PMC:7426526 / 56807-57421 JSONTXT

{"project":"TEST0","denotations":[{"id":"32849491-231-236-3396617","span":{"begin":384,"end":385},"obj":"[\"29681949\"]"},{"id":"32849491-234-240-3396618","span":{"begin":387,"end":389},"obj":"[\"30554963\"]"},{"id":"32849491-233-240-3396619","span":{"begin":391,"end":394},"obj":"[\"25200065\"]"},{"id":"32849491-224-231-3396620","span":{"begin":396,"end":399},"obj":"[\"27738343\"]"},{"id":"32849491-229-236-3396621","span":{"begin":401,"end":404},"obj":"[\"28397828\"]"},{"id":"32849491-116-121-3396622","span":{"begin":572,"end":573},"obj":"[\"31137841\"]"},{"id":"32849491-119-125-3396623","span":{"begin":575,"end":577},"obj":"[\"30328686\"]"}],"text":"As described above, a gain of stemness due to SASP and CSC maintenance or by plasticity of CSCs and non-CSCs, can cause increased resistance (Figure 2). CSCs (pre-existing or post-therapeutically generated de novo) can escape the treatment by the expression of drug exporters and detoxification proteins, entrance into dormancy as well as resistance to DNA damage induced cell death (4, 15, 185, 559, 560). Their survival causes tumor relapses (Figure 2). To interfere with the relapse, several strategies have been under investigation to block CSC resistance and growth (9, 13), as described below (Figures 3, 4)."}

{"project":"MyTest","denotations":[{"id":"32849491-29681949-34970997","span":{"begin":384,"end":385},"obj":"29681949"},{"id":"32849491-30554963-34970998","span":{"begin":387,"end":389},"obj":"30554963"},{"id":"32849491-25200065-34970999","span":{"begin":391,"end":394},"obj":"25200065"},{"id":"32849491-27738343-34971000","span":{"begin":396,"end":399},"obj":"27738343"},{"id":"32849491-28397828-34971001","span":{"begin":401,"end":404},"obj":"28397828"},{"id":"32849491-31137841-34971002","span":{"begin":572,"end":573},"obj":"31137841"},{"id":"32849491-30328686-34971003","span":{"begin":575,"end":577},"obj":"30328686"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"As described above, a gain of stemness due to SASP and CSC maintenance or by plasticity of CSCs and non-CSCs, can cause increased resistance (Figure 2). CSCs (pre-existing or post-therapeutically generated de novo) can escape the treatment by the expression of drug exporters and detoxification proteins, entrance into dormancy as well as resistance to DNA damage induced cell death (4, 15, 185, 559, 560). Their survival causes tumor relapses (Figure 2). To interfere with the relapse, several strategies have been under investigation to block CSC resistance and growth (9, 13), as described below (Figures 3, 4)."}

{"project":"2_test","denotations":[{"id":"32849491-29681949-34970997","span":{"begin":384,"end":385},"obj":"29681949"},{"id":"32849491-30554963-34970998","span":{"begin":387,"end":389},"obj":"30554963"},{"id":"32849491-25200065-34970999","span":{"begin":391,"end":394},"obj":"25200065"},{"id":"32849491-27738343-34971000","span":{"begin":396,"end":399},"obj":"27738343"},{"id":"32849491-28397828-34971001","span":{"begin":401,"end":404},"obj":"28397828"},{"id":"32849491-31137841-34971002","span":{"begin":572,"end":573},"obj":"31137841"},{"id":"32849491-30328686-34971003","span":{"begin":575,"end":577},"obj":"30328686"}],"text":"As described above, a gain of stemness due to SASP and CSC maintenance or by plasticity of CSCs and non-CSCs, can cause increased resistance (Figure 2). CSCs (pre-existing or post-therapeutically generated de novo) can escape the treatment by the expression of drug exporters and detoxification proteins, entrance into dormancy as well as resistance to DNA damage induced cell death (4, 15, 185, 559, 560). Their survival causes tumor relapses (Figure 2). To interfere with the relapse, several strategies have been under investigation to block CSC resistance and growth (9, 13), as described below (Figures 3, 4)."}