PMC:7435837 / 6185-12165
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T54 | 133-138 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T55 | 181-189 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T56 | 219-234 | Body_part | denotes | lung parenchyma | http://purl.org/sig/ont/fma/fma27360 |
| T57 | 278-282 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T58 | 398-408 | Body_part | denotes | parenchyma | http://purl.org/sig/ont/fma/fma45732 |
| T59 | 514-518 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T60 | 599-621 | Body_part | denotes | gastrointestinal tract | http://purl.org/sig/ont/fma/fma71132 |
| T61 | 623-626 | Body_part | denotes | GIT | http://purl.org/sig/ont/fma/fma71132 |
| T62 | 656-659 | Body_part | denotes | GIT | http://purl.org/sig/ont/fma/fma71132 |
| T63 | 879-887 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T64 | 906-910 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T65 | 990-998 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T66 | 1013-1017 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T67 | 1055-1059 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T68 | 1233-1240 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T69 | 1282-1288 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T70 | 1342-1349 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T71 | 1372-1379 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T72 | 1428-1442 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
| T73 | 1428-1432 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T74 | 1581-1588 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T75 | 1605-1609 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T76 | 1757-1761 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T77 | 1762-1775 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T78 | 2027-2035 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T79 | 2050-2054 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T80 | 2457-2465 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T81 | 2533-2536 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T82 | 2546-2549 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T83 | 2615-2622 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T84 | 2724-2731 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T85 | 2772-2780 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T86 | 3118-3133 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T87 | 3128-3133 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T88 | 3139-3154 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T89 | 3149-3154 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T90 | 3195-3203 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T91 | 3314-3319 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T92 | 3339-3351 | Body_part | denotes | T-lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
| T93 | 3417-3430 | Body_part | denotes | B-lymphocytes | http://purl.org/sig/ont/fma/fma62869 |
| T94 | 3485-3493 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T95 | 3599-3604 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T96 | 3667-3672 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T97 | 3701-3708 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T98 | 3730-3739 | Body_part | denotes | dendritic | http://purl.org/sig/ont/fma/fma67314 |
| T99 | 3756-3761 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T100 | 3767-3779 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
| T101 | 4613-4620 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T102 | 4663-4668 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T103 | 4686-4691 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T104 | 4732-4739 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T105 | 4865-4869 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T106 | 4895-4908 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T107 | 5057-5064 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T108 | 5142-5147 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T109 | 5213-5220 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T110 | 5254-5257 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T111 | 5374-5381 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T112 | 5398-5406 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T113 | 5471-5478 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T114 | 5554-5561 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T115 | 5765-5773 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 219-234 | Body_part | denotes | lung parenchyma | http://purl.obolibrary.org/obo/UBERON_0008946 |
| T4 | 219-223 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T5 | 224-234 | Body_part | denotes | parenchyma | http://purl.obolibrary.org/obo/UBERON_0000353 |
| T6 | 398-408 | Body_part | denotes | parenchyma | http://purl.obolibrary.org/obo/UBERON_0000353 |
| T7 | 514-518 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 4895-4908 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T7 | 164-172 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T8 | 461-465 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 477-485 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T10 | 519-525 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T11 | 686-694 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 721-729 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T13 | 2319-2327 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T14 | 2388-2392 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T15 | 2715-2723 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 3977-3985 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T17 | 4101-4109 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T18 | 4332-4341 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T19 | 4349-4357 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T20 | 4441-4449 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T21 | 5042-5050 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T80 | 67-70 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T81 | 133-138 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T82 | 199-202 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T83 | 219-223 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T84 | 219-223 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T85 | 278-282 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T86 | 488-495 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T87 | 514-518 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T88 | 514-518 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T89 | 571-572 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T90 | 599-621 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | gastrointestinal tract |
| T91 | 623-626 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | GIT |
| T92 | 656-659 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | GIT |
| T93 | 809-812 | http://purl.obolibrary.org/obo/PR_000001343 | denotes | aim |
| T94 | 906-910 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T95 | 942-945 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T96 | 1013-1017 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T97 | 1055-1059 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T98 | 1073-1078 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T99 | 1168-1170 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
| T100 | 1173-1174 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T101 | 1188-1196 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T102 | 1428-1432 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T103 | 1433-1442 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T104 | 1458-1466 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T105 | 1605-1609 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T106 | 1757-1761 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T107 | 2050-2054 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T108 | 2170-2171 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T109 | 2340-2343 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T110 | 2437-2447 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T111 | 2553-2554 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T112 | 2630-2637 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T113 | 2639-2641 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T114 | 2694-2702 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T115 | 3080-3081 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T116 | 3118-3133 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T117 | 3139-3159 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells will |
| T118 | 3173-3178 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
| T119 | 3183-3188 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T120 | 3230-3233 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T121 | 3235-3238 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T122 | 3240-3248 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T123 | 3312-3319 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T124 | 3417-3418 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T125 | 3558-3563 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T126 | 3597-3609 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells will |
| T127 | 3667-3672 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T128 | 3693-3694 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T129 | 3756-3761 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T130 | 3897-3899 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T131 | 4054-4059 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T132 | 4063-4064 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T133 | 4119-4122 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T134 | 4152-4157 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T135 | 4189-4190 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T136 | 4295-4296 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T137 | 4663-4668 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T138 | 4677-4678 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T139 | 4684-4691 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T140 | 4857-4858 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T141 | 4863-4869 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T142 | 4895-4908 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T143 | 4935-4936 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T144 | 5140-5147 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T145 | 5155-5156 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T146 | 5324-5331 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T147 | 5791-5792 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T54 | 181-189 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T55 | 764-778 | Chemical | denotes | pharmaceutical | http://purl.obolibrary.org/obo/CHEBI_52217 |
| T56 | 856-863 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T57 | 879-887 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T58 | 926-930 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T59 | 931-941 | Chemical | denotes | umifenovir | http://purl.obolibrary.org/obo/CHEBI_134730 |
| T60 | 990-998 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T61 | 1089-1099 | Chemical | denotes | umifenovir | http://purl.obolibrary.org/obo/CHEBI_134730 |
| T62 | 1233-1240 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T63 | 1282-1288 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T64 | 1342-1349 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T65 | 1372-1379 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T66 | 1581-1588 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T67 | 1711-1722 | Chemical | denotes | saccharides | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T68 | 1762-1775 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T69 | 1785-1792 | Chemical | denotes | quinine | http://purl.obolibrary.org/obo/CHEBI_137041|http://purl.obolibrary.org/obo/CHEBI_15854 |
| T71 | 1823-1833 | Chemical | denotes | saccharide | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T72 | 1852-1864 | Chemical | denotes | sialic acids | http://purl.obolibrary.org/obo/CHEBI_26667 |
| T73 | 1859-1864 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T74 | 1887-1892 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T75 | 1901-1919 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T76 | 2027-2035 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T77 | 2082-2089 | Chemical | denotes | quinine | http://purl.obolibrary.org/obo/CHEBI_137041|http://purl.obolibrary.org/obo/CHEBI_15854 |
| T79 | 2155-2166 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
| T80 | 2225-2235 | Chemical | denotes | nelfinavir | http://purl.obolibrary.org/obo/CHEBI_7496 |
| T81 | 2264-2274 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T82 | 2360-2379 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T84 | 2369-2379 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T85 | 2457-2465 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T86 | 2505-2517 | Chemical | denotes | polypeptides | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T87 | 2615-2622 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T88 | 2658-2667 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T89 | 2724-2731 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T90 | 2772-2780 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T91 | 2813-2818 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T92 | 2841-2860 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
| T94 | 2850-2860 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T95 | 3011-3016 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T96 | 3173-3178 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T97 | 3195-3203 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T98 | 3240-3248 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T99 | 3362-3370 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T100 | 3485-3493 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T101 | 3701-3708 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T102 | 3767-3779 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T103 | 4613-4620 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T104 | 4732-4739 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T105 | 4740-4747 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
| T106 | 4816-4824 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T107 | 5057-5064 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T108 | 5213-5220 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T109 | 5254-5257 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T110 | 5324-5331 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T111 | 5374-5381 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T112 | 5398-5406 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T113 | 5471-5478 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T114 | 5479-5486 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T115 | 5554-5561 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T116 | 5757-5764 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T6 | 278-288 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T7 | 1406-1427 | http://purl.obolibrary.org/obo/GO_0051701 | denotes | interaction with host |
| T8 | 1458-1473 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T9 | 1685-1694 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T10 | 2480-2491 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T11 | 2587-2596 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T12 | 3521-3533 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T13 | 3590-3596 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T14 | 5169-5184 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T15 | 5311-5320 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 115 | 110-115 | Gene | denotes | ACE-2 | Gene:59272 |
| 116 | 310-315 | Gene | denotes | ACE-2 | Gene:59272 |
| 117 | 544-549 | Gene | denotes | ACE-2 | Gene:59272 |
| 118 | 175-180 | Gene | denotes | spike | Gene:43740568 |
| 119 | 164-174 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 120 | 477-487 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 121 | 686-694 | Species | denotes | SARS-CoV | Tax:694009 |
| 122 | 695-703 | Species | denotes | patients | Tax:9606 |
| 123 | 741-749 | Species | denotes | patients | Tax:9606 |
| 124 | 514-525 | Disease | denotes | lung injury | MESH:D055370 |
| 125 | 721-740 | Disease | denotes | SARS-CoV-2 infected | MESH:C000657245 |
| 133 | 1018-1023 | Gene | denotes | ACE-2 | Gene:59272 |
| 134 | 873-878 | Gene | denotes | spike | Gene:43740568 |
| 135 | 795-808 | Species | denotes | coronaviruses | Tax:11118 |
| 136 | 856-863 | Chemical | denotes | glycans | MESH:D011134 |
| 137 | 931-941 | Chemical | denotes | umifenovir | MESH:C086979 |
| 138 | 1089-1099 | Chemical | denotes | umifenovir | MESH:C086979 |
| 139 | 1142-1150 | Disease | denotes | Covid-19 | MESH:C000657245 |
| 149 | 1251-1256 | Gene | denotes | ACE-2 | Gene:59272 |
| 150 | 1274-1281 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 151 | 1507-1514 | Gene | denotes | TMPRSS2 | Gene:7113 |
| 152 | 1523-1528 | Gene | denotes | ACE-2 | Gene:59272 |
| 153 | 1575-1580 | Gene | denotes | spike | Gene:43740568 |
| 154 | 1336-1341 | Gene | denotes | spike | Gene:43740568 |
| 155 | 1227-1232 | Gene | denotes | spike | Gene:43740568 |
| 156 | 1324-1335 | Species | denotes | coronavirus | Tax:11118 |
| 157 | 1282-1288 | Chemical | denotes | serine | MESH:D012694 |
| 169 | 2021-2026 | Gene | denotes | spike | Gene:43740568 |
| 170 | 2009-2020 | Species | denotes | coronaviral | Tax:11118 |
| 171 | 1711-1722 | Chemical | denotes | saccharides | MESH:D002241 |
| 172 | 1785-1792 | Chemical | denotes | quinine | MESH:D011803 |
| 173 | 1823-1833 | Chemical | denotes | saccharide | MESH:D002241 |
| 174 | 1852-1864 | Chemical | denotes | sialic acids | MESH:D012794 |
| 175 | 1901-1919 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 176 | 1969-1975 | Chemical | denotes | glycan | MESH:D011134 |
| 177 | 2082-2089 | Chemical | denotes | quinine | MESH:D011803 |
| 178 | 2119-2133 | Disease | denotes | cardiotoxicity | MESH:D066126 |
| 179 | 2186-2194 | Disease | denotes | Covid-19 | MESH:C000657245 |
| 187 | 2766-2771 | Gene | denotes | spike | Gene:43740568 |
| 188 | 2451-2456 | Gene | denotes | spike | Gene:43740568 |
| 189 | 2319-2327 | Species | denotes | SARS-CoV | Tax:694009 |
| 190 | 2715-2723 | Species | denotes | SARS-CoV | Tax:694009 |
| 191 | 2869-2882 | Species | denotes | coronaviruses | Tax:11118 |
| 192 | 2644-2653 | Chemical | denotes | Ritonavir | MESH:D019438 |
| 193 | 2658-2667 | Chemical | denotes | lopinavir | MESH:D061466 |
| 201 | 3695-3700 | Gene | denotes | spike | Gene:43740568 |
| 202 | 3479-3484 | Gene | denotes | spike | Gene:43740568 |
| 203 | 3189-3194 | Gene | denotes | spike | Gene:43740568 |
| 204 | 3209-3220 | Species | denotes | coronavirus | Tax:11118 |
| 205 | 3497-3510 | Species | denotes | coronaviruses | Tax:11118 |
| 206 | 3767-3779 | Chemical | denotes | carbohydrate | MESH:D002241 |
| 207 | 3832-3838 | Chemical | denotes | glycan | MESH:D011134 |
| 219 | 3977-3987 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 220 | 4088-4099 | Species | denotes | coronavirus | Tax:11118 |
| 221 | 4101-4109 | Species | denotes | SARS-CoV | Tax:694009 |
| 222 | 4152-4157 | Species | denotes | human | Tax:9606 |
| 223 | 4169-4182 | Species | denotes | coronaviruses | Tax:11118 |
| 224 | 4349-4359 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 225 | 4373-4425 | Species | denotes | Middle East respiratory syndrome-related coronavirus | Tax:1335626 |
| 226 | 4427-4435 | Species | denotes | MERS-CoV | Tax:1335626 |
| 227 | 4441-4449 | Species | denotes | SARS-CoV | Tax:694009 |
| 228 | 4469-4484 | Species | denotes | β-coronaviruses | Tax:694002 |
| 229 | 4320-4341 | Disease | denotes | coronavirus infection | MESH:D018352 |
| 238 | 5207-5212 | Gene | denotes | spike | Gene:43740568 |
| 239 | 5051-5056 | Gene | denotes | spike | Gene:43740568 |
| 240 | 4726-4731 | Gene | denotes | spike | Gene:43740568 |
| 241 | 4607-4612 | Gene | denotes | spike | Gene:43740568 |
| 242 | 4912-4925 | Species | denotes | coronaviruses | Tax:11118 |
| 243 | 5042-5050 | Species | denotes | SARS-CoV | Tax:694009 |
| 244 | 5071-5081 | Species | denotes | adenovirus | Tax:10508 |
| 245 | 5100-5110 | Species | denotes | adenovirus | Tax:10508 |
| 252 | 5368-5373 | Gene | denotes | spike | Gene:43740568 |
| 253 | 5392-5397 | Gene | denotes | Spike | Gene:43740568 |
| 254 | 5548-5553 | Gene | denotes | spike | Gene:43740568 |
| 255 | 5465-5470 | Gene | denotes | spike | Gene:43740568 |
| 256 | 5414-5422 | Species | denotes | MERS-CoV | Tax:1335626 |
| 257 | 5494-5502 | Species | denotes | MERS-CoV | Tax:1335626 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51 | 0-2 | Sentence | denotes | 3. |
| T52 | 3-63 | Sentence | denotes | Potential Targets for Drug Development against Coronaviruses |
| T53 | 64-195 | Sentence | denotes | It has been shown at the time of writing that ACE-2 receptors in the lungs are specific targets for SARS-CoV-2 spike proteins [15]. |
| T54 | 196-423 | Sentence | denotes | It has been found that lung parenchyma must be in the differentiated state of the cell cycle and must express the ACE-2 receptor on the apical side, i.e., the site of the first contact with air, of the parenchyma [16,17,18,19]. |
| T55 | 424-543 | Sentence | denotes | It is no surprise therefore that the SARS, MERS, and SARS-CoV-2 viruses cause significant lung injury [20,21,22,23,24]. |
| T56 | 544-755 | Sentence | denotes | ACE-2 is also expressed to a significant extent in the gastrointestinal tract (GIT) [25] which accounts for the GIT symptoms that appeared in SARS-CoV patients and currently in SARS-CoV-2 infected patients [26]. |
| T57 | 756-921 | Sentence | denotes | Current pharmaceutical efforts against coronaviruses aim to interfere with the binding of the viral glycans in their spike proteins to potential host cell receptors. |
| T58 | 922-1079 | Sentence | denotes | The drug umifenovir has been shown to prevent the fusion of viral S-proteins with the host cell ACE-2 receptors, therefore excluding cell entry of the virus. |
| T59 | 1080-1172 | Sentence | denotes | However, umifenovir was clinically inefficient to improve the Covid-19 disease outcome [27]. |
| T60 | 1173-1298 | Sentence | denotes | A contributing membrane-bound enzyme that facilitates spike protein entry via ACE-2 receptors is the TMPRSS2 serine protease. |
| T61 | 1299-1479 | Sentence | denotes | This protease primes the coronavirus spike protein for entry by cleaving protein domains that increase the interaction with host cell membranes that result in membrane fusion [28]. |
| T62 | 1480-1621 | Sentence | denotes | It was also suggested that TMPRSS2 cleaves ACE-2 sites that promote the affinity for the viral spike protein, hence enhances cell entry [29]. |
| T63 | 1622-1776 | Sentence | denotes | Another possible target for treatment is the inhibition of the synthesis of the required saccharides that are incorporated in the host cell glycoproteins. |
| T64 | 1777-1920 | Sentence | denotes | Several quinine derivatives showed that these saccharide moieties known as sialic acids could be inhibited by drugs such as hydroxychloroquine. |
| T65 | 1921-2072 | Sentence | denotes | The quinines, therefore, decrease the number of glycan targets that could be engaged by coronaviral spike proteins to facilitate cell entry [30,31,32]. |
| T66 | 2073-2200 | Sentence | denotes | However, quinine derivatives pose significant cardiotoxicity that precludes their application as a treatment for Covid-19 [33]. |
| T67 | 2201-2336 | Sentence | denotes | Antiretrovirals such as nelfinavir have proven to be efficient inhibitors of post-entry replication of the virions of SARS-CoV [34,35]. |
| T68 | 2337-2545 | Sentence | denotes | It has been found that protease inhibitors used in SARS and MERS studies prevented the cleavage and activation of spike proteins following the translation of precursor polypeptides from the viral RNA [36,37]. |
| T69 | 2546-2643 | Sentence | denotes | RNA is a vital step towards the ultimate formation of the structural protein of new viruses [34]. |
| T70 | 2644-2794 | Sentence | denotes | Ritonavir and lopinavir [38] have shown some good activity against the SARS-CoV protein cleavage that ultimately prevents spike proteins from forming. |
| T71 | 2795-2952 | Sentence | denotes | Some investigated drugs have been reviewed as protease inhibitors against coronaviruses and the reader is referred to the publication by Adedeji et al. [39]. |
| T72 | 2953-3034 | Sentence | denotes | Figure 2 shows the currently identified targets for which drugs are investigated. |
| T73 | 3035-3134 | Sentence | denotes | Vaccination efforts are attempting to create a substrate that can be recognized by dendritic cells. |
| T74 | 3135-3249 | Sentence | denotes | The dendritic cells will subsequently label the virus spike proteins with coronavirus specific CD4+/CD8+ peptides. |
| T75 | 3250-3371 | Sentence | denotes | These specifically loaded particles will then be presented to T-cells that interact with T-lymphocyte dependent antigens. |
| T76 | 3372-3564 | Sentence | denotes | This interaction results in the induction of B-lymphocytes that produces antibodies that can recognize the spike proteins of coronaviruses to afford phagocytosis and destructions of the virus. |
| T77 | 3565-3762 | Sentence | denotes | It is also expected that memory T-cells will form which could result in long-term immunity when these cells are replicated when a spike protein can be recognized by dendritic or other immune cells. |
| T78 | 3763-3901 | Sentence | denotes | The carbohydrate-based vaccine holds promise to present recognizable glycan arrays that are representative of the targeted pathogens [41]. |
| T79 | 3902-4115 | Sentence | denotes | Very recently, several targets have been identified for the development of SARS-CoV-2 vaccines that have been identified based on the similarity of the virus to a previously encountered coronavirus, SARS-CoV [42]. |
| T80 | 4116-4368 | Sentence | denotes | It has been proven that many of the human pathogenic coronaviruses share a significant genomic overlap of more than 99.9% and this provides the basis for developing vaccines from a previously encountered coronavirus infection before SARS-CoV-2 [15,43]. |
| T81 | 4369-4534 | Sentence | denotes | The Middle East respiratory syndrome-related coronavirus, MERS-CoV, and SARS-CoV form part of these β-coronaviruses which wreaked havoc in the last two decades [44]. |
| T82 | 4535-4692 | Sentence | denotes | Therefore, one of the most promising targets is the characterization of spike protein epitopes that can be recognized by immune cells such as B- and T-cells. |
| T83 | 4693-4934 | Sentence | denotes | Some form of replication of this spike protein epitope should, therefore, be developed and this will hopefully provide the antigens which can bind to, for example, B- or T-cell antibodies and alert the immune system to coronaviruses [44,45]. |
| T84 | 4935-5082 | Sentence | denotes | A recombinant vaccination approach could be demonstrated by expressing the receptor-binding domain [46] of SARS-CoV spike protein in an adenovirus. |
| T85 | 5083-5241 | Sentence | denotes | This recombinant adenovirus was administered nasally and T-cells showed a significant immune response towards the expressed spike protein-binding domain [47]. |
| T86 | 5242-5391 | Sentence | denotes | Recombinant DNA approaches have made significant strides towards the synthesis of peptide sequences that can directly bind to spike protein epitopes. |
| T87 | 5392-5460 | Sentence | denotes | Spike proteins of the MERS-CoV were neutralized in this way [48,49]. |
| T88 | 5461-5580 | Sentence | denotes | The spike protein antigen of the MERS-CoV was also reported and identified targets for spike protein deactivation [50]. |
| T89 | 5581-5718 | Sentence | denotes | It is emphasized that the discussion of chemotherapeutic and vaccination efforts is superficial and not covered in detail in this report. |
| T90 | 5719-5829 | Sentence | denotes | Of importance though is the fact that antigen-antibody interactions are a key interest in developing vaccines. |
| T91 | 5830-5980 | Sentence | denotes | This recognition mechanism is creating the prelude for the discussion of the layer-by-layer nanocoating process that will be elaborated in due course. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32731428-32007145-71421256 | 191-193 | 32007145 | denotes | 15 |
| 32731428-21887302-71421257 | 416-418 | 21887302 | denotes | 18 |
| 32731428-24083868-71421258 | 527-529 | 24083868 | denotes | 20 |
| 32731428-12781536-71421259 | 530-532 | 12781536 | denotes | 21 |
| 32731428-25294366-71421260 | 533-535 | 25294366 | denotes | 22 |
| 32731428-16116101-71421261 | 536-538 | 16116101 | denotes | 23 |
| 32731428-17934078-71421262 | 539-541 | 17934078 | denotes | 24 |
| 32731428-15141377-71421263 | 629-631 | 15141377 | denotes | 25 |
| 32731428-32241899-71421264 | 751-753 | 32241899 | denotes | 26 |
| 32731428-32344167-71421265 | 1168-1170 | 32344167 | denotes | 27 |
| 32731428-32347443-71421266 | 1475-1477 | 32347443 | denotes | 28 |
| 32731428-24227843-71421267 | 1617-1619 | 24227843 | denotes | 29 |
| 32731428-14592603-71421268 | 2062-2064 | 14592603 | denotes | 30 |
| 32731428-32171740-71421269 | 2065-2067 | 32171740 | denotes | 31 |
| 32731428-32391371-71421270 | 2068-2070 | 32391371 | denotes | 32 |
| 32731428-32285489-71421271 | 2196-2198 | 32285489 | denotes | 33 |
| 32731428-15200845-71421272 | 2329-2331 | 15200845 | denotes | 34 |
| 32731428-15144898-71421273 | 2332-2334 | 15144898 | denotes | 35 |
| 32731428-24121034-71421274 | 2538-2540 | 24121034 | denotes | 36 |
| 32731428-25445340-71421275 | 2541-2543 | 25445340 | denotes | 37 |
| 32731428-15200845-71421276 | 2639-2641 | 15200845 | denotes | 34 |
| 32731428-15878786-71421277 | 2669-2671 | 15878786 | denotes | 38 |
| 32731428-24997250-71421278 | 2948-2950 | 24997250 | denotes | 39 |
| 32731428-16080094-71421279 | 3897-3899 | 16080094 | denotes | 41 |
| 32731428-32007145-71421280 | 4361-4363 | 32007145 | denotes | 15 |
| 32731428-32181901-71421281 | 4364-4366 | 32181901 | denotes | 43 |
| 32731428-32094589-71421282 | 4530-4532 | 32094589 | denotes | 44 |
| 32731428-32094589-71421283 | 4927-4929 | 32094589 | denotes | 44 |
| 32731428-25810418-71421284 | 4930-4932 | 25810418 | denotes | 45 |
| 32731428-26935699-71421285 | 5035-5037 | 26935699 | denotes | 46 |
| 32731428-18178835-71421286 | 5237-5239 | 18178835 | denotes | 47 |
| 32731428-24324708-71421287 | 5453-5455 | 24324708 | denotes | 48 |
| 32731428-19683779-71421288 | 5456-5458 | 19683779 | denotes | 49 |
| 32731428-28807998-71421289 | 5576-5578 | 28807998 | denotes | 50 |