PMC:7417114 / 80049-80889
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T400 | 196-200 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T132 | 196-200 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T723 | 51-59 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T724 | 100-131 | Disease | denotes | Waldenstrom’s macroglobulinemia | http://purl.obolibrary.org/obo/MONDO_0007926 |
T725 | 114-131 | Disease | denotes | macroglobulinemia | http://purl.obolibrary.org/obo/MONDO_0005190 |
T726 | 219-227 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T909 | 49-50 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T910 | 78-79 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T911 | 196-200 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T912 | 196-200 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T913 | 492-493 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T2881 | 154-163 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
T6567 | 382-391 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
T61850 | 508-517 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
T32325 | 598-607 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
T8528 | 637-655 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T37513 | 657-669 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
T30666 | 674-685 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T20833 | 761-770 | Chemical | denotes | ibrutinib | http://purl.obolibrary.org/obo/CHEBI_76612 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
2475 | 132-140 | Species | denotes | patients | Tax:9606 |
2476 | 228-236 | Species | denotes | patients | Tax:9606 |
2477 | 353-361 | Species | denotes | patients | Tax:9606 |
2478 | 481-488 | Species | denotes | patient | Tax:9606 |
2479 | 717-724 | Species | denotes | patient | Tax:9606 |
2480 | 154-163 | Chemical | denotes | ibrutinib | MESH:C551803 |
2481 | 382-391 | Chemical | denotes | ibrutinib | MESH:C551803 |
2482 | 508-517 | Chemical | denotes | ibrutinib | MESH:C551803 |
2483 | 598-607 | Chemical | denotes | ibrutinib | MESH:C551803 |
2484 | 637-655 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
2485 | 657-669 | Chemical | denotes | azithromycin | MESH:D017963 |
2486 | 674-685 | Chemical | denotes | tocilizumab | MESH:C502936 |
2487 | 761-770 | Chemical | denotes | ibrutinib | MESH:C551803 |
2488 | 51-59 | Disease | denotes | COVID-19 | MESH:C000657245 |
2489 | 114-131 | Disease | denotes | macroglobulinemia | MESH:D008258 |
2490 | 196-207 | Disease | denotes | lung damage | MESH:D008171 |
2491 | 211-227 | Disease | denotes | hypoxic COVID-19 | MESH:C000657245 |
2492 | 338-343 | Disease | denotes | COVID | MESH:C000657245 |
2493 | 534-541 | Disease | denotes | dyspnea | MESH:D004417 |
2494 | 546-553 | Disease | denotes | hypoxia | MESH:D000860 |
2495 | 704-711 | Disease | denotes | hypoxia | MESH:D000860 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T240 | 100-131 | Phenotype | denotes | Waldenstrom’s macroglobulinemia | http://purl.obolibrary.org/obo/HP_0005508 |
T241 | 534-541 | Phenotype | denotes | dyspnea | http://purl.obolibrary.org/obo/HP_0002094 |
T242 | 546-553 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
T243 | 704-711 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T601 | 0-293 | Sentence | denotes | Though not included on www.ClinicalTrials.gov as a COVID-19 trial, results of a clinical trial with Waldenstrom’s macroglobulinemia patients suggest that ibrutinib might confer protection against lung damage in hypoxic COVID-19 patients, and it may possibly improve respiratory function (165). |
T602 | 294-472 | Sentence | denotes | However, the study was small and involved 6 COVID-positive patients, 5 of whom received ibrutinib at 420 mg and presented with mild symptoms that did not require hospitalization. |
T603 | 473-686 | Sentence | denotes | The 6th patient on a lower dose of ibrutinib had progressive dyspnea and hypoxia and was placed on treatments in addition to ibrutinib at the lower dose, including hydroxychloroquine, azithromycin and tocilizumab. |
T604 | 687-840 | Sentence | denotes | Due to worsening hypoxia, the patient was eventually placed on the higher ibrutinib dose (420 mg) and this was followed by improvement of symptoms (165). |