PMC:7417114 / 71787-72808 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7417114","sourcedb":"PMC","sourceid":"7417114","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7417114","text":"Adverse pulmonary effects associated with kinase inhibitors\nPulmonary toxicity is reportedly a rare event with many targeted treatments. The incidence of lung toxicity with tyrosine kinase inhibitors is relatively low, although there is substantial variability in their occurrence with a reported range from 0.2-10.9% (139). However certain adverse side effects, such as pleural effusions associated with ABL inhibitors dasatinib or imatinib, interstitial lung disease associated with EGFR inhibitors erlotinib and gefitinib, or ALK inhibitors ceritinib or crizotinib, can occur but often reverse quickly with lowering the dose or terminating use (140). The timing of onset of toxicities following initial dosing needs to be considered for patients afflicted with cancer and other diseases, for whom therapy can be implemented for months, versus patients infected with a respiratory virus that require immediate treatment. Reported cases of adverse pulmonary effects for the listed kinase inhibitors are shown in Table 3.","divisions":[{"label":"title","span":{"begin":0,"end":59}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T379","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T380","span":{"begin":173,"end":181},"obj":"Body_part"},{"id":"T381","span":{"begin":456,"end":460},"obj":"Body_part"}],"attributes":[{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T379","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T380","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T381","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T114","span":{"begin":154,"end":158},"obj":"Body_part"},{"id":"T115","span":{"begin":371,"end":388},"obj":"Body_part"},{"id":"T116","span":{"begin":456,"end":460},"obj":"Body_part"}],"attributes":[{"id":"A114","pred":"uberon_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A115","pred":"uberon_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/UBERON_0000175"},{"id":"A116","pred":"uberon_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T637","span":{"begin":405,"end":408},"obj":"Disease"},{"id":"T638","span":{"begin":443,"end":468},"obj":"Disease"},{"id":"T639","span":{"begin":456,"end":468},"obj":"Disease"},{"id":"T640","span":{"begin":764,"end":770},"obj":"Disease"}],"attributes":[{"id":"A637","pred":"mondo_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/MONDO_0008692"},{"id":"A638","pred":"mondo_id","subj":"T638","obj":"http://purl.obolibrary.org/obo/MONDO_0015925"},{"id":"A639","pred":"mondo_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A640","pred":"mondo_id","subj":"T640","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"subj":"T637","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T638","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T639","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T640","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T807","span":{"begin":93,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T808","span":{"begin":154,"end":158},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T809","span":{"begin":154,"end":158},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T810","span":{"begin":286,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T811","span":{"begin":371,"end":388},"obj":"http://purl.obolibrary.org/obo/UBERON_0000175"},{"id":"T812","span":{"begin":456,"end":460},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T813","span":{"begin":456,"end":460},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T814","span":{"begin":869,"end":870},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T815","span":{"begin":883,"end":888},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T807","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T808","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T809","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T810","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T811","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T812","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T813","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T814","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T815","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T60963","span":{"begin":49,"end":59},"obj":"Chemical"},{"id":"T52449","span":{"begin":173,"end":199},"obj":"Chemical"},{"id":"T1076","span":{"begin":173,"end":181},"obj":"Chemical"},{"id":"T81990","span":{"begin":189,"end":199},"obj":"Chemical"},{"id":"T25612","span":{"begin":405,"end":419},"obj":"Chemical"},{"id":"T30778","span":{"begin":405,"end":408},"obj":"Chemical"},{"id":"T61830","span":{"begin":409,"end":419},"obj":"Chemical"},{"id":"T39752","span":{"begin":420,"end":429},"obj":"Chemical"},{"id":"T15980","span":{"begin":433,"end":441},"obj":"Chemical"},{"id":"T72694","span":{"begin":485,"end":500},"obj":"Chemical"},{"id":"T69317","span":{"begin":490,"end":500},"obj":"Chemical"},{"id":"T76169","span":{"begin":501,"end":510},"obj":"Chemical"},{"id":"T88632","span":{"begin":515,"end":524},"obj":"Chemical"},{"id":"T78274","span":{"begin":529,"end":543},"obj":"Chemical"},{"id":"T69870","span":{"begin":533,"end":543},"obj":"Chemical"},{"id":"T8198","span":{"begin":544,"end":553},"obj":"Chemical"},{"id":"T59696","span":{"begin":557,"end":567},"obj":"Chemical"},{"id":"T242","span":{"begin":989,"end":999},"obj":"Chemical"}],"attributes":[{"id":"A3142","pred":"chebi_id","subj":"T60963","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A45036","pred":"chebi_id","subj":"T52449","obj":"http://purl.obolibrary.org/obo/CHEBI_38637"},{"id":"A63302","pred":"chebi_id","subj":"T1076","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A84644","pred":"chebi_id","subj":"T81990","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A11815","pred":"chebi_id","subj":"T25612","obj":"http://purl.obolibrary.org/obo/CHEBI_76617"},{"id":"A58629","pred":"chebi_id","subj":"T30778","obj":"http://purl.obolibrary.org/obo/CHEBI_30805"},{"id":"A3560","pred":"chebi_id","subj":"T61830","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A17986","pred":"chebi_id","subj":"T39752","obj":"http://purl.obolibrary.org/obo/CHEBI_49375"},{"id":"A20142","pred":"chebi_id","subj":"T39752","obj":"http://purl.obolibrary.org/obo/CHEBI_70839"},{"id":"A87308","pred":"chebi_id","subj":"T15980","obj":"http://purl.obolibrary.org/obo/CHEBI_45783"},{"id":"A40118","pred":"chebi_id","subj":"T72694","obj":"http://purl.obolibrary.org/obo/CHEBI_74440"},{"id":"A95531","pred":"chebi_id","subj":"T69317","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A38409","pred":"chebi_id","subj":"T76169","obj":"http://purl.obolibrary.org/obo/CHEBI_114785"},{"id":"A34574","pred":"chebi_id","subj":"T88632","obj":"http://purl.obolibrary.org/obo/CHEBI_49668"},{"id":"A14657","pred":"chebi_id","subj":"T78274","obj":"http://purl.obolibrary.org/obo/CHEBI_62434"},{"id":"A61636","pred":"chebi_id","subj":"T69870","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A50532","pred":"chebi_id","subj":"T8198","obj":"http://purl.obolibrary.org/obo/CHEBI_78432"},{"id":"A52389","pred":"chebi_id","subj":"T59696","obj":"http://purl.obolibrary.org/obo/CHEBI_64310"},{"id":"A18275","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T60963","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52449","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1076","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81990","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25612","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30778","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61830","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39752","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15980","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T72694","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69317","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T76169","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88632","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78274","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69870","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8198","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59696","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2136","span":{"begin":405,"end":408},"obj":"Gene"},{"id":"2137","span":{"begin":485,"end":489},"obj":"Gene"},{"id":"2138","span":{"begin":529,"end":532},"obj":"Gene"},{"id":"2139","span":{"begin":740,"end":748},"obj":"Species"},{"id":"2140","span":{"begin":846,"end":854},"obj":"Species"},{"id":"2141","span":{"begin":420,"end":429},"obj":"Chemical"},{"id":"2142","span":{"begin":433,"end":441},"obj":"Chemical"},{"id":"2143","span":{"begin":501,"end":510},"obj":"Chemical"},{"id":"2144","span":{"begin":515,"end":524},"obj":"Chemical"},{"id":"2145","span":{"begin":544,"end":553},"obj":"Chemical"},{"id":"2146","span":{"begin":557,"end":567},"obj":"Chemical"},{"id":"2147","span":{"begin":60,"end":78},"obj":"Disease"},{"id":"2148","span":{"begin":154,"end":167},"obj":"Disease"},{"id":"2149","span":{"begin":371,"end":388},"obj":"Disease"},{"id":"2150","span":{"begin":456,"end":468},"obj":"Disease"},{"id":"2151","span":{"begin":677,"end":687},"obj":"Disease"},{"id":"2152","span":{"begin":764,"end":770},"obj":"Disease"},{"id":"2153","span":{"begin":855,"end":863},"obj":"Disease"}],"attributes":[{"id":"A2136","pred":"tao:has_database_id","subj":"2136","obj":"Gene:25"},{"id":"A2137","pred":"tao:has_database_id","subj":"2137","obj":"Gene:1956"},{"id":"A2138","pred":"tao:has_database_id","subj":"2138","obj":"Gene:238"},{"id":"A2139","pred":"tao:has_database_id","subj":"2139","obj":"Tax:9606"},{"id":"A2140","pred":"tao:has_database_id","subj":"2140","obj":"Tax:9606"},{"id":"A2141","pred":"tao:has_database_id","subj":"2141","obj":"MESH:D000069439"},{"id":"A2142","pred":"tao:has_database_id","subj":"2142","obj":"MESH:D000068877"},{"id":"A2143","pred":"tao:has_database_id","subj":"2143","obj":"MESH:D000069347"},{"id":"A2144","pred":"tao:has_database_id","subj":"2144","obj":"MESH:D000077156"},{"id":"A2145","pred":"tao:has_database_id","subj":"2145","obj":"MESH:C586847"},{"id":"A2146","pred":"tao:has_database_id","subj":"2146","obj":"MESH:D000077547"},{"id":"A2147","pred":"tao:has_database_id","subj":"2147","obj":"MESH:D008171"},{"id":"A2148","pred":"tao:has_database_id","subj":"2148","obj":"MESH:D008171"},{"id":"A2149","pred":"tao:has_database_id","subj":"2149","obj":"MESH:D010996"},{"id":"A2150","pred":"tao:has_database_id","subj":"2150","obj":"MESH:D008171"},{"id":"A2151","pred":"tao:has_database_id","subj":"2151","obj":"MESH:D064420"},{"id":"A2152","pred":"tao:has_database_id","subj":"2152","obj":"MESH:D009369"},{"id":"A2153","pred":"tao:has_database_id","subj":"2153","obj":"MESH:D007239"},{"subj":"2136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2153","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T210","span":{"begin":371,"end":388},"obj":"Phenotype"},{"id":"T211","span":{"begin":443,"end":468},"obj":"Phenotype"},{"id":"T212","span":{"begin":764,"end":770},"obj":"Phenotype"}],"attributes":[{"id":"A210","pred":"hp_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/HP_0002202"},{"id":"A211","pred":"hp_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/HP_0006530"},{"id":"A212","pred":"hp_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"subj":"T210","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T221","span":{"begin":42,"end":59},"obj":"http://purl.obolibrary.org/obo/GO_0033673"},{"id":"T222","span":{"begin":182,"end":199},"obj":"http://purl.obolibrary.org/obo/GO_0033673"},{"id":"T223","span":{"begin":485,"end":489},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T224","span":{"begin":982,"end":999},"obj":"http://purl.obolibrary.org/obo/GO_0033673"}],"attributes":[{"subj":"T221","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T554","span":{"begin":0,"end":59},"obj":"Sentence"},{"id":"T555","span":{"begin":60,"end":136},"obj":"Sentence"},{"id":"T556","span":{"begin":137,"end":324},"obj":"Sentence"},{"id":"T557","span":{"begin":325,"end":653},"obj":"Sentence"},{"id":"T558","span":{"begin":654,"end":922},"obj":"Sentence"},{"id":"T559","span":{"begin":923,"end":1021},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T554","pred":"source","obj":"LitCovid-sentences"},{"subj":"T555","pred":"source","obj":"LitCovid-sentences"},{"subj":"T556","pred":"source","obj":"LitCovid-sentences"},{"subj":"T557","pred":"source","obj":"LitCovid-sentences"},{"subj":"T558","pred":"source","obj":"LitCovid-sentences"},{"subj":"T559","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32778962-22252615-84130818","span":{"begin":319,"end":322},"obj":"22252615"},{"id":"32778962-22076388-84130819","span":{"begin":648,"end":651},"obj":"22076388"}],"attributes":[{"subj":"32778962-22252615-84130818","pred":"source","obj":"2_test"},{"subj":"32778962-22076388-84130819","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#e5ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#d993ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecbf"},{"id":"LitCovid-PD-CLO","color":"#eca593"},{"id":"LitCovid-PD-CHEBI","color":"#939aec"},{"id":"LitCovid-PubTator","color":"#b4ec93"},{"id":"LitCovid-PD-HP","color":"#ec93ce"},{"id":"LitCovid-PD-GO-BP","color":"#93e8ec"},{"id":"LitCovid-sentences","color":"#ecd593"},{"id":"2_test","color":"#bb93ec"}]}]}}