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PMC:7441777 / 47915-49289 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T98 196-204 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T99 295-303 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T100 455-463 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 539-546 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 629-637 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T103 842-845 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 1039-1047 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T74 865-873 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 1147-1150 Disease denotes pie http://purl.obolibrary.org/obo/MONDO_0000923

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T318 226-227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 559-560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 1020-1021 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T321 1296-1303 http://purl.obolibrary.org/obo/CLO_0001658 denotes actives

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T667 45-56 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T668 91-99 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T669 170-187 Chemical denotes biomacromolecules http://purl.obolibrary.org/obo/CHEBI_33694
T670 196-204 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T671 268-279 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T672 295-303 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T673 391-402 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T674 455-463 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T675 539-546 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T676 573-581 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T677 629-637 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T678 650-654 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T679 668-671 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T680 677-687 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T681 772-783 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T682 939-950 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T683 1039-1047 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T684 1086-1090 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T685 1104-1107 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T686 1113-1123 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T687 1244-1246 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T688 1255-1257 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T37 539-554 http://purl.obolibrary.org/obo/GO_0006605 denotes protein targets
T38 842-857 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1464 662-666 Gene denotes TF2b Gene:2959
1465 797-801 Gene denotes RdRp Gene:43740578
1466 1098-1102 Gene denotes TF2b Gene:2959
1467 1334-1336 Gene denotes S7 Gene:6264
1468 865-875 Species denotes SARS-CoV-2 Tax:2697049
1469 45-56 Chemical denotes polyphenols MESH:D059808
1470 91-99 Chemical denotes hydrogen MESH:D006859
1471 268-279 Chemical denotes polyphenols MESH:D059808
1472 391-402 Chemical denotes polyphenols MESH:D059808
1473 650-654 Chemical denotes EGCG MESH:C045651
1474 677-687 Chemical denotes remdesivir MESH:C000606551
1475 772-783 Chemical denotes polyphenols MESH:D059808
1476 939-950 Chemical denotes polyphenols MESH:D059808
1477 1086-1090 Chemical denotes EGCG MESH:C045651
1478 1113-1123 Chemical denotes remdesivir MESH:C000606551
1479 1248-1257 Disease denotes ChEMBL ID MESH:C537985

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T508 0-205 Sentence denotes The polyphenolic structural motif of dietary polyphenols allows them to serve as excellent hydrogen bond donors which in turn help them to strongly interact with various biomacromolecules such as proteins.
T509 206-336 Sentence denotes This interaction is a critical step in the regulatory role of polyphenols on various key proteins involved in cellular physiology.
T510 337-482 Sentence denotes The majority, if not all, of the beneficial effect of polyphenols, can be explained via the functional consequence of proteins it interacts with.
T511 483-582 Sentence denotes Molecular target studies help us to predict therapeutic protein targets for a given small molecule.
T512 583-688 Sentence denotes Herein, we analyzed the predicted interacting proteins/enzymes for EGCG, TF2a, TF2b, TF3, and remdesivir.
T513 689-876 Sentence denotes This study is particularly important in the current context as we think that these polyphenols could target RdRp, an important enzyme that catalyzes the RNA replication in the SARS-CoV-2.
T514 877-1056 Sentence denotes Notably, the molecular target analysis suggests that all four polyphenols possess excellent properties of druggability, and they interact with a diverse class of proteins/enzymes.
T515 1057-1179 Sentence denotes The top 25 target classes of EGCG, TF2a, TF2b, TF3, and remdesivir are represented in the pie-chart, as shown in Figure 8.
T516 1180-1374 Sentence denotes The detailed output table with the target, common name, UniProt ID, ChEMBL ID, target class, probability, and known actives in 2D/3D are listed in Tables S7–S11 in the Supplementary Information.