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PMC:7417788 / 50814-51644 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1103 3-8 GO:0007568 denotes aging
T1104 24-29 SP_6;NCBITaxon:9606 denotes human
T1105 30-36 UBERON:0002405;CL:0000738 denotes immune
T1106 37-41 CL:0000738 denotes cell
T1107 97-102 GO:0007568 denotes aging
T1108 117-127 GO:0010467 denotes expression
T1109 131-141 SP_7 denotes SARS-CoV-2
T1110 157-162 SO:0000704 denotes genes
T1111 201-207 UBERON:0002405;CL:0000738 denotes immune
T1112 208-212 CL:0000738 denotes cell
T1113 262-267 GO:0007568 denotes aging
T1114 288-293 NCBITaxon:10239 denotes virus
T1115 307-315 SP_7 denotes COVID-19
T1116 335-344 GO:0030425;CL:0000451 denotes dendritic
T1117 345-350 CL:0000451 denotes cells
T1118 381-385 SO:0000704;GO:0010467 denotes gene
T1119 386-396 GO:0010467 denotes expression
T1120 413-420 CHEBI:59132;CHEBI:59132 denotes antigen
T1121 488-493 GO:0007568 denotes aging
T1122 560-568 CHEBI:35224;CHEBI:35224 denotes effector
T1123 679-685 UBERON:0002405;CL:0000738 denotes immune
T1124 686-691 CL:0000738 denotes cells
T1125 707-711 PR:000009232 denotes AP-1
T1126 748-754 GO:0007568 denotes ageing
T1127 821-829 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T365 37-41 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T366 208-212 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T367 335-350 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T368 345-350 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T369 381-385 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T370 451-455 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T371 636-640 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T372 641-652 Body_part denotes chromosomal http://purl.org/sig/ont/fma/fma67093
T373 686-691 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T374 766-770 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T98 131-139 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 242-254 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T100 288-303 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T101 294-303 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T102 307-315 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 821-829 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T905 24-29 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T906 37-41 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T907 157-162 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T908 178-181 http://purl.obolibrary.org/obo/CLO_0050938 denotes TCs
T909 178-181 http://purl.obolibrary.org/obo/CL_0000084 denotes TCs
T910 208-212 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T911 288-293 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T912 335-350 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T913 381-385 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T914 401-402 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T915 451-455 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T916 594-597 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T917 636-640 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T918 686-691 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T919 707-709 http://purl.obolibrary.org/obo/CLO_0001547 denotes AP
T920 766-776 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T66682 413-420 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T84787 560-568 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T89887 614-617 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T21 707-709 Chemical denotes AP http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T239 3-8 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T240 97-102 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T241 208-225 http://purl.obolibrary.org/obo/GO_0030010 denotes cell polarization
T242 242-254 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T243 262-267 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T244 381-396 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T245 488-493 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T246 748-754 http://purl.obolibrary.org/obo/GO_0007568 denotes ageing

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T260 0-830 Sentence denotes 1) aging reprograms the human immune cell landscape toward polarized and inflammatory states; 2) aging increases the expression of SARS-CoV-2 susceptibility genes, especially in TCs; 3) an increase in immune cell polarization and circulatory inflammation during aging can be amplified by virus infection in COVID-19; 4) age-associated dendritic cells have increased IFN-stimulated gene expression and a decreased antigen-presenting ability; 5) single-cell TCR and BCR analysis shows that aging is associated with decreased diversity and increased clonality of effector, cytotoxic and exhausted CD8+ TC subsets and ABC subset; 6) single-cell chromosomal accessibility profiles of immune cells shows that the AP-1 family TFs are the most affected by ageing across all cell types and subtypes and are further upregulated in COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1142 594-597 Gene denotes CD8 Gene:925
1143 707-711 Gene denotes AP-1 Gene:2353
1144 464-467 Gene denotes BCR Gene:613
1145 366-369 Gene denotes IFN Gene:3439
1146 456-459 Gene denotes TCR Gene:6962
1149 24-29 Species denotes human Tax:9606
1150 131-141 Species denotes SARS-CoV-2 Tax:2697049
1152 242-254 Disease denotes inflammation MESH:D007249
1153 288-303 Disease denotes virus infection MESH:D001102
1154 307-315 Disease denotes COVID-19 MESH:C000657245
1155 821-829 Disease denotes COVID-19 MESH:C000657245