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PMC:7441788 / 10539-12083 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T60 19-22 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T61 42-46 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 163-172 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T63 173-184 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T64 416-422 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T65 474-481 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 657-665 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 822-827 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 917-924 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 1066-1081 Body_part denotes early endosomes http://purl.org/sig/ont/fma/fma67463
T70 1121-1126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 1254-1263 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T72 1388-1396 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T73 1443-1452 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 680-688 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 736-745 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T78 794-802 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 904-912 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 1009-1017 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 1050-1058 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 1189-1197 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T106 23-30 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T107 42-46 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T108 71-72 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 128-136 http://purl.obolibrary.org/obo/UBERON_0000158 denotes Membrane
T110 276-286 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T111 482-492 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T112 511-519 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T113 624-634 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T114 638-639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 730-735 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T116 746-751 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T117 768-769 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T118 812-815 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T119 812-815 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T120 812-815 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T121 812-815 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T122 812-815 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T123 812-815 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T124 812-815 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T125 822-827 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 931-932 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T127 1114-1126 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T128 1335-1343 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T129 1443-1452 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T130 1500-1505 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T131 1515-1524 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T141 369-371 Chemical denotes PC http://purl.obolibrary.org/obo/CHEBI_16110|http://purl.obolibrary.org/obo/CHEBI_49183|http://purl.obolibrary.org/obo/CHEBI_53201|http://purl.obolibrary.org/obo/CHEBI_55395|http://purl.obolibrary.org/obo/CHEBI_57643|http://purl.obolibrary.org/obo/CHEBI_61433
T147 416-422 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T148 474-481 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 657-665 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T150 917-924 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 988-990 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T152 1156-1158 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T153 1233-1235 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T154 1347-1349 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T7 939-951 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T95 19-22 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T96 416-422 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T97 474-481 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98 657-665 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T99 917-924 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 988-990 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T101 1156-1158 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T102 1233-1235 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T103 1347-1349 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T79 19-30 Species denotes RNA viruses NCBItxid:2559587
T80 680-688 Species denotes SARS-CoV NCBItxid:694009
T81 695-703 Species denotes MERS-CoV NCBItxid:1335626
T82 710-719 Species denotes HCoV-229E NCBItxid:11137
T83 730-753 Species denotes mouse hepatitis virus 2 NCBItxid:76344
T84 755-758 Species denotes MHV NCBItxid:11138
T85 794-804 Species denotes SARS-CoV-2 NCBItxid:2697049
T86 904-914 Species denotes SARS-CoV-2 NCBItxid:2697049
T87 1009-1019 Species denotes SARS-CoV-2 NCBItxid:2697049
T88 1050-1060 Species denotes SARS-CoV-2 NCBItxid:2697049
T89 1189-1199 Species denotes SARS-CoV-2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T79 0-127 Sentence denotes CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28].
T80 128-292 Sentence denotes Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29].
T81 293-532 Sentence denotes Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30].
T82 533-767 Sentence denotes Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33].
T83 768-930 Sentence denotes A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24].
T84 931-1280 Sentence denotes A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17].
T85 1281-1544 Sentence denotes These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1).

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
442 339-344 Gene denotes furin Gene:5045
443 545-556 Gene denotes cathepsin L Gene:1514
444 865-876 Gene denotes cathepsin L Gene:1514
445 1233-1239 Gene denotes CQ/HCQ
446 988-994 Gene denotes CQ/HCQ
447 915-916 Gene denotes S Gene:43740568
448 0-4 Species denotes CoVs Tax:11118
452 730-751 Species denotes mouse hepatitis virus Tax:11138
453 794-804 Species denotes SARS-CoV-2 Tax:2697049
454 904-914 Species denotes SARS-CoV-2 Tax:2697049
455 1009-1019 Species denotes SARS-CoV-2 Tax:2697049
456 1050-1060 Species denotes SARS-CoV-2 Tax:2697049
457 1189-1199 Species denotes SARS-CoV-2 Tax:2697049
458 755-760 Species denotes MHV-2 Tax:502106
459 1331-1334 Species denotes CoV Tax:11118
460 416-422 Chemical denotes serine MESH:D012694
461 1156-1158 Chemical denotes CQ MESH:D002738
462 1347-1349 Chemical denotes CQ MESH:D002738
463 1350-1353 Chemical denotes HCQ MESH:D006886
464 651-665 Disease denotes CoV S proteins MESH:C000657245
465 1114-1120 CellLine denotes VeroE6 CVCL:0574

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T463 330-337 Protein denotes trypsin https://www.uniprot.org/uniprot/P83348|https://www.uniprot.org/uniprot/P81524|https://www.uniprot.org/uniprot/P81071|https://www.uniprot.org/uniprot/P70059|https://www.uniprot.org/uniprot/P51588|https://www.uniprot.org/uniprot/P35051|https://www.uniprot.org/uniprot/P35050|https://www.uniprot.org/uniprot/P35048|https://www.uniprot.org/uniprot/P35034|https://www.uniprot.org/uniprot/P19799|https://www.uniprot.org/uniprot/P00764|https://www.uniprot.org/uniprot/P00761|https://www.uniprot.org/uniprot/O97399
T476 339-344 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T484 407-415 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T728 446-454 Protein denotes elastase https://www.uniprot.org/uniprot/P32197
T729 472-481 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T762 545-556 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T784 655-665 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T817 865-876 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T839 915-924 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T83 23-30 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T84 42-46 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T85 746-751 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T86 822-827 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T87 1121-1126 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T88 1500-1505 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T89 1510-1514 http://purl.obolibrary.org/obo/IDO_0000531 denotes host

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T60 19-22 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T61 42-46 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T62 163-172 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T63 173-184 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T64 416-422 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T65 474-481 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T66 657-665 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 822-827 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T68 917-924 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 1066-1081 Body_part denotes early endosomes http://purl.org/sig/ont/fma/fma67463
T70 1121-1126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 1254-1263 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T72 1388-1396 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T73 1443-1452 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T25 92-121 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T26 110-121 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T27 128-143 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T28 191-202 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T29 247-260 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T30 511-526 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T31 843-854 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T32 1034-1046 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T33 1176-1185 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T34 1397-1410 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T69 680-688 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 736-745 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T71 794-804 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T72 904-914 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T73 1009-1019 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T74 1050-1060 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T75 1189-1199 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 736-745 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T24 92-121 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T25 110-121 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T26 128-143 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T27 191-202 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T28 247-260 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T29 511-526 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T30 843-854 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T31 1034-1046 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T32 1176-1185 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T33 1397-1410 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T24 92-121 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor-mediated endocytosis
T25 110-121 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T26 128-143 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T27 191-202 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T28 247-260 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T29 511-526 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T30 843-854 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T31 1034-1046 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T32 1176-1185 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T33 1397-1410 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
442 339-344 Gene denotes furin Gene:5045
443 545-556 Gene denotes cathepsin L Gene:1514
444 865-876 Gene denotes cathepsin L Gene:1514
445 1233-1239 Gene denotes CQ/HCQ
446 988-994 Gene denotes CQ/HCQ
447 915-916 Gene denotes S Gene:43740568
448 0-4 Species denotes CoVs Tax:11118
452 730-751 Species denotes mouse hepatitis virus Tax:11138
453 794-804 Species denotes SARS-CoV-2 Tax:2697049
454 904-914 Species denotes SARS-CoV-2 Tax:2697049
455 1009-1019 Species denotes SARS-CoV-2 Tax:2697049
456 1050-1060 Species denotes SARS-CoV-2 Tax:2697049
457 1189-1199 Species denotes SARS-CoV-2 Tax:2697049
458 755-760 Species denotes MHV-2 Tax:502106
459 1331-1334 Species denotes CoV Tax:11118
460 416-422 Chemical denotes serine MESH:D012694
461 1156-1158 Chemical denotes CQ MESH:D002738
462 1347-1349 Chemical denotes CQ MESH:D002738
463 1350-1353 Chemical denotes HCQ MESH:D006886
464 651-665 Disease denotes CoV S proteins MESH:C000657245
465 1114-1120 CellLine denotes VeroE6 CVCL:0574

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T79 0-127 Sentence denotes CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28].
T80 128-292 Sentence denotes Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29].
T81 293-532 Sentence denotes Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30].
T82 533-767 Sentence denotes Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33].
T83 768-930 Sentence denotes A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24].
T84 931-1280 Sentence denotes A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17].
T85 1281-1544 Sentence denotes These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 736-745 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32496926-22590686-132195676 123-125 22590686 denotes 28
32496926-22816037-132195677 288-290 22816037 denotes 29
32496926-25445340-132195678 528-530 25445340 denotes 30
32496926-25445340-132195679 667-669 25445340 denotes 30
32496926-24121034-132195680 690-692 24121034 denotes 19
32496926-23468491-132195681 705-707 23468491 denotes 31
32496926-18971274-132195682 721-723 18971274 denotes 32
32496926-16731916-132195683 763-765 16731916 denotes 33
32496926-32221306-132195684 926-928 32221306 denotes 24
32496926-32194981-132195685 1276-1278 32194981 denotes 17
32496926-28596841-132195686 1526-1528 28596841 denotes 34
32496926-14592603-132195687 1529-1531 14592603 denotes 35