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PMC:7441788 / 14475-35313 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T105 336-340 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T106 1758-1762 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T107 2625-2629 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T108 4068-4071 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T109 4102-4125 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T110 5061-5063 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T111 5921-5932 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T112 6008-6019 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T113 11821-11824 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T114 11856-11879 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T115 13081-13089 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T116 13090-13092 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T117 15457-15468 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 336-340 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 1758-1762 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 4102-4125 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T9 4108-4125 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T10 5921-5932 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T11 6008-6019 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T12 11856-11879 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T13 11862-11879 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T14 15457-15468 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T93 52-60 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 132-140 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 216-224 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 315-324 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T97 746-754 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 1368-1376 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 1492-1500 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 1723-1732 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T101 2337-2345 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 3496-3504 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 5023-5031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 6416-6424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 8392-8400 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 8579-8589 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T107 8879-8887 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 8969-8977 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T109 9328-9337 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T110 9781-9789 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 10064-10072 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 10347-10355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 10599-10603 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T114 10853-10861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 10878-10887 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T116 11202-11210 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 11647-11655 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 12175-12183 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 12752-12760 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 13431-13439 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 13661-13669 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 13742-13750 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T123 13920-13928 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 14161-14169 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T125 15136-15144 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 16488-16496 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 16919-16927 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 18023-18031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 18817-18827 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T130 19034-19045 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T131 19585-19595 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T132 19693-19701 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T133 19926-19934 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T134 20147-20155 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T135 20651-20659 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T136 20829-20837 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T167 336-340 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T168 336-340 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T169 476-478 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T170 628-629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 803-805 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T172 1193-1195 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T173 1247-1249 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T174 1595-1597 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T175 1758-1762 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T176 1758-1762 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T177 2069-2071 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T178 2395-2396 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 2917-2918 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T180 3222-3227 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T181 3543-3544 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T182 4345-4346 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 4804-4806 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T184 5095-5096 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 5270-5275 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T186 5498-5503 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T187 5507-5510 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T188 5532-5537 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T189 6533-6534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 6657-6658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 7109-7110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 7121-7122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 7246-7247 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 7258-7259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 7449-7450 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 8125-8126 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 8159-8160 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 8241-8242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 8277-8278 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 8304-8305 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T201 8902-8903 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 9422-9424 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T203 9463-9465 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T204 9480-9482 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T205 10261-10262 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T206 10317-10320 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T207 10433-10435 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T208 11026-11027 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 11109-11110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 11760-11761 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 12276-12277 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 12307-12309 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T213 12877-12879 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T214 13160-13162 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T215 13217-13219 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T216 13326-13334 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T217 13621-13622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 14129-14130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 14250-14252 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T220 14511-14516 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T221 14520-14523 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3–5
T222 14566-14571 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T223 14791-14792 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T224 15086-15087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 15663-15668 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 15918-15919 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T227 16267-16268 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 16856-16857 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 16900-16901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 17868-17869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 18051-18052 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T232 18157-18158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 18215-18216 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 18419-18420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 18487-18488 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 18678-18679 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 18734-18735 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 18794-18795 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 18922-18923 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 19067-19068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 19109-19110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 19254-19261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 19476-19479 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T244 19508-19509 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 19671-19672 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 20449-20451 http://purl.obolibrary.org/obo/CLO_0037161 denotes en

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T193 25-27 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T194 126-128 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T195 176-178 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T196 242-244 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T197 273-278 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T198 834-836 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T199 903-905 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T200 1014-1019 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T201 1058-1063 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T202 1099-1104 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T203 1235-1240 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T204 1299-1301 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T205 1429-1440 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T206 1442-1444 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T207 1446-1464 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T208 1643-1645 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T209 1681-1683 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T210 2030-2032 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T211 2033-2038 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T212 2056-2058 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T213 2082-2084 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T214 2127-2129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T215 2222-2227 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T216 2266-2271 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T217 2305-2307 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T218 2516-2521 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T219 2539-2544 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T220 2593-2598 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T221 2674-2679 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T222 2825-2830 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T223 2848-2853 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T224 2910-2915 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T225 3015-3020 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T226 3222-3227 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T227 3261-3266 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T228 3284-3289 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T229 3561-3566 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T230 3738-3747 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T231 4252-4257 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T232 4275-4280 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T233 4793-4798 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T234 4815-4820 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T235 4895-4900 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T236 4937-4942 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T237 5061-5063 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T239 5220-5225 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T240 5270-5275 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T241 5304-5309 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T242 5323-5335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T243 5336-5341 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T244 5358-5363 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T245 5442-5454 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T246 5669-5673 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T247 5773-5778 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T248 5849-5861 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T249 6074-6079 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T250 6227-6239 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T251 6323-6335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T252 7005-7017 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T253 7209-7211 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T254 7298-7310 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T255 7871-7883 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T256 8044-8049 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T257 8079-8081 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T258 8091-8093 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807
T259 8117-8119 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T260 8127-8136 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T261 8161-8170 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T262 8233-8235 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T263 8243-8252 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T264 8279-8288 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T265 8324-8326 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T266 8353-8362 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T267 8679-8683 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T268 8784-8788 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T269 9117-9122 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T270 9162-9167 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T271 9242-9247 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T272 9265-9270 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T273 9349-9354 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T274 9383-9388 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T275 9453-9458 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T276 9498-9503 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T277 10177-10182 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T278 10370-10376 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T279 10460-10465 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T280 10490-10495 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T281 10665-10670 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T282 10682-10687 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T283 10715-10720 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T284 11492-11497 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T285 11540-11545 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T286 11699-11708 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T287 11781-11790 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T288 12984-12989 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T289 13026-13031 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T290 13090-13092 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T292 13106-13111 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T293 14099-14101 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T294 14131-14140 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T295 14334-14346 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T296 14415-14420 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T297 14455-14467 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T298 14609-14621 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T299 14739-14750 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T300 14754-14766 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T301 14899-14904 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T302 14980-14985 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T303 15237-15249 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T304 15548-15560 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T305 15556-15560 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T306 15755-15760 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T307 15904-15916 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T308 16018-16030 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T309 16132-16144 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T310 16217-16222 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T311 16243-16255 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T312 16256-16261 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T313 16320-16325 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T314 16401-16413 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T315 16787-16799 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T316 17018-17030 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T317 17069-17081 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T318 17113-17117 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T319 17126-17138 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T320 17219-17231 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T321 17264-17276 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T322 17305-17309 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T323 17407-17411 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T324 17504-17516 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T325 17532-17544 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T326 17915-17917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T327 17952-17962 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T328 17973-17985 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T329 17990-18004 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T330 18131-18133 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T331 18149-18151 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T332 18159-18168 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T333 18217-18226 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T334 18256-18261 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T335 18377-18382 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T336 18391-18393 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T337 18394-18399 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T338 18411-18413 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T339 18421-18430 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T340 18431-18436 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T341 18452-18457 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T342 18476-18481 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T343 18489-18498 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T344 18515-18520 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T345 18639-18644 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T346 18653-18655 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T347 18656-18661 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T348 18670-18672 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T349 18680-18689 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T350 18690-18695 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T351 18708-18713 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T352 18736-18745 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T353 18746-18751 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T354 18880-18882 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T355 18924-18933 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T356 19201-19213 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T357 19425-19427 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T358 19432-19442 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T359 19444-19456 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T360 19460-19474 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T361 19644-19646 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T362 19828-19830 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T363 19986-19988 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T364 19993-20003 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T365 20005-20017 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T366 20021-20035 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T367 20127-20129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T368 20449-20451 Chemical denotes en http://purl.obolibrary.org/obo/CHEBI_30347
T369 20518-20520 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T370 20556-20558 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T371 20592-20602 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T372 20786-20791 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T8 2625-2641 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes body temperature http://purl.bioontology.org/ontology/MEDDRA/10005906
T9 3612-3624 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigator http://purl.bioontology.org/ontology/MEDDRA/10062026
T10 4138-4160 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes bronchoalveolar lavage http://purl.bioontology.org/ontology/MEDDRA/10049413
T11 4599-4608 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes weighting http://purl.bioontology.org/ontology/MEDDRA/10047890
T12 5933-5943 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T13 6020-6030 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T14 10752-10769 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes electrocardiogram http://purl.bioontology.org/ontology/MEDDRA/10014362
T15 11892-11914 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes bronchoalveolar lavage http://purl.bioontology.org/ontology/MEDDRA/10049413
T16 14070-14082 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 15063-15073 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T18 15469-15479 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes viral load http://purl.bioontology.org/ontology/MEDDRA/10062178
T19 15669-15676 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes culture http://purl.bioontology.org/ontology/MEDDRA/10061447

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T119 25-27 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T120 126-128 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T121 176-178 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T122 242-244 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T123 834-836 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T124 903-905 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T125 1299-1301 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T126 1429-1440 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T127 1442-1444 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T128 1446-1464 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T129 1643-1645 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T130 1681-1683 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T131 2030-2032 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T132 2056-2058 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T133 2082-2084 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T134 2127-2129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T135 2305-2307 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T136 4068-4071 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T137 5323-5335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T138 5442-5454 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T139 5849-5861 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T140 6227-6239 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T141 6323-6335 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T142 7005-7017 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T143 7298-7310 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T144 7871-7883 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T145 8079-8081 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T146 8117-8119 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T147 8127-8136 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T148 8161-8170 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T149 8233-8235 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T150 8243-8252 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T151 8279-8288 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T152 8324-8326 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T153 8353-8362 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T154 10370-10376 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T155 11821-11824 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T156 14099-14101 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T157 14131-14140 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T158 14334-14346 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T159 14455-14467 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T160 14609-14621 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T161 14754-14766 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T162 15237-15249 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T163 15548-15560 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T164 15904-15916 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T165 16018-16030 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T166 16132-16144 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T167 16243-16255 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T168 16401-16413 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T169 16787-16799 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T170 17018-17030 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T171 17069-17081 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T172 17126-17138 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T173 17219-17231 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T174 17264-17276 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T175 17504-17516 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T176 17532-17544 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T177 17915-17917 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T178 17952-17962 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T179 17973-17985 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T180 17990-18004 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T181 18131-18133 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T182 18149-18151 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T183 18159-18168 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T184 18217-18226 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T185 18391-18393 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T186 18411-18413 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T187 18421-18430 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T188 18489-18498 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T189 18653-18655 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T190 18670-18672 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T191 18680-18689 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T192 18736-18745 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T193 18880-18882 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T194 18924-18933 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T195 19201-19213 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T196 19425-19427 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T197 19432-19442 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T198 19444-19456 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T199 19460-19474 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T200 19644-19646 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T201 19828-19830 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T202 19986-19988 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T203 19993-20003 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T204 20005-20017 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T205 20021-20035 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T206 20127-20129 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T207 20518-20520 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T208 20556-20558 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T209 20592-20602 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T97 52-60 Species denotes COVID-19 NCBItxid:2697049
T98 132-140 Species denotes COVID-19 NCBItxid:2697049
T99 216-224 Species denotes COVID-19 NCBItxid:2697049
T100 746-754 Species denotes COVID-19 NCBItxid:2697049
T101 1368-1376 Species denotes COVID-19 NCBItxid:2697049
T102 1492-1500 Species denotes COVID-19 NCBItxid:2697049
T103 2337-2345 Species denotes COVID-19 NCBItxid:2697049
T104 3496-3504 Species denotes COVID-19 NCBItxid:2697049
T105 5023-5031 Species denotes COVID-19 NCBItxid:2697049
T106 6416-6424 Species denotes COVID-19 NCBItxid:2697049
T107 8392-8400 Species denotes COVID-19 NCBItxid:2697049
T108 8879-8887 Species denotes COVID-19 NCBItxid:2697049
T109 8969-8977 Species denotes COVID-19 NCBItxid:2697049
T110 9781-9789 Species denotes COVID-19 NCBItxid:2697049
T111 10064-10072 Species denotes COVID-19 NCBItxid:2697049
T112 10347-10355 Species denotes COVID-19 NCBItxid:2697049
T113 10853-10861 Species denotes COVID-19 NCBItxid:2697049
T114 11202-11210 Species denotes COVID-19 NCBItxid:2697049
T115 11647-11655 Species denotes COVID-19 NCBItxid:2697049
T116 12175-12183 Species denotes COVID-19 NCBItxid:2697049
T117 12752-12760 Species denotes COVID-19 NCBItxid:2697049
T118 13431-13439 Species denotes COVID-19 NCBItxid:2697049
T119 13661-13669 Species denotes COVID-19 NCBItxid:2697049
T120 13742-13750 Species denotes COVID-19 NCBItxid:2697049
T121 13920-13928 Species denotes COVID-19 NCBItxid:2697049
T122 14161-14169 Species denotes COVID-19 NCBItxid:2697049
T123 15136-15144 Species denotes COVID-19 NCBItxid:2697049
T124 16488-16496 Species denotes COVID-19 NCBItxid:2697049
T125 16919-16927 Species denotes COVID-19 NCBItxid:2697049
T126 18023-18031 Species denotes COVID-19 NCBItxid:2697049
T127 19254-19261 Species denotes viruses NCBItxid:10239
T128 19693-19701 Species denotes COVID-19 NCBItxid:2697049
T129 19926-19934 Species denotes COVID-19 NCBItxid:2697049
T130 20147-20155 Species denotes COVID-19 NCBItxid:2697049
T131 20651-20659 Species denotes COVID-19 NCBItxid:2697049
T132 20829-20837 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T104 0-2 Sentence denotes 5.
T105 4-60 Sentence denotes Clinical efficacy of CQ/HCQ in the treatment of COVID-19
T106 61-160 Sentence denotes Only two published clinical reports have studied the efficacy of CQ in COVID-19 patients (Table 1).
T107 161-414 Sentence denotes One study used CQ to treat more than 100 patients with COVID-19 and claimed that CQ was superior to the control group in suppressing the deterioration of pneumonia, improving lung imaging, promoting viral conversion and shortening the course of disease.
T108 415-480 Sentence denotes Serious adverse effects were not observed in these patients [48].
T109 481-617 Sentence denotes However, this report did not provide any details about the study design and patient data, thus it is difficult to evaluate the validity.
T110 618-720 Sentence denotes Recently, a parallel, double-blind, randomized, phase IIB clinical trial was performed in Brazil [49].
T111 721-802 Sentence denotes In this study, 81 severe COVID-19 patients were randomly divided into two groups:
T112 803-970 Sentence denotes 41 patients received high-dose CQ (600 mg/2 times/day for 10 day) and 40 patients received low-dose CQ (450 mg/2 times on day 1 and then 450 mg/1 time/day for 4 days).
T113 971-1082 Sentence denotes The 13-day mortality rate in the high-dose group was more than double that in low-dose group (39.0% vs. 16.0%).
T114 1083-1259 Sentence denotes The high-dosage group exhibited more instance of corrected QT (QTc) interval prolongation (>500 milliseconds (ms); 7 of 37 [18.9%]) than the low-dosage group (4 of 36 [11.1%]).
T115 1260-1382 Sentence denotes These findings suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 [49].
T116 1383-1391 Sentence denotes Table 1.
T117 1392-1501 Sentence denotes Outcomes and advantage/limitation of chloroquine (CQ)/hydroxychloroquine (HCQ) clinical studies for COVID-19.
T118 1502-1583 Sentence denotes Author (Reference) Study design Patients Treatment Outcomes Advantage Limitations
T119 1584-1599 Sentence denotes Gao et al [48].
T120 1600-1829 Sentence denotes Rough and simple description Not mentioned CQ (No specific dosage was mentioned) CQ was superior to control in suppressing pneumonia deterioration, improving lung imaging, promoting viral conversion and shortening disease course.
T121 1830-1846 Sentence denotes Not significant.
T122 1847-1973 Sentence denotes No study design and the specific number of patients and controls were provided and thus the result appears to be unconvincing.
T123 1974-1991 Sentence denotes Borba et al [49].
T124 1992-2478 Sentence denotes Randomized controlled trial High-dose CQ group: n = 40;Low-dose CQ group:n = 41 high-dose CQ (600 mg/2 times/day, for 10 day);low-dose CQ (450 mg/2 times/day for 5 days, double dose on 1st day) The mortality rate in the high-dose group was more than double that in low-dose group Double-blind study; 2 dosages of CQ for the first time in severe COVID-19 Small sample size; single-center design; Lack of a placebo control; Lack of exclusion criteria based on the QTc interval at baseline
T125 2479-2697 Sentence denotes Chen et al.[50] Randomized trial HCQ group: n = 31; control group: n = 30 HCQ (200 mg/2 times/day for 5 days) HCQ group have small improvement in body temperature and cough compered with control group Randomized trial.
T126 2698-2782 Sentence denotes Small sample size; Single-center design; Small improvement in temperature and cough.
T127 2783-2802 Sentence denotes Mahévas et al [53].
T128 2803-3021 Sentence denotes Comparative study HCQ group: n = 84; control group: n = 97 HCQ 600 mg/day for 7 days Compared with control group, a reduction of admissions to ICU or death 7 days after hospital admission was not observed in HCQ group.
T129 3022-3088 Sentence denotes Relatively larger sample size in HCQ treatment and control groups.
T130 3089-3199 Sentence denotes Nonrandomized design; In propensity score model, four possible important prognostic variables were unbalanced.
T131 3200-3216 Sentence denotes Tang et al [54].
T132 3217-3298 Sentence denotes Open label, randomized controlled trial HCQ group: n = 70; control group: n = 80.
T133 3299-3505 Sentence denotes HCQ 1200 mg daily for 3 days, 800 mg daily for 2 weeks (mild to moderate disease)/3 weeks(severe disease) HCQ did not show additional benefits of vial elimination in patients with mild to moderate COVID-19.
T134 3506-3534 Sentence denotes Randomized controlled study.
T135 3535-3733 Sentence denotes Lack of a placebo control group; Design introduces the possibility of biased investigator determined assessment and unbalanced dosage adjustment; Randomization of sequential envelopes may be biased.
T136 3734-3917 Sentence denotes The antiviral efficacy of HCQ was not assessed at an earlier stage; Most patients are mild to severe, and the effect of HCQ on disease progression or regression could not be provided.
T137 3918-3994 Sentence denotes The trial terminated early due to the difficulty to recruit enough patients.
T138 3995-4207 Sentence denotes Some secondary endpoints could not be analyzed by the cutoff date; Viral RNA specimens are mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T139 4208-4227 Sentence denotes Geleris et al [55].
T140 4228-4471 Sentence denotes Observational study HCQ group: n = 811; no-HCQ group: n = 565 HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) No correlation between the HCQ use and significant higher or lower risk of intubation or death was observed.
T141 4472-4643 Sentence denotes Large sample size; Minimization of the unmeasured confusion and error through multivariable Cox model with inverse probability weighting according to the propensity score.
T142 4644-4753 Sentence denotes Single-center design; missing of some variables; Potential for inaccuracies in the electronic health records.
T143 4754-4768 Sentence denotes Yu et al [56].
T144 4769-4943 Sentence denotes Retrospective study HCQ group: n = 48; no-HCQ group: n = 502 HCQ (200 mg/2 times/day, for 7 to 10 days) The fatalities of HCQ group was significantly lower than no-HCQ group.
T145 4944-5072 Sentence denotes HCQ treatment was related to significantly reduced mortality in critically ill COVID-19 patients and greatly lowered IL-6 level.
T146 5073-5163 Sentence denotes Mortality was used as a measure of outcome and the study included critically ill patients.
T147 5164-5245 Sentence denotes Retrospective design of the study and the number of HCQ group patients was small.
T148 5246-5516 Sentence denotes Gautret et al.[57] Open label, nonrandom cohort study HCQ group: n = 12; HCQ＋azithromycin group: n = 6; control group: n = 12 HCQ (200 mg/3 times/day for 10 days) HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T149 5517-5578 Sentence denotes Nasopharyngeal virus determination was used as main endpoint.
T150 5579-5728 Sentence denotes Small sample size; Six patients dropped out due to critical illness or intolerance to the drug; Lack of clinical outcomes; Limited follow-up results.
T151 5729-5748 Sentence denotes Gautret et al [58].
T152 5749-5992 Sentence denotes Observational study HCQ group: n = 80; no control HCQ, 200 mg/3 times/day for 10 days combined with azithromycin 500 mg on the 1st day, 250 mg/day afterward for 5 days The nasopharynx viral load in most patients received HCQ decreased rapidly.
T153 5993-6031 Sentence denotes Observation of nasopharynx viral load.
T154 6032-6116 Sentence denotes Observational study design and no control group; No clinical outcomes were analyzed.
T155 6117-6164 Sentence denotes Possible confounding factors were not adjusted.
T156 6165-6186 Sentence denotes Magagnoli et al [59].
T157 6187-6283 Sentence denotes Retrospective study HCQ group:n = 97HCQ＋azithromycin: n = 113No HCQ group:n = 158 Not specified.
T158 6284-6506 Sentence denotes The use of HCQ, either with or without azithromycin, didn’t reduce the risk of mechanical ventilation in patients hospitalized with COVID-19; Patients treated with HCQ alone was associated with increased overall mortality.
T159 6507-6728 Sentence denotes The study data comes from a comprehensive electronic medical record; Strictly defined covariates and outcomes; Using propensity scores adjustment for a large number of relevant confounders to make results more persuasive.
T160 6729-6922 Sentence denotes Retrospective nature of the study; The subjects included only men and most of them were black; Despite adjustments to many possible confounding factors, there may still be undiscovered factors.
T161 6923-7429 Sentence denotes Rosenberg et al[60] Retrospective multicenter cohort study HCQ group:n = 271;HCQ ＋azithromycin group:n = 735control group:n = 221 HCQ:200 mg/400 mg/600 mg/other/unknown, frequency: once a day/twice a day/other/unknownazithromycin:200 mg/250 mg/400 mg/500 mg/other/unknown, methods:Oral/IV/unknown,frequency: only once/once a day/twice a day/other/unknown Treatment with HCQ, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality.
T162 7430-7512 Sentence denotes This study include a large, random sample from 25 metropolitan New York hospitals.
T163 7513-7677 Sentence denotes The sample was drawnearly in the epidemic to include patients with long, complicated, and ongoing hospital stays; In-hospital mortality was used as primary outcome.
T164 7678-7819 Sentence denotes Retrospective study design; There may be missing information; Mortality was limited to in-hospital death; There may be potential confounders.
T165 7820-7899 Sentence denotes The dosing in the doses and frequencies of HCQ and azithromycin varied greatly.
T166 7900-7959 Sentence denotes The confidence intervals for some of the findings are wide.
T167 7960-8418 Sentence denotes Mehraet al[61] Multinational real-world analysis Teatment groups: n = 14,888Control group: n = 81,144 Mean daily dose: CQ 765 mg, (SD 308); HCQ 596 mg(126); CQ with a macrolide 790 mg(320); HCQ with a macrolide 597 mg(128).mean duration:CQ 6.6 days(2.4); HCQ 4.2 days(1.9);CQ with a macrolide 6.8 days(2.5); HCQ with a macrolide 4.3 days (2.0) A benefit of HCQ or CQ, when used alone or witha macrolide, on in-hospital outcomes for COVID-19 was not observed.
T168 8419-8493 Sentence denotes Large multinational real-world data and large number of study populations.
T169 8494-8812 Sentence denotes There may be potential confounders; It did not measure QT intervals and stratify the arrhythmia pattern; It did not determine whether the increased risk of death in-hospital and use of drug treatment regimens were directly related to cardiovascular risk; It did not observe the risk of the drug dose-response analysis.
T170 8813-8898 Sentence denotes Several trials evaluated the efficacy of HCQ for the treatment of COVID-19 (Table 1).
T171 8899-9051 Sentence denotes In a randomized clinical trial from Wuhan about HCQ treatment of mild COVID-19 [50], 31 out of 62 patients received HCQ (200 mg/2 times/day for 5 days).
T172 9052-9407 Sentence denotes The results showed that the temperature recovery time in the HCQ group was improved compared with the control group (average days, 2.2 vs. 3.2); the cough relief time was shorter in the HCQ group than the control group (average days, 2.4 vs. 3.1); and the improvement rate of pneumonia in the HCQ group was higher than the control group (80.6% vs. 54.8%).
T173 9408-9570 Sentence denotes However, only 48% of patients (15/31) in HCQ group and 71% of patients (22/31) in control group had cough at baseline and the duration of cough was not described.
T174 9571-9647 Sentence denotes Improvement of symptoms were small and the trial was terminated prematurely.
T175 9648-9742 Sentence denotes These factors and the low sample size compromise the reliability of the results of this study.
T176 9743-9949 Sentence denotes Importantly, evaluation of HCQ in the COVID-19 pandemic areas have shown that HCQ can help patients with mild symptoms, and may potentially reduce transmission in areas lacking isolation facilities [51,52].
T177 9950-10134 Sentence denotes However, in areas with strict isolation standards, the use of HCQ to reduce transmission or for treatment of mild COVID-19 cases may not be beneficial in risk-benefit analysis [51,52].
T178 10135-10260 Sentence denotes Nevertheless, there is an urgent need for drugs and therapeutics in severe cases, which require randomized controlled trials.
T179 10261-10387 Sentence denotes A study from four French tertiary care centers included 181 patients hospitalized for COVID-19 and requiring oxygen (2 L/min):
T180 10388-10502 Sentence denotes 84 patients received HCQ (600 mg/day) within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group) [53].
T181 10503-10688 Sentence denotes The results showed that the patients transferred to the ICU or died within 7 days and developed ARDS within 7 days had no significant differences between the HCQ group and no-HCQ group.
T182 10689-10782 Sentence denotes Eight patients in the HCQ group (9.5%) discontinued HCQ due to electrocardiogram alterations.
T183 10783-10897 Sentence denotes These results do not support the use of HCQ for treating hospitalized COVID-19-related hypoxic pneumonia patients.
T184 10898-11105 Sentence denotes It is worth noting that in the study’s propensity score model, four possible important prognostic variables were unbalanced and a center effect was not considered, which all can cause bias for study results.
T185 11106-11400 Sentence denotes In a multicenter, randomized, parallel trial about HCQ in patients with mainly mild to moderate COVID-19 [54], 80 patients received ‘standard care’ and 70 patients received HCQ (1200 mg daily for 3 days, and then 800 mg daily for 2 weeks [mild to moderate disease] or 3 weeks [severe disease]).
T186 11401-11554 Sentence denotes The results showed that the 28-days negative conversion probability in ‘standard care’＋HCQ group was 85.4%, similar to the ‘standard care’ group (81.2%).
T187 11555-11656 Sentence denotes HCQ did not show additional benefits of viral elimination in patients with mild to moderate COVID-19.
T188 11657-11801 Sentence denotes However, the study could not evaluate the antiviral effect of HCQ at early stages of disease, which is a critical period of antiviral treatment.
T189 11802-11961 Sentence denotes In addition, viral RNA specimens were mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T190 11962-12113 Sentence denotes Due to the small number of severe patients, this study could not provide evidence regarding the effect of HCQ on the disease progression or regression.
T191 12114-12350 Sentence denotes In another large observational study involving 1376 cases of COVID-19 from New York, 811 patients received HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) within 24 or 48 hours of admission and 565 did not [55].
T192 12351-12461 Sentence denotes This study found no correlation between HCQ use and significantly higher or lower risk of intubation or death.
T193 12462-12637 Sentence denotes However, in this study, even after the propensity score-matching, the diseases in patients receiving HCQ were more severe at baseline than those in the patients not receiving.
T194 12638-12787 Sentence denotes Notably, according to another recent study [56], low dose of HCQ reduced fatality of critically ill patients with COVID-19 without apparent toxicity.
T195 12788-12957 Sentence denotes This retrospective study included 550 patients who need mechanical ventilation, of which 48 received HCQ treatment (200 mg/2 times/day for 7 to 10 days) and 502 did not.
T196 12958-13248 Sentence denotes The fatalities of the HCQ group was significantly lower than no-HCQ group (18.8% vs 47.4%, P < 0.05), and the inflammatory cytokine IL-6 in the HCQ group decreased significantly from 22.2 (8.3 to 118.9 pg/mL) at the beginning of treatment to 5.2 (3.0 to 23.4 pg/mL) at the end of treatment.
T197 13249-13440 Sentence denotes The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19.
T198 13441-13553 Sentence denotes Yet, this study is flawed due to its retrospective nature and the small number of HCQ treated patients included.
T199 13554-13818 Sentence denotes In short, some initial studies have shown that HCQ appears to have a curative effect on patients with mild COVID-19, but subsequent studies indicate that HCQ had no significant benefit in COVID-19 patients with viral conversion and the risk of intubation or death.
T200 13819-14033 Sentence denotes Although some recent studies show that low-dose HCQ could potentially reduce the mortality of severe COVID-19 patients, there are other studies showing that the HCQ use had no effect on risk of intubation or death.
T201 14034-14180 Sentence denotes There are also several reports that investigated the efficacy of CQ or HCQ in combination with a macrolide in the treatment of COVID-19 (Table 1).
T202 14181-14364 Sentence denotes In an open nonrandom clinical trial conducted in France [57], of the 36 participants, 20 patients were given HCQ (200 mg/3 times) with 6 receiving added azithromycin, and 16 controls.
T203 14365-14529 Sentence denotes The results showed that compared with the control group, HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T204 14530-14699 Sentence denotes On the 6th day after treatment, the virus clearance rates of HCQ combined with azithromycin, HCQ alone and controls were 100%, 57.1% and 12.5%, respectively (P < 0.001).
T205 14700-14812 Sentence denotes This study indicated that the combined application of azithromycin and HCQ appears to have a synergistic effect.
T206 14813-15022 Sentence denotes However, the trial design and the results were unreliable, as six patients in the HCQ group discontinued treatment early due to critical illness or intolerance to the drugs and were excluded from the analysis.
T207 15023-15106 Sentence denotes The assessment of efficacy was based on viral load rather than a clinical endpoint.
T208 15107-15452 Sentence denotes An observational study in 80 COVID-19 patients evaluated the efficacy of HCQ (200 mg/3 times/day for 10 days) in combination with azithromycin (500 mg on the first day, 250 mg/day afterward for 5 days) and showed that all patients’ clinical symptoms were improved, except for one patient aged over 86 years who died due to critical illness [58].
T209 15453-15625 Sentence denotes The nasopharynx viral load in most patients decreased rapidly, and the negative rates of viral nucleic acid conversion on days 7 and 8 were about 83% and 93%, respectively.
T210 15626-15719 Sentence denotes About 97.5% of patients had negative virus culture in respiratory specimens on the fifth day.
T211 15720-15812 Sentence denotes However, this study had no control group, thus the results were difficult to interpret [58].
T212 15813-15917 Sentence denotes Some recent studies have yielded different results about the efficacy of HCQ combined with azithromycin.
T213 15918-16194 Sentence denotes A retrospective study including 368 patients (97 patients received HCQ, 113 patients received HCQ + azithromycin and 158 patients received no HCQ) from USA [59] showed that the rates of ventilation in the HCQ, HCQ+azithromycin and no HCQ groups had no significant differences.
T214 16195-16326 Sentence denotes Unfortunately, theHCQ group (but not in the HCQ+azithromycin group) had a higher risk of death from any case than the no HCQ group.
T215 16327-16497 Sentence denotes This study showed no evidence that the use of HCQ, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19.
T216 16498-16612 Sentence denotes Noticeably, in patients treated with HCQ alone, an association with increased overall mortality was observed [59].
T217 16613-16740 Sentence denotes In this study, the subjects included were only men and most of them were black, which may affect the generality of the results.
T218 16741-16852 Sentence denotes In addition, the patients who received HCQ or azithromycin were more severe, which may also affect the results.
T219 16853-17140 Sentence denotes In a retrospective multicenter cohort study of a random sample of COVID-19 patients from 25 hospitals in New York [60], totaling 1438 patients, 735 received HCQ and azithromycin, 271 received HCQ alone, 211 received azithromycin alone and 221 received neither drug (HCQ or azithromycin).
T220 17141-17320 Sentence denotes The results showed that the hospital mortality rate of patients receiving HCQ＋azithromycin was 25.7%, HCQ alone was 19.9%, azithromycin alone was 10.0% and neither drug was 12.7%.
T221 17321-17551 Sentence denotes In adjusted Cox proportional hazards models, compared with patients receiving neither drug, there were no significant differences in hospital mortality rate for patients receiving HC＋azithromycin, HCQ alone, or azithromycin alone.
T222 17552-17666 Sentence denotes In this study, the sample size is large and includes patients with long-term, complex and ongoing hospitalization.
T223 17667-17857 Sentence denotes However, the mortality rate of this study was limited to in-hospital deaths, and patients discharged during the study period were considered alive, which may underestimate the morality rate.
T224 17858-18050 Sentence denotes Recently, a multinational registry analysis about HCQ or CQ with or without second-generation macrolides (especial azithromycin and clarithromycin) for treatment of COVID-19 was reported [61].
T225 18051-18106 Sentence denotes A total of 96,032 patients were included in this study.
T226 18107-18262 Sentence denotes Of these, 1868 received CQ, 3783 received CQ with a macrolide, 3016 received HCQ and 6221 received HCQ with a macrolide and 8114 patients as control group.
T227 18263-18595 Sentence denotes After controlling various confounding factors related to disease, when compared with the mortality in the control group (9.3%), CQ group was 16.4%, CQ with a macrolide group was 22.2%, HCQ group was 18.0% and HCQ group with a macrolide was 23.8%; each group was associated with an increased risk of hospital mortality independently.
T228 18596-18856 Sentence denotes Apart from this, compared with the control group (0.3%), CQ group (4.3%), CQ with a macrolide group (6.5%), HCQ group (6.1%) and HCQ with a macrolide group (8.1%) were independently associated with a risk for ventricular arrhythmia during hospitalization [61].
T229 18857-19046 Sentence denotes This study showed that CQ or HCQ (used alone or combination with a macrolide) was associated with an increased hazard for in-hospital death and an increased risk of ventricular arrhythmias.
T230 19047-19137 Sentence denotes This study included a large number of patients, but it is not a randomized clinical trial.
T231 19138-19355 Sentence denotes In short, some small studies have shown that HCQ combined with azithromycin could quickly and effectively eliminate viruses, but the design of these studies was flawed in many aspects, making the results unconvincing.
T232 19356-19622 Sentence denotes Several subsequent studies have shown that the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) has no obvious correlation with a reduced risk for mechanical ventilation, and may even increase the risk of arrhythmia and in-hospital mortality.
T233 19623-19944 Sentence denotes In summary, although CQ/HCQ appeared to exhibit a favorable effect on COVID-19 patients in some initial studies of small numbers of patients, the most recent studies with larger sample sizes revealed that CQ/HCQ exhibited no significant improvement of disease but even an increased overall mortality in COVID-19 patients.
T234 19945-20070 Sentence denotes The studies on the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) also showed conflicting findings.
T235 20071-20261 Sentence denotes Therefore, caution should be taken regarding the use of CQ/HCQ treatment in COVID-19 due to the uncertainty of efficacy, the potential adverse effects and the various defects in the studies.
T236 20262-20525 Sentence denotes According to the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org.cn/index.aspx) and the International Clinical Trials Registry Platform (ICTRP) (https://www.who.int/ictrp/en/), currently, there are more than 200 ongoing clinical trials for CQ/HCQ.
T237 20526-20688 Sentence denotes Current findings suggest that CQ/HCQ alone or in combination with macrolides should not be recommended for widespread use in COVID-19 (except in clinical trials).
T238 20689-20838 Sentence denotes Results from these ongoing prospective, randomized, controlled studies are required before these drugs are recommended for the treatment of COVID-19.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 336-340 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 1758-1762 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 4102-4125 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T9 5921-5932 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T10 6008-6019 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728
T11 11856-11879 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T12 15457-15468 Body_part denotes nasopharynx http://purl.obolibrary.org/obo/UBERON_0001728

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
1086 14253-14265 Species denotes participants Tax:9606
1087 14270-14278 Species denotes patients Tax:9606
1088 14879-14887 Species denotes patients Tax:9606
1089 15145-15153 Species denotes patients Tax:9606
1090 15329-15337 Species denotes patients Tax:9606
1091 15387-15394 Species denotes patient Tax:9606
1092 15488-15496 Species denotes patients Tax:9606
1093 15641-15649 Species denotes patients Tax:9606
1094 15954-15962 Species denotes patients Tax:9606
1095 15967-15975 Species denotes patients Tax:9606
1096 15994-16002 Species denotes patients Tax:9606
1097 16039-16047 Species denotes patients Tax:9606
1098 16461-16469 Species denotes patients Tax:9606
1099 16513-16521 Species denotes patients Tax:9606
1100 16660-16663 Species denotes men Tax:9606
1101 16758-16766 Species denotes patients Tax:9606
1102 16928-16936 Species denotes patients Tax:9606
1103 16987-16995 Species denotes patients Tax:9606
1104 17196-17204 Species denotes patients Tax:9606
1105 17380-17388 Species denotes patients Tax:9606
1106 17482-17490 Species denotes patients Tax:9606
1107 17605-17613 Species denotes patients Tax:9606
1108 17748-17756 Species denotes patients Tax:9606
1109 18069-18077 Species denotes patients Tax:9606
1110 18236-18244 Species denotes patients Tax:9606
1111 19085-19093 Species denotes patients Tax:9606
1112 14099-14101 Chemical denotes CQ MESH:D002738
1113 14105-14108 Chemical denotes HCQ MESH:D006886
1114 14131-14140 Chemical denotes macrolide MESH:D018942
1115 14290-14293 Chemical denotes HCQ MESH:D006886
1116 14334-14346 Chemical denotes azithromycin MESH:D017963
1117 14422-14425 Chemical denotes HCQ MESH:D006886
1118 14455-14467 Chemical denotes azithromycin MESH:D017963
1119 14591-14594 Chemical denotes HCQ MESH:D006886
1120 14609-14621 Chemical denotes azithromycin MESH:D017963
1121 14623-14626 Chemical denotes HCQ MESH:D006886
1122 14754-14766 Chemical denotes azithromycin MESH:D017963
1123 14771-14774 Chemical denotes HCQ MESH:D006886
1124 14895-14898 Chemical denotes HCQ MESH:D006886
1125 15180-15183 Chemical denotes HCQ MESH:D006886
1126 15237-15249 Chemical denotes azithromycin MESH:D017963
1127 15886-15889 Chemical denotes HCQ MESH:D006886
1128 15904-15916 Chemical denotes azithromycin MESH:D017963
1129 15985-15988 Chemical denotes HCQ MESH:D006886
1130 16012-16015 Chemical denotes HCQ MESH:D006886
1131 16018-16030 Chemical denotes azithromycin MESH:D017963
1132 16060-16063 Chemical denotes HCQ MESH:D006886
1133 16123-16126 Chemical denotes HCQ MESH:D006886
1134 16128-16131 Chemical denotes HCQ MESH:D006886
1135 16132-16144 Chemical denotes azithromycin MESH:D017963
1136 16152-16155 Chemical denotes HCQ MESH:D006886
1137 16210-16216 Chemical denotes theHCQ
1138 16239-16242 Chemical denotes HCQ MESH:D006886
1139 16243-16255 Chemical denotes azithromycin MESH:D017963
1140 16316-16319 Chemical denotes HCQ MESH:D006886
1141 16373-16376 Chemical denotes HCQ MESH:D006886
1142 16401-16413 Chemical denotes azithromycin MESH:D017963
1143 16535-16538 Chemical denotes HCQ MESH:D006886
1144 16780-16783 Chemical denotes HCQ MESH:D006886
1145 16787-16799 Chemical denotes azithromycin MESH:D017963
1146 17010-17013 Chemical denotes HCQ MESH:D006886
1147 17018-17030 Chemical denotes azithromycin MESH:D017963
1148 17045-17048 Chemical denotes HCQ MESH:D006886
1149 17069-17081 Chemical denotes azithromycin MESH:D017963
1150 17119-17122 Chemical denotes HCQ MESH:D006886
1151 17126-17138 Chemical denotes azithromycin MESH:D017963
1152 17215-17219 Chemical denotes HCQ＋ MESH:D006886
1153 17219-17231 Chemical denotes azithromycin MESH:D017963
1154 17243-17246 Chemical denotes HCQ MESH:D006886
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1156 17504-17516 Chemical denotes azithromycin MESH:D017963
1157 17518-17521 Chemical denotes HCQ MESH:D006886
1158 17532-17544 Chemical denotes azithromycin MESH:D017963
1159 17908-17911 Chemical denotes HCQ MESH:D006886
1160 17952-17962 Chemical denotes macrolides MESH:D018942
1161 17973-17985 Chemical denotes azithromycin MESH:D017963
1162 17990-18004 Chemical denotes clarithromycin MESH:D017291
1163 18131-18133 Chemical denotes CQ MESH:D002738
1164 18149-18151 Chemical denotes CQ MESH:D002738
1165 18159-18168 Chemical denotes macrolide MESH:D018942
1166 18184-18187 Chemical denotes HCQ MESH:D006886
1167 18206-18209 Chemical denotes HCQ MESH:D006886
1168 18217-18226 Chemical denotes macrolide MESH:D018942
1169 18391-18393 Chemical denotes CQ MESH:D002738
1170 18411-18413 Chemical denotes CQ MESH:D002738
1171 18421-18430 Chemical denotes macrolide MESH:D018942
1172 18448-18451 Chemical denotes HCQ MESH:D006886
1173 18472-18475 Chemical denotes HCQ MESH:D006886
1174 18489-18498 Chemical denotes macrolide MESH:D018942
1175 18653-18655 Chemical denotes CQ MESH:D002738
1176 18670-18672 Chemical denotes CQ MESH:D002738
1177 18680-18689 Chemical denotes macrolide MESH:D018942
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1179 18725-18728 Chemical denotes HCQ MESH:D006886
1180 18736-18745 Chemical denotes macrolide MESH:D018942
1181 18880-18882 Chemical denotes CQ MESH:D002738
1182 18886-18889 Chemical denotes HCQ MESH:D006886
1183 18924-18933 Chemical denotes macrolide MESH:D018942
1184 19183-19186 Chemical denotes HCQ MESH:D006886
1185 19201-19213 Chemical denotes azithromycin MESH:D017963
1186 19418-19421 Chemical denotes HCQ MESH:D006886
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1189 19444-19456 Chemical denotes azithromycin MESH:D017963
1190 19460-19474 Chemical denotes clarithromycin MESH:D017291
1191 14161-14169 Disease denotes COVID-19 MESH:C000657245
1192 14941-14957 Disease denotes critical illness MESH:D016638
1193 15136-15144 Disease denotes COVID-19 MESH:C000657245
1194 15418-15422 Disease denotes died MESH:D003643
1195 15430-15446 Disease denotes critical illness MESH:D016638
1196 16284-16289 Disease denotes death MESH:D003643
1197 16488-16496 Disease denotes COVID-19 MESH:C000657245
1198 16584-16593 Disease denotes mortality MESH:D003643
1199 16919-16927 Disease denotes COVID-19 MESH:C000657245
1200 17178-17187 Disease denotes mortality MESH:D003643
1201 17463-17472 Disease denotes mortality MESH:D003643
1202 17680-17689 Disease denotes mortality MESH:D003643
1203 17736-17742 Disease denotes deaths MESH:D003643
1204 18023-18031 Disease denotes COVID-19 MESH:C000657245
1205 18352-18361 Disease denotes mortality MESH:D003643
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1207 18805-18827 Disease denotes ventricular arrhythmia MESH:D001145
1208 18991-18996 Disease denotes death MESH:D003643
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1210 19585-19595 Disease denotes arrhythmia MESH:D001145
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1234 19702-19710 Species denotes patients Tax:9606
1235 19755-19763 Species denotes patients Tax:9606
1236 19935-19943 Species denotes patients Tax:9606
1237 19644-19650 Chemical denotes CQ/HCQ
1238 19828-19834 Chemical denotes CQ/HCQ
1239 19979-19982 Chemical denotes HCQ MESH:D006886
1240 19986-19988 Chemical denotes CQ MESH:D002738
1241 19993-20003 Chemical denotes macrolides MESH:D018942
1242 20005-20017 Chemical denotes azithromycin MESH:D017963
1243 20021-20035 Chemical denotes clarithromycin MESH:D017291
1244 20127-20129 Chemical denotes CQ MESH:D002738
1245 20130-20133 Chemical denotes HCQ MESH:D006886
1246 20518-20520 Chemical denotes CQ MESH:D002738
1247 20521-20524 Chemical denotes HCQ MESH:D006886
1248 20556-20562 Chemical denotes CQ/HCQ
1249 20592-20602 Chemical denotes macrolides MESH:D018942
1250 19693-19701 Disease denotes COVID-19 MESH:C000657245
1251 19913-19922 Disease denotes mortality MESH:D003643
1252 19926-19934 Disease denotes COVID-19 MESH:C000657245
1253 20147-20155 Disease denotes COVID-19 MESH:C000657245
1254 20651-20659 Disease denotes COVID-19 MESH:C000657245
1255 20829-20837 Disease denotes COVID-19 MESH:C000657245
552 25-31 Chemical denotes CQ/HCQ
553 52-60 Disease denotes COVID-19 MESH:C000657245
641 5061-5065 Gene denotes IL-6 Gene:3569
642 1534-1542 Species denotes Patients Tax:9606
643 1890-1898 Species denotes patients Tax:9606
644 3465-3473 Species denotes patients Tax:9606
645 3807-3815 Species denotes patients Tax:9606
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647 5032-5040 Species denotes patients Tax:9606
648 5154-5162 Species denotes patients Tax:9606
649 5226-5234 Species denotes patients Tax:9606
657 1643-1645 Chemical denotes CQ MESH:D002738
658 1681-1683 Chemical denotes CQ MESH:D002738
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661 2082-2084 Chemical denotes CQ MESH:D002738
662 2127-2129 Chemical denotes CQ MESH:D002738
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664 2512-2515 Chemical denotes HCQ MESH:D006886
665 2553-2556 Chemical denotes HCQ MESH:D006886
666 2589-2592 Chemical denotes HCQ MESH:D006886
667 2821-2824 Chemical denotes HCQ MESH:D006886
668 2862-2865 Chemical denotes HCQ MESH:D006886
669 3011-3014 Chemical denotes HCQ MESH:D006886
670 3055-3058 Chemical denotes HCQ MESH:D006886
671 3257-3260 Chemical denotes HCQ MESH:D006886
672 3299-3302 Chemical denotes HCQ MESH:D006886
673 3405-3408 Chemical denotes HCQ MESH:D006886
674 3760-3763 Chemical denotes HCQ MESH:D006886
675 3854-3857 Chemical denotes HCQ MESH:D006886
676 4248-4251 Chemical denotes HCQ MESH:D006886
677 4271-4274 Chemical denotes HCQ MESH:D006886
678 4290-4293 Chemical denotes HCQ MESH:D006886
679 4390-4393 Chemical denotes HCQ MESH:D006886
680 4789-4792 Chemical denotes HCQ MESH:D006886
681 4811-4814 Chemical denotes HCQ MESH:D006886
682 4830-4833 Chemical denotes HCQ MESH:D006886
683 4891-4894 Chemical denotes HCQ MESH:D006886
684 4933-4936 Chemical denotes HCQ MESH:D006886
685 4944-4947 Chemical denotes HCQ MESH:D006886
686 5300-5303 Chemical denotes HCQ MESH:D006886
687 5319-5322 Chemical denotes HCQ MESH:D006886
688 16243-16255 Chemical denotes azithromycin MESH:D017963
689 20521-20524 Chemical denotes HCQ MESH:D006886
705 1723-1732 Disease denotes pneumonia MESH:D011014
706 2190-2199 Disease denotes mortality MESH:D003643
707 2337-2345 Disease denotes COVID-19 MESH:C000657245
708 2646-2651 Disease denotes cough MESH:D003371
709 2776-2781 Disease denotes cough MESH:D003371
710 2953-2958 Disease denotes death MESH:D003643
711 3496-3504 Disease denotes COVID-19 MESH:C000657245
712 4452-4457 Disease denotes death MESH:D003643
713 4995-5004 Disease denotes mortality MESH:D003643
714 5008-5022 Disease denotes critically ill MESH:D016638
715 5023-5031 Disease denotes COVID-19 MESH:C000657245
716 5073-5082 Disease denotes Mortality MESH:D003643
717 5139-5153 Disease denotes critically ill MESH:D016638
733 1429-1440 Chemical denotes chloroquine MESH:D002738
734 1442-1444 Chemical denotes CQ MESH:D002738
735 1446-1464 Chemical denotes hydroxychloroquine MESH:D006886
736 1466-1469 Chemical denotes HCQ MESH:D006886
737 1492-1500 Disease denotes COVID-19 MESH:C000657245
760 141-149 Species denotes patients Tax:9606
761 202-210 Species denotes patients Tax:9606
762 466-474 Species denotes patients Tax:9606
763 557-564 Species denotes patient Tax:9606
764 755-763 Species denotes patients Tax:9606
765 806-814 Species denotes patients Tax:9606
766 876-884 Species denotes patients Tax:9606
767 1354-1362 Species denotes patients Tax:9606
768 126-128 Chemical denotes CQ MESH:D002738
769 176-178 Chemical denotes CQ MESH:D002738
770 242-244 Chemical denotes CQ MESH:D002738
771 834-836 Chemical denotes CQ MESH:D002738
772 903-905 Chemical denotes CQ MESH:D002738
773 1299-1301 Chemical denotes CQ MESH:D002738
774 132-140 Disease denotes COVID-19 MESH:C000657245
775 216-224 Disease denotes COVID-19 MESH:C000657245
776 298-324 Disease denotes deterioration of pneumonia MESH:D011014
777 746-754 Disease denotes COVID-19 MESH:C000657245
778 982-991 Disease denotes mortality MESH:D003643
779 1142-1172 Disease denotes QT (QTc) interval prolongation MESH:D008133
780 1339-1353 Disease denotes critically ill MESH:D016638
781 1368-1376 Disease denotes COVID-19 MESH:C000657245
871 13090-13094 Gene denotes IL-6 Gene:3569
872 8997-9005 Species denotes patients Tax:9606
873 9429-9437 Species denotes patients Tax:9606
912 10823-10826 Chemical denotes HCQ MESH:D006886
874 9470-9478 Species denotes patients Tax:9606
875 9834-9842 Species denotes patients Tax:9606
876 10321-10329 Species denotes patients Tax:9606
877 10391-10399 Species denotes patients Tax:9606
878 10531-10539 Species denotes patients Tax:9606
879 10695-10703 Species denotes patients Tax:9606
880 10888-10896 Species denotes patients Tax:9606
881 11164-11172 Species denotes patients Tax:9606
882 11220-11228 Species denotes patients Tax:9606
883 11261-11269 Species denotes patients Tax:9606
884 11616-11624 Species denotes patients Tax:9606
885 11996-12004 Species denotes patients Tax:9606
886 12203-12211 Species denotes patients Tax:9606
887 12544-12552 Species denotes patients Tax:9606
888 12614-12622 Species denotes patients Tax:9606
889 12738-12746 Species denotes patients Tax:9606
890 12826-12834 Species denotes patients Tax:9606
891 13417-13425 Species denotes patients Tax:9606
892 13535-13543 Species denotes patients Tax:9606
893 13642-13650 Species denotes patients Tax:9606
894 13751-13759 Species denotes patients Tax:9606
895 13929-13937 Species denotes patients Tax:9606
896 8854-8857 Chemical denotes HCQ MESH:D006886
897 8947-8950 Chemical denotes HCQ MESH:D006886
898 9015-9018 Chemical denotes HCQ MESH:D006886
899 9113-9116 Chemical denotes HCQ MESH:D006886
900 9238-9241 Chemical denotes HCQ MESH:D006886
901 9345-9348 Chemical denotes HCQ MESH:D006886
902 9449-9452 Chemical denotes HCQ MESH:D006886
903 10012-10015 Chemical denotes HCQ MESH:D006886
904 10370-10376 Chemical denotes oxygen MESH:D010100
905 10409-10412 Chemical denotes HCQ MESH:D006886
906 10456-10459 Chemical denotes HCQ MESH:D006886
907 10486-10489 Chemical denotes HCQ MESH:D006886
908 10661-10664 Chemical denotes HCQ MESH:D006886
909 10678-10681 Chemical denotes HCQ MESH:D006886
910 10711-10714 Chemical denotes HCQ MESH:D006886
911 10741-10744 Chemical denotes HCQ MESH:D006886
913 11157-11160 Chemical denotes HCQ MESH:D006886
914 11279-11282 Chemical denotes HCQ MESH:D006886
915 11555-11558 Chemical denotes HCQ MESH:D006886
916 11719-11722 Chemical denotes HCQ MESH:D006886
917 12068-12071 Chemical denotes HCQ MESH:D006886
918 12221-12224 Chemical denotes HCQ MESH:D006886
919 12391-12394 Chemical denotes HCQ MESH:D006886
920 12563-12566 Chemical denotes HCQ MESH:D006886
921 12699-12702 Chemical denotes HCQ MESH:D006886
922 12889-12892 Chemical denotes HCQ MESH:D006886
923 12980-12983 Chemical denotes HCQ MESH:D006886
924 13022-13025 Chemical denotes HCQ MESH:D006886
925 13102-13105 Chemical denotes HCQ MESH:D006886
926 13314-13317 Chemical denotes HCQ MESH:D006886
927 13523-13526 Chemical denotes HCQ MESH:D006886
928 13601-13604 Chemical denotes HCQ MESH:D006886
929 13708-13711 Chemical denotes HCQ MESH:D006886
930 13867-13870 Chemical denotes HCQ MESH:D006886
931 13980-13983 Chemical denotes HCQ MESH:D006886
932 8879-8887 Disease denotes COVID-19 MESH:C000657245
933 8969-8977 Disease denotes COVID-19 MESH:C000657245
934 9201-9206 Disease denotes cough MESH:D003371
935 9328-9337 Disease denotes pneumonia MESH:D011014
936 9508-9513 Disease denotes cough MESH:D003371
937 9546-9551 Disease denotes cough MESH:D003371
938 9781-9789 Disease denotes COVID-19 MESH:C000657245
939 10064-10072 Disease denotes COVID-19 MESH:C000657245
940 10347-10355 Disease denotes COVID-19 MESH:C000657245
941 10566-10570 Disease denotes died MESH:D003643
942 10599-10603 Disease denotes ARDS MESH:D012128
943 10853-10861 Disease denotes COVID-19 MESH:C000657245
944 10870-10887 Disease denotes hypoxic pneumonia MESH:D011014
945 11202-11210 Disease denotes COVID-19 MESH:C000657245
946 11647-11655 Disease denotes COVID-19 MESH:C000657245
947 12175-12183 Disease denotes COVID-19 MESH:C000657245
948 12455-12460 Disease denotes death MESH:D003643
949 12723-12737 Disease denotes critically ill MESH:D016638
950 12752-12760 Disease denotes COVID-19 MESH:C000657245
951 12778-12786 Disease denotes toxicity MESH:D064420
952 13402-13416 Disease denotes critically ill MESH:D016638
953 13431-13439 Disease denotes COVID-19 MESH:C000657245
954 13661-13669 Disease denotes COVID-19 MESH:C000657245
955 13742-13750 Disease denotes COVID-19 MESH:C000657245
956 13812-13817 Disease denotes death MESH:D003643
957 13900-13909 Disease denotes mortality MESH:D003643
958 13920-13928 Disease denotes COVID-19 MESH:C000657245
959 14027-14032 Disease denotes death MESH:D003643

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1214 5061-5065 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T1258 13090-13094 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T115 406-413 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T116 1814-1828 http://purl.obolibrary.org/obo/OGMS_0000063 denotes disease course
T117 1814-1821 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T118 3372-3379 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T119 3396-3403 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T120 3738-3747 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T121 3861-3868 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T122 5498-5503 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T123 5532-5537 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T124 9586-9594 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T125 9853-9861 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T126 11362-11369 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T127 11390-11397 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T128 11699-11708 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T129 11742-11749 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T130 11781-11790 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T131 12079-12086 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T132 12532-12540 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T133 13355-13366 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T134 14511-14516 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T135 14566-14571 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T136 15348-15356 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T137 15663-15668 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T138 18320-18327 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T139 19254-19261 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T140 19875-19882 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T104 336-340 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T105 1758-1762 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T106 2625-2629 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T107 4068-4071 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T108 4102-4125 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T109 5061-5063 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T110 5921-5932 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T111 6008-6019 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878
T112 11821-11824 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T113 11856-11879 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T114 13081-13089 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T115 13090-13092 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T116 15457-15468 Body_part denotes nasopharynx http://purl.org/sig/ont/fma/fma54878

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T4 336-340 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T5 1758-1762 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T6 5921-5932 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx
T7 6008-6019 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx
T8 15457-15468 http://purl.obolibrary.org/obo/MAT_0000447 denotes nasopharynx

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T64 2953-2958 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T65 4452-4457 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T66 7777-7782 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T67 8650-8655 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T68 12455-12460 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T69 13338-13366 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T70 13349-13366 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T71 13349-13366 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T72 13812-13817 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T73 14027-14032 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T74 16284-16289 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T75 18991-18996 http://purl.obolibrary.org/obo/GO_0016265 denotes death

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T86 52-60 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 132-140 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T88 216-224 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 315-324 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T90 746-754 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 1368-1376 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 1492-1500 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 1723-1732 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T94 2337-2345 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 3496-3504 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 5023-5031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T97 6416-6424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T98 8392-8400 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 8579-8589 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T100 8879-8887 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T101 8969-8977 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 9328-9337 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T103 9781-9789 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 10064-10072 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 10347-10355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 10599-10603 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T107 10853-10861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 10878-10887 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T109 11202-11210 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 11647-11655 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T111 12175-12183 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 12752-12760 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 13431-13439 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 13661-13669 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 13742-13750 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 13920-13928 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 14161-14169 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 15136-15144 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 16488-16496 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 16919-16927 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 18023-18031 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 18817-18827 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T123 19034-19045 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T124 19585-19595 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T125 19693-19701 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 19926-19934 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 20147-20155 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 20651-20659 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 20829-20837 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T11 315-324 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T12 1723-1732 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 2646-2651 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T14 2776-2781 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T15 8579-8589 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T16 9201-9206 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T17 9328-9337 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 9508-9513 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T19 9546-9551 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T20 10878-10887 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T21 18805-18827 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T22 19022-19045 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T23 19585-19595 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T60 4184-4189 http://purl.obolibrary.org/obo/GO_0071878 denotes false
T61 4184-4189 http://purl.obolibrary.org/obo/GO_0071877 denotes false
T62 11938-11943 http://purl.obolibrary.org/obo/GO_0071878 denotes false
T63 11938-11943 http://purl.obolibrary.org/obo/GO_0071877 denotes false
T64 13338-13366 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T65 13349-13366 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T66 13349-13366 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T60 13338-13366 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T61 13349-13366 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T62 13349-13366 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
552 25-31 Chemical denotes CQ/HCQ
553 52-60 Disease denotes COVID-19 MESH:C000657245
641 5061-5065 Gene denotes IL-6 Gene:3569
642 1534-1542 Species denotes Patients Tax:9606
643 1890-1898 Species denotes patients Tax:9606
644 3465-3473 Species denotes patients Tax:9606
645 3807-3815 Species denotes patients Tax:9606
646 3985-3993 Species denotes patients Tax:9606
647 5032-5040 Species denotes patients Tax:9606
648 5154-5162 Species denotes patients Tax:9606
649 5226-5234 Species denotes patients Tax:9606
657 1643-1645 Chemical denotes CQ MESH:D002738
658 1681-1683 Chemical denotes CQ MESH:D002738
659 2030-2032 Chemical denotes CQ MESH:D002738
660 2056-2058 Chemical denotes CQ MESH:D002738
661 2082-2084 Chemical denotes CQ MESH:D002738
662 2127-2129 Chemical denotes CQ MESH:D002738
663 2305-2307 Chemical denotes CQ MESH:D002738
664 2512-2515 Chemical denotes HCQ MESH:D006886
665 2553-2556 Chemical denotes HCQ MESH:D006886
666 2589-2592 Chemical denotes HCQ MESH:D006886
667 2821-2824 Chemical denotes HCQ MESH:D006886
668 2862-2865 Chemical denotes HCQ MESH:D006886
669 3011-3014 Chemical denotes HCQ MESH:D006886
670 3055-3058 Chemical denotes HCQ MESH:D006886
671 3257-3260 Chemical denotes HCQ MESH:D006886
672 3299-3302 Chemical denotes HCQ MESH:D006886
673 3405-3408 Chemical denotes HCQ MESH:D006886
674 3760-3763 Chemical denotes HCQ MESH:D006886
675 3854-3857 Chemical denotes HCQ MESH:D006886
676 4248-4251 Chemical denotes HCQ MESH:D006886
677 4271-4274 Chemical denotes HCQ MESH:D006886
678 4290-4293 Chemical denotes HCQ MESH:D006886
679 4390-4393 Chemical denotes HCQ MESH:D006886
680 4789-4792 Chemical denotes HCQ MESH:D006886
681 4811-4814 Chemical denotes HCQ MESH:D006886
682 4830-4833 Chemical denotes HCQ MESH:D006886
683 4891-4894 Chemical denotes HCQ MESH:D006886
684 4933-4936 Chemical denotes HCQ MESH:D006886
685 4944-4947 Chemical denotes HCQ MESH:D006886
686 5300-5303 Chemical denotes HCQ MESH:D006886
687 5319-5322 Chemical denotes HCQ MESH:D006886
688 16243-16255 Chemical denotes azithromycin MESH:D017963
705 1723-1732 Disease denotes pneumonia MESH:D011014
706 2190-2199 Disease denotes mortality MESH:D003643
707 2337-2345 Disease denotes COVID-19 MESH:C000657245
708 2646-2651 Disease denotes cough MESH:D003371
709 2776-2781 Disease denotes cough MESH:D003371
710 2953-2958 Disease denotes death MESH:D003643
711 3496-3504 Disease denotes COVID-19 MESH:C000657245
712 4452-4457 Disease denotes death MESH:D003643
713 4995-5004 Disease denotes mortality MESH:D003643
714 5008-5022 Disease denotes critically ill MESH:D016638
715 5023-5031 Disease denotes COVID-19 MESH:C000657245
716 5073-5082 Disease denotes Mortality MESH:D003643
717 5139-5153 Disease denotes critically ill MESH:D016638
733 1429-1440 Chemical denotes chloroquine MESH:D002738
734 1442-1444 Chemical denotes CQ MESH:D002738
735 1446-1464 Chemical denotes hydroxychloroquine MESH:D006886
736 1466-1469 Chemical denotes HCQ MESH:D006886
737 1492-1500 Disease denotes COVID-19 MESH:C000657245
760 141-149 Species denotes patients Tax:9606
761 202-210 Species denotes patients Tax:9606
762 466-474 Species denotes patients Tax:9606
763 557-564 Species denotes patient Tax:9606
764 755-763 Species denotes patients Tax:9606
765 806-814 Species denotes patients Tax:9606
766 876-884 Species denotes patients Tax:9606
767 1354-1362 Species denotes patients Tax:9606
768 126-128 Chemical denotes CQ MESH:D002738
769 176-178 Chemical denotes CQ MESH:D002738
770 242-244 Chemical denotes CQ MESH:D002738
771 834-836 Chemical denotes CQ MESH:D002738
772 903-905 Chemical denotes CQ MESH:D002738
773 1299-1301 Chemical denotes CQ MESH:D002738
774 132-140 Disease denotes COVID-19 MESH:C000657245
775 216-224 Disease denotes COVID-19 MESH:C000657245
776 298-324 Disease denotes deterioration of pneumonia MESH:D011014
777 746-754 Disease denotes COVID-19 MESH:C000657245
778 982-991 Disease denotes mortality MESH:D003643
779 1142-1172 Disease denotes QT (QTc) interval prolongation MESH:D008133
780 1339-1353 Disease denotes critically ill MESH:D016638
781 1368-1376 Disease denotes COVID-19 MESH:C000657245
871 13090-13094 Gene denotes IL-6 Gene:3569
872 8997-9005 Species denotes patients Tax:9606
873 9429-9437 Species denotes patients Tax:9606
874 9470-9478 Species denotes patients Tax:9606
875 9834-9842 Species denotes patients Tax:9606
876 10321-10329 Species denotes patients Tax:9606
877 10391-10399 Species denotes patients Tax:9606
878 10531-10539 Species denotes patients Tax:9606
879 10695-10703 Species denotes patients Tax:9606
880 10888-10896 Species denotes patients Tax:9606
881 11164-11172 Species denotes patients Tax:9606
882 11220-11228 Species denotes patients Tax:9606
883 11261-11269 Species denotes patients Tax:9606
884 11616-11624 Species denotes patients Tax:9606
885 11996-12004 Species denotes patients Tax:9606
886 12203-12211 Species denotes patients Tax:9606
887 12544-12552 Species denotes patients Tax:9606
888 12614-12622 Species denotes patients Tax:9606
889 12738-12746 Species denotes patients Tax:9606
890 12826-12834 Species denotes patients Tax:9606
891 13417-13425 Species denotes patients Tax:9606
892 13535-13543 Species denotes patients Tax:9606
893 13642-13650 Species denotes patients Tax:9606
894 13751-13759 Species denotes patients Tax:9606
895 13929-13937 Species denotes patients Tax:9606
896 8854-8857 Chemical denotes HCQ MESH:D006886
897 8947-8950 Chemical denotes HCQ MESH:D006886
898 9015-9018 Chemical denotes HCQ MESH:D006886
899 9113-9116 Chemical denotes HCQ MESH:D006886
900 9238-9241 Chemical denotes HCQ MESH:D006886
901 9345-9348 Chemical denotes HCQ MESH:D006886
902 9449-9452 Chemical denotes HCQ MESH:D006886
903 10012-10015 Chemical denotes HCQ MESH:D006886
904 10370-10376 Chemical denotes oxygen MESH:D010100
905 10409-10412 Chemical denotes HCQ MESH:D006886
906 10456-10459 Chemical denotes HCQ MESH:D006886
907 10486-10489 Chemical denotes HCQ MESH:D006886
908 10661-10664 Chemical denotes HCQ MESH:D006886
909 10678-10681 Chemical denotes HCQ MESH:D006886
910 10711-10714 Chemical denotes HCQ MESH:D006886
911 10741-10744 Chemical denotes HCQ MESH:D006886
912 10823-10826 Chemical denotes HCQ MESH:D006886
913 11157-11160 Chemical denotes HCQ MESH:D006886
914 11279-11282 Chemical denotes HCQ MESH:D006886
915 11555-11558 Chemical denotes HCQ MESH:D006886
916 11719-11722 Chemical denotes HCQ MESH:D006886
917 12068-12071 Chemical denotes HCQ MESH:D006886
918 12221-12224 Chemical denotes HCQ MESH:D006886
919 12391-12394 Chemical denotes HCQ MESH:D006886
920 12563-12566 Chemical denotes HCQ MESH:D006886
921 12699-12702 Chemical denotes HCQ MESH:D006886
922 12889-12892 Chemical denotes HCQ MESH:D006886
923 12980-12983 Chemical denotes HCQ MESH:D006886
924 13022-13025 Chemical denotes HCQ MESH:D006886
925 13102-13105 Chemical denotes HCQ MESH:D006886
926 13314-13317 Chemical denotes HCQ MESH:D006886
927 13523-13526 Chemical denotes HCQ MESH:D006886
928 13601-13604 Chemical denotes HCQ MESH:D006886
929 13708-13711 Chemical denotes HCQ MESH:D006886
930 13867-13870 Chemical denotes HCQ MESH:D006886
931 13980-13983 Chemical denotes HCQ MESH:D006886
932 8879-8887 Disease denotes COVID-19 MESH:C000657245
933 8969-8977 Disease denotes COVID-19 MESH:C000657245
934 9201-9206 Disease denotes cough MESH:D003371
935 9328-9337 Disease denotes pneumonia MESH:D011014
936 9508-9513 Disease denotes cough MESH:D003371
937 9546-9551 Disease denotes cough MESH:D003371
938 9781-9789 Disease denotes COVID-19 MESH:C000657245
939 10064-10072 Disease denotes COVID-19 MESH:C000657245
940 10347-10355 Disease denotes COVID-19 MESH:C000657245
941 10566-10570 Disease denotes died MESH:D003643
942 10599-10603 Disease denotes ARDS MESH:D012128
943 10853-10861 Disease denotes COVID-19 MESH:C000657245
944 10870-10887 Disease denotes hypoxic pneumonia MESH:D011014
945 11202-11210 Disease denotes COVID-19 MESH:C000657245
946 11647-11655 Disease denotes COVID-19 MESH:C000657245
947 12175-12183 Disease denotes COVID-19 MESH:C000657245
948 12455-12460 Disease denotes death MESH:D003643
949 12723-12737 Disease denotes critically ill MESH:D016638
950 12752-12760 Disease denotes COVID-19 MESH:C000657245
951 12778-12786 Disease denotes toxicity MESH:D064420
952 13402-13416 Disease denotes critically ill MESH:D016638
953 13431-13439 Disease denotes COVID-19 MESH:C000657245
954 13661-13669 Disease denotes COVID-19 MESH:C000657245
955 13742-13750 Disease denotes COVID-19 MESH:C000657245
956 13812-13817 Disease denotes death MESH:D003643
957 13900-13909 Disease denotes mortality MESH:D003643
958 13920-13928 Disease denotes COVID-19 MESH:C000657245
959 14027-14032 Disease denotes death MESH:D003643
1086 14253-14265 Species denotes participants Tax:9606
1087 14270-14278 Species denotes patients Tax:9606
1088 14879-14887 Species denotes patients Tax:9606
1089 15145-15153 Species denotes patients Tax:9606
1090 15329-15337 Species denotes patients Tax:9606
1091 15387-15394 Species denotes patient Tax:9606
1092 15488-15496 Species denotes patients Tax:9606
1093 15641-15649 Species denotes patients Tax:9606
1094 15954-15962 Species denotes patients Tax:9606
1095 15967-15975 Species denotes patients Tax:9606
1096 15994-16002 Species denotes patients Tax:9606
1097 16039-16047 Species denotes patients Tax:9606
1098 16461-16469 Species denotes patients Tax:9606
1099 16513-16521 Species denotes patients Tax:9606
1100 16660-16663 Species denotes men Tax:9606
1101 16758-16766 Species denotes patients Tax:9606
1102 16928-16936 Species denotes patients Tax:9606
1103 16987-16995 Species denotes patients Tax:9606
1104 17196-17204 Species denotes patients Tax:9606
1105 17380-17388 Species denotes patients Tax:9606
1106 17482-17490 Species denotes patients Tax:9606
1107 17605-17613 Species denotes patients Tax:9606
1108 17748-17756 Species denotes patients Tax:9606
1109 18069-18077 Species denotes patients Tax:9606
1110 18236-18244 Species denotes patients Tax:9606
1111 19085-19093 Species denotes patients Tax:9606
1112 14099-14101 Chemical denotes CQ MESH:D002738
1113 14105-14108 Chemical denotes HCQ MESH:D006886
1114 14131-14140 Chemical denotes macrolide MESH:D018942
1115 14290-14293 Chemical denotes HCQ MESH:D006886
1116 14334-14346 Chemical denotes azithromycin MESH:D017963
1117 14422-14425 Chemical denotes HCQ MESH:D006886
1118 14455-14467 Chemical denotes azithromycin MESH:D017963
1119 14591-14594 Chemical denotes HCQ MESH:D006886
1120 14609-14621 Chemical denotes azithromycin MESH:D017963
1121 14623-14626 Chemical denotes HCQ MESH:D006886
1122 14754-14766 Chemical denotes azithromycin MESH:D017963
1123 14771-14774 Chemical denotes HCQ MESH:D006886
1124 14895-14898 Chemical denotes HCQ MESH:D006886
1125 15180-15183 Chemical denotes HCQ MESH:D006886
1126 15237-15249 Chemical denotes azithromycin MESH:D017963
1127 15886-15889 Chemical denotes HCQ MESH:D006886
1128 15904-15916 Chemical denotes azithromycin MESH:D017963
1129 15985-15988 Chemical denotes HCQ MESH:D006886
1130 16012-16015 Chemical denotes HCQ MESH:D006886
1131 16018-16030 Chemical denotes azithromycin MESH:D017963
1132 16060-16063 Chemical denotes HCQ MESH:D006886
1133 16123-16126 Chemical denotes HCQ MESH:D006886
1134 16128-16131 Chemical denotes HCQ MESH:D006886
1135 16132-16144 Chemical denotes azithromycin MESH:D017963
1136 16152-16155 Chemical denotes HCQ MESH:D006886
1137 16210-16216 Chemical denotes theHCQ
1138 16239-16242 Chemical denotes HCQ MESH:D006886
1140 16316-16319 Chemical denotes HCQ MESH:D006886
1141 16373-16376 Chemical denotes HCQ MESH:D006886
1142 16401-16413 Chemical denotes azithromycin MESH:D017963
1143 16535-16538 Chemical denotes HCQ MESH:D006886
1144 16780-16783 Chemical denotes HCQ MESH:D006886
1145 16787-16799 Chemical denotes azithromycin MESH:D017963
1146 17010-17013 Chemical denotes HCQ MESH:D006886
1147 17018-17030 Chemical denotes azithromycin MESH:D017963
1148 17045-17048 Chemical denotes HCQ MESH:D006886
1149 17069-17081 Chemical denotes azithromycin MESH:D017963
1150 17119-17122 Chemical denotes HCQ MESH:D006886
1151 17126-17138 Chemical denotes azithromycin MESH:D017963
1152 17215-17219 Chemical denotes HCQ＋ MESH:D006886
1153 17219-17231 Chemical denotes azithromycin MESH:D017963
1154 17243-17246 Chemical denotes HCQ MESH:D006886
1155 17264-17276 Chemical denotes azithromycin MESH:D017963
1156 17504-17516 Chemical denotes azithromycin MESH:D017963
1157 17518-17521 Chemical denotes HCQ MESH:D006886
1158 17532-17544 Chemical denotes azithromycin MESH:D017963
1159 17908-17911 Chemical denotes HCQ MESH:D006886
1160 17952-17962 Chemical denotes macrolides MESH:D018942
1161 17973-17985 Chemical denotes azithromycin MESH:D017963
1162 17990-18004 Chemical denotes clarithromycin MESH:D017291
1163 18131-18133 Chemical denotes CQ MESH:D002738
1164 18149-18151 Chemical denotes CQ MESH:D002738
1165 18159-18168 Chemical denotes macrolide MESH:D018942
1166 18184-18187 Chemical denotes HCQ MESH:D006886
1167 18206-18209 Chemical denotes HCQ MESH:D006886
1168 18217-18226 Chemical denotes macrolide MESH:D018942
1169 18391-18393 Chemical denotes CQ MESH:D002738
1170 18411-18413 Chemical denotes CQ MESH:D002738
1171 18421-18430 Chemical denotes macrolide MESH:D018942
1172 18448-18451 Chemical denotes HCQ MESH:D006886
1173 18472-18475 Chemical denotes HCQ MESH:D006886
1174 18489-18498 Chemical denotes macrolide MESH:D018942
1175 18653-18655 Chemical denotes CQ MESH:D002738
1176 18670-18672 Chemical denotes CQ MESH:D002738
1177 18680-18689 Chemical denotes macrolide MESH:D018942
1178 18704-18707 Chemical denotes HCQ MESH:D006886
1179 18725-18728 Chemical denotes HCQ MESH:D006886
1180 18736-18745 Chemical denotes macrolide MESH:D018942
1181 18880-18882 Chemical denotes CQ MESH:D002738
1182 18886-18889 Chemical denotes HCQ MESH:D006886
1183 18924-18933 Chemical denotes macrolide MESH:D018942
1184 19183-19186 Chemical denotes HCQ MESH:D006886
1185 19201-19213 Chemical denotes azithromycin MESH:D017963
1186 19418-19421 Chemical denotes HCQ MESH:D006886
1187 19425-19427 Chemical denotes CQ MESH:D002738
1188 19432-19442 Chemical denotes macrolides MESH:D018942
1189 19444-19456 Chemical denotes azithromycin MESH:D017963
1190 19460-19474 Chemical denotes clarithromycin MESH:D017291
1191 14161-14169 Disease denotes COVID-19 MESH:C000657245
1192 14941-14957 Disease denotes critical illness MESH:D016638
1193 15136-15144 Disease denotes COVID-19 MESH:C000657245
1194 15418-15422 Disease denotes died MESH:D003643
1195 15430-15446 Disease denotes critical illness MESH:D016638
1196 16284-16289 Disease denotes death MESH:D003643
1197 16488-16496 Disease denotes COVID-19 MESH:C000657245
1198 16584-16593 Disease denotes mortality MESH:D003643
1199 16919-16927 Disease denotes COVID-19 MESH:C000657245
1200 17178-17187 Disease denotes mortality MESH:D003643
1201 17463-17472 Disease denotes mortality MESH:D003643
1202 17680-17689 Disease denotes mortality MESH:D003643
1203 17736-17742 Disease denotes deaths MESH:D003643
1204 18023-18031 Disease denotes COVID-19 MESH:C000657245
1205 18352-18361 Disease denotes mortality MESH:D003643
1206 18571-18580 Disease denotes mortality MESH:D003643
1207 18805-18827 Disease denotes ventricular arrhythmia MESH:D001145
1208 18991-18996 Disease denotes death MESH:D003643
1209 19022-19045 Disease denotes ventricular arrhythmias MESH:D001145
1210 19585-19595 Disease denotes arrhythmia MESH:D001145
1211 19612-19621 Disease denotes mortality MESH:D003643
1234 19702-19710 Species denotes patients Tax:9606
1235 19755-19763 Species denotes patients Tax:9606
1236 19935-19943 Species denotes patients Tax:9606
1237 19644-19650 Chemical denotes CQ/HCQ
1238 19828-19834 Chemical denotes CQ/HCQ
1239 19979-19982 Chemical denotes HCQ MESH:D006886
1240 19986-19988 Chemical denotes CQ MESH:D002738
1241 19993-20003 Chemical denotes macrolides MESH:D018942
1242 20005-20017 Chemical denotes azithromycin MESH:D017963
1243 20021-20035 Chemical denotes clarithromycin MESH:D017291
1244 20127-20129 Chemical denotes CQ MESH:D002738
1245 20130-20133 Chemical denotes HCQ MESH:D006886
1246 20518-20520 Chemical denotes CQ MESH:D002738
1247 20521-20524 Chemical denotes HCQ MESH:D006886
1248 20556-20562 Chemical denotes CQ/HCQ
1249 20592-20602 Chemical denotes macrolides MESH:D018942
1250 19693-19701 Disease denotes COVID-19 MESH:C000657245
1251 19913-19922 Disease denotes mortality MESH:D003643
1252 19926-19934 Disease denotes COVID-19 MESH:C000657245
1253 20147-20155 Disease denotes COVID-19 MESH:C000657245
1254 20651-20659 Disease denotes COVID-19 MESH:C000657245
1255 20829-20837 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T104 0-2 Sentence denotes 5.
T105 4-60 Sentence denotes Clinical efficacy of CQ/HCQ in the treatment of COVID-19
T106 61-160 Sentence denotes Only two published clinical reports have studied the efficacy of CQ in COVID-19 patients (Table 1).
T107 161-414 Sentence denotes One study used CQ to treat more than 100 patients with COVID-19 and claimed that CQ was superior to the control group in suppressing the deterioration of pneumonia, improving lung imaging, promoting viral conversion and shortening the course of disease.
T108 415-480 Sentence denotes Serious adverse effects were not observed in these patients [48].
T109 481-617 Sentence denotes However, this report did not provide any details about the study design and patient data, thus it is difficult to evaluate the validity.
T110 618-720 Sentence denotes Recently, a parallel, double-blind, randomized, phase IIB clinical trial was performed in Brazil [49].
T111 721-802 Sentence denotes In this study, 81 severe COVID-19 patients were randomly divided into two groups:
T112 803-970 Sentence denotes 41 patients received high-dose CQ (600 mg/2 times/day for 10 day) and 40 patients received low-dose CQ (450 mg/2 times on day 1 and then 450 mg/1 time/day for 4 days).
T113 971-1082 Sentence denotes The 13-day mortality rate in the high-dose group was more than double that in low-dose group (39.0% vs. 16.0%).
T114 1083-1259 Sentence denotes The high-dosage group exhibited more instance of corrected QT (QTc) interval prolongation (>500 milliseconds (ms); 7 of 37 [18.9%]) than the low-dosage group (4 of 36 [11.1%]).
T115 1260-1382 Sentence denotes These findings suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 [49].
T116 1383-1391 Sentence denotes Table 1.
T117 1392-1501 Sentence denotes Outcomes and advantage/limitation of chloroquine (CQ)/hydroxychloroquine (HCQ) clinical studies for COVID-19.
T118 1502-1583 Sentence denotes Author (Reference) Study design Patients Treatment Outcomes Advantage Limitations
T119 1584-1599 Sentence denotes Gao et al [48].
T120 1600-1829 Sentence denotes Rough and simple description Not mentioned CQ (No specific dosage was mentioned) CQ was superior to control in suppressing pneumonia deterioration, improving lung imaging, promoting viral conversion and shortening disease course.
T121 1830-1846 Sentence denotes Not significant.
T122 1847-1973 Sentence denotes No study design and the specific number of patients and controls were provided and thus the result appears to be unconvincing.
T123 1974-1991 Sentence denotes Borba et al [49].
T124 1992-2478 Sentence denotes Randomized controlled trial High-dose CQ group: n = 40;Low-dose CQ group:n = 41 high-dose CQ (600 mg/2 times/day, for 10 day);low-dose CQ (450 mg/2 times/day for 5 days, double dose on 1st day) The mortality rate in the high-dose group was more than double that in low-dose group Double-blind study; 2 dosages of CQ for the first time in severe COVID-19 Small sample size; single-center design; Lack of a placebo control; Lack of exclusion criteria based on the QTc interval at baseline
T125 2479-2697 Sentence denotes Chen et al.[50] Randomized trial HCQ group: n = 31; control group: n = 30 HCQ (200 mg/2 times/day for 5 days) HCQ group have small improvement in body temperature and cough compered with control group Randomized trial.
T126 2698-2782 Sentence denotes Small sample size; Single-center design; Small improvement in temperature and cough.
T127 2783-2802 Sentence denotes Mahévas et al [53].
T128 2803-3021 Sentence denotes Comparative study HCQ group: n = 84; control group: n = 97 HCQ 600 mg/day for 7 days Compared with control group, a reduction of admissions to ICU or death 7 days after hospital admission was not observed in HCQ group.
T129 3022-3088 Sentence denotes Relatively larger sample size in HCQ treatment and control groups.
T130 3089-3199 Sentence denotes Nonrandomized design; In propensity score model, four possible important prognostic variables were unbalanced.
T131 3200-3216 Sentence denotes Tang et al [54].
T132 3217-3298 Sentence denotes Open label, randomized controlled trial HCQ group: n = 70; control group: n = 80.
T133 3299-3505 Sentence denotes HCQ 1200 mg daily for 3 days, 800 mg daily for 2 weeks (mild to moderate disease)/3 weeks(severe disease) HCQ did not show additional benefits of vial elimination in patients with mild to moderate COVID-19.
T134 3506-3534 Sentence denotes Randomized controlled study.
T135 3535-3733 Sentence denotes Lack of a placebo control group; Design introduces the possibility of biased investigator determined assessment and unbalanced dosage adjustment; Randomization of sequential envelopes may be biased.
T136 3734-3917 Sentence denotes The antiviral efficacy of HCQ was not assessed at an earlier stage; Most patients are mild to severe, and the effect of HCQ on disease progression or regression could not be provided.
T137 3918-3994 Sentence denotes The trial terminated early due to the difficulty to recruit enough patients.
T138 3995-4207 Sentence denotes Some secondary endpoints could not be analyzed by the cutoff date; Viral RNA specimens are mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T139 4208-4227 Sentence denotes Geleris et al [55].
T140 4228-4471 Sentence denotes Observational study HCQ group: n = 811; no-HCQ group: n = 565 HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) No correlation between the HCQ use and significant higher or lower risk of intubation or death was observed.
T141 4472-4643 Sentence denotes Large sample size; Minimization of the unmeasured confusion and error through multivariable Cox model with inverse probability weighting according to the propensity score.
T142 4644-4753 Sentence denotes Single-center design; missing of some variables; Potential for inaccuracies in the electronic health records.
T143 4754-4768 Sentence denotes Yu et al [56].
T144 4769-4943 Sentence denotes Retrospective study HCQ group: n = 48; no-HCQ group: n = 502 HCQ (200 mg/2 times/day, for 7 to 10 days) The fatalities of HCQ group was significantly lower than no-HCQ group.
T145 4944-5072 Sentence denotes HCQ treatment was related to significantly reduced mortality in critically ill COVID-19 patients and greatly lowered IL-6 level.
T146 5073-5163 Sentence denotes Mortality was used as a measure of outcome and the study included critically ill patients.
T147 5164-5245 Sentence denotes Retrospective design of the study and the number of HCQ group patients was small.
T148 5246-5516 Sentence denotes Gautret et al.[57] Open label, nonrandom cohort study HCQ group: n = 12; HCQ＋azithromycin group: n = 6; control group: n = 12 HCQ (200 mg/3 times/day for 10 days) HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T149 5517-5578 Sentence denotes Nasopharyngeal virus determination was used as main endpoint.
T150 5579-5728 Sentence denotes Small sample size; Six patients dropped out due to critical illness or intolerance to the drug; Lack of clinical outcomes; Limited follow-up results.
T151 5729-5748 Sentence denotes Gautret et al [58].
T152 5749-5992 Sentence denotes Observational study HCQ group: n = 80; no control HCQ, 200 mg/3 times/day for 10 days combined with azithromycin 500 mg on the 1st day, 250 mg/day afterward for 5 days The nasopharynx viral load in most patients received HCQ decreased rapidly.
T153 5993-6031 Sentence denotes Observation of nasopharynx viral load.
T154 6032-6116 Sentence denotes Observational study design and no control group; No clinical outcomes were analyzed.
T155 6117-6164 Sentence denotes Possible confounding factors were not adjusted.
T156 6165-6186 Sentence denotes Magagnoli et al [59].
T157 6187-6283 Sentence denotes Retrospective study HCQ group:n = 97HCQ＋azithromycin: n = 113No HCQ group:n = 158 Not specified.
T158 6284-6506 Sentence denotes The use of HCQ, either with or without azithromycin, didn’t reduce the risk of mechanical ventilation in patients hospitalized with COVID-19; Patients treated with HCQ alone was associated with increased overall mortality.
T159 6507-6728 Sentence denotes The study data comes from a comprehensive electronic medical record; Strictly defined covariates and outcomes; Using propensity scores adjustment for a large number of relevant confounders to make results more persuasive.
T160 6729-6922 Sentence denotes Retrospective nature of the study; The subjects included only men and most of them were black; Despite adjustments to many possible confounding factors, there may still be undiscovered factors.
T161 6923-7429 Sentence denotes Rosenberg et al[60] Retrospective multicenter cohort study HCQ group:n = 271;HCQ ＋azithromycin group:n = 735control group:n = 221 HCQ:200 mg/400 mg/600 mg/other/unknown, frequency: once a day/twice a day/other/unknownazithromycin:200 mg/250 mg/400 mg/500 mg/other/unknown, methods:Oral/IV/unknown,frequency: only once/once a day/twice a day/other/unknown Treatment with HCQ, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality.
T162 7430-7512 Sentence denotes This study include a large, random sample from 25 metropolitan New York hospitals.
T163 7513-7677 Sentence denotes The sample was drawnearly in the epidemic to include patients with long, complicated, and ongoing hospital stays; In-hospital mortality was used as primary outcome.
T164 7678-7819 Sentence denotes Retrospective study design; There may be missing information; Mortality was limited to in-hospital death; There may be potential confounders.
T165 7820-7899 Sentence denotes The dosing in the doses and frequencies of HCQ and azithromycin varied greatly.
T166 7900-7959 Sentence denotes The confidence intervals for some of the findings are wide.
T167 7960-8418 Sentence denotes Mehraet al[61] Multinational real-world analysis Teatment groups: n = 14,888Control group: n = 81,144 Mean daily dose: CQ 765 mg, (SD 308); HCQ 596 mg(126); CQ with a macrolide 790 mg(320); HCQ with a macrolide 597 mg(128).mean duration:CQ 6.6 days(2.4); HCQ 4.2 days(1.9);CQ with a macrolide 6.8 days(2.5); HCQ with a macrolide 4.3 days (2.0) A benefit of HCQ or CQ, when used alone or witha macrolide, on in-hospital outcomes for COVID-19 was not observed.
T168 8419-8493 Sentence denotes Large multinational real-world data and large number of study populations.
T169 8494-8812 Sentence denotes There may be potential confounders; It did not measure QT intervals and stratify the arrhythmia pattern; It did not determine whether the increased risk of death in-hospital and use of drug treatment regimens were directly related to cardiovascular risk; It did not observe the risk of the drug dose-response analysis.
T170 8813-8898 Sentence denotes Several trials evaluated the efficacy of HCQ for the treatment of COVID-19 (Table 1).
T171 8899-9051 Sentence denotes In a randomized clinical trial from Wuhan about HCQ treatment of mild COVID-19 [50], 31 out of 62 patients received HCQ (200 mg/2 times/day for 5 days).
T172 9052-9407 Sentence denotes The results showed that the temperature recovery time in the HCQ group was improved compared with the control group (average days, 2.2 vs. 3.2); the cough relief time was shorter in the HCQ group than the control group (average days, 2.4 vs. 3.1); and the improvement rate of pneumonia in the HCQ group was higher than the control group (80.6% vs. 54.8%).
T173 9408-9570 Sentence denotes However, only 48% of patients (15/31) in HCQ group and 71% of patients (22/31) in control group had cough at baseline and the duration of cough was not described.
T174 9571-9647 Sentence denotes Improvement of symptoms were small and the trial was terminated prematurely.
T175 9648-9742 Sentence denotes These factors and the low sample size compromise the reliability of the results of this study.
T176 9743-9949 Sentence denotes Importantly, evaluation of HCQ in the COVID-19 pandemic areas have shown that HCQ can help patients with mild symptoms, and may potentially reduce transmission in areas lacking isolation facilities [51,52].
T177 9950-10134 Sentence denotes However, in areas with strict isolation standards, the use of HCQ to reduce transmission or for treatment of mild COVID-19 cases may not be beneficial in risk-benefit analysis [51,52].
T178 10135-10260 Sentence denotes Nevertheless, there is an urgent need for drugs and therapeutics in severe cases, which require randomized controlled trials.
T179 10261-10387 Sentence denotes A study from four French tertiary care centers included 181 patients hospitalized for COVID-19 and requiring oxygen (2 L/min):
T180 10388-10502 Sentence denotes 84 patients received HCQ (600 mg/day) within 48 hours of admission (HCQ group) and 97 did not (no-HCQ group) [53].
T181 10503-10688 Sentence denotes The results showed that the patients transferred to the ICU or died within 7 days and developed ARDS within 7 days had no significant differences between the HCQ group and no-HCQ group.
T182 10689-10782 Sentence denotes Eight patients in the HCQ group (9.5%) discontinued HCQ due to electrocardiogram alterations.
T183 10783-10897 Sentence denotes These results do not support the use of HCQ for treating hospitalized COVID-19-related hypoxic pneumonia patients.
T184 10898-11105 Sentence denotes It is worth noting that in the study’s propensity score model, four possible important prognostic variables were unbalanced and a center effect was not considered, which all can cause bias for study results.
T185 11106-11400 Sentence denotes In a multicenter, randomized, parallel trial about HCQ in patients with mainly mild to moderate COVID-19 [54], 80 patients received ‘standard care’ and 70 patients received HCQ (1200 mg daily for 3 days, and then 800 mg daily for 2 weeks [mild to moderate disease] or 3 weeks [severe disease]).
T186 11401-11554 Sentence denotes The results showed that the 28-days negative conversion probability in ‘standard care’＋HCQ group was 85.4%, similar to the ‘standard care’ group (81.2%).
T187 11555-11656 Sentence denotes HCQ did not show additional benefits of viral elimination in patients with mild to moderate COVID-19.
T188 11657-11801 Sentence denotes However, the study could not evaluate the antiviral effect of HCQ at early stages of disease, which is a critical period of antiviral treatment.
T189 11802-11961 Sentence denotes In addition, viral RNA specimens were mostly from the upper respiratory tract rather than bronchoalveolar lavage fluid, which may cause false negative results.
T190 11962-12113 Sentence denotes Due to the small number of severe patients, this study could not provide evidence regarding the effect of HCQ on the disease progression or regression.
T191 12114-12350 Sentence denotes In another large observational study involving 1376 cases of COVID-19 from New York, 811 patients received HCQ (600 mg/2 times on the first day, then 400 mg once a day for 4 days) within 24 or 48 hours of admission and 565 did not [55].
T192 12351-12461 Sentence denotes This study found no correlation between HCQ use and significantly higher or lower risk of intubation or death.
T193 12462-12637 Sentence denotes However, in this study, even after the propensity score-matching, the diseases in patients receiving HCQ were more severe at baseline than those in the patients not receiving.
T194 12638-12787 Sentence denotes Notably, according to another recent study [56], low dose of HCQ reduced fatality of critically ill patients with COVID-19 without apparent toxicity.
T195 12788-12957 Sentence denotes This retrospective study included 550 patients who need mechanical ventilation, of which 48 received HCQ treatment (200 mg/2 times/day for 7 to 10 days) and 502 did not.
T196 12958-13248 Sentence denotes The fatalities of the HCQ group was significantly lower than no-HCQ group (18.8% vs 47.4%, P < 0.05), and the inflammatory cytokine IL-6 in the HCQ group decreased significantly from 22.2 (8.3 to 118.9 pg/mL) at the beginning of treatment to 5.2 (3.0 to 23.4 pg/mL) at the end of treatment.
T197 13249-13440 Sentence denotes The authors deemed that the anti-inflammatory effect of low-dose HCQ and the activity of inhibiting viral replication may have important significance in critically ill patients with COVID-19.
T198 13441-13553 Sentence denotes Yet, this study is flawed due to its retrospective nature and the small number of HCQ treated patients included.
T199 13554-13818 Sentence denotes In short, some initial studies have shown that HCQ appears to have a curative effect on patients with mild COVID-19, but subsequent studies indicate that HCQ had no significant benefit in COVID-19 patients with viral conversion and the risk of intubation or death.
T200 13819-14033 Sentence denotes Although some recent studies show that low-dose HCQ could potentially reduce the mortality of severe COVID-19 patients, there are other studies showing that the HCQ use had no effect on risk of intubation or death.
T201 14034-14180 Sentence denotes There are also several reports that investigated the efficacy of CQ or HCQ in combination with a macrolide in the treatment of COVID-19 (Table 1).
T202 14181-14364 Sentence denotes In an open nonrandom clinical trial conducted in France [57], of the 36 participants, 20 patients were given HCQ (200 mg/3 times) with 6 receiving added azithromycin, and 16 controls.
T203 14365-14529 Sentence denotes The results showed that compared with the control group, HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days.
T204 14530-14699 Sentence denotes On the 6th day after treatment, the virus clearance rates of HCQ combined with azithromycin, HCQ alone and controls were 100%, 57.1% and 12.5%, respectively (P < 0.001).
T205 14700-14812 Sentence denotes This study indicated that the combined application of azithromycin and HCQ appears to have a synergistic effect.
T206 14813-15022 Sentence denotes However, the trial design and the results were unreliable, as six patients in the HCQ group discontinued treatment early due to critical illness or intolerance to the drugs and were excluded from the analysis.
T207 15023-15106 Sentence denotes The assessment of efficacy was based on viral load rather than a clinical endpoint.
T208 15107-15452 Sentence denotes An observational study in 80 COVID-19 patients evaluated the efficacy of HCQ (200 mg/3 times/day for 10 days) in combination with azithromycin (500 mg on the first day, 250 mg/day afterward for 5 days) and showed that all patients’ clinical symptoms were improved, except for one patient aged over 86 years who died due to critical illness [58].
T209 15453-15625 Sentence denotes The nasopharynx viral load in most patients decreased rapidly, and the negative rates of viral nucleic acid conversion on days 7 and 8 were about 83% and 93%, respectively.
T210 15626-15719 Sentence denotes About 97.5% of patients had negative virus culture in respiratory specimens on the fifth day.
T211 15720-15812 Sentence denotes However, this study had no control group, thus the results were difficult to interpret [58].
T212 15813-15917 Sentence denotes Some recent studies have yielded different results about the efficacy of HCQ combined with azithromycin.
T213 15918-16194 Sentence denotes A retrospective study including 368 patients (97 patients received HCQ, 113 patients received HCQ + azithromycin and 158 patients received no HCQ) from USA [59] showed that the rates of ventilation in the HCQ, HCQ+azithromycin and no HCQ groups had no significant differences.
T214 16195-16326 Sentence denotes Unfortunately, theHCQ group (but not in the HCQ+azithromycin group) had a higher risk of death from any case than the no HCQ group.
T215 16327-16497 Sentence denotes This study showed no evidence that the use of HCQ, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with COVID-19.
T216 16498-16612 Sentence denotes Noticeably, in patients treated with HCQ alone, an association with increased overall mortality was observed [59].
T217 16613-16740 Sentence denotes In this study, the subjects included were only men and most of them were black, which may affect the generality of the results.
T218 16741-16852 Sentence denotes In addition, the patients who received HCQ or azithromycin were more severe, which may also affect the results.
T219 16853-17140 Sentence denotes In a retrospective multicenter cohort study of a random sample of COVID-19 patients from 25 hospitals in New York [60], totaling 1438 patients, 735 received HCQ and azithromycin, 271 received HCQ alone, 211 received azithromycin alone and 221 received neither drug (HCQ or azithromycin).
T220 17141-17320 Sentence denotes The results showed that the hospital mortality rate of patients receiving HCQ＋azithromycin was 25.7%, HCQ alone was 19.9%, azithromycin alone was 10.0% and neither drug was 12.7%.
T221 17321-17551 Sentence denotes In adjusted Cox proportional hazards models, compared with patients receiving neither drug, there were no significant differences in hospital mortality rate for patients receiving HC＋azithromycin, HCQ alone, or azithromycin alone.
T222 17552-17666 Sentence denotes In this study, the sample size is large and includes patients with long-term, complex and ongoing hospitalization.
T223 17667-17857 Sentence denotes However, the mortality rate of this study was limited to in-hospital deaths, and patients discharged during the study period were considered alive, which may underestimate the morality rate.
T224 17858-18050 Sentence denotes Recently, a multinational registry analysis about HCQ or CQ with or without second-generation macrolides (especial azithromycin and clarithromycin) for treatment of COVID-19 was reported [61].
T225 18051-18106 Sentence denotes A total of 96,032 patients were included in this study.
T226 18107-18262 Sentence denotes Of these, 1868 received CQ, 3783 received CQ with a macrolide, 3016 received HCQ and 6221 received HCQ with a macrolide and 8114 patients as control group.
T227 18263-18595 Sentence denotes After controlling various confounding factors related to disease, when compared with the mortality in the control group (9.3%), CQ group was 16.4%, CQ with a macrolide group was 22.2%, HCQ group was 18.0% and HCQ group with a macrolide was 23.8%; each group was associated with an increased risk of hospital mortality independently.
T228 18596-18856 Sentence denotes Apart from this, compared with the control group (0.3%), CQ group (4.3%), CQ with a macrolide group (6.5%), HCQ group (6.1%) and HCQ with a macrolide group (8.1%) were independently associated with a risk for ventricular arrhythmia during hospitalization [61].
T229 18857-19046 Sentence denotes This study showed that CQ or HCQ (used alone or combination with a macrolide) was associated with an increased hazard for in-hospital death and an increased risk of ventricular arrhythmias.
T230 19047-19137 Sentence denotes This study included a large number of patients, but it is not a randomized clinical trial.
T231 19138-19355 Sentence denotes In short, some small studies have shown that HCQ combined with azithromycin could quickly and effectively eliminate viruses, but the design of these studies was flawed in many aspects, making the results unconvincing.
T232 19356-19622 Sentence denotes Several subsequent studies have shown that the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) has no obvious correlation with a reduced risk for mechanical ventilation, and may even increase the risk of arrhythmia and in-hospital mortality.
T233 19623-19944 Sentence denotes In summary, although CQ/HCQ appeared to exhibit a favorable effect on COVID-19 patients in some initial studies of small numbers of patients, the most recent studies with larger sample sizes revealed that CQ/HCQ exhibited no significant improvement of disease but even an increased overall mortality in COVID-19 patients.
T234 19945-20070 Sentence denotes The studies on the combination of HCQ or CQ and macrolides (azithromycin or clarithromycin) also showed conflicting findings.
T235 20071-20261 Sentence denotes Therefore, caution should be taken regarding the use of CQ/HCQ treatment in COVID-19 due to the uncertainty of efficacy, the potential adverse effects and the various defects in the studies.
T236 20262-20525 Sentence denotes According to the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org.cn/index.aspx) and the International Clinical Trials Registry Platform (ICTRP) (https://www.who.int/ictrp/en/), currently, there are more than 200 ongoing clinical trials for CQ/HCQ.
T237 20526-20688 Sentence denotes Current findings suggest that CQ/HCQ alone or in combination with macrolides should not be recommended for widespread use in COVID-19 (except in clinical trials).
T238 20689-20838 Sentence denotes Results from these ongoing prospective, randomized, controlled studies are required before these drugs are recommended for the treatment of COVID-19.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 315-324 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 1723-1732 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 2646-2651 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T15 2776-2781 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T16 8579-8589 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T17 9201-9206 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T18 9328-9337 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T19 9508-9513 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T20 9546-9551 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T21 10878-10887 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T22 18805-18827 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T23 19022-19045 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T24 19585-19595 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675

2_test

Id Subject Object Predicate Lexical cue
32496926-32074550-132195701 476-478 32074550 denotes 48
32496926-32074550-132195702 1595-1597 32074550 denotes 48
32496926-32409561-132195703 3212-3214 32409561 denotes 54
32496926-32409561-132195704 11212-11214 32409561 denotes 54