PMC:7441788 / 10487-12083
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T60 | 71-74 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T61 | 94-98 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T62 | 215-224 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T63 | 225-236 | Body_part | denotes | compartment | http://purl.org/sig/ont/fma/fma76577 |
T64 | 468-474 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
T65 | 526-533 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T66 | 709-717 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T67 | 874-879 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T68 | 969-976 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T69 | 1118-1133 | Body_part | denotes | early endosomes | http://purl.org/sig/ont/fma/fma67463 |
T70 | 1173-1178 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 1306-1315 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T72 | 1440-1448 | Body_part | denotes | endosome | http://purl.org/sig/ont/fma/fma67180 |
T73 | 1495-1504 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T76 | 732-740 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T77 | 788-797 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
T78 | 846-854 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T79 | 956-964 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T80 | 1061-1069 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T81 | 1102-1110 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T82 | 1241-1249 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T105 | 28-36 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T106 | 75-82 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T107 | 94-98 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T108 | 123-124 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T109 | 180-188 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | Membrane |
T110 | 328-338 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T111 | 534-544 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T112 | 563-571 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T113 | 676-686 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T114 | 690-691 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T115 | 782-787 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T116 | 798-803 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T117 | 820-821 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T118 | 864-867 | http://purl.obolibrary.org/obo/CLO_0001230 | denotes | 293 |
T119 | 864-867 | http://purl.obolibrary.org/obo/CLO_0037237 | denotes | 293 |
T120 | 864-867 | http://purl.obolibrary.org/obo/CLO_0050903 | denotes | 293 |
T121 | 864-867 | http://purl.obolibrary.org/obo/CLO_0054249 | denotes | 293 |
T122 | 864-867 | http://purl.obolibrary.org/obo/CLO_0054250 | denotes | 293 |
T123 | 864-867 | http://purl.obolibrary.org/obo/CLO_0054251 | denotes | 293 |
T124 | 864-867 | http://purl.obolibrary.org/obo/CLO_0054252 | denotes | 293 |
T125 | 874-879 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T126 | 983-984 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T127 | 1166-1178 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | VeroE6 cells |
T128 | 1387-1395 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T129 | 1495-1504 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
T130 | 1552-1557 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T131 | 1567-1576 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T141 | 421-423 | Chemical | denotes | PC | http://purl.obolibrary.org/obo/CHEBI_16110|http://purl.obolibrary.org/obo/CHEBI_49183|http://purl.obolibrary.org/obo/CHEBI_53201|http://purl.obolibrary.org/obo/CHEBI_55395|http://purl.obolibrary.org/obo/CHEBI_57643|http://purl.obolibrary.org/obo/CHEBI_61433 |
T147 | 468-474 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
T148 | 526-533 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T149 | 709-717 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T150 | 969-976 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T151 | 1040-1042 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T152 | 1208-1210 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T153 | 1285-1287 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T154 | 1399-1401 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T7 | 991-1003 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | investigated | http://purl.bioontology.org/ontology/MEDDRA/10062026 |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T95 | 71-74 | Chemical | denotes | RNA | http://purl.obolibrary.org/obo/CHEBI_33697 |
T96 | 468-474 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
T97 | 526-533 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T98 | 709-717 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T99 | 969-976 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T100 | 1040-1042 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T101 | 1208-1210 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T102 | 1285-1287 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
T103 | 1399-1401 | Chemical | denotes | CQ | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T79 | 71-82 | Species | denotes | RNA viruses | NCBItxid:2559587 |
T80 | 732-740 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T81 | 747-755 | Species | denotes | MERS-CoV | NCBItxid:1335626 |
T82 | 762-771 | Species | denotes | HCoV-229E | NCBItxid:11137 |
T83 | 782-805 | Species | denotes | mouse hepatitis virus 2 | NCBItxid:76344 |
T84 | 807-810 | Species | denotes | MHV | NCBItxid:11138 |
T85 | 846-856 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T86 | 956-966 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T87 | 1061-1071 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T88 | 1102-1112 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
T89 | 1241-1251 | Species | denotes | SARS-CoV-2 | NCBItxid:2697049 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T77 | 0-6 | Sentence | denotes | 4.1.2. |
T78 | 8-51 | Sentence | denotes | Interference of the membrane fusion process |
T79 | 52-179 | Sentence | denotes | CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28]. |
T80 | 180-344 | Sentence | denotes | Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29]. |
T81 | 345-584 | Sentence | denotes | Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30]. |
T82 | 585-819 | Sentence | denotes | Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33]. |
T83 | 820-982 | Sentence | denotes | A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24]. |
T84 | 983-1332 | Sentence | denotes | A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17]. |
T85 | 1333-1596 | Sentence | denotes | These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1). |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
442 | 391-396 | Gene | denotes | furin | Gene:5045 |
443 | 597-608 | Gene | denotes | cathepsin L | Gene:1514 |
444 | 917-928 | Gene | denotes | cathepsin L | Gene:1514 |
445 | 1285-1291 | Gene | denotes | CQ/HCQ | |
446 | 1040-1046 | Gene | denotes | CQ/HCQ | |
447 | 967-968 | Gene | denotes | S | Gene:43740568 |
448 | 52-56 | Species | denotes | CoVs | Tax:11118 |
452 | 782-803 | Species | denotes | mouse hepatitis virus | Tax:11138 |
453 | 846-856 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
454 | 956-966 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
455 | 1061-1071 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
456 | 1102-1112 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
457 | 1241-1251 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
458 | 807-812 | Species | denotes | MHV-2 | Tax:502106 |
459 | 1383-1386 | Species | denotes | CoV | Tax:11118 |
460 | 468-474 | Chemical | denotes | serine | MESH:D012694 |
461 | 1208-1210 | Chemical | denotes | CQ | MESH:D002738 |
462 | 1399-1401 | Chemical | denotes | CQ | MESH:D002738 |
463 | 1402-1405 | Chemical | denotes | HCQ | MESH:D006886 |
464 | 703-717 | Disease | denotes | CoV S proteins | MESH:C000657245 |
465 | 1166-1172 | CellLine | denotes | VeroE6 | CVCL:0574 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T463 | 382-389 | Protein | denotes | trypsin | https://www.uniprot.org/uniprot/P83348|https://www.uniprot.org/uniprot/P81524|https://www.uniprot.org/uniprot/P81071|https://www.uniprot.org/uniprot/P70059|https://www.uniprot.org/uniprot/P51588|https://www.uniprot.org/uniprot/P35051|https://www.uniprot.org/uniprot/P35050|https://www.uniprot.org/uniprot/P35048|https://www.uniprot.org/uniprot/P35034|https://www.uniprot.org/uniprot/P19799|https://www.uniprot.org/uniprot/P00764|https://www.uniprot.org/uniprot/P00761|https://www.uniprot.org/uniprot/O97399 |
T476 | 391-396 | Protein | denotes | furin | https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958 |
T484 | 459-467 | Protein | denotes | protease | https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249 |
T728 | 498-506 | Protein | denotes | elastase | https://www.uniprot.org/uniprot/P32197 |
T729 | 524-533 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T762 | 597-608 | Protein | denotes | cathepsin L | https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1 |
T784 | 707-717 | Protein | denotes | S proteins | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
T817 | 917-928 | Protein | denotes | cathepsin L | https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1 |
T839 | 967-976 | Protein | denotes | S protein | https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T83 | 75-82 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T84 | 94-98 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T85 | 798-803 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T86 | 874-879 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T87 | 1173-1178 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T88 | 1552-1557 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T89 | 1562-1566 | http://purl.obolibrary.org/obo/IDO_0000531 | denotes | host |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T60 | 71-74 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T61 | 94-98 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T62 | 215-224 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T63 | 225-236 | Body_part | denotes | compartment | http://purl.org/sig/ont/fma/fma76577 |
T64 | 468-474 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
T65 | 526-533 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T66 | 709-717 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T67 | 874-879 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T68 | 969-976 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T69 | 1118-1133 | Body_part | denotes | early endosomes | http://purl.org/sig/ont/fma/fma67463 |
T70 | 1173-1178 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T71 | 1306-1315 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T72 | 1440-1448 | Body_part | denotes | endosome | http://purl.org/sig/ont/fma/fma67180 |
T73 | 1495-1504 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T24 | 28-43 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T25 | 144-173 | http://purl.obolibrary.org/obo/GO_0006898 | denotes | receptor-mediated endocytosis |
T26 | 162-173 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T27 | 180-195 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | Membrane fusion |
T28 | 243-254 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T29 | 299-312 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
T30 | 563-578 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T31 | 895-906 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T32 | 1086-1098 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
T33 | 1228-1237 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T34 | 1449-1462 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T69 | 732-740 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T70 | 788-797 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
T71 | 846-856 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T72 | 956-966 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T73 | 1061-1071 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T74 | 1102-1112 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T75 | 1241-1251 | Disease | denotes | SARS-CoV-2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T9 | 788-797 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23 | 28-43 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T24 | 144-173 | http://purl.obolibrary.org/obo/GO_0006898 | denotes | receptor-mediated endocytosis |
T25 | 162-173 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T26 | 180-195 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | Membrane fusion |
T27 | 243-254 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T28 | 299-312 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
T29 | 563-578 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T30 | 895-906 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T31 | 1086-1098 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
T32 | 1228-1237 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T33 | 1449-1462 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T23 | 28-43 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T24 | 144-173 | http://purl.obolibrary.org/obo/GO_0006898 | denotes | receptor-mediated endocytosis |
T25 | 162-173 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T26 | 180-195 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | Membrane fusion |
T27 | 243-254 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T28 | 299-312 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
T29 | 563-578 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T30 | 895-906 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
T31 | 1086-1098 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
T32 | 1228-1237 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T33 | 1449-1462 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
442 | 391-396 | Gene | denotes | furin | Gene:5045 |
443 | 597-608 | Gene | denotes | cathepsin L | Gene:1514 |
444 | 917-928 | Gene | denotes | cathepsin L | Gene:1514 |
445 | 1285-1291 | Gene | denotes | CQ/HCQ | |
446 | 1040-1046 | Gene | denotes | CQ/HCQ | |
447 | 967-968 | Gene | denotes | S | Gene:43740568 |
448 | 52-56 | Species | denotes | CoVs | Tax:11118 |
452 | 782-803 | Species | denotes | mouse hepatitis virus | Tax:11138 |
453 | 846-856 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
454 | 956-966 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
455 | 1061-1071 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
456 | 1102-1112 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
457 | 1241-1251 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
458 | 807-812 | Species | denotes | MHV-2 | Tax:502106 |
459 | 1383-1386 | Species | denotes | CoV | Tax:11118 |
460 | 468-474 | Chemical | denotes | serine | MESH:D012694 |
461 | 1208-1210 | Chemical | denotes | CQ | MESH:D002738 |
462 | 1399-1401 | Chemical | denotes | CQ | MESH:D002738 |
463 | 1402-1405 | Chemical | denotes | HCQ | MESH:D006886 |
464 | 703-717 | Disease | denotes | CoV S proteins | MESH:C000657245 |
465 | 1166-1172 | CellLine | denotes | VeroE6 | CVCL:0574 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T77 | 0-6 | Sentence | denotes | 4.1.2. |
T78 | 8-51 | Sentence | denotes | Interference of the membrane fusion process |
T79 | 52-179 | Sentence | denotes | CoVs are enveloped RNA viruses, and their cell entry processes involve a principal route of receptor-mediated endocytosis [28]. |
T80 | 180-344 | Sentence | denotes | Membrane fusion takes place in the endosomal compartment after endocytosis, which needs additional triggers such as pH acidification or proteolytic activation [29]. |
T81 | 345-584 | Sentence | denotes | Multiple cellular proteases, such as trypsin, furin, proprotein convertase (PC) family, cathepsins, transmembrane protease/serine (TMPRSS) proteases and elastase, are involved in S protein activation, which can induce membrane fusion [30]. |
T82 | 585-819 | Sentence | denotes | Among them, cathepsin L, with anoptimal pH of 3.0 to 6.5, is most commonly associated with activation of a variety of CoV S proteins [30], such as SARS-CoV [19], MERS-CoV [31], HCoV-229E [32], and mouse hepatitis virus 2 (MHV-2) [33]. |
T83 | 820-982 | Sentence | denotes | A recent study found that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, in which cathepsin L is critical for priming of SARS-CoV-2 S protein [24]. |
T84 | 983-1332 | Sentence | denotes | A study investigated the detailed mechanism of action of CQ/HCQ in inhibiting SARS-CoV-2 entry, and co-localization of SARS-CoV-2 with early endosomes (EEs) or endolysosomes (ELs) in VeroE6 cells, and the results showed that CQ/HCQ hampered the transport of SARS-CoV-2 from EEs to ELs, indicating that CQ/HCQ might inhibit endosomal maturation [17]. |
T85 | 1333-1596 | Sentence | denotes | These studies revealed that the mechanism of anti-CoV activity of CQ/HCQ may involve the inhibition of the endosome acidification process, which might inactivate lysosomal proteases, thus interfering with the fusion of virus and host membranes [34,35] (Figure 1). |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T9 | 788-797 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32496926-22590686-132195676 | 175-177 | 22590686 | denotes | 28 |
32496926-22816037-132195677 | 340-342 | 22816037 | denotes | 29 |
32496926-25445340-132195678 | 580-582 | 25445340 | denotes | 30 |
32496926-25445340-132195679 | 719-721 | 25445340 | denotes | 30 |
32496926-24121034-132195680 | 742-744 | 24121034 | denotes | 19 |
32496926-23468491-132195681 | 757-759 | 23468491 | denotes | 31 |
32496926-18971274-132195682 | 773-775 | 18971274 | denotes | 32 |
32496926-16731916-132195683 | 815-817 | 16731916 | denotes | 33 |
32496926-32221306-132195684 | 978-980 | 32221306 | denotes | 24 |
32496926-32194981-132195685 | 1328-1330 | 32194981 | denotes | 17 |
32496926-28596841-132195686 | 1578-1580 | 28596841 | denotes | 34 |
32496926-14592603-132195687 | 1581-1583 | 14592603 | denotes | 35 |