PMC:7441777 / 26416-27661 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T167	151-152	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T168	186-187	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T169	336-337	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T170	398-399	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T171	475-481	http://purl.obolibrary.org/obo/CLO_0001658	denotes	active

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T378	92-97	Chemical	denotes	atoms	http://purl.obolibrary.org/obo/CHEBI_33250
T379	235-245	Chemical	denotes	remdesivir	http://purl.obolibrary.org/obo/CHEBI_145994
T380	258-269	Chemical	denotes	polyphenols	http://purl.obolibrary.org/obo/CHEBI_26195
T381	359-369	Chemical	denotes	remdesivir	http://purl.obolibrary.org/obo/CHEBI_145994
T382	379-390	Chemical	denotes	polyphenols	http://purl.obolibrary.org/obo/CHEBI_26195
T383	976-985	Chemical	denotes	inhibitor	http://purl.obolibrary.org/obo/CHEBI_35222
T384	1017-1020	Chemical	denotes	TF3	http://purl.obolibrary.org/obo/CHEBI_136608
T385	1119-1129	Chemical	denotes	polyphenol	http://purl.obolibrary.org/obo/CHEBI_26195
T386	1160-1163	Chemical	denotes	TF3	http://purl.obolibrary.org/obo/CHEBI_136608
T387	1233-1244	Chemical	denotes	polyphenols	http://purl.obolibrary.org/obo/CHEBI_26195

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
652	306-310	Gene	denotes	RdRp	Gene:43740578
653	354-358	Gene	denotes	RdRp	Gene:43740578
654	374-378	Gene	denotes	RdRp	Gene:43740578
655	971-975	Gene	denotes	RdRp	Gene:43740578
656	1012-1016	Gene	denotes	RdRp	Gene:43740578
657	1025-1029	Gene	denotes	RdRp	Gene:43740578
658	1114-1118	Gene	denotes	RdRp	Gene:43740578
659	1199-1203	Gene	denotes	RdRp	Gene:43740578
660	510-511	Gene	denotes	N	Gene:43740575
661	235-245	Chemical	denotes	remdesivir	MESH:C000606551
662	258-269	Chemical	denotes	polyphenols	MESH:D059808
663	359-369	Chemical	denotes	remdesivir	MESH:C000606551
664	379-390	Chemical	denotes	polyphenols	MESH:D059808
665	553-559	Chemical	denotes	Asn150
666	561-567	Chemical	denotes	Asp260
667	569-575	Chemical	denotes	Arg305
668	577-583	Chemical	denotes	Asn360
669	589-595	Chemical	denotes	Phe440
670	1119-1129	Chemical	denotes	polyphenol	MESH:D059808
671	1233-1244	Chemical	denotes	polyphenols	MESH:D059808

Id	Subject	Object	Predicate	Lexical cue
T255	0-154	Sentence	denotes	To identify the regions which are flexible, the root-mean-square fluctuations (RMSFs) of Cα atoms of each residue are calculated and shown in Figure 3(B).
T256	155-326	Sentence	denotes	From this analysis, we can get a better insight into what extent the binding of remdesivir and natural polyphenols affects the residual flexibility of RdRp (mainly Nsp12).
T257	327-421	Sentence	denotes	Figure 3(B) indicates that RdRp/remdesivir and RdRp-polyphenols shared a similar RMSF pattern.
T258	422-537	Sentence	denotes	Notable dynamic fluctuations were located in the non-active site domain, including both N-terminals and C-terminal.
T259	538-671	Sentence	denotes	Regions around Asn150, Asp260, Arg305, Asn360, and Phe440 are found to be more flexible compared to the other area for all complexes.
T260	672-996	Sentence	denotes	The binding pocket residues, such as Asp452, Lys545, Lys551, Tyr455, Arg553, Ala554, Arg555, Thr556, Asp618, Tyr619, pro620, Lys621, Cys622, Asp623 Arg624, Asn691, Asp760, Asp761, Phe793, Met794, Ser795, Lys798, Trp800, Glu811, Phe812, and Ser814 exhibited considerably low fluctuations for all the RdRp-inhibitor complexes.
T261	997-1140	Sentence	denotes	In the case of RdRp/TF3 and RdRp/TF2a, the binding site residues displayed lesser fluctuations compared to the other RdRp-polyphenol complexes.
T262	1141-1245	Sentence	denotes	This suggests that TF3 and TF2a are likely to be bound to RdRp more strongly than the other polyphenols.