PMC:7441777 / 22039-22346 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T60","span":{"begin":38,"end":46},"obj":"Disease"},{"id":"T61","span":{"begin":175,"end":183},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T119","span":{"begin":228,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T318","span":{"begin":22,"end":29},"obj":"Chemical"},{"id":"T319","span":{"begin":116,"end":127},"obj":"Chemical"}],"attributes":[{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_26195"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T8","span":{"begin":287,"end":306},"obj":"http://purl.obolibrary.org/obo/GO_0019083"},{"id":"T9","span":{"begin":293,"end":306},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}

{"project":"LitCovid-PubTator","denotations":[{"id":"519","span":{"begin":49,"end":53},"obj":"Gene"},{"id":"520","span":{"begin":186,"end":190},"obj":"Gene"},{"id":"521","span":{"begin":223,"end":227},"obj":"Gene"},{"id":"523","span":{"begin":38,"end":48},"obj":"Species"},{"id":"524","span":{"begin":175,"end":185},"obj":"Species"},{"id":"537","span":{"begin":116,"end":127},"obj":"Chemical"}],"attributes":[{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"Gene:43740578"},{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"Gene:43740578"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"Gene:43740578"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"Tax:2697049"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"Tax:2697049"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"MESH:D059808"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}

{"project":"LitCovid-sentences","denotations":[{"id":"T220","span":{"begin":0,"end":307},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The top-eight scoring ligands for the SARS-CoV-2 RdRp (as highlighted in Table 1) suggest that these set of natural polyphenols can strongly bind to the catalytic site of the SARS-CoV-2 RdRp and are expected to inhibit the RdRp activity, and thus blocking the replication and preventing viral transcription."}