PMC:7417114 / 69501-70243 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T368","span":{"begin":137,"end":146},"obj":"Body_part"},{"id":"T369","span":{"begin":289,"end":297},"obj":"Body_part"},{"id":"T370","span":{"begin":302,"end":306},"obj":"Body_part"},{"id":"T371","span":{"begin":612,"end":617},"obj":"Body_part"}],"attributes":[{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma7197"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T111","span":{"begin":302,"end":306},"obj":"Body_part"},{"id":"T112","span":{"begin":612,"end":617},"obj":"Body_part"}],"attributes":[{"id":"A111","pred":"uberon_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A112","pred":"uberon_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T619","span":{"begin":194,"end":202},"obj":"Disease"},{"id":"T620","span":{"begin":251,"end":269},"obj":"Disease"},{"id":"T621","span":{"begin":260,"end":269},"obj":"Disease"},{"id":"T622","span":{"begin":318,"end":323},"obj":"Disease"},{"id":"T623","span":{"begin":336,"end":340},"obj":"Disease"},{"id":"T624","span":{"begin":536,"end":554},"obj":"Disease"}],"attributes":[{"id":"A619","pred":"mondo_id","subj":"T619","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A620","pred":"mondo_id","subj":"T620","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A621","pred":"mondo_id","subj":"T621","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A622","pred":"mondo_id","subj":"T622","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A623","pred":"mondo_id","subj":"T623","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A624","pred":"mondo_id","subj":"T624","obj":"http://purl.obolibrary.org/obo/MONDO_0002771"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T780","span":{"begin":63,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T781","span":{"begin":219,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0001053"},{"id":"T782","span":{"begin":225,"end":228},"obj":"http://purl.obolibrary.org/obo/CLO_0001053"},{"id":"T783","span":{"begin":235,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T784","span":{"begin":302,"end":306},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T785","span":{"begin":302,"end":306},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T786","span":{"begin":349,"end":354},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T787","span":{"begin":428,"end":431},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T788","span":{"begin":453,"end":459},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T789","span":{"begin":558,"end":559},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T790","span":{"begin":612,"end":617},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T791","span":{"begin":612,"end":617},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T31825","span":{"begin":4,"end":8},"obj":"Chemical"},{"id":"T73974","span":{"begin":40,"end":47},"obj":"Chemical"},{"id":"T74929","span":{"begin":96,"end":100},"obj":"Chemical"},{"id":"T59466","span":{"begin":277,"end":287},"obj":"Chemical"},{"id":"T95336","span":{"begin":401,"end":405},"obj":"Chemical"},{"id":"T35704","span":{"begin":485,"end":494},"obj":"Chemical"},{"id":"T18580","span":{"begin":496,"end":505},"obj":"Chemical"},{"id":"T3241","span":{"begin":518,"end":527},"obj":"Chemical"},{"id":"T20152","span":{"begin":685,"end":689},"obj":"Chemical"}],"attributes":[{"id":"A40911","pred":"chebi_id","subj":"T31825","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A73365","pred":"chebi_id","subj":"T73974","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A79438","pred":"chebi_id","subj":"T74929","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A77496","pred":"chebi_id","subj":"T59466","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A39935","pred":"chebi_id","subj":"T95336","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A9031","pred":"chebi_id","subj":"T35704","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A15061","pred":"chebi_id","subj":"T18580","obj":"http://purl.obolibrary.org/obo/CHEBI_50924"},{"id":"A38425","pred":"chebi_id","subj":"T3241","obj":"http://purl.obolibrary.org/obo/CHEBI_22907"},{"id":"A16787","pred":"chebi_id","subj":"T20152","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2032","span":{"begin":0,"end":8},"obj":"Gene"},{"id":"2033","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"2034","span":{"begin":72,"end":76},"obj":"Gene"},{"id":"2035","span":{"begin":92,"end":100},"obj":"Gene"},{"id":"2036","span":{"begin":397,"end":405},"obj":"Gene"},{"id":"2037","span":{"begin":642,"end":647},"obj":"Gene"},{"id":"2038","span":{"begin":681,"end":689},"obj":"Gene"},{"id":"2039","span":{"begin":695,"end":701},"obj":"Gene"},{"id":"2040","span":{"begin":194,"end":202},"obj":"Species"},{"id":"2041","span":{"begin":203,"end":211},"obj":"Species"},{"id":"2042","span":{"begin":235,"end":240},"obj":"Species"},{"id":"2043","span":{"begin":496,"end":505},"obj":"Chemical"},{"id":"2044","span":{"begin":518,"end":527},"obj":"Chemical"},{"id":"2045","span":{"begin":251,"end":269},"obj":"Disease"},{"id":"2046","span":{"begin":336,"end":340},"obj":"Disease"},{"id":"2047","span":{"begin":536,"end":554},"obj":"Disease"},{"id":"2048","span":{"begin":600,"end":608},"obj":"Disease"},{"id":"2049","span":{"begin":612,"end":626},"obj":"Disease"}],"attributes":[{"id":"A2032","pred":"tao:has_database_id","subj":"2032","obj":"Gene:7039"},{"id":"A2033","pred":"tao:has_database_id","subj":"2033","obj":"Gene:1956"},{"id":"A2034","pred":"tao:has_database_id","subj":"2034","obj":"Gene:1956"},{"id":"A2035","pred":"tao:has_database_id","subj":"2035","obj":"Gene:7039"},{"id":"A2036","pred":"tao:has_database_id","subj":"2036","obj":"Gene:7039"},{"id":"A2037","pred":"tao:has_database_id","subj":"2037","obj":"Gene:6774"},{"id":"A2038","pred":"tao:has_database_id","subj":"2038","obj":"Gene:7039"},{"id":"A2039","pred":"tao:has_database_id","subj":"2039","obj":"Gene:5156"},{"id":"A2040","pred":"tao:has_database_id","subj":"2040","obj":"Tax:694009"},{"id":"A2041","pred":"tao:has_database_id","subj":"2041","obj":"Tax:9606"},{"id":"A2042","pred":"tao:has_database_id","subj":"2042","obj":"Tax:10090"},{"id":"A2043","pred":"tao:has_database_id","subj":"2043","obj":"MESH:D000077157"},{"id":"A2044","pred":"tao:has_database_id","subj":"2044","obj":"MESH:D001761"},{"id":"A2045","pred":"tao:has_database_id","subj":"2045","obj":"MESH:C000657245"},{"id":"A2046","pred":"tao:has_database_id","subj":"2046","obj":"MESH:D012128"},{"id":"A2047","pred":"tao:has_database_id","subj":"2047","obj":"MESH:D011658"},{"id":"A2048","pred":"tao:has_database_id","subj":"2048","obj":"MESH:D005355"},{"id":"A2049","pred":"tao:has_database_id","subj":"2049","obj":"MESH:D008103"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T203","span":{"begin":536,"end":554},"obj":"Phenotype"},{"id":"T204","span":{"begin":612,"end":626},"obj":"Phenotype"}],"attributes":[{"id":"A203","pred":"hp_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"id":"A204","pred":"hp_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/HP_0001395"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T209","span":{"begin":35,"end":39},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T210","span":{"begin":72,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T211","span":{"begin":318,"end":331},"obj":"http://purl.obolibrary.org/obo/GO_0042060"},{"id":"T212","span":{"begin":478,"end":494},"obj":"http://purl.obolibrary.org/obo/GO_0033673"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T540","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T541","span":{"begin":78,"end":361},"obj":"Sentence"},{"id":"T542","span":{"begin":362,"end":473},"obj":"Sentence"},{"id":"T543","span":{"begin":474,"end":742},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}

{"project":"2_test","denotations":[{"id":"32778962-15030519-84130801","span":{"begin":213,"end":216},"obj":"15030519"},{"id":"32778962-15602737-84130802","span":{"begin":219,"end":222},"obj":"15602737"},{"id":"32778962-19420084-84130803","span":{"begin":356,"end":359},"obj":"19420084"},{"id":"32778962-9259574-84130804","span":{"begin":468,"end":471},"obj":"9259574"},{"id":"32778962-23764846-84130805","span":{"begin":579,"end":582},"obj":"23764846"},{"id":"32778962-26039995-84130806","span":{"begin":737,"end":740},"obj":"26039995"}],"text":"TGF-beta induces the expression of EGFR ligands, which in turn activate EGFR. Of relevance, TGF-beta was one of several pro-inflammatory cytokines that were observed to be highly upregulated in SARS-CoV patients (120) (121) (122), and mouse models of SARS-CoV infection showed interferon, cytokine and lung-associated wound-healing and ARDS-related genes (123). These findings are consistent with TGF-beta being profibrotic, as has been demonstrated in animal models (124). The kinase inhibitor, sorafenib, attenuated bleomycin-induced pulmonary fibrosis in a preclinical model (125) and ameliorated fibrosis in liver fibrosis models through STAT3 inhibition and downregulation of TGF-beta- and PDGFRβ-mediated pathways of fibrogenesis (126)."}