies show that CQ/HCQ can prevent receptor recognition by CoVs, inhibit endosome acidification, which interferes membrane fusion, and exhibit immunomodulatory activity.
T271 37917-38003 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T272 38004-38165 Sentence denotes A number of in vitro studies have revealed that CQ/HCQ have inhibitory effects on various CoVs, including SARS-CoV [12,13], MERS-CoV [10] and SARS-CoV-2 [16–18].
T273 38166-38268 Sentence denotes However, conflicting results also exist on the in vitro activity of CQ/HCQ against SARS-CoV-2 [17,18].
T274 38269-38483 Sentence denotes Several clinical studies have shown that CQ/HCQ may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay the progression of the disease, with less serious adverse effects [48,50,57,58,].
T275 38484-38628 Sentence denotes However, previous studies showed that CQ had anti-Ebola virus activity in cell culture, but it had conflicting results in animal models [71,72].
T276 38629-38793 Sentence denotes In addition, CQ has shown beneficial results against chikungunya virus in vitro, but in animal models it aggravates the infection and lacks therapeutic effect [73].
T277 38794-39039 Sentence denotes More importantly, in recent studies the use of HCQ did not show any favorable effect on patients with COVID-19 and high-dose CQ treatment of severe COVID-19 patients may even increase the risks of mortality and QTc interval prolongation [49,55].
T278 39040-39127 Sentence denotes In addition, the optimal daily dose and duration of treatment course are not yet clear.
T279 39128-39289 Sentence denotes One study suggested that the dose of HCQ should be 400 mg/2 times for 1 day, 200 mg/2 times/day for 4 days based on the physiological pharmacokinetic model [18].
T280 39290-39626 Sentence denotes A prospective study of HCQ on COVID-19 patients (13 cases) admitted to the ICU in France showed that the first daily dose of 800 mg/1 time for 1 day, and 200 mg/2 times/day for 7 days was recommended to maintain the HCQ treatment level (1–2 mg/l) based on physiologically pharmacokinetic (PBPK) models for COVID-19 patients in ICU [67].
T281 39627-39719 Sentence denotes Whether the dosage of CQ or HCQ should be varied according disease severity is also unclear.
T282 39720-39835 Sentence denotes A rodent study showed that CQ could exert anti-HCoV-OC43 activity transplacentally or by way of maternal milk [14].
T283 39836-39991 Sentence denotes However, in humans, the efficacy of CQ in the prevention and treatment of SARS-CoV-2 infection to both the mother and the child remains to be investigated.
T284 39992-40169 Sentence denotes Clinical trials in France showed that HCQ combined with azithromycin could enhance the virus clearance [50], but the subsequent reports did not support this combination [59,61].
T285 40170-40340 Sentence denotes Furthermore, CQ/HCQ alone or in combination with a macrolide induced high rate of adverse effects, especially prolonged QTc, in the use for COVID-19 treatment [61,68,69].
T286 40341-40684 Sentence denotes Therefore, current data are not sufficient enough to support the routine use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken for the application of CQ/HCQ, alone or in combination with other drugs, in COVID-19 before the conclusive findings are obtained by well-designed, multicenter, randomized, controlled studies.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 1179-1198 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T3 1207-1235 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T4 1237-1240 Phenotype denotes SLE http://purl.obolibrary.org/obo/HP_0002725
T5 1246-1266 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T6 1268-1270 Phenotype denotes RA http://purl.obolibrary.org/obo/HP_0001370
T7 1582-1591 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T8 7888-7893 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T9 9588-9597 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T10 11802-11807 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T11 12591-12616 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T12 13103-13112 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 14511-14520 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 15434-15439 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T15 15564-15569 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T16 21367-21377 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T17 21989-21994 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T18 22116-22125 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 22296-22301 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T20 22334-22339 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T21 23666-23675 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T22 31593-31615 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T23 31810-31833 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T24 32373-32383 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T25 33943-33959 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T26 33961-33969 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T27 33975-33983 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T28 34204-34212 Phenotype denotes deafness http://purl.obolibrary.org/obo/HP_0000365
T29 34234-34248 Phenotype denotes cardiomyopathy http://purl.obolibrary.org/obo/HP_0001638
T30 34254-34264 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T31 34587-34598 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T32 35208-35230 Phenotype denotes prolonged QTc interval http://purl.obolibrary.org/obo/HP_0005184
T33 35276-35311 Phenotype denotes first-degree atrioventricular block http://purl.obolibrary.org/obo/HP_0011705
T34 35447-35455 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T35 35460-35464 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T36 35472-35493 Phenotype denotes Prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T37 35639-35648 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T38 36363-36385 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T39 37225-37241 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 37136-37143 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose

2_test

Id Subject Object Predicate Lexical cue
32496926-30042604-132195648 1071-1072 30042604 denotes 2
32496926-25693996-132195649 1314-1315 25693996 denotes 3
32496926-17629679-132195650 1398-1399 17629679 denotes 4
32496926-11166662-132195651 1503-1504 11166662 denotes 5
32496926-1658391-132195652 1541-1542 1658391 denotes 7
32496926-19760134-132195653 1601-1602 19760134 denotes 8
32496926-20466822-132195654 1630-1631 20466822 denotes 9
32496926-24841269-132195655 2191-2193 24841269 denotes 10
32496926-24841269-132195656 2518-2520 24841269 denotes 10
32496926-24841269-132195657 2703-2705 24841269 denotes 10
32496926-16640347-132195658 2706-2708 16640347 denotes 11
32496926-15351731-132195659 2788-2790 15351731 denotes 12
32496926-16115318-132195660 3421-3423 16115318 denotes 13
32496926-19506054-132195661 3568-3570 19506054 denotes 14
32496926-19506054-132195662 3937-3939 19506054 denotes 14
32496926-19506054-132195663 4025-4027 19506054 denotes 14
32496926-32020029-132195664 4534-4536 32020029 denotes 16
32496926-32194981-132195665 4898-4900 32194981 denotes 17
32496926-24121034-132195666 5949-5951 24121034 denotes 19
32496926-24121034-132195667 6133-6135 24121034 denotes 19
32496926-16115318-132195668 6522-6524 16115318 denotes 13
32496926-18279660-132195669 8169-8171 18279660 denotes 21
32496926-16115318-132195670 8188-8190 16115318 denotes 13
32496926-31160783-132195671 8191-8193 31160783 denotes 22
32496926-23873408-132195672 8194-8196 23873408 denotes 23
32496926-32221306-132195673 8390-8392 32221306 denotes 24
32496926-15078100-132195674 8639-8641 15078100 denotes 26
32496926-9068613-132195675 8642-8644 9068613 denotes 27
32496926-22590686-132195676 8975-8977 22590686 denotes 28
32496926-22816037-132195677 9140-9142 22816037 denotes 29
32496926-25445340-132195678 9380-9382 25445340 denotes 30
32496926-25445340-132195679 9519-9521 25445340 denotes 30
32496926-24121034-132195680 9542-9544 24121034 denotes 19
32496926-23468491-132195681 9557-9559 23468491 denotes 31
32496926-18971274-132195682 9573-9575 18971274 denotes 32
32496926-16731916-132195683 9615-9617 16731916 denotes 33
32496926-32221306-132195684 9778-9780 32221306 denotes 24
32496926-32194981-132195685 10128-10130 32194981 denotes 17
32496926-28596841-132195686 10378-10380 28596841 denotes 34
32496926-14592603-132195687 10381-10383 14592603 denotes 35
32496926-12021326-132195688 10621-10623 12021326 denotes 36
32496926-16378980-132195689 10639-10641 16378980 denotes 37
32496926-18055026-132195690 10779-10781 18055026 denotes 38
32496926-25321315-132195691 10945-10947 25321315 denotes 39
32496926-25321315-132195692 11103-11105 25321315 denotes 39
32496926-2250716-132195693 11623-11625 2250716 denotes 40
32496926-28793932-132195694 11734-11736 28793932 denotes 41
32496926-16418198-132195695 11867-11869 16418198 denotes 42
32496926-18820679-132195696 12058-12060 18820679 denotes 43
32496926-25821216-132195697 12210-12212 25821216 denotes 44
32496926-4016141-132195698 12359-12361 4016141 denotes 45
32496926-31986264-132195699 12567-12569 31986264 denotes 46
32496926-32007143-132195700 12570-12572 32007143 denotes 47
32496926-32074550-132195701 13264-13266 32074550 denotes 48
32496926-32074550-132195702 14383-14385 32074550 denotes 48
32496926-32409561-132195703 16000-16002 32409561 denotes 54
32496926-32409561-132195704 24000-24002 32409561 denotes 54
32496926-25693996-132195705 33728-33729 25693996 denotes 3
32496926-20513543-132195706 33730-33732 20513543 denotes 62
32496926-7040501-132195707 33851-33853 7040501 denotes 63
32496926-25693996-132195708 34053-34054 25693996 denotes 3
32496926-25693996-132195709 34310-34311 25693996 denotes 3
32496926-6408923-132195710 34461-34463 6408923 denotes 64
32496926-30401979-132195711 34600-34602 30401979 denotes 65
32496926-25693996-132195712 34776-34777 25693996 denotes 3
32496926-22009248-132195713 34778-34780 22009248 denotes 66
32496926-31701865-132195714 37243-37245 31701865 denotes 70
32496926-15351731-132195715 38120-38122 15351731 denotes 12
32496926-16115318-132195716 38123-38125 16115318 denotes 13
32496926-24841269-132195717 38138-38140 24841269 denotes 10
32496926-32020029-132195718 38158-38160 32020029 denotes 16
32496926-32194981-132195718 38158-38160 32194981 denotes 16
32496926-32194981-132195719 38261-38263 32194981 denotes 17
32496926-23577127-132195720 38621-38623 23577127 denotes 71
32496926-26459826-132195721 38624-38626 26459826 denotes 72
32496926-19506054-132195722 39831-39833 19506054 denotes 14