PMC:7417114 / 70644-71785
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T373 | 396-398 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T374 | 549-553 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T375 | 671-680 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T376 | 804-813 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T377 | 996-1004 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T378 | 1094-1102 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T113 | 549-553 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T625 | 249-269 | Disease | denotes | aspiration pneumonia | http://purl.obolibrary.org/obo/MONDO_0000265|http://purl.obolibrary.org/obo/MONDO_0002572 |
| T627 | 260-269 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T628 | 304-333 | Disease | denotes | idiopathic pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0008345 |
| T629 | 315-333 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T630 | 489-506 | Disease | denotes | neuroinflammation | http://purl.obolibrary.org/obo/MONDO_0004466 |
| T631 | 554-566 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T632 | 581-603 | Disease | denotes | pneumococcal pneumonia | http://purl.obolibrary.org/obo/MONDO_0005972 |
| T633 | 594-603 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T634 | 857-875 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T635 | 1118-1124 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T636 | 1125-1134 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T794 | 117-160 | http://purl.obolibrary.org/obo/PR_000001971 | denotes | vascular endothelial growth factor receptor |
| T795 | 365-373 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T796 | 478-479 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T797 | 524-527 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T798 | 549-553 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T799 | 549-553 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T800 | 570-571 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T801 | 605-608 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 133 |
| T802 | 650-658 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T803 | 763-771 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T804 | 958-967 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T805 | 1014-1015 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T806 | 1016-1021 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T70760 | 28-38 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T15602 | 83-91 | Chemical | denotes | axitinib | http://purl.obolibrary.org/obo/CHEBI_66910 |
| T58583 | 207-213 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T76532 | 386-391 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T70815 | 396-398 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T52057 | 819-828 | Chemical | denotes | sunitinib | http://purl.obolibrary.org/obo/CHEBI_38940 |
| T36046 | 839-848 | Chemical | denotes | bleomycin | http://purl.obolibrary.org/obo/CHEBI_22907 |
| T92485 | 897-906 | Chemical | denotes | Sunitinib | http://purl.obolibrary.org/obo/CHEBI_38940 |
| T27318 | 1044-1053 | Chemical | denotes | sunitinib | http://purl.obolibrary.org/obo/CHEBI_38940 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2092 | 108-115 | Gene | denotes | VEGFR-3 | Gene:2324 |
| 2093 | 117-162 | Gene | denotes | vascular endothelial growth factor receptor-3 | Gene:2324 |
| 2094 | 382-391 | Gene | denotes | TNF-alpha | Gene:7124 |
| 2095 | 396-400 | Gene | denotes | IL-6 | Gene:3569 |
| 2096 | 719-723 | Gene | denotes | CDK9 | Gene:1025 |
| 2097 | 943-948 | Gene | denotes | PDGFR | Gene:18596 |
| 2098 | 1090-1093 | Gene | denotes | TNF | Gene:7124 |
| 2099 | 879-883 | Species | denotes | mice | Tax:10090 |
| 2100 | 1016-1021 | Species | denotes | mouse | Tax:10090 |
| 2101 | 83-91 | Chemical | denotes | axitinib | MESH:D000077784 |
| 2102 | 207-213 | Chemical | denotes | oxygen | MESH:D010100 |
| 2103 | 277-287 | Chemical | denotes | Nintedanib | MESH:C530716 |
| 2104 | 431-440 | Chemical | denotes | Ibrutinib | MESH:C551803 |
| 2105 | 611-620 | Chemical | denotes | Alvocidib | MESH:C077990 |
| 2106 | 731-740 | Chemical | denotes | Pazopanib | MESH:C516667 |
| 2107 | 819-828 | Chemical | denotes | sunitinib | MESH:D000077210 |
| 2108 | 839-848 | Chemical | denotes | bleomycin | MESH:D001761 |
| 2109 | 897-906 | Chemical | denotes | Sunitinib | MESH:D000077210 |
| 2110 | 1044-1053 | Chemical | denotes | sunitinib | MESH:D000077210 |
| 2111 | 249-269 | Disease | denotes | aspiration pneumonia | MESH:D011015 |
| 2112 | 304-333 | Disease | denotes | idiopathic pulmonary fibrosis | MESH:D054990 |
| 2113 | 489-522 | Disease | denotes | neuroinflammation-related disease | MESH:D000076082 |
| 2114 | 549-566 | Disease | denotes | lung inflammation | MESH:D011014 |
| 2115 | 581-603 | Disease | denotes | pneumococcal pneumonia | MESH:D011008 |
| 2116 | 857-875 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 2117 | 1125-1134 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T205 | 249-269 | Phenotype | denotes | aspiration pneumonia | http://purl.obolibrary.org/obo/HP_0011951 |
| T206 | 315-333 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T207 | 594-603 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T208 | 857-875 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T209 | 996-1010 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T216 | 21-38 | http://purl.obolibrary.org/obo/GO_0033673 | denotes | kinase inhibitors |
| T217 | 138-144 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T218 | 185-202 | http://purl.obolibrary.org/obo/GO_0001946 | denotes | lymphangiogenesis |
| T219 | 554-566 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T220 | 958-967 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T547 | 0-276 | Sentence | denotes | Among numerous other kinase inhibitors with demonstrated therapeutic potential are axitinib, which, through VEGFR-3 (vascular endothelial growth factor receptor-3) inhibition, improved lymphangiogenesis and oxygen saturation in preclinical model of aspiration pneumonia (128). |
| T548 | 277-430 | Sentence | denotes | Nintedanib is approved for idiopathic pulmonary fibrosis and displays anti-inflammatory activity through TNF-alpha and IL-6 inhibition (129) (130) (131). |
| T549 | 431-610 | Sentence | denotes | Ibrutinib exerted anti-inflammatory effects in a model of neuroinflammation-related disease (132) and mitigated acute lung inflammation in a model of pneumococcal pneumonia (133). |
| T550 | 611-730 | Sentence | denotes | Alvocidib also shows anti-inflammatory activity by blocking leukocyte-endothelial association by inhibiting CDK9 (134). |
| T551 | 731-896 | Sentence | denotes | Pazopanib exhibits antifibrotic activity through modulating inflammatory cytokines, and sunitinib inhibited bleomycin-induced pulmonary fibrosis in mice (135) (136). |
| T552 | 897-1034 | Sentence | denotes | Sunitinib, believed to primarily work through PDGFR-mediated signaling, was also shown to suppress cytokine storm in a mouse model (137). |
| T553 | 1035-1141 | Sentence | denotes | Finally, sunitinib was shown to synergize with an anti-TNF antibody against lethal dengue infection (138). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32778962-25348279-84130807 | 271-274 | 25348279 | denotes | 128 |
| 32778962-29327616-84130808 | 413-416 | 29327616 | denotes | 129 |
| 32778962-31217321-84130809 | 419-422 | 31217321 | denotes | 130 |
| 32778962-31646446-84130810 | 425-428 | 31646446 | denotes | 131 |
| 32778962-30231870-84130811 | 524-527 | 30231870 | denotes | 132 |
| 32778962-30646846-84130812 | 605-608 | 30646846 | denotes | 133 |
| 32778962-21088252-84130813 | 725-728 | 21088252 | denotes | 134 |
| 32778962-27439438-84130814 | 885-888 | 27439438 | denotes | 135 |
| 32778962-26269412-84130815 | 891-894 | 26269412 | denotes | 136 |
| 32778962-31039345-84130816 | 1029-1032 | 31039345 | denotes | 137 |
| 32778962-30071205-84130817 | 1136-1139 | 30071205 | denotes | 138 |