PMC:7417788 / 36838-37246 JSONTXT

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T813","span":{"begin":23,"end":28},"obj":"GO:0007568"},{"id":"T814","span":{"begin":120,"end":125},"obj":"SO:0000704"},{"id":"T815","span":{"begin":292,"end":295},"obj":"CL:0002488"},{"id":"T816","span":{"begin":365,"end":373},"obj":"GO:0051866"},{"id":"T817","span":{"begin":374,"end":380},"obj":"GO:0006955;UBERON:0002405"}],"text":"To further explore the aging-associated changes on V(D)J rearrangements in TC and BC, we next examined the frequency of genes (variable region) in the YA and AA groups and found that the frequency of several TRAVs, TRBVs, IGHVs, IGKVs and IGLVs changed with age (Fig. S9A–E), indicating that TCs and BCs had experienced unique clonal V(D)J rearrangements under the adaptive immune environment of the elderly."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T690","span":{"begin":82,"end":88},"obj":"http://purl.obolibrary.org/obo/CLO_0001782"},{"id":"T691","span":{"begin":120,"end":125},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T692","span":{"begin":158,"end":160},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T693","span":{"begin":292,"end":295},"obj":"http://purl.obolibrary.org/obo/CLO_0050938"},{"id":"T694","span":{"begin":292,"end":295},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T695","span":{"begin":300,"end":303},"obj":"http://purl.obolibrary.org/obo/CL_0000236"}],"text":"To further explore the aging-associated changes on V(D)J rearrangements in TC and BC, we next examined the frequency of genes (variable region) in the YA and AA groups and found that the frequency of several TRAVs, TRBVs, IGHVs, IGKVs and IGLVs changed with age (Fig. S9A–E), indicating that TCs and BCs had experienced unique clonal V(D)J rearrangements under the adaptive immune environment of the elderly."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T304","span":{"begin":151,"end":153},"obj":"Chemical"},{"id":"T305","span":{"begin":158,"end":160},"obj":"Chemical"}],"attributes":[{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_74879"},{"id":"A305","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A306","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_72816"}],"text":"To further explore the aging-associated changes on V(D)J rearrangements in TC and BC, we next examined the frequency of genes (variable region) in the YA and AA groups and found that the frequency of several TRAVs, TRBVs, IGHVs, IGKVs and IGLVs changed with age (Fig. S9A–E), indicating that TCs and BCs had experienced unique clonal V(D)J rearrangements under the adaptive immune environment of the elderly."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T195","span":{"begin":23,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0007568"}],"text":"To further explore the aging-associated changes on V(D)J rearrangements in TC and BC, we next examined the frequency of genes (variable region) in the YA and AA groups and found that the frequency of several TRAVs, TRBVs, IGHVs, IGKVs and IGLVs changed with age (Fig. S9A–E), indicating that TCs and BCs had experienced unique clonal V(D)J rearrangements under the adaptive immune environment of the elderly."}

{"project":"LitCovid-sentences","denotations":[{"id":"T189","span":{"begin":0,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To further explore the aging-associated changes on V(D)J rearrangements in TC and BC, we next examined the frequency of genes (variable region) in the YA and AA groups and found that the frequency of several TRAVs, TRBVs, IGHVs, IGKVs and IGLVs changed with age (Fig. S9A–E), indicating that TCs and BCs had experienced unique clonal V(D)J rearrangements under the adaptive immune environment of the elderly."}