PMC:7441777 / 45693-47823 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T93","span":{"begin":454,"end":458},"obj":"Body_part"},{"id":"T94","span":{"begin":846,"end":850},"obj":"Body_part"},{"id":"T95","span":{"begin":1239,"end":1243},"obj":"Body_part"},{"id":"T96","span":{"begin":1632,"end":1636},"obj":"Body_part"},{"id":"T97","span":{"begin":2031,"end":2035},"obj":"Body_part"}],"attributes":[{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma7163"}],"text":"Table 7. Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T28","span":{"begin":454,"end":458},"obj":"Body_part"},{"id":"T29","span":{"begin":846,"end":850},"obj":"Body_part"},{"id":"T30","span":{"begin":1239,"end":1243},"obj":"Body_part"},{"id":"T31","span":{"begin":1632,"end":1636},"obj":"Body_part"},{"id":"T32","span":{"begin":2031,"end":2035},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"Table 7. Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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7. Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}

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Predicted toxicity profile of EGCG, TF3, TF2b, TF2a, and remdesivir.\nS. No. Compounds name Toxicity prediction  \n    Properties Predicted values\n1 EGCG AMES toxicity No\n    Maximum tolerated dose (Human) 0.441 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.522 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 3.065 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 7.713 log mM\n2 TF3 AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 7.443 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 9.738 log mM\n3 TF2b AMES toxicity No\n    Maximum tolerated dose (Human) 0.438 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.482 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.322 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 8.685 log mM\n4 TF2a AMES toxicity No\n    Maximum tolerated dose (Human) 0.439 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.484 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 5.035 (log mg/kg_bw/day)\n    Hepatotoxicity No\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 4.898 log mM\n5 Remdesivir AMES toxicity No\n    Maximum tolerated dose (Human) 0.15 (log mg/kg/day)\n    hERG I inhibitor No\n    hERG II inhibitor Yes\n    Oral rat acute toxicity (LD50) 2.043 (mol/kg)\n    Oral rat chronic toxicity (LOAEL) 1.639 (log mg/kg_bw/day)\n    Hepatotoxicity Yes\n    Skin sensitivity No\n    T. pyriformis toxicity 0.285 (µg/L)\n    Minnow toxicity 0.291 log mM"}