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PMC:7441777 / 5337-8775 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T23 678-681 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T24 1444-1447 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T25 3370-3380 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T32 300-316 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T33 701-706 Disease denotes polio http://purl.obolibrary.org/obo/MONDO_0017373
T34 979-982 Disease denotes NS5 http://purl.obolibrary.org/obo/MONDO_0012690
T35 1223-1232 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T36 1426-1435 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T37 1719-1727 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 2212-2220 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 2302-2310 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 2571-2579 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 2717-2725 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 3020-3028 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T38 177-180 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T39 192-200 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T40 204-209 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T41 633-634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 682-689 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T43 707-712 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T44 735-740 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T45 775-780 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T46 960-968 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T47 1081-1089 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T48 1207-1215 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T49 1233-1238 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T50 1308-1309 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 1362-1363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 1414-1422 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T53 1436-1437 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T54 1438-1443 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T55 2037-2038 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56 2162-2163 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 2505-2506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 2814-2817 http://purl.obolibrary.org/obo/CLO_0009325 denotes TF1
T59 2993-2999 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T60 3036-3037 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 3104-3105 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 3174-3175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 3354-3355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T52 93-101 Chemical denotes vitamins http://purl.obolibrary.org/obo/CHEBI_33229
T53 119-130 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T54 132-142 Chemical denotes flavonoids http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T56 144-153 Chemical denotes flavonols http://purl.obolibrary.org/obo/CHEBI_28802
T57 159-170 Chemical denotes carotenoids http://purl.obolibrary.org/obo/CHEBI_23044
T58 649-658 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T59 814-817 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T60 917-927 Chemical denotes flavonoids http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T62 1014-1024 Chemical denotes flavonoids http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T64 1026-1039 Chemical denotes quercetagetin http://purl.obolibrary.org/obo/CHEBI_8695
T65 1178-1187 Chemical denotes catechins http://purl.obolibrary.org/obo/CHEBI_23053
T66 1356-1360 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T67 1374-1384 Chemical denotes polyphenol http://purl.obolibrary.org/obo/CHEBI_26195
T68 1460-1464 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T69 1565-1567 Chemical denotes Ho http://purl.obolibrary.org/obo/CHEBI_49648
T70 1681-1691 Chemical denotes flavonoids http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T72 1692-1702 Chemical denotes polyphenol http://purl.obolibrary.org/obo/CHEBI_26195
T73 1883-1887 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T74 1901-1905 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T75 2311-2316 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T76 2369-2380 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T77 2444-2458 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T78 2444-2453 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T79 2454-2458 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T80 2523-2534 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T81 2587-2597 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T82 2685-2696 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T83 2789-2800 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T84 2802-2812 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T85 2820-2830 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T86 2836-2843 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918
T87 2852-2862 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T88 2866-2873 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918
T89 2882-2892 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T90 2898-2907 Chemical denotes digallate http://purl.obolibrary.org/obo/CHEBI_17866
T91 2909-2912 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T92 2915-2925 Chemical denotes hesperidin http://purl.obolibrary.org/obo/CHEBI_28775
T93 2927-2931 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T94 2933-2942 Chemical denotes myricetin http://purl.obolibrary.org/obo/CHEBI_18152|http://purl.obolibrary.org/obo/CHEBI_58395
T96 2948-2961 Chemical denotes quercetagetin http://purl.obolibrary.org/obo/CHEBI_8695
T97 3238-3249 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T98 3309-3311 Chemical denotes MM http://purl.obolibrary.org/obo/CHEBI_53458|http://purl.obolibrary.org/obo/CHEBI_74707
T100 3349-3352 Chemical denotes GTP http://purl.obolibrary.org/obo/CHEBI_15996|http://purl.obolibrary.org/obo/CHEBI_37565
T102 3370-3380 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 300-316 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T4 1401-1422 http://purl.obolibrary.org/obo/GO_0004519 denotes endonuclease activity
T5 1500-1517 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T6 1500-1517 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
243 1250-1263 Gene denotes neuraminidase Gene:4758
244 2582-2586 Gene denotes RdRp Gene:43740578
245 2705-2709 Gene denotes RdRp Gene:43740578
246 2875-2879 Gene denotes TF2b Gene:2959
247 3008-3012 Gene denotes RdRp Gene:43740578
248 1207-1215 Gene denotes membrane Gene:43740571
249 2223-2227 Gene denotes RdRp Gene:43740578
250 204-209 Species denotes human Tax:9606
251 721-747 Species denotes parainfluenza virus type 3 Tax:11216
252 753-780 Species denotes respiratory syncytial virus Tax:12814
253 1223-1238 Species denotes influenza virus Tax:11308
254 1426-1443 Species denotes influenza A virus Tax:11320
255 1719-1729 Species denotes SARS-CoV-2 Tax:2697049
256 2212-2222 Species denotes SARS-CoV-2 Tax:2697049
257 2571-2581 Species denotes SARS-CoV-2 Tax:2697049
258 2717-2727 Species denotes SARS-CoV-2 Tax:2697049
259 3020-3030 Species denotes SARS-CoV-2 Tax:2697049
260 979-982 Species denotes NS5 Tax:260743
261 119-130 Chemical denotes polyphenols MESH:D059808
262 132-142 Chemical denotes flavonoids MESH:D005419
263 144-153 Chemical denotes flavonols MESH:D044948
264 159-170 Chemical denotes carotenoids MESH:D002338
265 917-927 Chemical denotes flavonoids MESH:D005419
266 1014-1024 Chemical denotes flavonoids MESH:D005419
267 1026-1039 Chemical denotes quercetagetin MESH:C079163
268 1178-1187 Chemical denotes catechins MESH:D002392
269 1356-1360 Chemical denotes EGCG MESH:C045651
270 1374-1384 Chemical denotes polyphenol MESH:D059808
271 1460-1464 Chemical denotes EGCG MESH:C045651
272 1681-1691 Chemical denotes flavonoids MESH:D005419
273 1692-1702 Chemical denotes polyphenol MESH:D059808
274 2369-2380 Chemical denotes polyphenols MESH:D059808
275 2523-2534 Chemical denotes polyphenols MESH:D059808
276 2685-2696 Chemical denotes polyphenols MESH:D059808
277 2789-2800 Chemical denotes polyphenols MESH:D059808
278 2802-2812 Chemical denotes theaflavin MESH:C056068
279 2820-2843 Chemical denotes theaflavin-3′-O-gallate
280 2852-2873 Chemical denotes theaflavin-3′-gallate
281 2882-2907 Chemical denotes theaflavin 3,3′-digallate MESH:C585473
282 2909-2912 Chemical denotes TF3 MESH:C585473
283 2915-2925 Chemical denotes hesperidin MESH:D006569
284 2927-2931 Chemical denotes EGCG MESH:C045651
285 2933-2942 Chemical denotes myricetin MESH:C040015
286 2948-2961 Chemical denotes quercetagetin MESH:C079163
287 3238-3249 Chemical denotes polyphenols MESH:D059808
288 3312-3316 Chemical denotes PBSA MESH:C437084
289 3318-3328 Chemical denotes Remdesivir MESH:C000606551
290 3349-3352 Chemical denotes GTP MESH:D006160
291 279-286 Disease denotes cancers MESH:D009369
292 300-316 Disease denotes viral infections MESH:D001102
293 454-462 Disease denotes toxicity MESH:D064420
294 2302-2310 Disease denotes COVID-19 MESH:C000657245
295 2353-2365 Disease denotes cytotoxicity MESH:D064420

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T2 2814-2817 GlycoEpitope denotes TF1 http://www.glycoepitope.jp/epitopes/AN0049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T43 0-363 Sentence denotes Epidemiological studies repetitively suggested that consumption of bioactive compounds (e.g. vitamins, phytochemicals, polyphenols, flavonoids, flavonols, and carotenoids etc.) has beneficial activity on human health and could minimize the risk of various diseases starting from cancers to different viral infections (Khan et al., 2020; Szajdek & Borowska, 2008).
T44 364-546 Sentence denotes Traditional natural compounds have been consumed since ancient times as they exhibit less toxicity, low-cost availability, minimum side-effects and are rich in therapeutic resources.
T45 547-832 Sentence denotes Some of the previous findings also suggest that naturally occurring compounds possess a wide range of antiviral properties against RNA viruses, including polio-virus type 1, parainfluenza virus type 3, and respiratory syncytial virus by inhibiting their replication (Lin et al., 2014).
T46 833-1129 Sentence denotes In that context, Ahmed-Belkacem et al. have screened more than forty potent natural flavonoids for their polymerase inhibition activity using HCV-NS5 strain and among the different flavonoids, quercetagetin showed strong HCV replication inhibitory activity in vitro (Ahmed-Belkacem et al., 2014).
T47 1130-1304 Sentence denotes Previously, song et al. reported that green tea catechins, by disrupting the membrane of the influenza virus, inhibited neuraminidase in the crude system (Song et al., 2005).
T48 1305-1459 Sentence denotes On a separate report, Takashi et al. reported that EGCG, a green tea polyphenol can inhibit the endonuclease activity of influenza A virus RNA polymerase.
T49 1460-1605 Sentence denotes EGCG is also reported to interfere with viral replication via modulating the cellular redox environment (Ho et al., 2009; Kuzuhara et al., 2009).
T50 1606-1812 Sentence denotes Therefore, the existing scientific evidence strongly suggests that natural flavonoids/polyphenol can act against SARS-CoV-2 (Aanouz et al., 2020; Elfiky 2020b; Elmezayen et al., 2020; Enmozhi et al., 2020).
T51 1813-2154 Sentence denotes Because of the time-consuming process of new synthetic/semi-synthetic drug development, drug repurposing of phytomolecules is an ideal alternative in this urgent situation as the latter process is economical and scalable in a very short period of time (Adeoye et al., 2020; Islam et al., 2020; Muralidharan et al., 2020; Sinha et al., 2020).
T52 2155-2317 Sentence denotes Hence, a comprehensive understanding of their binding to SARS-CoV-2 RdRp can yield interesting findings that can further be capitalized to develop COVID-19 drugs.
T53 2318-2470 Sentence denotes Nevertheless, the apparent lack of cytotoxicity of polyphenols at even significantly high concentrations makes them potential antiviral drug candidates.
T54 2471-2598 Sentence denotes In the present study, we selected a hundred natural polyphenols to assess their potential to act as SARS-CoV-2 RdRp inhibitors.
T55 2599-2769 Sentence denotes The selected library was then explored to evaluate the binding affinity of individual polyphenols towards RdRp of the SARS-CoV-2 by molecular docking using AutoDock vina.
T56 2770-3088 Sentence denotes Among the selected polyphenols, theaflavin (TF1), theaflavin-3′-O-gallate (TF2a), theaflavin-3′-gallate (TF2b), theaflavin 3,3′-digallate (TF3), hesperidin, EGCG, myricetin, and quercetagetin were found to be docked in the active site of RdRp of the SARS-CoV-2 with a highly favourable affinity for the binding pocket.
T57 3089-3250 Sentence denotes Further to get a better understanding of the dynamics of the complexes, we performed a 150-nanoseconds molecular dynamic simulation with those eight polyphenols.
T58 3251-3317 Sentence denotes The binding free energy components were calculated by the MM-PBSA.
T59 3318-3438 Sentence denotes Remdesivir (Hendaus, 2020) and GTP (a physiological nucleotide) were taken as positive controls to validate our results.

2_test

Id Subject Object Predicate Lexical cue
32720577-24872930-56195096 826-830 24872930 denotes 2014
32720577-25053847-56195097 1123-1127 25053847 denotes 2014
32720577-16137775-56195098 1298-1302 16137775 denotes 2005
32720577-19537794-56195099 1576-1580 19537794 denotes 2009
32720577-20025206-56195100 1599-1603 20025206 denotes 2009