PMC:7417788 / 37852-38149 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T822","span":{"begin":84,"end":89},"obj":"GO:0007568"},{"id":"T823","span":{"begin":90,"end":96},"obj":"UBERON:0002405;CL:0000738"},{"id":"T824","span":{"begin":97,"end":102},"obj":"CL:0000738"},{"id":"T825","span":{"begin":150,"end":155},"obj":"SO:0000704"},{"id":"T826","span":{"begin":166,"end":171},"obj":"GO:0007568"},{"id":"T827","span":{"begin":250,"end":256},"obj":"UBERON:0002405"},{"id":"T828","span":{"begin":291,"end":296},"obj":"GO:0007568"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T304","span":{"begin":97,"end":102},"obj":"Body_part"}],"attributes":[{"id":"A304","pred":"fma_id","subj":"T304","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T699","span":{"begin":97,"end":102},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T700","span":{"begin":118,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T701","span":{"begin":150,"end":155},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T200","span":{"begin":84,"end":89},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T201","span":{"begin":166,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0007568"},{"id":"T202","span":{"begin":291,"end":296},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}

{"project":"LitCovid-sentences","denotations":[{"id":"T193","span":{"begin":0,"end":297},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}

{"project":"LitCovid-PubTator","denotations":[{"id":"804","span":{"begin":200,"end":203},"obj":"Gene"},{"id":"805","span":{"begin":208,"end":211},"obj":"Gene"}],"attributes":[{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"Gene:6962"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Gene:613"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Taken together, these data show that increased clonality and decreased diversity in aging immune cells, combined with a skewed use of variable region genes, underlie aging-associated abnormalities of TCR and BCR repertoires, elucidating the abnormal immune states and disease spectra during aging."}