PMC:7441788 / 1687-3433
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T3 | 967-981 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
T4 | 967-971 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T5 | 1007-1017 | Body_part | denotes | organelles | http://purl.org/sig/ont/fma/fma63832 |
T6 | 1027-1036 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T7 | 1038-1059 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
T8 | 1477-1480 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T9 | 1498-1501 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T10 | 1556-1559 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T17 | 41-49 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T18 | 61-108 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T19 | 61-94 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T20 | 110-118 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T21 | 240-248 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T22 | 329-337 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T23 | 586-594 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T24 | 1112-1119 | Disease | denotes | malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
T25 | 1179-1198 | Disease | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/MONDO_0007179 |
T26 | 1207-1235 | Disease | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0007915 |
T27 | 1216-1235 | Disease | denotes | lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0004670 |
T28 | 1237-1240 | Disease | denotes | SLE | http://purl.obolibrary.org/obo/MONDO_0007915 |
T29 | 1246-1266 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
T30 | 1257-1266 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
T31 | 1268-1270 | Disease | denotes | RA | http://purl.obolibrary.org/obo/MONDO_0005272|http://purl.obolibrary.org/obo/MONDO_0008383 |
T33 | 1507-1513 | Disease | denotes | rabies | http://purl.obolibrary.org/obo/MONDO_0019173 |
T34 | 1528-1533 | Disease | denotes | polio | http://purl.obolibrary.org/obo/MONDO_0017373 |
T35 | 1582-1593 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
T36 | 1582-1591 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
T37 | 1608-1622 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
T38 | 1692-1700 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T39 | 1737-1745 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7 | 261-262 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T8 | 810-811 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T9 | 967-971 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10 | 972-981 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
T11 | 1027-1036 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
T12 | 1157-1165 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T13 | 1304-1312 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T14 | 1386-1396 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
T15 | 1460-1468 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T16 | 1481-1488 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T17 | 1514-1519 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T18 | 1534-1539 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T19 | 1560-1567 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T20 | 1592-1593 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T21 | 1594-1599 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T22 | 1623-1628 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T19 | 371-386 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
T20 | 371-380 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T21 | 381-386 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T22 | 533-538 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T23 | 614-619 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T24 | 669-674 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T25 | 675-686 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T26 | 688-690 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T27 | 707-725 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T28 | 763-768 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T29 | 867-869 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T30 | 895-909 | Chemical | denotes | aminoquinoline | http://purl.obolibrary.org/obo/CHEBI_36709 |
T31 | 936-941 | Chemical | denotes | bases | http://purl.obolibrary.org/obo/CHEBI_22695 |
T32 | 1075-1077 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T33 | 1268-1270 | Chemical | denotes | RA | http://purl.obolibrary.org/obo/CHEBI_73810 |
T34 | 1331-1333 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T35 | 1361-1371 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
T36 | 1376-1385 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T37 | 1435-1437 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T38 | 1450-1459 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T39 | 1556-1559 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T40 | 1677-1679 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T2 | 626-639 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | investigation | http://purl.bioontology.org/ontology/MEDDRA/10062026 |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T15 | 675-686 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T16 | 688-690 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T17 | 707-725 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T18 | 867-869 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T19 | 895-909 | Chemical | denotes | aminoquinoline | http://purl.obolibrary.org/obo/CHEBI_36709 |
T20 | 1075-1077 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T21 | 1331-1333 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T22 | 1435-1437 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T23 | 1477-1480 | Chemical | denotes | RNA | http://purl.obolibrary.org/obo/CHEBI_33697 |
T24 | 1556-1559 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T25 | 1677-1679 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T15 | 41-49 | Species | denotes | COVID-19 | NCBItxid:2697049 |
T16 | 61-108 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | NCBItxid:2697049 |
T17 | 110-120 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T18 | 240-248 | Species | denotes | COVID-19 | NCBItxid:2697049 |
T19 | 329-337 | Species | denotes | COVID-19 | NCBItxid:2697049 |
T20 | 586-594 | Species | denotes | COVID-19 | NCBItxid:2697049 |
T21 | 1146-1156 | Species | denotes | plasmodium | NCBItxid:5820|NCBItxid:418103 |
T23 | 1477-1488 | Species | denotes | RNA viruses | NCBItxid:2559587 |
T24 | 1498-1501 | Species | denotes | HIV | NCBItxid:57667|NCBItxid:35274|NCBItxid:12721|NCBItxid:11709|NCBItxid:11676 |
T29 | 1507-1519 | Species | denotes | rabies virus | NCBItxid:11292 |
T30 | 1528-1539 | Species | denotes | polio virus | NCBItxid:138950 |
T31 | 1556-1567 | Species | denotes | DNA viruses | NCBItxid:2080735 |
T32 | 1582-1599 | Species | denotes | hepatitis B virus | NCBItxid:10407 |
T33 | 1615-1628 | Species | denotes | simplex virus | NCBItxid:10294 |
T34 | 1692-1702 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T35 | 1737-1745 | Species | denotes | COVID-19 | NCBItxid:2697049 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T17 | 0-2 | Sentence | denotes | 1. |
T18 | 4-16 | Sentence | denotes | Introduction |
T19 | 17-223 | Sentence | denotes | Coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide, resulting in the third outbreak of coronaviruses in the 21st century. |
T20 | 224-301 | Sentence | denotes | The pandemic of COVID-19 constitutes a serious threat to the whole world [1]. |
T21 | 302-509 | Sentence | denotes | To control the pandemic of COVID-19, effective and easily accessible antiviral drugs and vaccines are urgently needed, in addition to the implementation of epidemiological measures such as strict quarantine. |
T22 | 510-595 | Sentence | denotes | However, until now, no drugs have been demonstrated to be effective against COVID-19. |
T23 | 596-866 | Sentence | denotes | Among the various drugs under investigation are repurposed anti-malarial drugs chloroquine (CQ) and its analog hydroxychloroquine (HCQ), which are among the most used drugs because they are easy to obtain and have a proven favorable safety record at relatively low cost. |
T24 | 867-910 | Sentence | denotes | CQ/HCQ are derivatives of 4-aminoquinoline. |
T25 | 911-1074 | Sentence | denotes | They are lipophilic weak bases that quickly pass across cell membranes and accumulate in acidic organelles, such as lysosomes, endoplasmic reticulum and Golgi [2]. |
T26 | 1075-1317 | Sentence | denotes | CQ/HCQ are used to treat and prevent malaria attacks due to their anti-plasmodium activity and to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) owing to their immunomodulatory activity [3]. |
T27 | 1318-1401 | Sentence | denotes | In addition, CQ/HCQ display antibacterial, antifungal and antiviral activities [4]. |
T28 | 1402-1633 | Sentence | denotes | In vitro studies have shown that CQ/HCQ possess antiviral activity against RNA viruses, such as HIV [5], rabies virus [6] and polio virus [7] and various DNA viruses as diverse as hepatitis B virus [8] and herpes simplex virus [9]. |
T29 | 1634-1746 | Sentence | denotes | This article reviews the current status of CQ/HCQ against SARS-CoV-2 and their use in the treatment of COVID-19. |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
103 | 1677-1683 | Gene | denotes | CQ/HCQ | |
104 | 1435-1441 | Gene | denotes | CQ/HCQ | |
105 | 61-108 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
106 | 110-120 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
107 | 189-202 | Species | denotes | coronaviruses | Tax:11118 |
108 | 1507-1519 | Species | denotes | rabies virus | Tax:11292 |
109 | 1556-1567 | Species | denotes | DNA viruses | Tax:2080735 |
110 | 1692-1702 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
111 | 675-686 | Chemical | denotes | chloroquine | MESH:D002738 |
112 | 688-690 | Chemical | denotes | CQ | MESH:D002738 |
113 | 707-725 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
114 | 727-730 | Chemical | denotes | HCQ | MESH:D006886 |
115 | 867-873 | Chemical | denotes | CQ/HCQ | |
116 | 893-909 | Chemical | denotes | 4-aminoquinoline | MESH:C001920 |
117 | 1075-1081 | Chemical | denotes | CQ/HCQ | |
118 | 1331-1337 | Chemical | denotes | CQ/HCQ | |
120 | 41-49 | Disease | denotes | COVID-19 | MESH:C000657245 |
121 | 240-248 | Disease | denotes | COVID-19 | MESH:C000657245 |
122 | 329-337 | Disease | denotes | COVID-19 | MESH:C000657245 |
123 | 586-594 | Disease | denotes | COVID-19 | MESH:C000657245 |
124 | 1112-1119 | Disease | denotes | malaria | MESH:D008288 |
125 | 1179-1198 | Disease | denotes | autoimmune diseases | MESH:D001327 |
126 | 1207-1235 | Disease | denotes | systemic lupus erythematosus | MESH:D008180 |
127 | 1237-1240 | Disease | denotes | SLE | MESH:D008180 |
128 | 1246-1266 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
129 | 1268-1270 | Disease | denotes | RA | MESH:D001172 |
130 | 1498-1501 | Disease | denotes | HIV | MESH:D015658 |
131 | 1737-1745 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5 | 29-36 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | disease |
T6 | 371-380 | http://purl.obolibrary.org/obo/IDO_0000559 | denotes | antiviral |
T7 | 967-971 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T8 | 1190-1198 | http://purl.obolibrary.org/obo/OGMS_0000031 | denotes | diseases |
T9 | 1346-1359 | http://purl.obolibrary.org/obo/IDO_0000562 | denotes | antibacterial |
T10 | 1361-1371 | http://purl.obolibrary.org/obo/IDO_0000560 | denotes | antifungal |
T11 | 1376-1385 | http://purl.obolibrary.org/obo/IDO_0000559 | denotes | antiviral |
T12 | 1450-1459 | http://purl.obolibrary.org/obo/IDO_0000559 | denotes | antiviral |
T13 | 1481-1488 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T14 | 1514-1519 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T15 | 1534-1539 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T16 | 1560-1567 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T17 | 1594-1599 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T18 | 1623-1628 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T3 | 967-981 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
T4 | 967-971 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T5 | 1007-1017 | Body_part | denotes | organelles | http://purl.org/sig/ont/fma/fma63832 |
T6 | 1027-1036 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T7 | 1038-1059 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
T8 | 1477-1480 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T9 | 1498-1501 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T10 | 1556-1559 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T15 | 17-39 | Disease | denotes | Coronavirus disease-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T16 | 41-49 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T17 | 61-108 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T18 | 110-120 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T19 | 240-248 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T20 | 329-337 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T21 | 586-594 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T22 | 1112-1119 | Disease | denotes | malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
T23 | 1179-1198 | Disease | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/MONDO_0007179 |
T24 | 1207-1235 | Disease | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/MONDO_0007915 |
T25 | 1237-1240 | Disease | denotes | SLE | http://purl.obolibrary.org/obo/MONDO_0007915 |
T26 | 1246-1266 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
T27 | 1268-1270 | Disease | denotes | RA | http://purl.obolibrary.org/obo/MONDO_0008383 |
T28 | 1507-1513 | Disease | denotes | rabies | http://purl.obolibrary.org/obo/MONDO_0019173 |
T29 | 1528-1533 | Disease | denotes | polio | http://purl.obolibrary.org/obo/MONDO_0017373 |
T30 | 1582-1593 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
T31 | 1608-1622 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
T32 | 1692-1702 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T33 | 1737-1745 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 1179-1198 | Phenotype | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/HP_0002960 |
T3 | 1207-1235 | Phenotype | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/HP_0002725 |
T4 | 1237-1240 | Phenotype | denotes | SLE | http://purl.obolibrary.org/obo/HP_0002725 |
T5 | 1246-1266 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
T6 | 1268-1270 | Phenotype | denotes | RA | http://purl.obolibrary.org/obo/HP_0001370 |
T7 | 1582-1591 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
103 | 1677-1683 | Gene | denotes | CQ/HCQ | |
104 | 1435-1441 | Gene | denotes | CQ/HCQ | |
105 | 61-108 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
106 | 110-120 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
107 | 189-202 | Species | denotes | coronaviruses | Tax:11118 |
108 | 1507-1519 | Species | denotes | rabies virus | Tax:11292 |
109 | 1556-1567 | Species | denotes | DNA viruses | Tax:2080735 |
110 | 1692-1702 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
111 | 675-686 | Chemical | denotes | chloroquine | MESH:D002738 |
112 | 688-690 | Chemical | denotes | CQ | MESH:D002738 |
113 | 707-725 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
114 | 727-730 | Chemical | denotes | HCQ | MESH:D006886 |
115 | 867-873 | Chemical | denotes | CQ/HCQ | |
116 | 893-909 | Chemical | denotes | 4-aminoquinoline | MESH:C001920 |
117 | 1075-1081 | Chemical | denotes | CQ/HCQ | |
118 | 1331-1337 | Chemical | denotes | CQ/HCQ | |
119 | 17-39 | Disease | denotes | Coronavirus disease-19 | MESH:C000657245 |
120 | 41-49 | Disease | denotes | COVID-19 | MESH:C000657245 |
121 | 240-248 | Disease | denotes | COVID-19 | MESH:C000657245 |
122 | 329-337 | Disease | denotes | COVID-19 | MESH:C000657245 |
123 | 586-594 | Disease | denotes | COVID-19 | MESH:C000657245 |
124 | 1112-1119 | Disease | denotes | malaria | MESH:D008288 |
125 | 1179-1198 | Disease | denotes | autoimmune diseases | MESH:D001327 |
126 | 1207-1235 | Disease | denotes | systemic lupus erythematosus | MESH:D008180 |
127 | 1237-1240 | Disease | denotes | SLE | MESH:D008180 |
128 | 1246-1266 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
129 | 1268-1270 | Disease | denotes | RA | MESH:D001172 |
130 | 1498-1501 | Disease | denotes | HIV | MESH:D015658 |
131 | 1737-1745 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T17 | 0-2 | Sentence | denotes | 1. |
T18 | 4-16 | Sentence | denotes | Introduction |
T19 | 17-223 | Sentence | denotes | Coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide, resulting in the third outbreak of coronaviruses in the 21st century. |
T20 | 224-301 | Sentence | denotes | The pandemic of COVID-19 constitutes a serious threat to the whole world [1]. |
T21 | 302-509 | Sentence | denotes | To control the pandemic of COVID-19, effective and easily accessible antiviral drugs and vaccines are urgently needed, in addition to the implementation of epidemiological measures such as strict quarantine. |
T22 | 510-595 | Sentence | denotes | However, until now, no drugs have been demonstrated to be effective against COVID-19. |
T23 | 596-866 | Sentence | denotes | Among the various drugs under investigation are repurposed anti-malarial drugs chloroquine (CQ) and its analog hydroxychloroquine (HCQ), which are among the most used drugs because they are easy to obtain and have a proven favorable safety record at relatively low cost. |
T24 | 867-910 | Sentence | denotes | CQ/HCQ are derivatives of 4-aminoquinoline. |
T25 | 911-1074 | Sentence | denotes | They are lipophilic weak bases that quickly pass across cell membranes and accumulate in acidic organelles, such as lysosomes, endoplasmic reticulum and Golgi [2]. |
T26 | 1075-1317 | Sentence | denotes | CQ/HCQ are used to treat and prevent malaria attacks due to their anti-plasmodium activity and to treat autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) owing to their immunomodulatory activity [3]. |
T27 | 1318-1401 | Sentence | denotes | In addition, CQ/HCQ display antibacterial, antifungal and antiviral activities [4]. |
T28 | 1402-1633 | Sentence | denotes | In vitro studies have shown that CQ/HCQ possess antiviral activity against RNA viruses, such as HIV [5], rabies virus [6] and polio virus [7] and various DNA viruses as diverse as hepatitis B virus [8] and herpes simplex virus [9]. |
T29 | 1634-1746 | Sentence | denotes | This article reviews the current status of CQ/HCQ against SARS-CoV-2 and their use in the treatment of COVID-19. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 1179-1198 | Phenotype | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/HP_0002960 |
T3 | 1207-1235 | Phenotype | denotes | systemic lupus erythematosus | http://purl.obolibrary.org/obo/HP_0002725 |
T4 | 1237-1240 | Phenotype | denotes | SLE | http://purl.obolibrary.org/obo/HP_0002725 |
T5 | 1246-1266 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
T6 | 1268-1270 | Phenotype | denotes | RA | http://purl.obolibrary.org/obo/HP_0001370 |
T7 | 1582-1591 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32496926-30042604-132195648 | 1071-1072 | 30042604 | denotes | 2 |
32496926-25693996-132195649 | 1314-1315 | 25693996 | denotes | 3 |
32496926-17629679-132195650 | 1398-1399 | 17629679 | denotes | 4 |
32496926-11166662-132195651 | 1503-1504 | 11166662 | denotes | 5 |
32496926-1658391-132195652 | 1541-1542 | 1658391 | denotes | 7 |
32496926-19760134-132195653 | 1601-1602 | 19760134 | denotes | 8 |
32496926-20466822-132195654 | 1630-1631 | 20466822 | denotes | 9 |