PMC:7426526 / 61449-64854 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7426526","sourcedb":"PMC","sourceid":"7426526","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7426526","text":"Table 9 Overview of clinical trials using current CAR-cell-based approaches in solid and hematological cancers targeting CSC.\nPhase ID number Approach Target Cell-based therapy Condition\nI NCT03423992 CAR T CD133, EGFRvIII, IL13RvIII2, Her-2,EphA2, GD2, Autologous CAR T-cells Recurrent malignant glioma\nI NCT03563326 CAR T EpCAM WCH-GC-CAR T Neoplasm, stomach metastases\nI NCT02915445 CAR T EpCAM CAR T-cells Malignant neoplasm of nasopharynx TNM stagingdistant metastasis (M), Breast cancer recurrent\nI NCT03766126 CAR T CD123 Autologous CAR T-cells Relapsed/refractory AML\nI NCT03672851 CAR T CD123 Autologous CAR T-cells Relapsed/refractory AML\nI NCT03190278 UCAR T CD123 Allogeneic CAR T-cells Relapsed/refractory AML\nI NCT04106076 UCAR T CD123 Allogeneic CAR T-cells Newly diagnosed AML\nI NCT02159495 CAR T CD123 Autologous/allogeneic CAR T-cells AML (various) or blastic plasmacytoid dendritic cell neoplasms\nI NCT03585517 CAR T CD123 CAR T-cells Relapsed/refractory AML\nI NCT04014881 CAR T CD123 CAR T-cells Relapsed/refractory AML\nI NCT03114670 CAR T CD123 Donor-derived CAR T-cells Recurred AML after allogeneic hematopoetic stem cell transplantation\nI NCT03796390 CAR T CD123 Autologous CAR T-cells Relapsed/refractory AML\nI NCT03126864 CAR T CD33 Autologous CAR T-cells Relapsed/refractory AML\nI NCT03795779 cCAR T CLL1-CD33 CAR T-cells Relapsed and/or refractory, high risk hematologic malignancies\nI NCT02799680 CAR T CD33 Allogeneic CAR T-cells Relapsed/refractory AML\nI/II NCT04097301 CAR T CD44v6 Autologous CAR T- cells AML, multiple myeloma\nI/II NCT02541370 CAR T CD133 Autologous or donor-derived T-cells Liver cancer, pancreatic cancer, brain tumor, breast cancer, ovarian tumor, colorectal cancer, acute myeloid, and lymphoid leukemias\nI/II NCT03356782 CAR T CD133 Autologous CAR T cells Sarcoma, osteoid sarcoma, ewing sarcoma\nI/II NCT03013712 CAR T EpCAM Autologous CAR T-cells Colon cancer; esophageal carcinoma; pancreatic, prostate cancer; gastric cancer, hepatic carcinoma\nI/II NCT03556982 CAR T CD123 Autologous/allogeneic CAR T-cells Relapsed/refractory AML\nI/II NCT03222674 Multi-CAR T CD33, CD38, CD123, CD56, MucI, CLL-1 Autologous CAR T-cells Relapsed/refractory AML\nI/II NCT04010877 Multiple CAR T CLL-1, CD33, and/or CD123 Autologous/allogeneic CAR T-cells AML\nI/II NCT04109482 CAR T CD123 Autologous CAR T-cells Relapsed or refractory blastic plasmacytoid dendritic cell neoplasm, acute myeloid leukemia, and high risk myelodysplastic syndrome\nI/II NCT02944162 CAR NK CD33 NK-92-cells Relapsed/refractory AML\nI/II NCT01864902 CAR T CD33 Autologous or donor-derived T-cells Relapsed/refractory AML\nI/II NCT03971799 CAR T CD33 CAR T-cells Children and adolescents/young adults (AYAs) with relapsed/refractory acute myeloid leukemia (AML)\nII/III NCT03631576 CAR T CD123/CLL-1 CAR T-cells Relapsed/refractory AML\n- NCT03473457 Single or double CAR T CD33,CD38, CD56, CD123, CD117, CD133,CD34, or Mucl CAR T-cells Relapsed/refractory AML\nII NCT02729493 CAR T EpCAM Autologous CAR T-cells Relapsed or refractory liver cancer\nII NCT02725125 CAR T EpCAM Autologous CAR T-cells Relapsed or refractory stomach cancer\nN.A. NCT04151186 CAR T EpCAM,TM4SF1 CAR T-cells Solid tumor\nSource: 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