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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T91","span":{"begin":444,"end":448},"obj":"Body_part"},{"id":"T92","span":{"begin":1011,"end":1015},"obj":"Body_part"}],"attributes":[{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma7163"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T27","span":{"begin":1011,"end":1015},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T277","span":{"begin":145,"end":149},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T278","span":{"begin":416,"end":421},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T279","span":{"begin":428,"end":429},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T280","span":{"begin":444,"end":448},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T281","span":{"begin":483,"end":486},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T282","span":{"begin":655,"end":660},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T283","span":{"begin":1011,"end":1015},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T284","span":{"begin":1011,"end":1015},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T285","span":{"begin":1011,"end":1015},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T286","span":{"begin":1011,"end":1015},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T287","span":{"begin":1011,"end":1015},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T629","span":{"begin":48,"end":52},"obj":"Chemical"},{"id":"T630","span":{"begin":66,"end":69},"obj":"Chemical"},{"id":"T631","span":{"begin":81,"end":91},"obj":"Chemical"},{"id":"T632","span":{"begin":352,"end":356},"obj":"Chemical"},{"id":"T633","span":{"begin":370,"end":373},"obj":"Chemical"},{"id":"T634","span":{"begin":379,"end":389},"obj":"Chemical"},{"id":"T635","span":{"begin":422,"end":427},"obj":"Chemical"},{"id":"T636","span":{"begin":449,"end":451},"obj":"Chemical"},{"id":"T637","span":{"begin":458,"end":460},"obj":"Chemical"},{"id":"T638","span":{"begin":531,"end":535},"obj":"Chemical"},{"id":"T639","span":{"begin":549,"end":552},"obj":"Chemical"},{"id":"T640","span":{"begin":683,"end":693},"obj":"Chemical"},{"id":"T641","span":{"begin":723,"end":733},"obj":"Chemical"},{"id":"T642","span":{"begin":734,"end":738},"obj":"Chemical"},{"id":"T643","span":{"begin":752,"end":755},"obj":"Chemical"},{"id":"T644","span":{"begin":844,"end":848},"obj":"Chemical"},{"id":"T645","span":{"begin":866,"end":869},"obj":"Chemical"}],"attributes":[{"id":"A629","pred":"chebi_id","subj":"T629","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A630","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A631","pred":"chebi_id","subj":"T631","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A632","pred":"chebi_id","subj":"T632","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A633","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A634","pred":"chebi_id","subj":"T634","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A635","pred":"chebi_id","subj":"T635","obj":"http://purl.obolibrary.org/obo/CHEBI_25698"},{"id":"A636","pred":"chebi_id","subj":"T636","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A637","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A638","pred":"chebi_id","subj":"T638","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A639","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A640","pred":"chebi_id","subj":"T640","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A641","pred":"chebi_id","subj":"T641","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"},{"id":"A642","pred":"chebi_id","subj":"T642","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A643","pred":"chebi_id","subj":"T643","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A644","pred":"chebi_id","subj":"T644","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A645","pred":"chebi_id","subj":"T645","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":1016,"end":1029},"obj":"http://purl.obolibrary.org/obo/GO_0046960"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PubTator

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T442","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"T443","span":{"begin":107,"end":275},"obj":"Sentence"},{"id":"T444","span":{"begin":276,"end":351},"obj":"Sentence"},{"id":"T445","span":{"begin":352,"end":462},"obj":"Sentence"},{"id":"T446","span":{"begin":463,"end":605},"obj":"Sentence"},{"id":"T447","span":{"begin":606,"end":787},"obj":"Sentence"},{"id":"T448","span":{"begin":788,"end":942},"obj":"Sentence"},{"id":"T449","span":{"begin":943,"end":1030},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T9","span":{"begin":914,"end":919},"obj":"Phenotype"}],"attributes":[{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002527"}],"text":"We have also analyzed the toxicity profiles for EGCG, TF2a, TF2b, TF3 as well as remdesivir (see Table 7). The toxicity prediction from the AMES test (Salmonella typhimurium reverse mutation assay) exhibited that all the compounds could be considered as non-mutagenic agents. High toxicity was observed for all the compounds in Tetrahymena pyriformis. EGCG, TF2a, TF2b, TF3, and remdesivir were shown to inhibit the human ether-a-go-go-related gene II (hERG II). However, Remdesivir has been shown to induce hepatotoxicity, whilst EGCG, TF2a, TF2b, TF3 are not likely to be associated with hepatotoxicity. The maximum recommended tolerated dose (MRTD) in human prediction shows that remdesivir violate MRTD whereas natural polyphenol EGCG, TF2a, TF2b, TF3 do not fall into this category. Remdesivir does not possess high acute toxicity whereas EGCG, TF2a, TF2b, and TF3 regarded as high acute toxic compound as it falls under minnow toxicity. Additionally, none of the compounds predicted to be associated with skin sensitization."}

PMC:7441777 / 44662-45692 JSONTXT

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PMC:7441777 / 44662-45692 JSON TXT