PMC:7426526 / 6959-7929 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7426526","sourcedb":"PMC","sourceid":"7426526","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7426526","text":"The origin of CSCs at tumor initiation: The two hypotheses of CSC generation. (A) The proliferation and differentiation of adult tissue resident stem cells is part of the physiological regeneration program that maintains tissue homeostasis. Adult tissue resident stem cells divide asymmetrically and generate transient amplifying cells, which possess a high proliferative capacity. These cells terminally differentiate; a process during which they will lose their proliferative capacity to finally support organ homeostasis. (B) Tumors can be generated by step-wise accumulation of several mutations (red lightening) that transform differentiated cells and cause a de-differentiation. Tissue resident stem cells as well as their progeny can accumulate mutations that lead to uncontrolled and niche independent growth. Heterogeneous tumors are generated. CSCs share phenotypic characteristics and several markers have been described in solid as well as in liquid cancers.","tracks":[]}