PMC:7441777 / 45772-47823 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T93","span":{"begin":375,"end":379},"obj":"Body_part"},{"id":"T94","span":{"begin":767,"end":771},"obj":"Body_part"},{"id":"T95","span":{"begin":1160,"end":1164},"obj":"Body_part"},{"id":"T96","span":{"begin":1553,"end":1557},"obj":"Body_part"},{"id":"T97","span":{"begin":1952,"end":1956},"obj":"Body_part"}],"attributes":[{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma7163"}],"text":"S. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T28","span":{"begin":375,"end":379},"obj":"Body_part"},{"id":"T29","span":{"begin":767,"end":771},"obj":"Body_part"},{"id":"T30","span":{"begin":1160,"end":1164},"obj":"Body_part"},{"id":"T31","span":{"begin":1553,"end":1557},"obj":"Body_part"},{"id":"T32","span":{"begin":1952,"end":1956},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"S. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T288","span":{"begin":139,"end":144},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T289","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T290","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T291","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T292","span":{"begin":375,"end":379},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T293","span":{"begin":375,"end":379},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T294","span":{"begin":531,"end":536},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T295","span":{"begin":767,"end":771},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T296","span":{"begin":767,"end":771},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T297","span":{"begin":767,"end":771},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T298","span":{"begin":767,"end":771},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T299","span":{"begin":767,"end":771},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T300","span":{"begin":924,"end":929},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T301","span":{"begin":1160,"end":1164},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T302","span":{"begin":1160,"end":1164},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T303","span":{"begin":1160,"end":1164},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T304","span":{"begin":1160,"end":1164},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T305","span":{"begin":1160,"end":1164},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T306","span":{"begin":1317,"end":1322},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T307","span":{"begin":1553,"end":1557},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T308","span":{"begin":1553,"end":1557},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T309","span":{"begin":1553,"end":1557},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T310","span":{"begin":1553,"end":1557},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T311","span":{"begin":1553,"end":1557},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T312","span":{"begin":1716,"end":1721},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T313","span":{"begin":1952,"end":1956},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T314","span":{"begin":1952,"end":1956},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T315","span":{"begin":1952,"end":1956},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T316","span":{"begin":1952,"end":1956},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T317","span":{"begin":1952,"end":1956},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"}],"text":"S. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}