PMC:7417788 / 67741-68823
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1450 | 13-23 | GO:0010467 | denotes | expression |
| T1451 | 46-56 | GO:0010467 | denotes | expression |
| T1452 | 236-241 | SO:0005855 | denotes | genes |
| T1453 | 316-325 | GO:0010467 | denotes | expressed |
| T1454 | 326-331 | SO:0000704 | denotes | genes |
| T1455 | 455-465 | GO:0010467 | denotes | expression |
| T1456 | 584-589 | GO:0007568 | denotes | aging |
| T1457 | 881-886 | GO:0007568 | denotes | aging |
| T1458 | 996-1001 | GO:0007568 | denotes | aging |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T486 | 75-79 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T487 | 414-419 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T488 | 496-500 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T489 | 549-554 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1123 | 75-84 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell type |
| T1124 | 118-120 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
| T1125 | 196-203 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test as |
| T1126 | 326-331 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T1127 | 366-370 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T1128 | 414-419 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1129 | 496-506 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
| T1130 | 549-554 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1131 | 729-731 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
| T1132 | 932-934 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
| T1133 | 1047-1049 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T129 | 111-113 | Chemical | denotes | YA | http://purl.obolibrary.org/obo/CHEBI_74879 |
| T54395 | 118-120 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
| T44057 | 137-139 | Chemical | denotes | YH | http://purl.obolibrary.org/obo/CHEBI_73695 |
| T133 | 141-143 | Chemical | denotes | AH | http://purl.obolibrary.org/obo/CHEBI_73771 |
| T80739 | 729-731 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
| T136 | 736-738 | Chemical | denotes | YA | http://purl.obolibrary.org/obo/CHEBI_74879 |
| T9469 | 759-761 | Chemical | denotes | AH | http://purl.obolibrary.org/obo/CHEBI_73771 |
| T69573 | 766-768 | Chemical | denotes | YH | http://purl.obolibrary.org/obo/CHEBI_73695 |
| T34079 | 797-799 | Chemical | denotes | AH | http://purl.obolibrary.org/obo/CHEBI_73771 |
| T140 | 828-830 | Chemical | denotes | YH | http://purl.obolibrary.org/obo/CHEBI_73695 |
| T78586 | 932-934 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
| T1215 | 935-940 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T63662 | 958-960 | Chemical | denotes | YA | http://purl.obolibrary.org/obo/CHEBI_74879 |
| T145 | 961-966 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T146 | 1047-1049 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
| T52090 | 1050-1055 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T149 | 1073-1075 | Chemical | denotes | YA | http://purl.obolibrary.org/obo/CHEBI_74879 |
| T90180 | 1076-1081 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T297 | 584-589 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T298 | 881-886 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
| T299 | 996-1001 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T377 | 0-32 | Sentence | denotes | Differential expression analysis |
| T378 | 33-282 | Sentence | denotes | Differential expression analysis for each cell type between different groups (YA and AA in cohort-1 and YH, AH, YCR and ACR in cohort-3) was performed using the t-test as implemented in the ‘‘sc.tl.rank_genes_groups’’ function of the Scanpy package. |
| T379 | 283-420 | Sentence | denotes | For each cluster, differentially-expressed genes (DEGs) were performed using the t-test and generated relative to all of the other cells. |
| T380 | 421-580 | Sentence | denotes | Before executing the differential expression analysis, we filtered out the cell types that were missing or had fewer than three cells in the comparison groups. |
| T381 | 581-850 | Sentence | denotes | An aging-associated and disease-related DEG dataset was established (adjusted P value < 0.05, |Log2FC| > 0.25) after identification of DEGs between AA and YA groups in cohort-1, AH and YH groups in cohort-3, ACR and AH groups in cohort-3, YCR and YH groups in cohort-3. |
| T382 | 851-967 | Sentence | denotes | The ‘‘upregulated DEGs during aging’’ were defined as the DEGs that increased in AA group and decreased in YA group. |
| T383 | 968-1082 | Sentence | denotes | The ‘‘downregulated DEGs in aging’’ were defined as the DEGs that decreased in AA group and increased in YA group. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1462 | 292-299 | Species | denotes | cluster | Tax:100569 |
| 1463 | 141-143 | Disease | denotes | AH | MESH:D007039 |
| 1464 | 759-761 | Disease | denotes | AH | MESH:D007039 |
| 1465 | 797-799 | Disease | denotes | AH | MESH:D007039 |