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PMC:7417788 / 26097-27296 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T612 38-43 GO:0007568 denotes aging
T613 292-298 PR:P25859 denotes cDC2-B
T614 305-315 GO:0010467 denotes expression
T615 329-333 PR:P24100 denotes cDC2
T616 351-358 CHEBI:59132;CHEBI:59132;GO:0019882 denotes antigen
T617 359-371 GO:0019882 denotes presentation
T618 380-385 SO:0000704 denotes genes
T619 394-397 PR:000003858 denotes AHR
T620 399-405 PR:000005570 denotes CLEC4E
T621 411-418 PR:000005559 denotes CLEC12A
T622 432-442 GO:0010467 denotes expression
T623 456-460 PR:P25859 denotes cDC2
T624 461-468 CL:0000236 denotes B cells
T625 495-500 GO:0007568 denotes aging
T626 512-517 SO:0000704 denotes genes
T627 541-546 SO:0000704 denotes genes
T628 548-552 PR:000001136 denotes IL1B
T629 554-560 PR:000005279 denotes CDKN2D
T630 562-567 PR:000006348 denotes DDIT4
T631 569-574 PR:000001395 denotes CXCL8
T632 580-585 PR:000006746 denotes DUSP2
T633 700-704 PR:P24100 denotes cDC2
T634 718-724 UBERON:0002405 denotes immune
T635 725-735 GO:0065007 denotes regulation
T636 740-747 CHEBI:59132;CHEBI:59132;GO:0019882 denotes antigen
T637 748-760 GO:0019882 denotes presentation
T638 777-782 GO:0007568 denotes aging
T639 791-797 PR:P25859 denotes cDC2-B
T640 808-816 PR:000002014 denotes HLA-DQA2
T641 817-827 GO:0010467 denotes expression
T642 969-976 PR:000005559 denotes CLEC12A
T643 1002-1007 GO:0007568 denotes aging
T644 1079-1084 GO:0007568 denotes aging
T645 1097-1104 CHEBI:59132;CHEBI:59132;GO:0019882 denotes antigen
T646 1105-1117 GO:0019882 denotes presentation
T647 1159-1164 GO:0007568 denotes aging
T648 1176-1180 SO:0000704;GO:0010467 denotes gene
T649 1181-1191 GO:0010467 denotes expression

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T236 117-120 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T237 132-137 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T238 217-222 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T239 336-341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 463-468 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 808-811 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T242 917-921 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T243 917-919 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T244 1176-1180 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T45 113-116 Disease denotes SNE http://purl.obolibrary.org/obo/MONDO_0018859
T46 1011-1015 Disease denotes FACS http://purl.obolibrary.org/obo/MONDO_0018262

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T511 132-137 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T512 205-206 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T513 217-222 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T514 226-228 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T515 269-273 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3, 4
T516 282-284 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T517 297-298 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T518 334-335 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T519 336-341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T520 380-385 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T521 461-468 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T522 512-517 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T523 541-546 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T524 548-552 http://purl.obolibrary.org/obo/PR_000001136 denotes IL1B
T525 705-706 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T526 796-797 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T527 861-870 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T528 922-931 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T529 1176-1180 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T530 1195-1198 http://purl.obolibrary.org/obo/CL_0000451 denotes DCs

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T163 147-149 Chemical denotes YA http://purl.obolibrary.org/obo/CHEBI_74879
T164 150-155 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T165 226-228 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T167 229-234 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T168 351-358 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T169 740-747 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T170 917-919 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T172 1097-1104 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T139 38-43 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T140 351-371 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T141 495-500 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T142 725-735 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T143 740-760 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T144 777-782 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T145 861-879 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T146 861-870 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T147 893-912 http://purl.obolibrary.org/obo/GO_0001666 denotes response to hypoxia
T148 922-931 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T149 1002-1007 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T150 1079-1084 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T151 1097-1117 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen presentation
T152 1159-1164 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T153 1176-1191 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T131 0-131 Sentence denotes Within DC clusters, we found distinct aging manifestations in the cDC2 subsets by comparing DC clusters in the t-SNE map (Fig. 3J).
T132 132-300 Sentence denotes Cells from the YA group grouped together in clusters 0 and 1 (named cDC2-A), whereas cells in AA group grouped distinctively in clusters 3, 4, 10 and 11 (named cDC2-B).
T133 301-605 Sentence denotes The expression signature of cDC2-A cells included antigen presentation-related genes such as AHR, CLEC4E, and CLEC12A, whereas the expression signature of cDC2-B cells included inflammatory and aging-associated genes such as IFN-stimulated genes, IL1B, CDKN2D, DDIT4, CXCL8, and DUSP2 (Fig. S7J and S7K).
T134 606-942 Sentence denotes Moreover, the comparative functional analysis of DEGs between the two clusters indicated that cDC2-A had intact immune regulation and antigen presentation function, while aging-related cDC2-B with high HLA-DQA2 expression exhibited increased inflammatory signaling pathways, such as the response to hypoxia and IL-1 signaling (Fig. 3K).
T135 943-1033 Sentence denotes We further confirmed that CLEC12A+ cDC2s were decreased in aging by FACS (Fig. 3L and 3M).
T136 1034-1199 Sentence denotes Taken together, these findings indicate that aging curtails DC antigen presentation ability and upregulates inflammatory and aging-associated gene expression in DCs.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 905-912 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
590 66-70 Gene denotes cDC2 Gene:983
591 394-397 Gene denotes AHR Gene:196
592 399-405 Gene denotes CLEC4E Gene:26253
593 411-418 Gene denotes CLEC12A Gene:160364
594 548-552 Gene denotes IL1B Gene:3553
595 554-560 Gene denotes CDKN2D Gene:1032
596 562-567 Gene denotes DDIT4 Gene:54541
597 569-574 Gene denotes CXCL8 Gene:3576
598 580-585 Gene denotes DUSP2 Gene:1844
599 808-816 Gene denotes HLA-DQA2 Gene:3118
600 917-921 Gene denotes IL-1 Gene:3553
601 969-976 Gene denotes CLEC12A Gene:160364
602 978-982 Gene denotes cDC2 Gene:983
603 329-333 Gene denotes cDC2 Gene:983
604 526-529 Gene denotes IFN Gene:3439
605 905-912 Disease denotes hypoxia MESH:D000860