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PMC:7435837 / 46831-48059 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T311 67-75 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T312 170-174 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T313 237-245 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T314 291-298 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 563-566 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T316 705-713 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T317 866-874 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T318 878-881 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T319 1050-1054 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T320 1093-1108 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T321 1103-1108 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T457 47-48 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T458 55-60 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T459 150-155 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T460 170-174 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T461 385-390 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T462 396-404 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T463 462-463 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T464 495-500 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T465 510-518 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T466 926-927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T467 976-981 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T468 991-994 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T469 1018-1023 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T470 1050-1054 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T471 1060-1065 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T472 1093-1108 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T558 32-36 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T559 67-75 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T560 193-200 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T561 237-245 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T562 291-298 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T563 372-380 Chemical denotes camostat http://purl.obolibrary.org/obo/CHEBI_135632
T564 434-439 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T565 448-459 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T566 599-611 Chemical denotes polypeptides http://purl.obolibrary.org/obo/CHEBI_15841
T567 617-629 Chemical denotes polypeptides http://purl.obolibrary.org/obo/CHEBI_15841
T568 705-713 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T569 775-784 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T570 866-874 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T571 948-957 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T38 396-411 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T39 720-731 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T40 976-990 http://purl.obolibrary.org/obo/GO_0019068 denotes Virus assembly

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1435 90-95 Gene denotes ACE-2 Gene:59272
1436 327-332 Gene denotes ACE-2 Gene:59272
1437 285-290 Gene denotes spike Gene:43740568
1438 231-236 Gene denotes spike Gene:43740568
1439 61-66 Gene denotes spike Gene:43740568
1440 541-552 Species denotes coronavirus Tax:11118
1441 972-981 Species denotes D). Virus Tax:10809
1442 193-200 Chemical denotes arbidol MESH:C086979
1443 448-459 Chemical denotes chloroquine MESH:D002738
1444 775-784 Chemical denotes lopinavir MESH:D061466
1445 912-922 Chemical denotes Remdesivir MESH:C000606551

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T363 0-50 Sentence denotes Figure 2 Potential targets for drug therapy. (A).
T364 51-175 Sentence denotes The virus spike proteins interact with ACE-2 receptors and this provides the route of entry of the virus into the host cell.
T365 176-178 Sentence denotes 1.
T366 179-266 Sentence denotes Drugs such as arbidol interfere with the binding of spike proteins with ACE-2 receptor.
T367 267-269 Sentence denotes 2.
T368 270-381 Sentence denotes Priming of the spike protein to enhance its affinity for ACE-2 receptors is hampered by, for example, camostat.
T369 382-384 Sentence denotes 3.
T370 385-465 Sentence denotes Virus-host membrane fusion could be prevented by drugs such as chloroquine. (B).
T371 466-536 Sentence denotes The successful fusion of the virus and host membrane is achieved. (C).
T372 537-612 Sentence denotes The coronavirus sheds its RNA which can then be translated to polypeptides.
T373 613-714 Sentence denotes The polypeptides as cleaved by the enzyme, 3-chymotrypsin protease to render non-structural proteins.
T374 715-785 Sentence denotes This proteolysis step, 4, can be inhibited by, for example, lopinavir.
T375 786-911 Sentence denotes Drug target 5, prohibits the further conversion of non-structural to structural proteins by RNA-dependent polymerase enzymes.
T376 912-975 Sentence denotes Remdesivir is a prime example of an inhibitor of target 5. (D).
T377 976-1055 Sentence denotes Virus assembly has been completed and the virus is expelled from the host cell.
T378 1056-1202 Sentence denotes The virus can then be intercepted by dendritic cells or other immune factors such as interferons (not discussed) or restart the replication cycle.
T379 1203-1228 Sentence denotes Figure adapted from [40].