PMC:7441777 / 41101-41391 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T56","span":{"begin":95,"end":102},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T217","span":{"begin":15,"end":22},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T218","span":{"begin":56,"end":57},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T219","span":{"begin":221,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T220","span":{"begin":283,"end":284},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T560","span":{"begin":64,"end":72},"obj":"Chemical"},{"id":"T561","span":{"begin":95,"end":102},"obj":"Chemical"},{"id":"T562","span":{"begin":206,"end":215},"obj":"Chemical"},{"id":"T563","span":{"begin":285,"end":289},"obj":"Chemical"}],"attributes":[{"id":"A560","pred":"chebi_id","subj":"T560","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A561","pred":"chebi_id","subj":"T561","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A562","pred":"chebi_id","subj":"T562","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A563","pred":"chebi_id","subj":"T563","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T15","span":{"begin":155,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T16","span":{"begin":167,"end":176},"obj":"http://purl.obolibrary.org/obo/GO_0007588"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1183","span":{"begin":182,"end":190},"obj":"Disease"}],"attributes":[{"id":"A1183","pred":"tao:has_database_id","subj":"1183","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}

{"project":"LitCovid-sentences","denotations":[{"id":"T420","span":{"begin":0,"end":290},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In addition to testing the physiochemical efficiency of a given molecule to inhibit the target protein, other parameters such as absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the inhibitor play a critical role on demonstrating the likelihood of success of a drug."}