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PMC:7441788 / 12957-14473 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T81 29-33 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 49-57 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T83 220-229 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T84 271-303 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T85 305-308 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T86 385-389 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 457-462 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 485-494 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89 503-514 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T90 515-521 Body_part denotes (IL)-1 http://purl.org/sig/ont/fma/fma86583
T91 516-518 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T92 523-525 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T93 578-583 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94 590-595 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 631-640 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T96 777-786 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T97 878-887 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T98 888-891 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T99 993-995 Body_part denotes A2 http://purl.org/sig/ont/fma/fma66595
T100 1155-1164 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T101 1202-1204 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T102 1211-1213 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T103 1237-1243 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T104 1321-1329 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T86 532-537 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T87 1285-1293 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 1348-1351 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T90 1463-1466 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T92 1496-1504 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T148 27-33 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T149 34-44 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T150 220-229 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T151 230-238 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T152 341-351 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T153 383-389 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T154 390-400 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T155 449-452 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T156 455-462 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T157 464-466 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T158 576-583 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T159 588-595 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T160 688-697 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T161 748-758 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T162 855-863 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T163 910-927 http://purl.obolibrary.org/obo/PR_000024990 denotes type I interferon
T164 993-995 http://purl.obolibrary.org/obo/CLO_0001562 denotes A2
T165 1089-1091 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T166 1237-1243 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T165 69-71 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T166 154-170 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T167 204-206 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T168 251-258 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T169 316-318 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T170 469-471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T171 516-518 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T173 523-525 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T175 793-795 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T176 816-830 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T177 823-826 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T179 827-830 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T182 888-891 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T183 917-927 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T184 955-957 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T185 1024-1040 Chemical denotes arachidonic acid http://purl.obolibrary.org/obo/CHEBI_15843
T186 1036-1040 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T187 1073-1087 Chemical denotes prostaglandins http://purl.obolibrary.org/obo/CHEBI_26333
T188 1202-1204 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T190 1211-1213 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T192 1428-1430 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T109 69-71 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T110 204-206 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T111 469-471 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T112 793-795 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T113 816-830 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T114 888-891 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T115 955-957 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T116 1024-1040 Chemical denotes arachidonic acid http://purl.obolibrary.org/obo/CHEBI_15843
T117 1073-1087 Chemical denotes prostaglandins http://purl.obolibrary.org/obo/CHEBI_26333
T118 1428-1430 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T95 1285-1295 Species denotes SARS-CoV-2 NCBItxid:2697049
T96 1496-1504 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T93 0-4 Sentence denotes 4.2.
T94 6-68 Sentence denotes Inhibitory effect on T cell activation and cytokine production
T95 69-171 Sentence denotes CQ/HCQ regulate the release of various pro-inflammatory factors, which are important immunomodulators.
T96 172-357 Sentence denotes Intracellular alkalinization by CQ/HCQ inhibits lysosomal activity, preventing antigen processing, major histocompatibility complex (MHC) class II expression and immune activation [40].
T97 358-468 Sentence denotes This process can inhibit T cell activation and block expression of CD154 on the surface of CD4 + T cells [41].
T98 469-601 Sentence denotes CQ also reduces cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α) produced by T cells and B cells [42].
T99 602-792 Sentence denotes At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43].
T100 793-944 Sentence denotes CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44].
T101 945-1093 Sentence denotes In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of prostaglandins [45].
T102 1094-1389 Sentence denotes Some clinical studies have found that high concentrations of cytokines and pro-inflammatory factors such as IL-6 and IL-10 are elevated in the plasma of critically ill patients infected with SARS-CoV-2 [46,47], suggesting that cytokine release syndrome (CRS) is associated with disease severity.
T103 1390-1516 Sentence denotes In the aspect of immune response, HCQ/CQ therefore are likely to inhibit CRS, delaying the progression of COVID-19 (Figure 1).

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
520 425-430 Gene denotes CD154 Gene:959
521 449-452 Gene denotes CD4 Gene:920
522 503-521 Gene denotes interleukin (IL)-1 Gene:3552
523 523-527 Gene denotes IL-6 Gene:3569
524 532-555 Gene denotes tumor necrosis factor-α Gene:7124
525 557-562 Gene denotes TNF-α Gene:7124
526 707-711 Gene denotes TLR7 Gene:51284
527 716-720 Gene denotes TLR9 Gene:54106
528 816-847 Gene denotes cyclic GMP-AMP (cGAMP) synthase Gene:115004
529 849-853 Gene denotes cGAS Gene:115004
530 979-995 Gene denotes phospholipase A2 Gene:5319
531 1202-1206 Gene denotes IL-6 Gene:3569
532 1211-1216 Gene denotes IL-10 Gene:3586
533 1262-1270 Species denotes patients Tax:9606
534 1285-1295 Species denotes SARS-CoV-2 Tax:2697049
535 204-206 Chemical denotes CQ MESH:D002738
536 207-210 Chemical denotes HCQ MESH:D006886
537 469-471 Chemical denotes CQ MESH:D002738
538 793-796 Chemical denotes CQ/ MESH:D002738
539 796-799 Chemical denotes HCQ MESH:D006886
540 955-961 Chemical denotes CQ/HCQ
541 1024-1040 Chemical denotes arachidonic acid MESH:D016718
542 1073-1087 Chemical denotes prostaglandins MESH:D011453
543 1424-1427 Chemical denotes HCQ MESH:D006886
544 1428-1430 Chemical denotes CQ MESH:D002738
545 1247-1261 Disease denotes critically ill MESH:D016638
546 1271-1279 Disease denotes infected MESH:D007239
547 1348-1351 Disease denotes CRS MESH:D003398
548 1463-1466 Disease denotes CRS MESH:D003398
549 1496-1504 Disease denotes COVID-19 MESH:C000657245

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T897 425-430 Protein denotes CD154 https://www.uniprot.org/uniprot/Q9Z2V2|https://www.uniprot.org/uniprot/Q9R254|https://www.uniprot.org/uniprot/Q9BDN3|https://www.uniprot.org/uniprot/Q9BDM7|https://www.uniprot.org/uniprot/Q9BDM3|https://www.uniprot.org/uniprot/Q9BDC7|https://www.uniprot.org/uniprot/Q95MQ5|https://www.uniprot.org/uniprot/P63305|https://www.uniprot.org/uniprot/P63304|https://www.uniprot.org/uniprot/P51749|https://www.uniprot.org/uniprot/P29965|https://www.uniprot.org/uniprot/P27548|https://www.uniprot.org/uniprot/O97626|https://www.uniprot.org/uniprot/O97605
T911 449-452 Protein denotes CD4 https://www.uniprot.org/uniprot/Q9XS78|https://www.uniprot.org/uniprot/Q9UDE5|https://www.uniprot.org/uniprot/Q5U066|https://www.uniprot.org/uniprot/Q4ZGK2|https://www.uniprot.org/uniprot/Q29617|https://www.uniprot.org/uniprot/Q29037|https://www.uniprot.org/uniprot/Q28217|https://www.uniprot.org/uniprot/Q08340|https://www.uniprot.org/uniprot/Q08339|https://www.uniprot.org/uniprot/Q08338|https://www.uniprot.org/uniprot/Q08336|https://www.uniprot.org/uniprot/P79196|https://www.uniprot.org/uniprot/P79185|https://www.uniprot.org/uniprot/P79184|https://www.uniprot.org/uniprot/P46630|https://www.uniprot.org/uniprot/P33705|https://www.uniprot.org/uniprot/P16004|https://www.uniprot.org/uniprot/P16003|https://www.uniprot.org/uniprot/P06332|https://www.uniprot.org/uniprot/P05542|https://www.uniprot.org/uniprot/P05540|https://www.uniprot.org/uniprot/P01730|https://www.uniprot.org/uniprot/O77593|https://www.uniprot.org/uniprot/O02805|https://www.uniprot.org/uniprot/D3DUS5|https://www.uniprot.org/uniprot/B2R737
T937 523-527 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T981 532-553 Protein denotes tumor necrosis factor https://www.uniprot.org/uniprot/Q9UIV3|https://www.uniprot.org/uniprot/Q9TTJ3|https://www.uniprot.org/uniprot/Q9P1Q2|https://www.uniprot.org/uniprot/Q9MYZ2|https://www.uniprot.org/uniprot/Q9JI27|https://www.uniprot.org/uniprot/Q9JI26|https://www.uniprot.org/uniprot/Q9BEA1|https://www.uniprot.org/uniprot/Q91VF3|https://www.uniprot.org/uniprot/Q8WNR1|https://www.uniprot.org/uniprot/Q8MKG8|https://www.uniprot.org/uniprot/Q8JFG3|https://www.uniprot.org/uniprot/Q8HZD9|https://www.uniprot.org/uniprot/Q8HZD6|https://www.uniprot.org/uniprot/Q8HYM0|https://www.uniprot.org/uniprot/Q75N23|https://www.uniprot.org/uniprot/Q6EE11|https://www.uniprot.org/uniprot/Q62326|https://www.uniprot.org/uniprot/Q5TM21|https://www.uniprot.org/uniprot/Q539C2|https://www.uniprot.org/uniprot/Q2MH05|https://www.uniprot.org/uniprot/P29553|https://www.uniprot.org/uniprot/P23563|https://www.uniprot.org/uniprot/P23383|https://www.uniprot.org/uniprot/P19101|https://www.uniprot.org/uniprot/P16599|https://www.uniprot.org/uniprot/P13296|https://www.uniprot.org/uniprot/P06804|https://www.uniprot.org/uniprot/P04924|https://www.uniprot.org/uniprot/P01375|https://www.uniprot.org/uniprot/O77764|https://www.uniprot.org/uniprot/O77510|https://www.uniprot.org/uniprot/O43647|https://www.uniprot.org/uniprot/O35853|https://www.uniprot.org/uniprot/O35734|https://www.uniprot.org/uniprot/O18779|https://www.uniprot.org/uniprot/A9QWR7|https://www.uniprot.org/uniprot/A5D9N8|https://www.uniprot.org/uniprot/A4IFT5|https://www.uniprot.org/uniprot/Q28339|https://www.uniprot.org/uniprot/Q28320|https://www.uniprot.org/uniprot/Q27978|https://www.uniprot.org/uniprot/Q1XHZ6|https://www.uniprot.org/uniprot/Q1WM27|https://www.uniprot.org/uniprot/Q1G1A2|https://www.uniprot.org/uniprot/Q19LH4|https://www.uniprot.org/uniprot/Q06599|https://www.uniprot.org/uniprot/Q006K5|https://www.uniprot.org/uniprot/P79374|https://www.uniprot.org/uniprot/P79337|https://www.uniprot.org/uniprot/P59695|https://www.uniprot.org/uniprot/P59694|https://www.uniprot.org/uniprot/P59693|https://www.uniprot.org/uniprot/P59684|https://www.uniprot.org/uniprot/P51743|https://www.uniprot.org/uniprot/P51742|https://www.uniprot.org/uniprot/P51435|https://www.uniprot.org/uniprot/P48094|https://www.uniprot.org/uniprot/P36939|https://www.uniprot.org/uniprot/P33620
T1040 831-847 Protein denotes (cGAMP) synthase https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T1052 849-853 Protein denotes cGAS https://www.uniprot.org/uniprot/Q96E45|https://www.uniprot.org/uniprot/Q8N884|https://www.uniprot.org/uniprot/Q8C6L5|https://www.uniprot.org/uniprot/Q5SWL1|https://www.uniprot.org/uniprot/Q5SWL0|https://www.uniprot.org/uniprot/Q3ULW3|https://www.uniprot.org/uniprot/Q32NC9|https://www.uniprot.org/uniprot/Q14CV6|https://www.uniprot.org/uniprot/L0L2J9|https://www.uniprot.org/uniprot/I3LM39|https://www.uniprot.org/uniprot/E1BGN7|https://www.uniprot.org/uniprot/A7SFB5
T1064 917-927 Protein denotes interferon https://www.uniprot.org/uniprot/P51527|https://www.uniprot.org/uniprot/P51526
T1066 979-995 Protein denotes phospholipase A2 https://www.uniprot.org/uniprot/Q05017|https://www.uniprot.org/uniprot/P86780|https://www.uniprot.org/uniprot/P86517|https://www.uniprot.org/uniprot/P86043|https://www.uniprot.org/uniprot/P82971|https://www.uniprot.org/uniprot/P59066|https://www.uniprot.org/uniprot/P50393|https://www.uniprot.org/uniprot/P50392|https://www.uniprot.org/uniprot/P49147|https://www.uniprot.org/uniprot/P47713|https://www.uniprot.org/uniprot/P47712|https://www.uniprot.org/uniprot/P43434|https://www.uniprot.org/uniprot/P18999|https://www.uniprot.org/uniprot/P14419|https://www.uniprot.org/uniprot/P0DPT8|https://www.uniprot.org/uniprot/P0DP54|https://www.uniprot.org/uniprot/P0CV89|https://www.uniprot.org/uniprot/P0C8L9|https://www.uniprot.org/uniprot/P06596|https://www.uniprot.org/uniprot/P04362|https://www.uniprot.org/uniprot/P04055|https://www.uniprot.org/uniprot/P04054|https://www.uniprot.org/uniprot/P00630|https://www.uniprot.org/uniprot/P00594|https://www.uniprot.org/uniprot/P00593|https://www.uniprot.org/uniprot/O77793|https://www.uniprot.org/uniprot/O70320|https://www.uniprot.org/uniprot/O54728|https://www.uniprot.org/uniprot/F5CPF0|https://www.uniprot.org/uniprot/C0HLL2|https://www.uniprot.org/uniprot/C0HLB8|https://www.uniprot.org/uniprot/B3EWQ8|https://www.uniprot.org/uniprot/B3EWP6|https://www.uniprot.org/uniprot/B2R4H5|https://www.uniprot.org/uniprot/B1WAZ6|https://www.uniprot.org/uniprot/B1AKG4|https://www.uniprot.org/uniprot/A8KAX2|https://www.uniprot.org/uniprot/A6H6K5|https://www.uniprot.org/uniprot/A5JGM7|https://www.uniprot.org/uniprot/A4IFJ5|https://www.uniprot.org/uniprot/A0A5C2A2T2|https://www.uniprot.org/uniprot/A0A5C1ZXT8|https://www.uniprot.org/uniprot/A0A5C1ZW08|https://www.uniprot.org/uniprot/Q9Z0Y2|https://www.uniprot.org/uniprot/Q9TWL9|https://www.uniprot.org/uniprot/Q9TT38|https://www.uniprot.org/uniprot/Q9PRZ0|https://www.uniprot.org/uniprot/Q9D884|https://www.uniprot.org/uniprot/Q9D7E2|https://www.uniprot.org/uniprot/Q9D4Y6|https://www.uniprot.org/uniprot/Q9BMK4|https://www.uniprot.org/uniprot/Q96DP9|https://www.uniprot.org/uniprot/Q8WPH5|https://www.uniprot.org/uniprot/Q8IUP7|https://www.uniprot.org/uniprot/Q7T0T9|https://www.uniprot.org/uniprot/Q7M4I6|https://www.uniprot.org/uniprot/Q7M4I5|https://www.uniprot.org/uniprot/Q7M3V3|https://www.uniprot.org/uniprot/Q7M334|https://www.uniprot.org/uniprot/Q7LZG3|https://www.uniprot.org/uniprot/Q6T178|https://www.uniprot.org/uniprot/Q6P1J6|https://www.uniprot.org/uniprot/Q5R8A5|https://www.uniprot.org/uniprot/Q53S03|https://www.uniprot.org/uniprot/Q3TTY0|https://www.uniprot.org/uniprot/Q3KPI1|https://www.uniprot.org/uniprot/Q29R80|https://www.uniprot.org/uniprot/Q1XD55|https://www.uniprot.org/uniprot/Q0VEX7|https://www.uniprot.org/uniprot/Q06HQ7
T1136 1202-1206 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T1180 1211-1216 Protein denotes IL-10 https://www.uniprot.org/uniprot/Q9Z1Y5|https://www.uniprot.org/uniprot/Q9TSJ7|https://www.uniprot.org/uniprot/Q9TSJ4|https://www.uniprot.org/uniprot/Q9JHK7|https://www.uniprot.org/uniprot/Q8MKG9|https://www.uniprot.org/uniprot/Q865X4|https://www.uniprot.org/uniprot/Q6A2H5|https://www.uniprot.org/uniprot/Q6A2H4|https://www.uniprot.org/uniprot/Q63263|https://www.uniprot.org/uniprot/Q5Q0V6|https://www.uniprot.org/uniprot/Q2PE73|https://www.uniprot.org/uniprot/Q29408|https://www.uniprot.org/uniprot/Q29055|https://www.uniprot.org/uniprot/Q28374|https://www.uniprot.org/uniprot/Q25BC1|https://www.uniprot.org/uniprot/Q1W5D6|https://www.uniprot.org/uniprot/Q0Z972|https://www.uniprot.org/uniprot/Q0VBJ1|https://www.uniprot.org/uniprot/P79338|https://www.uniprot.org/uniprot/P55029|https://www.uniprot.org/uniprot/P51746|https://www.uniprot.org/uniprot/P51497|https://www.uniprot.org/uniprot/P51496|https://www.uniprot.org/uniprot/P48411|https://www.uniprot.org/uniprot/P47965|https://www.uniprot.org/uniprot/P46651|https://www.uniprot.org/uniprot/P43480|https://www.uniprot.org/uniprot/P29456|https://www.uniprot.org/uniprot/P22301|https://www.uniprot.org/uniprot/P18893|https://www.uniprot.org/uniprot/O97798|https://www.uniprot.org/uniprot/O46673|https://www.uniprot.org/uniprot/A9QWR2|https://www.uniprot.org/uniprot/A2T6Z6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T102 29-33 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T103 58-68 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T104 385-389 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T105 457-462 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T106 564-577 http://purl.obolibrary.org/obo/IDO_0000607 denotes produced by T
T107 578-583 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T108 590-595 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T109 763-773 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T110 928-938 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T111 1059-1069 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T112 1271-1279 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T113 1372-1379 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T114 1407-1422 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T81 29-33 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 49-57 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T83 220-229 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T84 271-303 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T85 305-308 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T86 385-389 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T87 457-462 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 485-494 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T89 503-514 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T90 515-521 Body_part denotes (IL)-1 http://purl.org/sig/ont/fma/fma86583
T91 516-518 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T92 523-525 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T93 578-583 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T94 590-595 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 631-640 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T96 777-786 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T97 878-887 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T98 888-891 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T99 1155-1164 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T100 1202-1204 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T101 1211-1213 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T102 1237-1243 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T103 1321-1329 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T44 27-44 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T45 29-44 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T46 49-68 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T47 172-200 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T48 251-269 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T49 271-303 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T50 305-308 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T51 375-400 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T52 383-400 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T53 385-400 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T54 538-546 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 538-546 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T56 538-546 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T57 538-546 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T58 688-697 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T59 910-938 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T60 917-938 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T61 979-992 http://purl.obolibrary.org/obo/GO_0004623 denotes phospholipase
T62 1010-1020 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T63 1407-1422 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T79 532-537 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T80 1285-1295 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T81 1348-1351 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T83 1463-1466 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361
T85 1496-1504 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 532-537 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T41 27-44 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T42 29-44 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T43 49-68 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T44 172-200 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T45 251-269 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T46 271-303 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T47 305-308 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T48 375-400 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T49 383-400 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T50 385-400 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T51 538-546 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T52 538-546 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T53 538-546 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T54 538-546 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 688-697 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 910-938 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T57 917-938 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T58 1010-1020 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T59 1407-1422 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T41 27-44 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T42 29-44 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T43 49-68 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T44 172-200 http://purl.obolibrary.org/obo/GO_0051454 denotes Intracellular alkalinization
T45 251-269 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T46 271-303 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T47 305-308 http://purl.obolibrary.org/obo/GO_0046776 denotes MHC
T48 375-400 http://purl.obolibrary.org/obo/GO_0050868 denotes inhibit T cell activation
T49 383-400 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T50 385-400 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T51 538-546 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T52 538-546 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T53 538-546 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T54 538-546 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T55 688-697 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 910-938 http://purl.obolibrary.org/obo/GO_0032606 denotes type I interferon production
T57 917-938 http://purl.obolibrary.org/obo/GO_0001816 denotes interferon production
T58 1010-1020 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T59 1407-1422 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
520 425-430 Gene denotes CD154 Gene:959
521 449-452 Gene denotes CD4 Gene:920
522 503-521 Gene denotes interleukin (IL)-1 Gene:3552
523 523-527 Gene denotes IL-6 Gene:3569
524 532-555 Gene denotes tumor necrosis factor-α Gene:7124
525 557-562 Gene denotes TNF-α Gene:7124
526 707-711 Gene denotes TLR7 Gene:51284
527 716-720 Gene denotes TLR9 Gene:54106
528 816-847 Gene denotes cyclic GMP-AMP (cGAMP) synthase Gene:115004
529 849-853 Gene denotes cGAS Gene:115004
530 979-995 Gene denotes phospholipase A2 Gene:5319
531 1202-1206 Gene denotes IL-6 Gene:3569
532 1211-1216 Gene denotes IL-10 Gene:3586
533 1262-1270 Species denotes patients Tax:9606
534 1285-1295 Species denotes SARS-CoV-2 Tax:2697049
535 204-206 Chemical denotes CQ MESH:D002738
536 207-210 Chemical denotes HCQ MESH:D006886
537 469-471 Chemical denotes CQ MESH:D002738
538 793-796 Chemical denotes CQ/ MESH:D002738
539 796-799 Chemical denotes HCQ MESH:D006886
540 955-961 Chemical denotes CQ/HCQ
541 1024-1040 Chemical denotes arachidonic acid MESH:D016718
542 1073-1087 Chemical denotes prostaglandins MESH:D011453
543 1424-1427 Chemical denotes HCQ MESH:D006886
544 1428-1430 Chemical denotes CQ MESH:D002738
545 1247-1261 Disease denotes critically ill MESH:D016638
546 1271-1279 Disease denotes infected MESH:D007239
547 1348-1351 Disease denotes CRS MESH:D003398
548 1463-1466 Disease denotes CRS MESH:D003398
549 1496-1504 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T93 0-4 Sentence denotes 4.2.
T94 6-68 Sentence denotes Inhibitory effect on T cell activation and cytokine production
T95 69-171 Sentence denotes CQ/HCQ regulate the release of various pro-inflammatory factors, which are important immunomodulators.
T96 172-357 Sentence denotes Intracellular alkalinization by CQ/HCQ inhibits lysosomal activity, preventing antigen processing, major histocompatibility complex (MHC) class II expression and immune activation [40].
T97 358-468 Sentence denotes This process can inhibit T cell activation and block expression of CD154 on the surface of CD4 + T cells [41].
T98 469-601 Sentence denotes CQ also reduces cytokines such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α) produced by T cells and B cells [42].
T99 602-792 Sentence denotes At the same time, changes of endosomal pH can interfere with Toll-like receptor (TLR) signaling, such as TLR7 and TLR9 processing, inhibiting the activation and production of cytokines [43].
T100 793-944 Sentence denotes CQ/HCQ also weaken the cyclic GMP-AMP (cGAMP) synthase (cGAS) activity by inhibiting cytosolic DNA, thereby reducing type I interferon production [44].
T101 945-1093 Sentence denotes In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of prostaglandins [45].
T102 1094-1389 Sentence denotes Some clinical studies have found that high concentrations of cytokines and pro-inflammatory factors such as IL-6 and IL-10 are elevated in the plasma of critically ill patients infected with SARS-CoV-2 [46,47], suggesting that cytokine release syndrome (CRS) is associated with disease severity.
T103 1390-1516 Sentence denotes In the aspect of immune response, HCQ/CQ therefore are likely to inhibit CRS, delaying the progression of COVID-19 (Figure 1).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 532-537 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T11 1321-1346 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32496926-2250716-132195693 353-355 2250716 denotes 40
32496926-28793932-132195694 464-466 28793932 denotes 41
32496926-16418198-132195695 597-599 16418198 denotes 42
32496926-18820679-132195696 788-790 18820679 denotes 43
32496926-25821216-132195697 940-942 25821216 denotes 44
32496926-4016141-132195698 1089-1091 4016141 denotes 45
32496926-31986264-132195699 1297-1299 31986264 denotes 46
32496926-32007143-132195700 1300-1302 32007143 denotes 47