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PMC:7417114 / 74243-75179 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T386 38-42 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T387 206-210 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T388 441-445 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T389 446-450 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T390 489-493 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T391 530-534 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T123 38-42 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T124 206-210 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T125 446-450 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T126 489-493 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 530-534 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T652 25-50 Disease denotes Interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T653 38-50 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T654 51-62 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T655 206-225 Disease denotes lung adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005061
T656 211-225 Disease denotes adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004970
T657 253-273 Disease denotes organizing pneumonia http://purl.obolibrary.org/obo/MONDO_0015265|http://purl.obolibrary.org/obo/MONDO_0056821
T659 264-273 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T660 431-457 Disease denotes non-small cell lung cancer http://purl.obolibrary.org/obo/MONDO_0005233
T661 435-457 Disease denotes small cell lung cancer http://purl.obolibrary.org/obo/MONDO_0008433
T662 446-457 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T663 451-457 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T664 476-501 Disease denotes interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T665 489-501 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T666 517-542 Disease denotes interstitial lung disease http://purl.obolibrary.org/obo/MONDO_0015925
T667 530-542 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T668 699-704 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T669 844-855 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T831 38-42 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T832 38-42 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T833 155-156 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T834 171-172 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T835 206-210 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T836 206-210 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T837 253-263 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizing
T838 365-366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T839 373-380 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T840 441-445 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T841 446-450 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T842 446-450 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T843 489-493 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T844 489-493 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T845 530-534 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T846 530-534 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T847 675-676 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T848 875-877 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T849 919-921 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T74266 14-24 Chemical denotes crizotinib http://purl.obolibrary.org/obo/CHEBI_64310
T9846 78-92 Chemical denotes ALK inhibitors http://purl.obolibrary.org/obo/CHEBI_62434
T68367 82-92 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35142 235-244 Chemical denotes ceritinib http://purl.obolibrary.org/obo/CHEBI_78432
T65233 335-346 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T79481 381-391 Chemical denotes crizotinib http://purl.obolibrary.org/obo/CHEBI_64310
T2655 604-614 Chemical denotes crizotinib http://purl.obolibrary.org/obo/CHEBI_64310
T64112 727-741 Chemical denotes ALK inhibitors http://purl.obolibrary.org/obo/CHEBI_62434
T98570 731-741 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T36968 753-763 Chemical denotes crizotinib http://purl.obolibrary.org/obo/CHEBI_64310
T44152 767-776 Chemical denotes ceritinib http://purl.obolibrary.org/obo/CHEBI_78432

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2216 0-9 Chemical denotes Ceritinib MESH:C586847
2217 14-24 Chemical denotes crizotinib MESH:D000077547
2244 78-81 Gene denotes ALK Gene:238
2245 180-183 Gene denotes ALK Gene:238
2246 418-421 Gene denotes ALK Gene:238
2247 727-730 Gene denotes ALK Gene:238
2248 123-131 Species denotes patients Tax:9606
2249 226-233 Species denotes patient Tax:9606
2250 310-317 Species denotes patient Tax:9606
2251 404-412 Species denotes patients Tax:9606
2252 577-585 Species denotes patients Tax:9606
2253 656-664 Species denotes patients Tax:9606
2254 705-713 Species denotes patients Tax:9606
2255 885-893 Species denotes patients Tax:9606
2256 235-244 Chemical denotes ceritinib MESH:C586847
2257 381-391 Chemical denotes crizotinib MESH:D000077547
2258 604-614 Chemical denotes crizotinib MESH:D000077547
2259 753-763 Chemical denotes crizotinib MESH:D000077547
2260 767-776 Chemical denotes ceritinib MESH:C586847
2261 38-50 Disease denotes lung disease MESH:D008171
2262 51-62 Disease denotes pneumonitis MESH:D011014
2263 206-225 Disease denotes lung adenocarcinoma MESH:D000077192
2264 264-273 Disease denotes pneumonia MESH:D011014
2265 446-457 Disease denotes lung cancer MESH:D008175
2266 476-501 Disease denotes interstitial lung disease MESH:D017563
2267 530-542 Disease denotes lung disease MESH:D008171
2268 699-704 Disease denotes NSCLC MESH:D002289
2269 844-855 Disease denotes pneumonitis MESH:D011014

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T219 25-50 Phenotype denotes Interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530
T220 206-225 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T221 264-273 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T222 431-457 Phenotype denotes non-small cell lung cancer http://purl.obolibrary.org/obo/HP_0030358
T223 476-501 Phenotype denotes interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530
T224 517-542 Phenotype denotes interstitial lung disease http://purl.obolibrary.org/obo/HP_0006530
T225 699-704 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T571 0-24 Sentence denotes Ceritinib and crizotinib
T572 25-151 Sentence denotes Interstitial lung disease/pneumonitis resulting from ALK inhibitors is relatively rare (1.2-8% of patients) (149) (150) (151).
T573 152-280 Sentence denotes In a case study of a Korean ALK-rearranged metastatic lung adenocarcinoma patient, ceritinib induced organizing pneumonia (152).
T574 281-361 Sentence denotes Treatment was ceased and the patient was treated with antibiotics and recovered.
T575 362-671 Sentence denotes In a study testing crizotinib in Japanese patients with ALK-positive non-small cell lung cancer, the incidence of interstitial lung disease was 5.77%, and interstitial lung disease developed within 4 weeks in 41.9% patients from the start of crizotinib treatment and within 8 weeks in 69.2% of patients (153).
T576 672-936 Sentence denotes In a clinical study of 250 NSCLC patients treated with ALK inhibitors, including crizotinib or ceritinib, the median time from the start of treatment to the development of pneumonitis, which occurred in 11 of the patients, was 5 months (range 0.5-11 months) (154).

2_test

Id Subject Object Predicate Lexical cue
32778962-28501140-84130828 134-137 28501140 denotes 149
32778962-25170012-84130829 140-143 25170012 denotes 150
32778962-28373069-84130830 146-149 28373069 denotes 151
32778962-30075548-84130831 275-278 30075548 denotes 152
32778962-30521972-84130832 666-669 30521972 denotes 153
32778962-31770246-84130833 931-934 31770246 denotes 154