PMC:7441788 / 13750-13901 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T97","span":{"begin":85,"end":94},"obj":"Body_part"},{"id":"T98","span":{"begin":95,"end":98},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T162","span":{"begin":62,"end":70},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T163","span":{"begin":117,"end":134},"obj":"http://purl.obolibrary.org/obo/PR_000024990"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T175","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T176","span":{"begin":23,"end":37},"obj":"Chemical"},{"id":"T177","span":{"begin":30,"end":33},"obj":"Chemical"},{"id":"T179","span":{"begin":34,"end":37},"obj":"Chemical"},{"id":"T182","span":{"begin":95,"end":98},"obj":"Chemical"},{"id":"T183","span":{"begin":124,"end":134},"obj":"Chemical"}],"attributes":[{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_71580"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_17345"},{"id":"A178","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_58115"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_16027"},{"id":"A180","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_28971"},{"id":"A181","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_456215"},{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T112","span":{"begin":0,"end":2},"obj":"Chemical"},{"id":"T113","span":{"begin":23,"end":37},"obj":"Chemical"},{"id":"T114","span":{"begin":95,"end":98},"obj":"Chemical"}],"attributes":[{"id":"A112","pred":"chebi_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_71580"},{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T100","span":{"begin":0,"end":151},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"528","span":{"begin":23,"end":54},"obj":"Gene"},{"id":"529","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"538","span":{"begin":0,"end":3},"obj":"Chemical"},{"id":"539","span":{"begin":3,"end":6},"obj":"Chemical"}],"attributes":[{"id":"A528","pred":"pubann:denotes","subj":"528","obj":"Gene:115004"},{"id":"A529","pred":"pubann:denotes","subj":"529","obj":"Gene:115004"},{"id":"A538","pred":"pubann:denotes","subj":"538","obj":"MESH:D002738"},{"id":"A539","pred":"pubann:denotes","subj":"539","obj":"MESH:D006886"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1040","span":{"begin":38,"end":54},"obj":"Protein"},{"id":"T1052","span":{"begin":56,"end":60},"obj":"Protein"},{"id":"T1064","span":{"begin":124,"end":134},"obj":"Protein"}],"attributes":[{"id":"A1040","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q96E45"},{"id":"A1041","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q8N884"},{"id":"A1042","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q8C6L5"},{"id":"A1043","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q5SWL1"},{"id":"A1044","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q5SWL0"},{"id":"A1045","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q3ULW3"},{"id":"A1046","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q32NC9"},{"id":"A1047","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q14CV6"},{"id":"A1048","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/L0L2J9"},{"id":"A1049","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/I3LM39"},{"id":"A1050","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/E1BGN7"},{"id":"A1051","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/A7SFB5"},{"id":"A1052","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q96E45"},{"id":"A1053","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q8N884"},{"id":"A1054","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q8C6L5"},{"id":"A1055","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q5SWL1"},{"id":"A1056","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q5SWL0"},{"id":"A1057","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q3ULW3"},{"id":"A1058","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q32NC9"},{"id":"A1059","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q14CV6"},{"id":"A1060","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/L0L2J9"},{"id":"A1061","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/I3LM39"},{"id":"A1062","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/E1BGN7"},{"id":"A1063","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/A7SFB5"},{"id":"A1064","pred":"uniprot_id","subj":"T1064","obj":"https://www.uniprot.org/uniprot/P51527"},{"id":"A1065","pred":"uniprot_id","subj":"T1064","obj":"https://www.uniprot.org/uniprot/P51526"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T110","span":{"begin":135,"end":145},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T97","span":{"begin":85,"end":94},"obj":"Body_part"},{"id":"T98","span":{"begin":95,"end":98},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T59","span":{"begin":117,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T60","span":{"begin":124,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0001816"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T56","span":{"begin":117,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T57","span":{"begin":124,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0001816"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T56","span":{"begin":117,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T57","span":{"begin":124,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0001816"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"528","span":{"begin":23,"end":54},"obj":"Gene"},{"id":"529","span":{"begin":56,"end":60},"obj":"Gene"},{"id":"538","span":{"begin":0,"end":3},"obj":"Chemical"},{"id":"539","span":{"begin":3,"end":6},"obj":"Chemical"}],"attributes":[{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Gene:115004"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"Gene:115004"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"MESH:D002738"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"MESH:D006886"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T100","span":{"begin":0,"end":151},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}

{"project":"2_test","denotations":[{"id":"32496926-25821216-132195697","span":{"begin":147,"end":149},"obj":"25821216"}],"text":"CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]."}