PMC:7441777 / 42741-43695
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T68 | 67-72 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T69 | 102-108 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T70 | 132-138 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T71 | 139-147 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T72 | 159-167 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T73 | 346-352 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T74 | 398-413 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T75 | 649-671 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T76 | 676-681 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T77 | 682-687 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T78 | 760-765 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T79 | 794-816 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T80 | 930-944 | Body_part | denotes | nervous system | http://purl.org/sig/ont/fma/fma7157 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T9 | 649-671 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T10 | 657-671 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T11 | 676-695 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T12 | 676-681 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T13 | 682-687 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T14 | 760-765 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T15 | 794-816 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T16 | 802-816 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T17 | 930-944 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T244 | 20-21 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T245 | 102-108 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T246 | 132-138 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T247 | 280-281 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T248 | 346-352 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T249 | 398-404 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T250 | 405-413 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T251 | 649-671 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T252 | 649-671 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T253 | 649-671 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
| T254 | 676-681 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T255 | 676-681 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T256 | 682-687 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T257 | 682-687 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T258 | 760-765 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T259 | 760-765 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T260 | 794-816 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T261 | 794-816 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T262 | 794-816 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T596 | 22-26 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T597 | 67-72 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T598 | 139-147 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T599 | 159-167 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T600 | 238-242 | Chemical | denotes | EGCG | http://purl.obolibrary.org/obo/CHEBI_4806 |
| T601 | 256-259 | Chemical | denotes | TF3 | http://purl.obolibrary.org/obo/CHEBI_136608 |
| T602 | 265-275 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T603 | 447-457 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T604 | 460-464 | Chemical | denotes | EGCG | http://purl.obolibrary.org/obo/CHEBI_4806 |
| T605 | 481-484 | Chemical | denotes | TF3 | http://purl.obolibrary.org/obo/CHEBI_136608 |
| T606 | 492-494 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T607 | 635-640 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T608 | 872-877 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T25 | 139-158 | http://purl.obolibrary.org/obo/GO_0015031 | denotes | proteins, transport |
| T26 | 149-158 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1230 | 250-254 | Gene | denotes | TF2b | Gene:2959 |
| 1231 | 474-478 | Gene | denotes | TF2b | Gene:2959 |
| 1232 | 405-413 | Gene | denotes | membrane | Gene:43740571 |
| 1233 | 67-72 | Chemical | denotes | lipid | MESH:D008055 |
| 1234 | 238-242 | Chemical | denotes | EGCG | MESH:C045651 |
| 1235 | 265-275 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 1236 | 447-457 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 1237 | 460-464 | Chemical | denotes | EGCG | MESH:C045651 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T428 | 0-173 | Sentence | denotes | The distribution of a drug is regulated by many parameters such as lipid-solubility, concentration in plasma and binding ability to plasma proteins, transport proteins, etc. |
| T429 | 174-353 | Sentence | denotes | The volume of distribution at steady-state (VDss) suggests that EGCG, TF2a, TF2b, TF3, and remdesivir had a lower theoretical dose required for uniform distribution in the plasma. |
| T430 | 354-586 | Sentence | denotes | Further, the degree of diffusion across the plasma membrane increases in the following order remdesivir < EGCG < TF2a < TF2b < TF3 (Table S4 in the Supplementary Information) as measured by the fraction that is in the unbound state. |
| T431 | 587-817 | Sentence | denotes | The predictions through the distribution of the drugs via the central nervous system and blood-brain barrier suggest that these five compounds are poorly distributed to the brain and unable to penetrate the central nervous system. |
| T432 | 818-954 | Sentence | denotes | However, the medium level of the lipophilicity of the drugs suggests that they would have no negative impact on nervous system exposure. |