PMC:7441777 / 25868-26415 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T163","span":{"begin":298,"end":301},"obj":"http://purl.obolibrary.org/obo/CLO_0009325"},{"id":"T164","span":{"begin":317,"end":318},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T165","span":{"begin":382,"end":383},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T166","span":{"begin":535,"end":536},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T367","span":{"begin":50,"end":60},"obj":"Chemical"},{"id":"T368","span":{"begin":71,"end":82},"obj":"Chemical"},{"id":"T369","span":{"begin":125,"end":130},"obj":"Chemical"},{"id":"T370","span":{"begin":266,"end":270},"obj":"Chemical"},{"id":"T371","span":{"begin":272,"end":281},"obj":"Chemical"},{"id":"T373","span":{"begin":283,"end":296},"obj":"Chemical"},{"id":"T374","span":{"begin":303,"end":306},"obj":"Chemical"},{"id":"T375","span":{"begin":394,"end":404},"obj":"Chemical"},{"id":"T376","span":{"begin":421,"end":431},"obj":"Chemical"},{"id":"T377","span":{"begin":493,"end":504},"obj":"Chemical"}],"attributes":[{"id":"A367","pred":"chebi_id","subj":"T367","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A368","pred":"chebi_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"},{"id":"A369","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A370","pred":"chebi_id","subj":"T370","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A371","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_18152"},{"id":"A372","pred":"chebi_id","subj":"T371","obj":"http://purl.obolibrary.org/obo/CHEBI_58395"},{"id":"A373","pred":"chebi_id","subj":"T373","obj":"http://purl.obolibrary.org/obo/CHEBI_8695"},{"id":"A374","pred":"chebi_id","subj":"T374","obj":"http://purl.obolibrary.org/obo/CHEBI_136608"},{"id":"A375","pred":"chebi_id","subj":"T375","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A376","pred":"chebi_id","subj":"T376","obj":"http://purl.obolibrary.org/obo/CHEBI_28775"},{"id":"A377","pred":"chebi_id","subj":"T377","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":325,"end":333},"obj":"http://purl.obolibrary.org/obo/GO_0007610"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}

{"project":"LitCovid-PubTator","denotations":[{"id":"623","span":{"begin":412,"end":416},"obj":"Gene"},{"id":"624","span":{"begin":50,"end":60},"obj":"Chemical"},{"id":"625","span":{"begin":71,"end":82},"obj":"Chemical"},{"id":"626","span":{"begin":266,"end":270},"obj":"Chemical"},{"id":"627","span":{"begin":272,"end":281},"obj":"Chemical"},{"id":"628","span":{"begin":283,"end":296},"obj":"Chemical"},{"id":"629","span":{"begin":394,"end":404},"obj":"Chemical"},{"id":"630","span":{"begin":421,"end":431},"obj":"Chemical"},{"id":"631","span":{"begin":493,"end":504},"obj":"Chemical"}],"attributes":[{"id":"A623","pred":"tao:has_database_id","subj":"623","obj":"Gene:2959"},{"id":"A624","pred":"tao:has_database_id","subj":"624","obj":"MESH:C000606551"},{"id":"A625","pred":"tao:has_database_id","subj":"625","obj":"MESH:D059808"},{"id":"A626","pred":"tao:has_database_id","subj":"626","obj":"MESH:C045651"},{"id":"A627","pred":"tao:has_database_id","subj":"627","obj":"MESH:C040015"},{"id":"A628","pred":"tao:has_database_id","subj":"628","obj":"MESH:C079163"},{"id":"A629","pred":"tao:has_database_id","subj":"629","obj":"MESH:C000606551"},{"id":"A630","pred":"tao:has_database_id","subj":"630","obj":"MESH:D006569"},{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"MESH:D059808"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T12","span":{"begin":298,"end":301},"obj":"GlycoEpitope"}],"attributes":[{"id":"A12","pred":"glyco_epitope_db_id","subj":"T12","obj":"http://www.glycoepitope.jp/epitopes/AN0049"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}

{"project":"LitCovid-sentences","denotations":[{"id":"T253","span":{"begin":231,"end":384},"obj":"Sentence"},{"id":"T254","span":{"begin":385,"end":547},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Next, we investigated the structural stability of remdesivir and eight polyphenols by estimating the temporal RMSDs of heavy atoms relative to their respective initial coordinates (see Figure S2B in the Supplementary Information). It is evident from Figure S2B that EGCG, myricetin, quercetagetin, TF1, TF3 displayed a rigid behavior in the bound form with an average RMSD of \u003c 1.0 Å. However, remdesivir, TF2a, TF2b and hesperidin showed higher fluctuations as compared to the abovementioned polyphenols, and an average RMSD of \u003e 2.0 Å was noted."}