PMC:7441788 / 13554-13818 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T95","span":{"begin":34,"end":43},"obj":"Body_part"},{"id":"T96","span":{"begin":180,"end":189},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T160","span":{"begin":91,"end":100},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T161","span":{"begin":151,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T175","span":{"begin":196,"end":198},"obj":"Chemical"},{"id":"T176","span":{"begin":219,"end":233},"obj":"Chemical"},{"id":"T177","span":{"begin":226,"end":229},"obj":"Chemical"},{"id":"T179","span":{"begin":230,"end":233},"obj":"Chemical"}],"attributes":[{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_71580"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_17345"},{"id":"A178","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_58115"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_16027"},{"id":"A180","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_28971"},{"id":"A181","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_456215"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T112","span":{"begin":196,"end":198},"obj":"Chemical"},{"id":"T113","span":{"begin":219,"end":233},"obj":"Chemical"}],"attributes":[{"id":"A112","pred":"chebi_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_71580"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T99","span":{"begin":5,"end":195},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"526","span":{"begin":110,"end":114},"obj":"Gene"},{"id":"527","span":{"begin":119,"end":123},"obj":"Gene"},{"id":"528","span":{"begin":219,"end":250},"obj":"Gene"},{"id":"529","span":{"begin":252,"end":256},"obj":"Gene"},{"id":"538","span":{"begin":196,"end":199},"obj":"Chemical"},{"id":"539","span":{"begin":199,"end":202},"obj":"Chemical"}],"attributes":[{"id":"A526","pred":"pubann:denotes","subj":"526","obj":"Gene:51284"},{"id":"A527","pred":"pubann:denotes","subj":"527","obj":"Gene:54106"},{"id":"A528","pred":"pubann:denotes","subj":"528","obj":"Gene:115004"},{"id":"A529","pred":"pubann:denotes","subj":"529","obj":"Gene:115004"},{"id":"A538","pred":"pubann:denotes","subj":"538","obj":"MESH:D002738"},{"id":"A539","pred":"pubann:denotes","subj":"539","obj":"MESH:D006886"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1040","span":{"begin":234,"end":250},"obj":"Protein"},{"id":"T1052","span":{"begin":252,"end":256},"obj":"Protein"}],"attributes":[{"id":"A1040","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q96E45"},{"id":"A1041","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q8N884"},{"id":"A1042","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q8C6L5"},{"id":"A1043","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q5SWL1"},{"id":"A1044","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q5SWL0"},{"id":"A1045","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q3ULW3"},{"id":"A1046","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q32NC9"},{"id":"A1047","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/Q14CV6"},{"id":"A1048","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/L0L2J9"},{"id":"A1049","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/I3LM39"},{"id":"A1050","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/E1BGN7"},{"id":"A1051","pred":"uniprot_id","subj":"T1040","obj":"https://www.uniprot.org/uniprot/A7SFB5"},{"id":"A1052","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q96E45"},{"id":"A1053","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q8N884"},{"id":"A1054","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q8C6L5"},{"id":"A1055","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q5SWL1"},{"id":"A1056","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q5SWL0"},{"id":"A1057","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q3ULW3"},{"id":"A1058","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q32NC9"},{"id":"A1059","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/Q14CV6"},{"id":"A1060","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/L0L2J9"},{"id":"A1061","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/I3LM39"},{"id":"A1062","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/E1BGN7"},{"id":"A1063","pred":"uniprot_id","subj":"T1052","obj":"https://www.uniprot.org/uniprot/A7SFB5"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T109","span":{"begin":166,"end":176},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T95","span":{"begin":34,"end":43},"obj":"Body_part"},{"id":"T96","span":{"begin":180,"end":189},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T58","span":{"begin":91,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T55","span":{"begin":91,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T55","span":{"begin":91,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-PubTator","denotations":[{"id":"526","span":{"begin":110,"end":114},"obj":"Gene"},{"id":"527","span":{"begin":119,"end":123},"obj":"Gene"},{"id":"528","span":{"begin":219,"end":250},"obj":"Gene"},{"id":"529","span":{"begin":252,"end":256},"obj":"Gene"},{"id":"538","span":{"begin":196,"end":199},"obj":"Chemical"},{"id":"539","span":{"begin":199,"end":202},"obj":"Chemical"}],"attributes":[{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"Gene:51284"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"Gene:54106"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Gene:115004"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"Gene:115004"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"MESH:D002738"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"MESH:D006886"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"LitCovid-sentences","denotations":[{"id":"T99","span":{"begin":5,"end":195},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}

{"project":"2_test","denotations":[{"id":"32496926-16418198-132195695","span":{"begin":0,"end":2},"obj":"16418198"},{"id":"32496926-18820679-132195696","span":{"begin":191,"end":193},"obj":"18820679"}],"text":"42]. At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43]. CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activi"}