> top > docs > PMC:7441777 > spans > 238-2000 > annotations

PMC:7441777 / 238-2000 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T3 372-375 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T4 386-389 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T5 429-432 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 591-594 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 44-52 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 68-115 Disease denotes Severe Acute Respiratory Syndrome Coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 117-125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 235-243 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 362-370 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 418-426 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 801-809 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 853-861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1753-1761 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 135-136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 595-602 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T3 681-682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 879-880 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 1090-1093 http://purl.obolibrary.org/obo/CLO_0009325 denotes TF1
T6 1253-1259 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T7 1283-1284 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1536-1537 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 203-207 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6 283-287 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T7 301-305 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T8 343-351 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T9 481-495 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T10 481-490 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T11 491-495 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T12 541-552 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T13 622-633 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T14 784-795 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T15 892-903 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T16 1072-1076 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T17 1078-1088 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T18 1096-1106 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T19 1112-1119 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918
T20 1128-1138 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T21 1142-1149 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918
T22 1158-1183 Chemical denotes theaflavin 3,3'-digallate http://purl.obolibrary.org/obo/CHEBI_136608
T23 1158-1168 Chemical denotes theaflavin http://purl.obolibrary.org/obo/CHEBI_136609
T24 1174-1183 Chemical denotes digallate http://purl.obolibrary.org/obo/CHEBI_17866
T25 1185-1188 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T26 1191-1201 Chemical denotes hesperidin http://purl.obolibrary.org/obo/CHEBI_28775
T27 1203-1216 Chemical denotes quercetagetin http://purl.obolibrary.org/obo/CHEBI_8695
T28 1222-1231 Chemical denotes myricetin http://purl.obolibrary.org/obo/CHEBI_18152|http://purl.obolibrary.org/obo/CHEBI_58395
T30 1335-1339 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T31 1353-1356 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608
T32 1465-1467 Chemical denotes MM http://purl.obolibrary.org/obo/CHEBI_53458|http://purl.obolibrary.org/obo/CHEBI_74707
T34 1675-1679 Chemical denotes EGCG http://purl.obolibrary.org/obo/CHEBI_4806
T35 1693-1696 Chemical denotes TF3 http://purl.obolibrary.org/obo/CHEBI_136608

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 429-444 http://purl.obolibrary.org/obo/GO_0039703 denotes RNA replication
T2 731-742 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
44 402-406 Gene denotes RdRp Gene:43740578
45 577-581 Gene denotes RdRp Gene:43740578
46 812-816 Gene denotes RdRp Gene:43740578
47 1035-1039 Gene denotes RdRp Gene:43740578
48 1151-1155 Gene denotes TF2b Gene:2959
49 1268-1272 Gene denotes RdRp Gene:43740578
50 1347-1351 Gene denotes TF2b Gene:2959
51 1406-1410 Gene denotes RdRp Gene:43740578
52 1687-1691 Gene denotes TF2b Gene:2959
53 1709-1713 Gene denotes RdRp Gene:43740578
54 68-115 Species denotes Severe Acute Respiratory Syndrome Coronavirus 2 Tax:2697049
55 117-127 Species denotes SARS-CoV-2 Tax:2697049
56 418-428 Species denotes SARS-CoV-2 Tax:2697049
57 801-811 Species denotes SARS-CoV-2 Tax:2697049
58 541-552 Chemical denotes polyphenols MESH:D059808
59 622-633 Chemical denotes polyphenols MESH:D059808
60 784-795 Chemical denotes polyphenols MESH:D059808
61 892-903 Chemical denotes polyphenols MESH:D059808
62 1072-1076 Chemical denotes EGCG MESH:C045651
63 1078-1088 Chemical denotes theaflavin MESH:C056068
64 1096-1119 Chemical denotes theaflavin-3’-O-gallate
65 1128-1149 Chemical denotes theaflavin-3’-gallate
66 1158-1183 Chemical denotes theaflavin 3,3'-digallate MESH:C585473
67 1185-1188 Chemical denotes TF3 MESH:C585473
68 1191-1201 Chemical denotes hesperidin MESH:D006569
69 1203-1216 Chemical denotes quercetagetin MESH:C079163
70 1222-1231 Chemical denotes myricetin MESH:C040015
71 1335-1339 Chemical denotes EGCG MESH:C045651
72 1468-1472 Chemical denotes PBSA MESH:C437084
73 1559-1563 Chemical denotes ADME
74 1675-1679 Chemical denotes EGCG MESH:C045651
75 23-42 Disease denotes Coronavirus disease MESH:D018352
76 44-52 Disease denotes COVID-19 MESH:C000657245
77 235-243 Disease denotes COVID-19 MESH:C000657245
78 362-370 Disease denotes COVID-19 MESH:C000657245
79 853-861 Disease denotes COVID-19 MESH:C000657245
80 1576-1584 Disease denotes toxicity MESH:D064420
81 1753-1761 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 1090-1093 GlycoEpitope denotes TF1 http://www.glycoepitope.jp/epitopes/AN0049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-176 Sentence denotes The sudden outburst of Coronavirus disease (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a massive threat to global public health.
T8 177-244 Sentence denotes Currently, no therapeutic drug or vaccine exists to treat COVID-19.
T9 245-371 Sentence denotes Due to the time taking process of new drug development, drug repurposing might be the only viable solution to tackle COVID-19.
T10 372-503 Sentence denotes RNA‐dependent RNA polymerase (RdRp) catalyzes SARS-CoV-2 RNA replication and hence, is an obvious target for antiviral drug design.
T11 504-603 Sentence denotes Interestingly, several plant-derived polyphenols effectively inhibit the RdRp of other RNA viruses.
T12 604-743 Sentence denotes More importantly, polyphenols have been used as dietary supplementations for a long time and played beneficial roles in immune homeostasis.
T13 744-862 Sentence denotes We were curious to study the binding of polyphenols with SARS-CoV-2 RdRp and assess their potential to treat COVID-19.
T14 863-977 Sentence denotes Herein, we made a library of polyphenols that have shown substantial therapeutic effects against various diseases.
T15 978-1040 Sentence denotes They were successfully docked in the catalytic pocket of RdRp.
T16 1041-1273 Sentence denotes The investigation reveals that EGCG, theaflavin (TF1), theaflavin-3’-O-gallate (TF2a), theaflavin-3’-gallate (TF2b), theaflavin 3,3'-digallate (TF3), hesperidin, quercetagetin, and myricetin strongly bind to the active site of RdRp.
T17 1274-1411 Sentence denotes Further, a 150-ns molecular dynamic simulation revealed that EGCG, TF2a, TF2b, TF3 result in highly stable bound conformations with RdRp.
T18 1412-1517 Sentence denotes The binding free energy components calculated by the MM-PBSA also confirm the stability of the complexes.
T19 1518-1640 Sentence denotes We also performed a detailed analysis of ADME prediction, toxicity prediction, and target analysis for their druggability.
T20 1641-1762 Sentence denotes Overall, our results suggest that EGCG, TF2a, TF2b, TF3 can inhibit RdRp and represent an effective therapy for COVID-19.