PMC:7435837 / 46831-48059
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T311 | 67-75 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T312 | 170-174 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T313 | 237-245 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T314 | 291-298 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T315 | 563-566 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T316 | 705-713 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T317 | 866-874 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T318 | 878-881 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T319 | 1050-1054 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T320 | 1093-1108 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T321 | 1103-1108 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T457 | 47-48 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T458 | 55-60 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T459 | 150-155 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T460 | 170-174 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T461 | 385-390 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T462 | 396-404 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T463 | 462-463 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T464 | 495-500 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T465 | 510-518 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T466 | 926-927 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T467 | 976-981 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T468 | 991-994 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T469 | 1018-1023 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T470 | 1050-1054 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T471 | 1060-1065 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T472 | 1093-1108 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T558 | 32-36 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T559 | 67-75 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T560 | 193-200 | Chemical | denotes | arbidol | http://purl.obolibrary.org/obo/CHEBI_134730 |
| T561 | 237-245 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T562 | 291-298 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T563 | 372-380 | Chemical | denotes | camostat | http://purl.obolibrary.org/obo/CHEBI_135632 |
| T564 | 434-439 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T565 | 448-459 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T566 | 599-611 | Chemical | denotes | polypeptides | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T567 | 617-629 | Chemical | denotes | polypeptides | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T568 | 705-713 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T569 | 775-784 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T570 | 866-874 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T571 | 948-957 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T38 | 396-411 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
| T39 | 720-731 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
| T40 | 976-990 | http://purl.obolibrary.org/obo/GO_0019068 | denotes | Virus assembly |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1435 | 90-95 | Gene | denotes | ACE-2 | Gene:59272 |
| 1436 | 327-332 | Gene | denotes | ACE-2 | Gene:59272 |
| 1437 | 285-290 | Gene | denotes | spike | Gene:43740568 |
| 1438 | 231-236 | Gene | denotes | spike | Gene:43740568 |
| 1439 | 61-66 | Gene | denotes | spike | Gene:43740568 |
| 1440 | 541-552 | Species | denotes | coronavirus | Tax:11118 |
| 1441 | 972-981 | Species | denotes | D). Virus | Tax:10809 |
| 1442 | 193-200 | Chemical | denotes | arbidol | MESH:C086979 |
| 1443 | 448-459 | Chemical | denotes | chloroquine | MESH:D002738 |
| 1444 | 775-784 | Chemical | denotes | lopinavir | MESH:D061466 |
| 1445 | 912-922 | Chemical | denotes | Remdesivir | MESH:C000606551 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T363 | 0-50 | Sentence | denotes | Figure 2 Potential targets for drug therapy. (A). |
| T364 | 51-175 | Sentence | denotes | The virus spike proteins interact with ACE-2 receptors and this provides the route of entry of the virus into the host cell. |
| T365 | 176-178 | Sentence | denotes | 1. |
| T366 | 179-266 | Sentence | denotes | Drugs such as arbidol interfere with the binding of spike proteins with ACE-2 receptor. |
| T367 | 267-269 | Sentence | denotes | 2. |
| T368 | 270-381 | Sentence | denotes | Priming of the spike protein to enhance its affinity for ACE-2 receptors is hampered by, for example, camostat. |
| T369 | 382-384 | Sentence | denotes | 3. |
| T370 | 385-465 | Sentence | denotes | Virus-host membrane fusion could be prevented by drugs such as chloroquine. (B). |
| T371 | 466-536 | Sentence | denotes | The successful fusion of the virus and host membrane is achieved. (C). |
| T372 | 537-612 | Sentence | denotes | The coronavirus sheds its RNA which can then be translated to polypeptides. |
| T373 | 613-714 | Sentence | denotes | The polypeptides as cleaved by the enzyme, 3-chymotrypsin protease to render non-structural proteins. |
| T374 | 715-785 | Sentence | denotes | This proteolysis step, 4, can be inhibited by, for example, lopinavir. |
| T375 | 786-911 | Sentence | denotes | Drug target 5, prohibits the further conversion of non-structural to structural proteins by RNA-dependent polymerase enzymes. |
| T376 | 912-975 | Sentence | denotes | Remdesivir is a prime example of an inhibitor of target 5. (D). |
| T377 | 976-1055 | Sentence | denotes | Virus assembly has been completed and the virus is expelled from the host cell. |
| T378 | 1056-1202 | Sentence | denotes | The virus can then be intercepted by dendritic cells or other immune factors such as interferons (not discussed) or restart the replication cycle. |
| T379 | 1203-1228 | Sentence | denotes | Figure adapted from [40]. |