PMC:7435837 / 14806-15241
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7435837","sourcedb":"PMC","sourceid":"7435837","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7435837","text":"eparin sulfate proteoglycans, one of the most commonly occurring glycoproteins in eukaryotic organisms, and facilitate virion adsorption to cell membranes [63]. The spike protein of SARS-CoV-2 is shown to interact with heparin which is derived from the GAG, heparan sulfate and this indicated a potential target for heparan and heparin-derived drugs against SARS-CoV-2 [64,65,66,67]. Heparan sulfate is a promising target since heparin","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T161","span":{"begin":15,"end":28},"obj":"Body_part"},{"id":"T162","span":{"begin":65,"end":78},"obj":"Body_part"},{"id":"T163","span":{"begin":140,"end":154},"obj":"Body_part"},{"id":"T164","span":{"begin":140,"end":144},"obj":"Body_part"},{"id":"T165","span":{"begin":171,"end":178},"obj":"Body_part"},{"id":"T166","span":{"begin":219,"end":226},"obj":"Body_part"},{"id":"T167","span":{"begin":253,"end":256},"obj":"Body_part"},{"id":"T168","span":{"begin":258,"end":273},"obj":"Body_part"},{"id":"T169","span":{"begin":316,"end":323},"obj":"Body_part"},{"id":"T170","span":{"begin":328,"end":335},"obj":"Body_part"},{"id":"T171","span":{"begin":384,"end":399},"obj":"Body_part"},{"id":"T172","span":{"begin":384,"end":391},"obj":"Body_part"},{"id":"T173","span":{"begin":428,"end":435},"obj":"Body_part"}],"attributes":[{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma63015"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma63011"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma67110"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma67110"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma82839"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T173","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T27","span":{"begin":182,"end":190},"obj":"Disease"},{"id":"T28","span":{"begin":358,"end":366},"obj":"Disease"}],"attributes":[{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T168","span":{"begin":82,"end":92},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2759"},{"id":"T169","span":{"begin":93,"end":102},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T170","span":{"begin":93,"end":102},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T171","span":{"begin":140,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T172","span":{"begin":145,"end":154},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T173","span":{"begin":293,"end":294},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T174","span":{"begin":403,"end":404},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T168","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T173","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T174","span":{"begin":7,"end":14},"obj":"Chemical"},{"id":"T175","span":{"begin":15,"end":28},"obj":"Chemical"},{"id":"T176","span":{"begin":65,"end":78},"obj":"Chemical"},{"id":"T177","span":{"begin":171,"end":178},"obj":"Chemical"},{"id":"T178","span":{"begin":219,"end":226},"obj":"Chemical"},{"id":"T179","span":{"begin":253,"end":256},"obj":"Chemical"},{"id":"T181","span":{"begin":258,"end":273},"obj":"Chemical"},{"id":"T182","span":{"begin":258,"end":265},"obj":"Chemical"},{"id":"T183","span":{"begin":266,"end":273},"obj":"Chemical"},{"id":"T184","span":{"begin":316,"end":323},"obj":"Chemical"},{"id":"T185","span":{"begin":328,"end":335},"obj":"Chemical"},{"id":"T186","span":{"begin":344,"end":349},"obj":"Chemical"},{"id":"T187","span":{"begin":384,"end":399},"obj":"Chemical"},{"id":"T188","span":{"begin":392,"end":399},"obj":"Chemical"},{"id":"T189","span":{"begin":428,"end":435},"obj":"Chemical"}],"attributes":[{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A175","pred":"chebi_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A177","pred":"chebi_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_143889"},{"id":"A180","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A181","pred":"chebi_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A189","pred":"chebi_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T176","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T182","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T183","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T184","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T185","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T186","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"355","span":{"begin":165,"end":170},"obj":"Gene"},{"id":"357","span":{"begin":182,"end":192},"obj":"Species"},{"id":"358","span":{"begin":358,"end":368},"obj":"Species"},{"id":"366","span":{"begin":219,"end":226},"obj":"Chemical"},{"id":"367","span":{"begin":253,"end":256},"obj":"Chemical"},{"id":"368","span":{"begin":258,"end":273},"obj":"Chemical"},{"id":"369","span":{"begin":316,"end":323},"obj":"Chemical"},{"id":"370","span":{"begin":328,"end":335},"obj":"Chemical"},{"id":"371","span":{"begin":384,"end":399},"obj":"Chemical"},{"id":"372","span":{"begin":428,"end":435},"obj":"Chemical"}],"attributes":[{"id":"A355","pred":"tao:has_database_id","subj":"355","obj":"Gene:43740568"},{"id":"A357","pred":"tao:has_database_id","subj":"357","obj":"Tax:2697049"},{"id":"A358","pred":"tao:has_database_id","subj":"358","obj":"Tax:2697049"},{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"MESH:D006493"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"MESH:D006025"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"MESH:D006497"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"MESH:D006493"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"MESH:D006497"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"MESH:D006493"},{"subj":"355","pred":"source","obj":"LitCovid-PubTator"},{"subj":"357","pred":"source","obj":"LitCovid-PubTator"},{"subj":"358","pred":"source","obj":"LitCovid-PubTator"},{"subj":"366","pred":"source","obj":"LitCovid-PubTator"},{"subj":"367","pred":"source","obj":"LitCovid-PubTator"},{"subj":"368","pred":"source","obj":"LitCovid-PubTator"},{"subj":"369","pred":"source","obj":"LitCovid-PubTator"},{"subj":"370","pred":"source","obj":"LitCovid-PubTator"},{"subj":"371","pred":"source","obj":"LitCovid-PubTator"},{"subj":"372","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T3","span":{"begin":258,"end":273},"obj":"GlycoEpitope"},{"id":"T4","span":{"begin":384,"end":399},"obj":"GlycoEpitope"}],"attributes":[{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T112","span":{"begin":161,"end":383},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T112","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ce93ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ecb4"},{"id":"LitCovid-PD-CLO","color":"#ec9a93"},{"id":"LitCovid-PD-CHEBI","color":"#93a5ec"},{"id":"LitCovid-PubTator","color":"#bfec93"},{"id":"LitCovid-PD-GlycoEpitope","color":"#ec93d9"},{"id":"LitCovid-sentences","color":"#93ece5"}]}]}}