PMC:7417788 / 20008-21937 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417788","sourcedb":"PMC","sourceid":"7417788","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417788","text":"Changes in transcriptional profiles during aging. (A) UpSet Plot showing the integrated comparative analysis of upregulated DEGs in major immune cell lineages between YA and AA groups. Upregulated DEGs: upregulated in AA, downregulated in YA group. (B) Representative GO terms and pathways enriched in upregulated DEGs based on functional enrichment analysis in major immune cell populations. P value was derived by a hypergeometric test. (C) Distribution and comparison of the aging score in immune cell populations. (D) Distribution and comparison of the aging score in all cells of each sample. (E) UpSet plot showing the integrated comparative analysis of upregulated DEGs in CD4+ T cells between YA and AA groups. Upregulated DEGs: upregulated in AA, downregulated in YA. The count showing the number of DEGs. (F) Representative GO terms and pathways enriched in upregulated DEGs based on functional enrichment analysis in CD4+ T cells. P value was derived by a hypergeometric test. (G) Venn diagram showing integrated comparative analysis of upregulated DEGs in monocytes between YA and AA groups. Upregulated DEGs: upregulated in AA, downregulated in YA. The count showing the number of DEGs. (H) Representative GO terms and pathways enriched in upregulated DEGs based on functional enrichment analysis in monocytes. P value was derived by a hypergeometric test. (I) Violin plots showing the distribution of normalized expression levels of selected aging-associated genes in all DC cluster between YA and AA groups. (J) t-SNE plots segregated on the basis of DC subsets. (K) Representative GO terms and pathways enriched in biased DEGs of cDC2-A and cDC2-B clusters. P value was derived by a hypergeometric test. (L) CLEC12A expression in cDC2 is shown as flow cytometry histogram. (M) Percentage of CLEC12A+ cells in cDC2. 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