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PMC:7441788 / 12154-12955 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T75 22-29 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 79-91 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 79-83 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 235-239 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 240-256 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 251-256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T5 235-239 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T83 123-132 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 162-170 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 613-619 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T134 12-21 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T135 62-69 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T136 79-83 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T137 154-156 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T138 219-224 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T139 235-256 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T140 258-262 http://purl.obolibrary.org/obo/CLO_0007158 denotes L132
T141 288-298 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T142 447-457 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T143 569-578 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T144 620-625 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 626-634 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T146 690-698 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T147 718-728 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T155 4-11 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T156 22-29 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T157 99-106 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T158 177-179 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T159 380-403 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T160 389-395 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T161 405-408 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T162 559-568 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T163 652-654 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T164 680-689 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T104 22-29 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 177-179 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T106 380-403 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T107 405-408 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T108 652-654 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T90 149-152 Species denotes MHV NCBItxid:11138
T91 162-170 Species denotes SARS-CoV NCBItxid:694009
T92 194-203 Species denotes HCoV-229E NCBItxid:11137
T93 219-224 Species denotes human NCBItxid:9606
T94 613-625 Species denotes dengue virus NCBItxid:12637

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T88 0-176 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 177-316 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 317-482 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 483-640 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 641-801 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T5 235-239 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
478 545-578 Gene denotes mitochondrial antiviral signaling Gene:57506
479 580-584 Gene denotes MAVS Gene:57506
480 136-140 Species denotes CoVs Tax:11118
482 194-203 Species denotes HCoV-229E Tax:11137
483 219-224 Species denotes human Tax:9606
484 327-330 Chemical denotes HCQ MESH:D006886
485 380-403 Chemical denotes reactive oxygen species MESH:D017382
486 405-408 Chemical denotes ROS MESH:D017382
487 483-486 Chemical denotes HCQ MESH:D006886
488 652-658 Chemical denotes CQ/HCQ
489 123-132 Disease denotes infection MESH:D007239

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T872 225-234 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T873 302-310 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0
T877 580-584 Protein denotes MAVS https://www.uniprot.org/uniprot/Q9ULE9|https://www.uniprot.org/uniprot/Q9H8D3|https://www.uniprot.org/uniprot/Q9H4Y1|https://www.uniprot.org/uniprot/Q9H1H3|https://www.uniprot.org/uniprot/Q8VCF0|https://www.uniprot.org/uniprot/Q86VY7|https://www.uniprot.org/uniprot/Q7Z434|https://www.uniprot.org/uniprot/Q66HG9|https://www.uniprot.org/uniprot/Q5T7I6|https://www.uniprot.org/uniprot/Q3I0Y2|https://www.uniprot.org/uniprot/Q2HWT5|https://www.uniprot.org/uniprot/M1P2Z0|https://www.uniprot.org/uniprot/F5H6C8|https://www.uniprot.org/uniprot/B2BD34|https://www.uniprot.org/uniprot/B2BD33|https://www.uniprot.org/uniprot/A8K6X0
T893 732-740 Protein denotes p38 MAPK https://www.uniprot.org/uniprot/Q9TXB4|https://www.uniprot.org/uniprot/O62618|https://www.uniprot.org/uniprot/O46216|https://www.uniprot.org/uniprot/A4V3C0

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T92 79-83 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T93 123-132 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T94 204-215 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T95 251-256 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T96 357-367 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T97 510-514 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T98 559-568 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T99 620-625 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T100 680-689 http://purl.obolibrary.org/obo/IDO_0000559 denotes antiviral
T101 767-771 http://purl.obolibrary.org/obo/IDO_0000531 denotes host

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T75 22-29 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 79-91 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T77 79-83 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T78 235-239 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T79 240-256 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T80 251-256 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T3 235-239 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T37 38-42 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 302-305 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T39 306-310 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T40 461-476 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T41 569-578 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T42 732-735 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T43 736-740 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 123-132 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 162-170 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 613-619 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T36 38-42 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 306-310 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 461-476 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 569-578 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 736-740 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T36 38-42 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T37 306-310 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T38 461-476 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T39 569-578 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T40 736-740 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
478 545-578 Gene denotes mitochondrial antiviral signaling Gene:57506
479 580-584 Gene denotes MAVS Gene:57506
480 136-140 Species denotes CoVs Tax:11118
481 162-170 Species denotes SARS-CoV Tax:694009
482 194-203 Species denotes HCoV-229E Tax:11137
483 219-224 Species denotes human Tax:9606
484 327-330 Chemical denotes HCQ MESH:D006886
485 380-403 Chemical denotes reactive oxygen species MESH:D017382
486 405-408 Chemical denotes ROS MESH:D017382
487 483-486 Chemical denotes HCQ MESH:D006886
488 652-658 Chemical denotes CQ/HCQ
489 123-132 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T88 0-176 Sentence denotes The mitogen-activated protein kinase (MAPK) pathway transmits signals from the cell surface to the nucleus involved in the infection of CoVs such as MHV [36] and SARS-CoV [37].
T89 177-316 Sentence denotes CQ could inhibit HCoV-229E replication in human embryonic lung epithelial cells (L132) through suppressing the activation of p38 MAPK [38].
T90 317-482 Sentence denotes Moreover, HCQ could markedly induce the production of cellular reactive oxygen species (ROS), which play an important role in the activation of innate immunity [39].
T91 483-640 Sentence denotes HCQ also could trigger the host defense mechanism through the mitochondrial antiviral signaling (MAVS) pathway, resulting in anti-dengue virus activity [39].
T92 641-801 Sentence denotes Therefore, CQ/HCQ may also exert their antiviral activity by suppressing the activation of p38 MAPK pathway and affecting the host defense machinery (Figure 1).

2_test

Id Subject Object Predicate Lexical cue
32496926-12021326-132195688 154-156 12021326 denotes 36
32496926-16378980-132195689 172-174 16378980 denotes 37
32496926-18055026-132195690 312-314 18055026 denotes 38
32496926-25321315-132195691 478-480 25321315 denotes 39
32496926-25321315-132195692 636-638 25321315 denotes 39