PMC:7441777 / 7678-8124 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T40","span":{"begin":230,"end":238},"obj":"Disease"},{"id":"T41","span":{"begin":376,"end":384},"obj":"Disease"}],"attributes":[{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates. In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors. The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina. Among the selecte"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T57","span":{"begin":164,"end":165},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"ent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates. In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors. The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina. Among the selecte"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T76","span":{"begin":28,"end":39},"obj":"Chemical"},{"id":"T77","span":{"begin":103,"end":117},"obj":"Chemical"},{"id":"T78","span":{"begin":103,"end":112},"obj":"Chemical"},{"id":"T79","span":{"begin":113,"end":117},"obj":"Chemical"},{"id":"T80","span":{"begin":182,"end":193},"obj":"Chemical"},{"id":"T81","span":{"begin":246,"end":256},"obj":"Chemical"},{"id":"T82","span":{"begin":344,"end":355},"obj":"Chemical"}],"attributes":[{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"}],"text":"ent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates. In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors. The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina. Among the selecte"}

{"project":"LitCovid-PubTator","denotations":[{"id":"244","span":{"begin":241,"end":245},"obj":"Gene"},{"id":"245","span":{"begin":364,"end":368},"obj":"Gene"},{"id":"257","span":{"begin":230,"end":240},"obj":"Species"},{"id":"258","span":{"begin":376,"end":386},"obj":"Species"},{"id":"274","span":{"begin":28,"end":39},"obj":"Chemical"},{"id":"275","span":{"begin":182,"end":193},"obj":"Chemical"},{"id":"276","span":{"begin":344,"end":355},"obj":"Chemical"},{"id":"295","span":{"begin":12,"end":24},"obj":"Disease"}],"attributes":[{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"Gene:43740578"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"Gene:43740578"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"Tax:2697049"},{"id":"A258","pred":"tao:has_database_id","subj":"258","obj":"Tax:2697049"},{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:D059808"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:D059808"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:D059808"},{"id":"A295","pred":"tao:has_database_id","subj":"295","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates. In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors. The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina. Among the selecte"}

{"project":"LitCovid-sentences","denotations":[{"id":"T54","span":{"begin":130,"end":257},"obj":"Sentence"},{"id":"T55","span":{"begin":258,"end":428},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates. In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors. The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina. Among the selecte"}