PMC:7417788 / 50814-51644
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1103 | 3-8 | GO:0007568 | denotes | aging |
T1104 | 24-29 | SP_6;NCBITaxon:9606 | denotes | human |
T1105 | 30-36 | UBERON:0002405;CL:0000738 | denotes | immune |
T1106 | 37-41 | CL:0000738 | denotes | cell |
T1107 | 97-102 | GO:0007568 | denotes | aging |
T1108 | 117-127 | GO:0010467 | denotes | expression |
T1109 | 131-141 | SP_7 | denotes | SARS-CoV-2 |
T1110 | 157-162 | SO:0000704 | denotes | genes |
T1111 | 201-207 | UBERON:0002405;CL:0000738 | denotes | immune |
T1112 | 208-212 | CL:0000738 | denotes | cell |
T1113 | 262-267 | GO:0007568 | denotes | aging |
T1114 | 288-293 | NCBITaxon:10239 | denotes | virus |
T1115 | 307-315 | SP_7 | denotes | COVID-19 |
T1116 | 335-344 | GO:0030425;CL:0000451 | denotes | dendritic |
T1117 | 345-350 | CL:0000451 | denotes | cells |
T1118 | 381-385 | SO:0000704;GO:0010467 | denotes | gene |
T1119 | 386-396 | GO:0010467 | denotes | expression |
T1120 | 413-420 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T1121 | 488-493 | GO:0007568 | denotes | aging |
T1122 | 560-568 | CHEBI:35224;CHEBI:35224 | denotes | effector |
T1123 | 679-685 | UBERON:0002405;CL:0000738 | denotes | immune |
T1124 | 686-691 | CL:0000738 | denotes | cells |
T1125 | 707-711 | PR:000009232 | denotes | AP-1 |
T1126 | 748-754 | GO:0007568 | denotes | ageing |
T1127 | 821-829 | SP_7 | denotes | COVID-19 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T365 | 37-41 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T366 | 208-212 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T367 | 335-350 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
T368 | 345-350 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T369 | 381-385 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T370 | 451-455 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T371 | 636-640 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T372 | 641-652 | Body_part | denotes | chromosomal | http://purl.org/sig/ont/fma/fma67093 |
T373 | 686-691 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T374 | 766-770 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T98 | 131-139 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T99 | 242-254 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T100 | 288-303 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T101 | 294-303 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T102 | 307-315 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T103 | 821-829 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T905 | 24-29 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T906 | 37-41 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T907 | 157-162 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
T908 | 178-181 | http://purl.obolibrary.org/obo/CLO_0050938 | denotes | TCs |
T909 | 178-181 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | TCs |
T910 | 208-212 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T911 | 288-293 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T912 | 335-350 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
T913 | 381-385 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T914 | 401-402 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T915 | 451-455 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T916 | 594-597 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T917 | 636-640 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T918 | 686-691 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T919 | 707-709 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
T920 | 766-776 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T66682 | 413-420 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T84787 | 560-568 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T89887 | 614-617 | Chemical | denotes | ABC | http://purl.obolibrary.org/obo/CHEBI_421707 |
T21 | 707-709 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T239 | 3-8 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
T240 | 97-102 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
T241 | 208-225 | http://purl.obolibrary.org/obo/GO_0030010 | denotes | cell polarization |
T242 | 242-254 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T243 | 262-267 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
T244 | 381-396 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T245 | 488-493 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | aging |
T246 | 748-754 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | ageing |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T260 | 0-830 | Sentence | denotes | 1) aging reprograms the human immune cell landscape toward polarized and inflammatory states; 2) aging increases the expression of SARS-CoV-2 susceptibility genes, especially in TCs; 3) an increase in immune cell polarization and circulatory inflammation during aging can be amplified by virus infection in COVID-19; 4) age-associated dendritic cells have increased IFN-stimulated gene expression and a decreased antigen-presenting ability; 5) single-cell TCR and BCR analysis shows that aging is associated with decreased diversity and increased clonality of effector, cytotoxic and exhausted CD8+ TC subsets and ABC subset; 6) single-cell chromosomal accessibility profiles of immune cells shows that the AP-1 family TFs are the most affected by ageing across all cell types and subtypes and are further upregulated in COVID-19. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1142 | 594-597 | Gene | denotes | CD8 | Gene:925 |
1143 | 707-711 | Gene | denotes | AP-1 | Gene:2353 |
1144 | 464-467 | Gene | denotes | BCR | Gene:613 |
1145 | 366-369 | Gene | denotes | IFN | Gene:3439 |
1146 | 456-459 | Gene | denotes | TCR | Gene:6962 |
1149 | 24-29 | Species | denotes | human | Tax:9606 |
1150 | 131-141 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1152 | 242-254 | Disease | denotes | inflammation | MESH:D007249 |
1153 | 288-303 | Disease | denotes | virus infection | MESH:D001102 |
1154 | 307-315 | Disease | denotes | COVID-19 | MESH:C000657245 |
1155 | 821-829 | Disease | denotes | COVID-19 | MESH:C000657245 |